<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3I6</accession>
    <name>R1E3I6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdaD</name>
        <name evidence="7" type="ORF">Nst1_625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PdaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42208">
        <property type="protein sequence ID" value="EOD42208"/>
        <property type="gene ID" value="Nst1_625"/>
    </dbReference>
    <dbReference type="OMA" id="SEHHSFG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5023311571" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023311570" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="161" mass="18234" checksum="EFA3FB712A4E0156" modified="2013-06-26" version="1">MNPRSLVPKKVFFTSGIGVADDPLLSFEYALRDAKIERFNLVPVSSIAPPNVKIIDIDEGLKHLKAGQVVFCVLSRFTSNEEGKEIFSSVGVALPKDKKYNGYFTEYHGYYTGKEEGYAKNMAKNMLKSIYNIEIDREFEIFRKTKVEKYSTVISAAVFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3N9</accession>
    <name>R1E3N9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Nst1_528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42268">
        <property type="protein sequence ID" value="EOD42268"/>
        <property type="gene ID" value="Nst1_528"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.512"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="329"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOD42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="443" mass="49322" checksum="749A4545992B1BD2" modified="2013-06-26" version="1">MKKTKIVATIGPSSIDKIKELDKYVDVYRINFSHGDKKSHEEYFKIIRENSEKPILVDLPGPKLRIGNLKEKILLKPGDKIIFSQDEGIPVEDPLFYKVVKENTEIYLDDGNIKVHIDKIDNNRVEGTVLDGGMLTSRKGINIPDINLDSGVTQRDLELLKEALDLGADFIGVSFVLSKEDIIKVKEIVKNKAWVIAKIETKKALNDLENIIKVSDGVMVARGDLGVDIGFQNLIFAQKRIIKISRLYGKPVILATQVLESMVNNTVPTRAEIIDASVSVLEGVDAIMLSDETAIGNYPIDSVKILEEIILNVEKELKPELLPPNNIDDSIAAGAVSTSEFDNDIKLIVAHSRTGNSIISVSRLRPKQIIIGITPNKKLYRKLYLLYGVYPELEGAESKDILDIINNSKVIAKKYINNGYILILGGDPKSEIGRTDFIKIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3S5</accession>
    <name>R1E3S5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42303">
        <property type="protein sequence ID" value="EOD42303"/>
        <property type="gene ID" value="Nst1_563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="70" mass="8087" checksum="0CDFBF249FF0EE28" modified="2013-06-26" version="1">MGLIHIGGLKILNIKLKYYIVNHYIIMVDQNTILELIKLRSNARRKNLGSNTKAIRNLRKKMARENIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3V5</accession>
    <name>R1E3V5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42333">
        <property type="protein sequence ID" value="EOD42333"/>
        <property type="gene ID" value="Nst1_491"/>
    </dbReference>
    <dbReference type="OMA" id="FGWQIVK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="210" mass="22352" checksum="ABDB474C2591C2D0" modified="2013-06-26" version="1">MANEDSIGKALTRVIIYSVIFVIAMGIVQWFFTAGLQILYNMTGIGAILGLENYSIYAIILVLIIFGWFVIVAVASMFYAIFKPKYGESTASAIRSLIKILGIGGLFAGIAGAVGGGVAGVALGGFIGMVIGFATQQILGQAIAGIFLLLSRPFEIGDVIDVAGETDIKVLDINAMFTKALRTDGNIVLIPNNMIISQKIVIKKKNNEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3W0</accession>
    <name>R1E3W0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine dimer DNA glycosylase, T4 endoV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42338">
        <property type="protein sequence ID" value="EOD42338"/>
        <property type="gene ID" value="Nst1_496"/>
    </dbReference>
    <dbReference type="OMA" id="MRLWSIH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="151" mass="18279" checksum="554C51A97E39704E" modified="2013-06-26" version="1">MRLWSLHPKYLDKLGLLGLWREALLAQKVLLGKTKGYRNHPQLIRFKKTEDPILYIGTYLYYVYLEGKRRGYNFNKDKIIKYDLNLKMPVTIGQINFEFQHLLEKLKVRDKEKYEEIKDEKTIEPNPIFYIIDGDIEEWEKDKKVLNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Y0</accession>
    <name>R1E3Y0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain, predicted RNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42358">
        <property type="protein sequence ID" value="EOD42358"/>
        <property type="gene ID" value="Nst1_517"/>
    </dbReference>
    <dbReference type="OMA" id="ADFPYEG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="186" mass="21728" checksum="4E7A90A752B54A11" modified="2013-06-26" version="1">MKHLQFLGKYVDDIIKGNKNLTIRLSKGNLKPGDIFILHAGGKVIGKFRVKNIYTKKLYQITDEEAKRDGYNNKEELINDLKRIYKRLDLNREVAIIEFEPIEIINNISSEEFAWGGKKIDLIELAKLILKYDEKLNEKERKLLNILIESGSLRKAAIKLGGLNKRYIIRKILKKGFYRLKEKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Z2</accession>
    <name>R1E3Z2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tmcA</name>
        <name evidence="13" type="ORF">Nst1_401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42368">
        <property type="protein sequence ID" value="EOD42368"/>
        <property type="gene ID" value="Nst1_401"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.387"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUF1726" evidence="11">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase_RecD" evidence="10">
        <location>
            <begin position="246"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="462"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="9">
        <location>
            <begin position="553"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="770" mass="90704" checksum="A18DE025F73C39D6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E437</accession>
    <name>R1E437_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42403">
        <property type="protein sequence ID" value="EOD42403"/>
        <property type="gene ID" value="Nst1_437"/>
    </dbReference>
    <dbReference type="OMA" id="LIAWINK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="282" mass="33082" checksum="FDAAEA3EBD877D7A" modified="2013-06-26" version="1">MVTNAGAEFYAAKEKYENAKTPEEKLKYLYEMLKTAPKHKGSEHLIAWINKKISEYEKIIEEGKYKKGGSGIKLIEKSGDILISILGIENSGKSYFLRKFTNANVEVSEIPFSTINPAIGTIFYNCVYYQFVEIPSTFERKFRSILSLSDYYILILDEKRDIKEQLERINKFSEGIIEFSTIPNNKYKIIYNKFDDFKDVNLQEILENIIKDLDLIRIKPIDSDHCVILNKESTIKDFIEKINKKWIDKFRYAKIIRENKIIRAGLNYKLEDKDIIELKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4B7</accession>
    <name>R1E4B7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42242">
        <property type="protein sequence ID" value="EOD42242"/>
        <property type="gene ID" value="Nst1_659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="257" mass="30044" checksum="E380FB0C5C35548D" modified="2013-06-26" version="1">MGNIIILFLIFVSLYLYIFKIIYSSLFIIFAIFLFLVAYFNSNEILIVKTKIYEKISKIYKYKKYIFLLIFLIIILQIIIAINKLLLYNGLIIESSTGKYIIYEYESLIFLSIYEFIIYFLVYRNLRYNNYTSYFLLFTMVLIIFFGELYLSNVDFTSAALHTRYLIAMLFFFMGIHHKIYKNSKRVITKALGISIGILILLQNITGEFLESVLFGGPSSIHLVSIPNILIALGIIHGLVTPILILTFIYLHIKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G9</accession>
    <name>R1E4G9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42518">
        <property type="protein sequence ID" value="EOD42518"/>
        <property type="gene ID" value="Nst1_248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="70" mass="8080" checksum="0439A9ED0DC08A17" modified="2013-06-26" version="1">MKYIVDIDYSKCINCLACYLINKNVFSIENNRIIIKNNIISSEEDIEDIKTAAKACPTNAIYYQEILDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4H6</accession>
    <name>R1E4H6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42528">
        <property type="protein sequence ID" value="EOD42528"/>
        <property type="gene ID" value="Nst1_258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="56" mass="6631" checksum="2957B2601A7FC54B" modified="2013-06-26" version="1">MGNKIGECKYCNRPVYDDEKYRIINLNGEKMIFHISCFRKLKKEAIDLAKKGFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4I8</accession>
    <name>R1E4I8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase subunit secY/sec61 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42548">
        <property type="protein sequence ID" value="EOD42548"/>
        <property type="gene ID" value="Nst1_278"/>
    </dbReference>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="131"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOD42548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="451" mass="49909" checksum="E04367A52357FE72" modified="2013-06-26" version="1">MNIIDKIVSYLPTVEEPKKLLSLRERVYNTLLVIALYTVLASIPLFGISPEVSARLEQFLWLFGSNLGTLASVGIAPVVVAGIFMQLLVGLGIINIDINTDEGKTKFDNYARFIAIIFIIIESIILIVSGNISPNIFLGINPIILYIILFLQLFIGGLIILLLDDFSYKYGITSGINIIILTTISIALALRLFNPLSPPSSSPSLFAQPTGYIPEGILYLSQGNINLGLAFLFAAMVTIGILIFAVYLQSLKIEVPLLYLNINGEIIKYPIQLLYTSVIPAIFIYALIIELQSLFGFNPNNPIVQLLSPPNIIINIGQFGIDYLYVPFNIFHIIFYFLLFTIGGMFISKFWIYATGLDPKNLANYLTSNPNSPLYTRDPRIVEDMLKKYIDPIGYLSGFLMGLLASLGDILSSAVSGVSILLLIVIAGQIYNDLKRVDALYLIPLIGKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4J8</accession>
    <name>R1E4J8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein, required for N-linked glycosylation</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Nst1_577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42317">
        <property type="protein sequence ID" value="EOD42317"/>
        <property type="gene ID" value="Nst1_577"/>
    </dbReference>
    <dbReference type="OMA" id="YPYWNHL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="28"/>
            <end position="49"/>
        </location>
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        </location>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOD42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="1175" mass="137375" checksum="20B5F56F91CA5FA3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4K4</accession>
    <name>R1E4K4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42573">
        <property type="protein sequence ID" value="EOD42573"/>
        <property type="gene ID" value="Nst1_303"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="124" mass="14972" checksum="89869BD9306C9F20" modified="2013-06-26" version="1">MNKLLKLRKIIKRKKPYYFRFQWWKVIKLRNKKESWRRPRGIHNKIRRKLKSRVSMVEVGYGSPKEIRGLLPNGKKPVLVHNIEELEKIDKEKECAIIASNVGKRKREQIINRAKELNIEIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4M4</accession>
    <name>R1E4M4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THUMP domain associated with SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42603">
        <property type="protein sequence ID" value="EOD42603"/>
        <property type="gene ID" value="Nst1_333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="119" mass="14368" checksum="21BCD1818D70F0C7" modified="2013-06-26" version="1">MENYIIPSTSQILIFLILSFALIVSTYTRKYIEDDIEKYYKKMGIISFIILISLIYFNYYIIIFIFIYLLIYRKNYKNFIIALQTSIIIFLSLLNTINSYYEFSLILLFIIFSSFSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4M8</accession>
    <name>R1E4M8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein, contains TRAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42608">
        <property type="protein sequence ID" value="EOD42608"/>
        <property type="gene ID" value="Nst1_338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="69" mass="7450" checksum="BF307373872F1B95" modified="2013-06-26" version="1">MAVRGIKVGDVYEVEIKSLTQRGDGFARINGVATFVKNVNVGWKGNVKVVKVGPTYVVAEPVVSEESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4P0</accession>
    <name>R1E4P0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42628">
        <property type="protein sequence ID" value="EOD42628"/>
        <property type="gene ID" value="Nst1_360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.346"/>
    <dbReference type="OMA" id="MLDIHVA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="97"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="398" mass="46445" checksum="F921303F373E2E14" modified="2013-06-26" version="1">MKNLFRIIDILKKNRIINKLYGFIKKYPFYIILGILLLIYTYQTVSVFYPINSYISDEVWYAPSSYNIMTKIFHLNINQTVPFPSGKDLTNYFNLEHPPLAKYIIGVFIYFLGYNYWVWRIPSWILGDLIIILSFLITRKIVGNSIFGNIAGIITSVLIISDPNMWVMHGIATLDIYVSFFSLLSLYYLIKDDILKSSISFGLAFSSKFPGAFLIFPLLYYIKGINISRIKRFLYVVILPLLVYLSLNLPLIIYFGFSSWFNQSFLGALEWDITSGHIVNAPNQISSPWQWLLNIHPFDLGTYSGNDLYLNSFHALVNNYIMILWLILTPLIFILKDKKVTVSYLYPLSIYLGFFLVYFLGNTTIFTYYITDFMPMVYVYVVSSLFLLGLRYYKNLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Q9</accession>
    <name>R1E4Q9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42653">
        <property type="protein sequence ID" value="EOD42653"/>
        <property type="gene ID" value="Nst1_385"/>
    </dbReference>
    <dbReference type="OMA" id="YLESIVW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="375" mass="44527" checksum="B0DD6EDD3574A5BD" modified="2013-06-26" version="1">MDLPKISIIFPIYKKSKHLENNIKKILEDPYPNDLKEIIISIDSPEDDFLNKLMELKSKYKNITLVISRERRGKVSATNDAVKISSGEILFFFDADVFIDYINIKGIVDELKEYDIIEFYKEIIKKGWLGYLMFIEFSLYFDIIDPILNKTKSPLFLNGSGFATKKSVWNDVEGYSKVYVEDVDFAMKAGKKGYKYHMSKNVILLIEPLKSLRQWIDQRKRWSFGLIEVILNHLDYMVAFFIQNMLISIFILLILYLPYLIWTYIYIYLPASFLYQIAIGMYENLSKNISFIYLIILNPTSIFKVFYILYLTLLYTILTSSYIYLLISIKRRKLYNFLSFILFSVLYIPLYEIILIYDIIYYGIFERAPKMNWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4S2</accession>
    <name>R1E4S2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42382">
        <property type="protein sequence ID" value="EOD42382"/>
        <property type="gene ID" value="Nst1_415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="387" mass="46432" checksum="F3FD95531421BA41" modified="2013-06-26" version="1">MDLNKDIDIIDEFFSYVKNFNNRLLEIKRNLNNFVSREEFNNQLRALKEELENVEKILNNYKEILNEDLLDKVRYLNDLKLRVDVLENNQKNFVDYSAIVNIKSKINKLEFDINSLSNKITKYEDVINSVKDLRNKIEDLNDKLNKIEDSYTNINDFNDLKLKVSNLTNLLSKTLDNLSKDLLQYNKISEMISEIKEKDLYNVNSKLEEIEKKYEEKYSEINNKISNMNYLLQLTNDDIKNIKQFKAYEELYNKYVNFENRLNSIYALFEELNNLVVDLRSKVNDIDKIEEINEKYNKLEEGLNNIKEEIRKIKAELYDSKDILESVLSDYENLMNRIKKIENFIDLTNFEYIINEIEKIKIIENDIENIKRLLLSKNIKVEEEYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4S8</accession>
    <name>R1E4S8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42673">
        <property type="protein sequence ID" value="EOD42673"/>
        <property type="gene ID" value="Nst1_011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="52" mass="5910" checksum="7DC32E63E27C5F59" modified="2013-06-26" version="1">MIMIKINKVNMIIFGVIILLGILTYVLTHSKTLSIIPFIIGIFYLLESNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4T2</accession>
    <name>R1E4T2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replicative DNA helicase Mcm</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42678">
        <property type="protein sequence ID" value="EOD42678"/>
        <property type="gene ID" value="Nst1_016"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.16"/>
    <dbReference type="OMA" id="MHAKARL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="272"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="666" mass="75892" checksum="775D940B3DAE6A5A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4U7</accession>
    <name>R1E4U7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42698">
        <property type="protein sequence ID" value="EOD42698"/>
        <property type="gene ID" value="Nst1_037"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.36"/>
    <dbReference type="OMA" id="TINYNGH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="378" mass="41763" checksum="E669F16129971B05" modified="2013-06-26" version="1">MKPFKNSKGGLDDILHKVEDKVKGDFRNFKDKVDESLKYLDERLEDVRDKTYYGLQKVKGGILEYGIAIKDKIEKLPEYLDKKLEEIKYKILEYGPKIMLSALPSPARVSISEGLYIMNADKSPRGKLIGYGLIIVGAGTSIVYFIMVGLNAIHSLPSNNEHVQYLGSGYIAFVPNGQTINYNGHIDPEGELILPNGSEIKNVIWDGQYSNTIIQNHNQIVQLNNQFVGQTDPINGQPYVPLQDLYVIDANNSQVPIQQAIINGQTYYVIEANNINPGNIAGFYTYDNWVSNFVEAMNTPGTYAAGLPGNSPVYDWTNTTGTVAYQTELYGHYGLGGGGLVLVQPNGTVISYGENINIPAGTYLSNFVAPQQVYNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4V4</accession>
    <name>R1E4V4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42708">
        <property type="protein sequence ID" value="EOD42708"/>
        <property type="gene ID" value="Nst1_047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="495" mass="58102" checksum="61A7B367557BDF62" modified="2013-06-26" version="1">MKTSLAPVALFVGVIILVLFGIFYLNSQIQLATQSLKYLSEDYIAYQGFLYILFVYIPFDIRYNLLNNLFTNIFSGSTYNINYVFGNNVPNYYSQCEIPFLFNLTNIENNGNNYNVIYSLCVPVIPLNNVNNYQNIENIFFNIGSTVKKDLNQEIEYLNGNLNFKHANFSYQDFYYDGSNNFILANPQYSFFVLNKYERNLFFPQLNNQIDYSIYPFLLYYNELIDYLYNQTFQFIYYNLTNQSDYIYLYQNAYSEETIGDNLYLNFSFNNPYYYVLDLYTSQLLPVEYPNITNVTIAIPCESVGQIVNNQCIVNNIYSEYMQECLNNTSAILSKLNYQVLNKINIFNGYWYNITGVNIINEKNVEVDKNFVENILENYTYYTDGYYPALIPVDIQINYNNVSCSINNETLQFGPYTDSFDCSLSLVIINSLSSCIVESECYNNNGNYYFNATCNISEAYVNNQFTYNYYLYEFVKINDETMNNYCDNSYCYIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4X7</accession>
    <name>R1E4X7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42733">
        <property type="protein sequence ID" value="EOD42733"/>
        <property type="gene ID" value="Nst1_072"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.70"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="813" mass="91864" checksum="7DF5CA876F6253EC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1E513</accession>
    <name>R1E513_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERCC4-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42778">
        <property type="protein sequence ID" value="EOD42778"/>
        <property type="gene ID" value="Nst1_117"/>
    </dbReference>
    <dbReference type="OMA" id="HRAVGNY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
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        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="181"/>
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    </feature>
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            <end position="500"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="748" mass="87518" checksum="4A39B05137C54B54" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E527</accession>
    <name>R1E527_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHH/CopG DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42462">
        <property type="protein sequence ID" value="EOD42462"/>
        <property type="gene ID" value="Nst1_190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="65" mass="7693" checksum="47E55D8B375DB533" modified="2013-06-26" version="1">MNIKNQKSSVINIFEVLKKALREKIKRKEEEKMLEAIKRLGELLEKTGATPEETIKIIREIREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E529</accession>
    <name>R1E529_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42798">
        <property type="protein sequence ID" value="EOD42798"/>
        <property type="gene ID" value="Nst1_137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="128" mass="14655" checksum="EC619980158B52B1" modified="2013-06-26" version="1">MIRELIYLFILFVAGYFVLSTFFNFYSSAGKIIANEISNITTPTYESQVNYIVNYYNYGNYSILYLVQNINPSNCINSIEVGNTMVNFTYKVLNQYTIELNISYPVNAGNNLTITFCNGQSSLYYISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E534</accession>
    <name>R1E534_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative archaeal flagellar protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42467">
        <property type="protein sequence ID" value="EOD42467"/>
        <property type="gene ID" value="Nst1_195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="148" mass="17014" checksum="985B9B0F7A244AAB" modified="2013-06-26" version="1">MRSDLGSIIGAIIGFVIFIVSASVLYLILNNYYKNFYYTANSIDNQIKNIVGENIKFLNNQTNYANPYLIIYNNGNKALDLSCFQLYVNGYFSPFNYSINYLYPLNLLLPGENATVYFNNNHLVNNSWNYIILVSCYGVKFQTLIYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E537</accession>
    <name>R1E537_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42808">
        <property type="protein sequence ID" value="EOD42808"/>
        <property type="gene ID" value="Nst1_147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="197" mass="22978" checksum="E51A0044DA99F602" modified="2013-06-26" version="1">MYDQPADKSSEGKSELLEKIDKWLLEYDIKELKNSLNEIVENIKERVGISKIEGSYTSISLYCCNRDNGRMWCKYDSKIEIYNKGKKISCEPNIPFLPDKLECINYRDKSLFEISNLRDKLSYIEGKILDIHKTAYPGVLMNLGNQSITISIDTYIDSKQETKKANSKIIKDNNSLIYEKDGFYIRIYWHTDEPCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E592</accession>
    <name>R1E592_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA-processing protein RRP41/SKI6</fullName>
            <ecNumber evidence="4">3.1.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42512">
        <property type="protein sequence ID" value="EOD42512"/>
        <property type="gene ID" value="Nst1_242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="3">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="252" mass="28066" checksum="98D63EA9625F6DFA" modified="2013-06-26" version="1">MVKRFDGREYNELRKINIKLNVIDNAKGSAIFSFGDTVALAAVYGPKPSKMSLDYDKAFLRVRYNMLTFSTPERKKPTPGRREIELSEVIKRALEPALLLEEIPGSIIDVYVEILNADAGTRTASINAASLALSLAGIPMKDLVIGLAVGKVGEKIVVDLNKEEEDYDSEKLRKDPEKSKYIEYYGEGRATDIPVAIIPSEKKFTLIQLDGEISNRELNDALNLALEKALEIKNLMKSNILKHLSSSGNFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E599</accession>
    <name>R1E599_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42522">
        <property type="protein sequence ID" value="EOD42522"/>
        <property type="gene ID" value="Nst1_252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="626" mass="69717" checksum="C368BEFB1C03DDBB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5G2</accession>
    <name>R1E5G2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42622">
        <property type="protein sequence ID" value="EOD42622"/>
        <property type="gene ID" value="Nst1_352"/>
    </dbReference>
    <dbReference type="OMA" id="KMCHISK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="108" mass="12840" checksum="6882F2158AF90AB4" modified="2013-06-26" version="1">MTLRCELFVKELLPSIRKELSKILYDNYKMSQEEIADKLSITQSAVSQYLKGIRGKSYFEFDKEDKIILIKMAELLKNDKNIKLIDLQSMLCQLCEKRYKYVKCYIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5G6</accession>
    <name>R1E5G6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42627">
        <property type="protein sequence ID" value="EOD42627"/>
        <property type="gene ID" value="Nst1_359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="397" mass="45218" checksum="9E859FFA0BB84297" modified="2013-06-26" version="1">MNVKGILAVLIIVLIIFGIIHYLIYQSKTYGNGNILKLVIYNPTNCTVYSPFQQEIYINSSIMKEYKINENGSNVFFFINLSNITGSILYSWFAGYYNNYSIWWVRLPTPISPYSNITIYMYIGPVGENYYEEYSPYVGISSYVYNNYSWGPLSIYDNGQFVFDFYGWFYDTRDNWILNVENGNYFPTPTINGIEMINYSLSQGSYIEPPNDGSIPNIPIIIEEGWYYNGEADANVISMYGGKSVTYAAGANMFGGYTPTLLNSIFVQYEYYNLQPAIYISYANEEAPIQLYEGPFINKNQSYIYSYFLVNFCNNTYIQAGYLAVNNTPPISLLGTLENTNQTLKIGIDRNLLSGDYFSINSGSGPQSTSSQSIYWVVGRTYPPDGIMPEVYIESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5N1</accession>
    <name>R1E5N1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42707">
        <property type="protein sequence ID" value="EOD42707"/>
        <property type="gene ID" value="Nst1_046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="160" mass="18326" checksum="70158A8D1CCCB101" modified="2013-06-26" version="1">MKIQIGFFLSFIAAVIIVIVLLFIFLFNIFSYGNPTLNNIASLNAVGIEYKSANGFLDSLIYFDNVTVPVIDIYAGFYNNTALDNYIINELANEELYYLNNSTTILSFYFNNNTIIGVCPNKEYINYDVYLNGESYTFYVCPPTVLYNFYVNYSSYITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5Q4</accession>
    <name>R1E5Q4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prephenate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42732">
        <property type="protein sequence ID" value="EOD42732"/>
        <property type="gene ID" value="Nst1_071"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.69"/>
    <dbReference type="OMA" id="HNHAIHE"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="177" mass="20625" checksum="532E6C3473B97FC0" modified="2013-06-26" version="1">MGIKLFLASKDGKIKNTLYTNHYAYKESEESIKNLNINKIEFVSSTSEAAKLAKENNSMCICSKLAVENYGLNIIKEINIENNYTKFALISNKPSYEGNRSIILFTIKNKPGALYNVLKIFYKENINLTMIYSRPLKTIPWEYYFYLEFEGKYNKKLLEKLKSVTEILKFKGSYKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E617</accession>
    <name>R1E617_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42832">
        <property type="protein sequence ID" value="EOD42832"/>
        <property type="gene ID" value="Nst1_172"/>
    </dbReference>
    <dbReference type="OMA" id="IWIDHED"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD_assoc" evidence="1">
        <location>
            <begin position="196"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="507" mass="59530" checksum="D68970307AE5E58F" modified="2013-06-26" version="1">MKIEKPEIHYNALDVLANQIVGMTLEYGEVNVDLVWDTIKRSYIYKDLTYEEFLNIINFLDSIKILIYDRENKKLIKTRKGLFYFLDNISMIPDEKSYDVYDITTGQKIGILHEEFVAKHGNPGTIFILRSLPWKIEKIEKKKIFVGLEKDFESAIPSWEGELLPVPLEVAQEAQEIKRDLLNFDELKNQELYFYPNKDNIYIEQYRDWFIIHSPFGSKINDALSRLISQILSEKYGIVVGIKTDPYRIMLKAGYVTKENIKEVIENIDLDNVENILEKAIVNTDLFLWKFSHVAKRFGVIRKDADYSKSTLRRILDHLIGTPVYKETLNELFIEKLDVKNLKMILKKIKERKIKVNIVDRENISPLAILGLEEYVSDVLISDKWREVLKLVKERIENTELIFVCMACGTKYKIKVKDYDEKFKCKKCGGQYFGVAKSEKDLEDEKKLNITAELLRNYGKKFVFIYAGKGISYLSAKFLLKKEYKNEDELLMNIIEYEKRGIKFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSU1</accession>
    <name>R1FSU1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42190">
        <property type="protein sequence ID" value="EOD42190"/>
        <property type="gene ID" value="Nst1_607"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.588"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="293" mass="33876" checksum="C23F814C0D3EF6E6" modified="2013-06-26" version="1">MLEDLKKASEITKKVKREAEKLLKPGESIYNIAETIEQKIIDLGGFPSFPVNISINNIAAHYTPTINDNTILKDGDVVKFDFGAQVNGYCIDTAFTVEINDNKYKDLIEASRNALENVKKIIKKDIEISEIGKVIENTIKSYNYNPIYNLSGHKIEQYILHSKITIPNYDNKSKIKLNEGIYAIEPFATNGIGFVKEGKPSGIYSIISDKPIRDPNVKKFFQEIYNKYKTLPFAYRWLYKDYNNKINLKLFIEYLKKNGNIYEYPILVEQSNGIVSQFETTFYIYDRVYDMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSW0</accession>
    <name>R1FSW0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42210">
        <property type="protein sequence ID" value="EOD42210"/>
        <property type="gene ID" value="Nst1_627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="271" mass="30720" checksum="BCD0061A02737D7F" modified="2013-06-26" version="1">MVYDLLISIGYFIGFLVLGGIIGYFVGWIVYKVLNWLFTKYVKIENIYEKLKSTFSKMPEINVAVLLSYLGGVILGILVFNSVLSLMPNLLTATQYSYVSNILQLTMMVSSTLLLISIVVLIIAAGVIFSIFFTSYLYILIEGYNSHIAELLRLLLFLGFVWIITYYSLQLLGFQYTLFDNIIGVFVILSIGLIVMKYITENISENTYYKNVRPFIQIFIYSIFVISSLSVLTVGYSNISASVENIFAWGFVILFVLTLVPVLVKAIRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT01</accession>
    <name>R1FT01_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42255">
        <property type="protein sequence ID" value="EOD42255"/>
        <property type="gene ID" value="Nst1_596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="211"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="534" mass="64898" checksum="287A5D4DAEEB9612" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT05</accession>
    <name>R1FT05_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (pseudouridine(54)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmY</name>
        <name evidence="6" type="ORF">Nst1_602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:55292"/>
            <dbReference type="Rhea" id="RHEA-COMP:14140"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="EC" id="2.1.1.257"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. TrmY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.257" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42260">
        <property type="protein sequence ID" value="EOD42260"/>
        <property type="gene ID" value="Nst1_602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18087">
        <property type="entry name" value="TrmY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00587">
        <property type="entry name" value="tRNA_methyltr_TrmY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40703">
        <property type="entry name" value="PTHR40703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="24161" checksum="63F242BB5F1CBB38" modified="2013-06-26" version="1">MRIFIFYSNTIRTDGNFKNIYYSGRLDIAINSIIHAFFVSNGLRKNIRFDLYLNGKPVPPRLIRIESDINTPWSKKDISTLLSISLKKYNKKNIKNPFPGIYVDKIDFFDLLDEYKNNGKNIYLLDKDGEFIENIKIENPVFIIGDFLGIPKDIKKKIDSDVIKISLGDINYFSSQVIVILNYYLDKMNFERDIYDTSYKFIYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT97</accession>
    <name>R1FT97_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secredted protein (TAT signal)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42335">
        <property type="protein sequence ID" value="EOD42335"/>
        <property type="gene ID" value="Nst1_493"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.477"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="329" mass="36035" checksum="DD867CE7F9248406" modified="2013-06-26" version="1">MGLTRRDFLKALLISGAGFLGGFVGGYLSSPKTNEIIYEGNATETVTITVTETYTSNTTVTETVTGTTTQTNTTTTTTTQPQSQPQSLEQILFGNSNKQFIPLKLTGAQIGINNAYLTVYDYLTNTKLQMKIPIKYVSNGNINIGNILSAVNAYNRQYGTNYKVYLVLGRAGLSQAILQNGEWILPDSQIPYNIVISDRDWQDVYNAFQNLLNGNAMVVMPTSNQGPYSNSLWEWINGIGSVIILYQDGQQVNSVGNDINLADYILGTPGNSNPSSGGILHVDTIANVQQIGTYQSQQGQQYPVYEINDYYGTYIVLIQSQGTSLFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTA4</accession>
    <name>R1FTA4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Nst1_498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42340">
        <property type="protein sequence ID" value="EOD42340"/>
        <property type="gene ID" value="Nst1_498"/>
    </dbReference>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="125"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="432" mass="50027" checksum="5EC7DA7DA5C63DA5" modified="2013-06-26" version="1">MKFSIITLGCTLNKAEGDIMKNILIKKGYQYTENPDESEILIINTCTVKGPTESKAIKLINKYKDKKLILAGCLVQHQPELFKGYPLIGLDHIDEVDKVLEDYLNGKIDVLIDRKNINKLLLPSVDQYPIKTIILQEGCLWNCLYCATKLARGNAKSYPPEYIYKEVRDAKLKGLKIIYFTGTDLATYGYDLNIDLADLLFGLKDIKGEYYVRVGMANPGILNKFIDKLLESYDNENIFKFFHIPVQSGSNNVLKTMGRGYSIEDFYELVEKIRKKYYEGAIATDIIVGYPTETEEDFRKTLELVENIKFDIINISKYWSRPKTLSSKLYKQLPGHIVKERSRKLKIIFNKYSYERNKQWINWEGYAIVESKGKYENTWIARNYAYKQIIVKSDKNILGKTIKVKINNATPIDLRGELIEIKEENLLEKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTA9</accession>
    <name>R1FTA9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42345">
        <property type="protein sequence ID" value="EOD42345"/>
        <property type="gene ID" value="Nst1_504"/>
    </dbReference>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="9">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="552" mass="64438" checksum="EAA6BDB5797DC20D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTJ8</accession>
    <name>R1FTJ8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42420">
        <property type="protein sequence ID" value="EOD42420"/>
        <property type="gene ID" value="Nst1_455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="250" mass="30392" checksum="D324854C64CF83BB" modified="2013-06-26" version="1">MNLYQIFYQYFIYPVIGYQYQYNIYNTFLYGLLFVVGFILFYYLFVKNKKVIIDRYFLLDLIILTTIFIIPRVNIDLGYTIKTYLLFTPLLELWILISFLPVLFLYKYRKYYLYILLVILILEIPFFIFGRPINLLPSLIFILLFSILIYLSYTEKLFYLSIFGEIYETIFSIISVYYFNLQSEHQLLNILIFQYNNPLLFYGLKLFLTLFIALYTKYYLKDDLRNVIYLMLFYLGFLPGLRTSLIDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTR6</accession>
    <name>R1FTR6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42475">
        <property type="protein sequence ID" value="EOD42475"/>
        <property type="gene ID" value="Nst1_203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="314" mass="37020" checksum="02EF3E5AE383E035" modified="2013-06-26" version="1">MDKGVFIILDGLGDNLIKELRYKTPLEDAKKPNIDKLVRYSECGLLYIKERGHIPKCIESNLSLLGYDFKYDELIFKALVYKELKENQFLIEIESKEDPKIEDIYDIIKYKDNNYILIFDNYDKKIIKKLKKYKIKNKTIYKDLNKKDLFENKYKVKALYLSSSLIHLSIAKYLKIDYEKPLGTTGKSNENLFSFSEYAIANRNKYDIIFIHIRAPDILSHLKNPFKKKKIIEEIDEYLIKRIKEYFDVILITGDHSTSSIKGRHISDPVPVMIYSKYSRYGFVKNFSERKCIKGTLGILNSKDIIKIFIDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTU4</accession>
    <name>R1FTU4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein containing a von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42490">
        <property type="protein sequence ID" value="EOD42490"/>
        <property type="gene ID" value="Nst1_219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="180"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="352" mass="41278" checksum="027E061F12BF744B" modified="2013-06-26" version="1">MNRPGESFKYSSKDIKKNINELIEKMIKEGYPIFDIDKIMENKEEYSDILSKLTEYDEKRIREDKDYRFNKEFRKSLNKIKEILISEGYIDEKGELTEKSLMEYSKYLIGNIEKEIEGIFEYGKYSSYYIGNDEEFYKKYFSIGDKYNKIDIKETIRKYIKNKDAVRFVINVNRENKGGKYIILLDVSGSMIGEKIFEAKKALILLTSKILEDNNLLDIILFNDKIVKEYNNVRGLKDIIDILRIIPNGSTDIALAFNYLLNKGENGHIILITDALPTKGKNPVERTLRLAKELSQYYYISIIGIQLNDEGEKIAKEIVKYGRGRLFISKDIKDLKKLLLLEYVISRQQMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTV2</accession>
    <name>R1FTV2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="7" type="ORF">Nst1_230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42500">
        <property type="protein sequence ID" value="EOD42500"/>
        <property type="gene ID" value="Nst1_230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.222"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="136" mass="15754" checksum="C6DEA58A61475FDC" modified="2013-06-26" version="1">MPEFMIRGYTLDQLKNMSIEEFAQKVADSRTRRTLLRRLKIGFPPEWENFYKKCYLQLQGKYKKTIKTHAREIVILPSIVGAKVGVYNGKEFVEFEIKPEMIGRRLGEFVHTTKKVQHSAPGIGASKSSKFMKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTV4</accession>
    <name>R1FTV4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42505">
        <property type="protein sequence ID" value="EOD42505"/>
        <property type="gene ID" value="Nst1_235"/>
    </dbReference>
    <dbReference type="OMA" id="FSVFHTS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="171" mass="20481" checksum="21CC12DBC286BACD" modified="2013-06-26" version="1">MDDCIYCKIANKTLTSYILYEDNDIICVLDILPPSKGSFLVFPKLHIEDYTSLNDEINQKMFTISKYISIVLKNKLKFDGLNILLSSGETGQKYRHIVIQVIPRFKDDNIKIYFNRFREDPSFLEELKKYITTELIRMSQQYLNSEKKEEREEIKKDIDYKLLNQWFEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTY3</accession>
    <name>R1FTY3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L14E/L6E/L27E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42545">
        <property type="protein sequence ID" value="EOD42545"/>
        <property type="gene ID" value="Nst1_275"/>
    </dbReference>
    <dbReference type="OMA" id="GRYCVVI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="PTHR11127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="121" mass="13949" checksum="C0D3DF2DE89A7C80" modified="2013-06-26" version="1">MLLDIGRVCIKLKGREAGRYCVVIDVIDNNFVLVDGDIRRRRVNIKHLEPTDKVLNINKGIKTEDLIKEMLKNKIPVSYWKLKKDNLLTSEIIELYKQNFGEKWEEIAKSIGSPGKGKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTY7</accession>
    <name>R1FTY7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42550">
        <property type="protein sequence ID" value="EOD42550"/>
        <property type="gene ID" value="Nst1_280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="560" mass="65940" checksum="B82BC6076DE99378" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTZ9</accession>
    <name>R1FTZ9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42565">
        <property type="protein sequence ID" value="EOD42565"/>
        <property type="gene ID" value="Nst1_295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="386" mass="45452" checksum="B0E28E83FE385F21" modified="2013-06-26" version="1">MYSHHFDVDGKDKKISSDEIIKWDHTILEGDVIESEGYEKISLKEIVKWKLQRRKIKSNGYKKKSDGYKKISSLDEILSIAKGNDGELKFMFARQIAPFNIETILALLDIEGAIKKADEYGYKVNKVILDILQWKDNKFSFSNIEKKIFVEPQMLYSKLQYNIAVESKRKIRIGKYRIGDVYLDVIKIIKMIYEIGFEYMEKALNHLENERKVKDDSVNILDFWGLATLYYIGEISKDIFGIDKYEIKEFKDKIKLANGDEFDISGYELTFKYNGKELKFRVYDASHIYKEESEKYKTETNLYITLALLSGSRYILLEEDPGKEDNKIKHFYREAKKKTGYDILLFELDEQKLIERGIIGKDDYVKLIHKNKIKKIINIIKEIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU05</accession>
    <name>R1FU05_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42575">
        <property type="protein sequence ID" value="EOD42575"/>
        <property type="gene ID" value="Nst1_305"/>
    </dbReference>
    <dbReference type="OMA" id="INLEWHT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="161" mass="19267" checksum="B43C91E3ED0FA3E3" modified="2013-06-26" version="1">MPPKERIVDGKTFSYTGLIDFQKFYKSMKEFWDNKGFDFFENKHEEKVKDDGSRSINLEWHTEKKITDYVTYSYDINITIDTLKLLDNMKQYVENLNIKINGDLITDYQKYFGDKPFNIFLRGLFEKYLYDSELKDHKKNVGKIADEFLNLVKDFTASFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU25</accession>
    <name>R1FU25_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ORF">Nst1_330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42600">
        <property type="protein sequence ID" value="EOD42600"/>
        <property type="gene ID" value="Nst1_330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.320"/>
    <dbReference type="OMA" id="DCKTEDC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="329"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOD42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="564" mass="64929" checksum="DAC715E966CD978A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU47</accession>
    <name>R1FU47_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42630">
        <property type="protein sequence ID" value="EOD42630"/>
        <property type="gene ID" value="Nst1_362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="228" mass="26950" checksum="AD65B42C361B0C30" modified="2013-06-26" version="1">MVPKDSTGKIEDLILGQSKDITYYTVCKKLEPIENYEKELKYVRKKVKEFVPEVLPSLEKLLDRMKKLDYSLISEDIIREYGHLICPLTQMFYDGISKGIDSNIQKSIDNLKTTLEYLASGDILERFFKAYLKRVEEGFHNETGYTISKLLEIGYKIPGFIRNKDIRDRNVRYLLNIKIKDEDKYLDTFTNLSMKESERIVDIVKNLIEHPEQYKKDFEEYIGYKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU50</accession>
    <name>R1FU50_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42635">
        <property type="protein sequence ID" value="EOD42635"/>
        <property type="gene ID" value="Nst1_367"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.353"/>
    <dbReference type="OMA" id="ANTIWKA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="110" mass="12486" checksum="5415E4268961FF1C" modified="2013-06-26" version="1">MAQIIEEGVITLDLSIKEVANALWKKILMEEMKEDIATKILYDLLKGEAIIIVNQDEYLIEAFKIANRNKITIYDSLFIALAKSKNLELVTSDKKQYEIAKNEGVNAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU65</accession>
    <name>R1FU65_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42650">
        <property type="protein sequence ID" value="EOD42650"/>
        <property type="gene ID" value="Nst1_382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="219" mass="24790" checksum="5D7DAB132EC06748" modified="2013-06-26" version="1">MVISLFKKKNKNEEDFYGDLDNLKNQLGGMGGMSADMGNNYNILGTGQNLYDYNNNPGSFGVLGNQNQQPTFGSQGFGQQPQFSGMGQQNMSGVQNINNQQFGGFGNQQSMLGSQGLSQKLSLEENKPLLKEKVKEGVHKKHLKEEKPLEVRKELLIKIEDYKRVRELLQQLKEKMSEVEKIVSELKEDENKRLESIKGLKEKLEESKSNINSVLDIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU79</accession>
    <name>R1FU79_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42665">
        <property type="protein sequence ID" value="EOD42665"/>
        <property type="gene ID" value="Nst1_003"/>
    </dbReference>
    <dbReference type="OMA" id="IRTWTET"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="172" mass="19892" checksum="AB655963943CD18E" modified="2013-06-26" version="1">MKYMDTDIVKKRARIIIPVLVFMVFLSFISAITLIALGNTVSSIISILIIVFLIYEIKRIKSIIPPEPADILAVGKYGILSTIYWYNKSGVWKNNKMIFTWSDVSDIFIIRTWTETNRSTRTVLSTTGEFLTYTFGLVRFVMKNGEYIDIDRVVDPETMVSFIKKMYIKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUA5</accession>
    <name>R1FUA5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42695">
        <property type="protein sequence ID" value="EOD42695"/>
        <property type="gene ID" value="Nst1_034"/>
    </dbReference>
    <dbReference type="OMA" id="KICLWCT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="146" mass="17220" checksum="706ACF480BD9D8FB" modified="2013-06-26" version="1">MDLKFDKRLLLLTIFSIIGLIIYIYLEYVVLINNSSPLFCSINNTPINCEKVIESQYSKLFGIPLETYAIVYFIIDIFLVLLLYKKKLKIIYNLFYRLIGILFVIFSLYVMLFLIHSICLYCSTADGILIINFGIILYYYKKKVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUA9</accession>
    <name>R1FUA9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42700">
        <property type="protein sequence ID" value="EOD42700"/>
        <property type="gene ID" value="Nst1_039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="400" mass="43514" checksum="BCD364434F8FCD12" modified="2013-06-26" version="1">MKSISDSVIELIIAIIIIIFVIIFFFSALKGLSYAGRPEAKFGYALAGSISFMINPVAQGISDAATIANDVLIGVFVAATVAGIVSGIKANYDENVQFLESIGYDEEAIQNINNKYLLFEDIENGGFPTDKIASGIVNAYKTTFLNPLGASLLGGTLGLDAISYLLNNLAHSMQAPILYYLVPEGVVAVNLSNIGNAQVNEMLNDLNQSYANYIEQNNICSNPTSSECQNLYATYLIAKYLFYTYGETLGQSVTISGNHNEYAILLFDYNSDYSVTLNDVLCMLEMMKYYNQVPLEVMYGNNTIYNSNNNIACQVLSNVYSSAMSSNPQDANNVYNKLLVNSYEVDQSGNANQLSSTSNNPEPNDVIIIPAIQPPDGIIIEYTYEGGNRAILLTSISGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUB3</accession>
    <name>R1FUB3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42705">
        <property type="protein sequence ID" value="EOD42705"/>
        <property type="gene ID" value="Nst1_044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="370" mass="41461" checksum="9F3E5F46D1CEDF14" modified="2013-06-26" version="1">MDVDGLLDAIVASIFLIIVSLIGIYFPYIVARIFGTHNPYLILEVAGFITYSTSEPGNMTAAFLVTNAPDFFYEFRIIPPIQSSALFIPLYNNNDFLVSIGECYVNNLWQQLADDALNSFLTEVFSYLPGLKNGVITKPLADVLNDVFKSSSQIAKQTAIGAAGMYGLYTYQSTLLQYTSGNYNIWGDIFNALQSSVGPTLWSTVEFTIMQVGDMILDETLPPPADFVAGFAFNLAFTSAITLYQYWQDTSNPYASCYYNQFIQQNTKFLFLSIPNGEYTVYQPYLTLTIYYNPNFTFYNGCNDYYLCDTSFTYIYDPQDNSQDNIFKLDLGNVDNNGNQVFPEFIILSKVGMQSGGPYLNVSILSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUJ6</accession>
    <name>R1FUJ6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase (DHH superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42780">
        <property type="protein sequence ID" value="EOD42780"/>
        <property type="gene ID" value="Nst1_119"/>
    </dbReference>
    <dbReference type="OMA" id="MEFRTHT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="285" mass="33907" checksum="BA8EF765FF74423F" modified="2013-06-26" version="1">MIAITHWDVDGIACLSILYKKFGDKFKVYFSSPRLINNTLVKVIENNDKEEELYITDIATNQEAIYLSSYFKKVYWIDHHEKNFNEITSRINVYIKNYKSTARVLSEYLNVEFKYLDIIDDIDSGEIKNDIERNFADYIVSIRYFYPKSYDLYFISIAKNILNKDIKEIIDYDIIKRFRKELNEIYKNLDKNITIINKKYKIYIIKLDKNIPSNYILEYIKEKIKDNPDFIITLYEKSKRGEIRTLNNKDVSKIAKLLNGGGHKYAAGFSFNNEKEVYEKILNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUP8</accession>
    <name>R1FUP8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42820">
        <property type="protein sequence ID" value="EOD42820"/>
        <property type="gene ID" value="Nst1_159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="212" mass="25248" checksum="4B3C3C85211E5DA8" modified="2013-06-26" version="1">MRDEKIQSQTLDEMLIELVSETAKYSFTLGDWGEYIWIIMDLKGKGHNAESVGAKLSEIRRGFDVRYIYHREYDYNTNTYSTIFGNYIRELNKNIEKVADITINIETRAIDIYKRVVNSYLDPSRKYAKILIYFKRKIDDYNKIIEEIDESIIFGQSISNKYGFVYQPAFKFMTLREKEKDKNENITELSKPDYYEFSYTVYELSEFSLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2C9</accession>
    <name>R1G2C9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42231">
        <property type="protein sequence ID" value="EOD42231"/>
        <property type="gene ID" value="Nst1_648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="43" mass="4498" checksum="E2CE1CB455AB313C" modified="2013-06-26" version="1">MGPNNLIANYTQSEIVVSENISPTDLIGIGGLIVGLLALFNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2E7</accession>
    <name>R1G2E7_NANST</name>
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        <submittedName>
            <fullName evidence="2">CobQ/CobB/MinD/ParA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42251">
        <property type="protein sequence ID" value="EOD42251"/>
        <property type="gene ID" value="Nst1_592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="220" mass="26048" checksum="DD8CE35A8955FBA5" modified="2013-06-26" version="1">MIVSFISLKGGVGKTTLTNNLAAYLKKEYNYKVLIIDTNGTYSSNLIFLNNEKLFGNKIYEGIKVLPYFHLKIIDNLDFNISDLNYLKRYYDVIIFDVLPNINYILSIEKISDINFLVINPDFYSLYVNKKLYDLLDKNKVKIVLNKYDKSIEIDFIEDVYNKEVYVVIPVIKDFIKYQFQYQPIAFYNEKSKALKYIDELAYCITGNKRRRSIFDILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2T7</accession>
    <name>R1G2T7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42386">
        <property type="protein sequence ID" value="EOD42386"/>
        <property type="gene ID" value="Nst1_419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="389" mass="45417" checksum="6BE8431D9D29F329" modified="2013-06-26" version="1">MNYKEKIIIISNNLVGGMLNSLFFVYPYYFNFPSNVYYSLVSISYIGSIISSAIFGNIKINEKNYINIAMIGVIGPLLSSLLLIYPNIYLLILSFLLFTITYSSTYFSFLLYYKDVSLNFHFNIYWTFGEVIPQISLLFLSIIYNIYIVSIILLLSIIVIMYRKLYLFLFSSAYELNLLERIDKMFSVAENNIDKFGAIYPIFEGLIFPLNIKKLRIGYLELYNLFVLIGFSLVWTSLVYSVNIFSLSIIFPFLLFINGLYTSILYKIYKREIDFRKIKIGILSRFLIGIIILLSLILSLSKIYNAIILLILFILAAFSWTMFQYFFDNYIILNYPQKFGNIYLFRNLGGAIGSLLLYYISVQYGLFLSFIILGISFFFLNYVLKNYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2W4</accession>
    <name>R1G2W4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42411">
        <property type="protein sequence ID" value="EOD42411"/>
        <property type="gene ID" value="Nst1_446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="131" mass="15144" checksum="767241D2525FE21A" modified="2013-06-26" version="1">MDKRETIIVGIILLILLALGFIIAPLLYPINNNQNLNQNQLYQIYQIAQYCQDLCIYAKYNLSISNLSNTCLVSENSILYQSWISYPNAYNWGCEVSDNNLNLCNNSNYIVLDDNCSIINIYYQNRQLNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2X5</accession>
    <name>R1G2X5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42421">
        <property type="protein sequence ID" value="EOD42421"/>
        <property type="gene ID" value="Nst1_456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="130" mass="15093" checksum="B944F1355D8CC6E8" modified="2013-06-26" version="1">MALDFIKNLFGKRDNEDYGINQQGDFMNYPPEGPGNYPPGPYPNEPLLPPPPPPIQSQNTLQQNQFPGQLNPQAYLPNFPQNYGYNNQYSNFDYNLIQMLNTKLDTIATKLDNIIALLNNLLQYFQYYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Z8</accession>
    <name>R1G2Z8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42441">
        <property type="protein sequence ID" value="EOD42441"/>
        <property type="gene ID" value="Nst1_476"/>
    </dbReference>
    <dbReference type="OMA" id="IDFENKW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="98" mass="11367" checksum="45598F8B5DF07A70" modified="2014-02-19" version="1">MVKIEDILNKLREVTDPELGYDIVSLGEIEDVREENGIYTIKFLPTSPLCPFISAILEQIDEKLKELNIYDNSKIEIDFENKWSLDRVSPEVRKQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G304</accession>
    <name>R1G304_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42446">
        <property type="protein sequence ID" value="EOD42446"/>
        <property type="gene ID" value="Nst1_174"/>
    </dbReference>
    <dbReference type="OMA" id="TRHIIDW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="492" mass="58446" checksum="71AA6B129745F526" modified="2013-06-26" version="1" fragment="single">MLIIAEKPSVARKISSFLSNNRYKTIKFSKNIYYYYFNLEGKNVNVVPSIGHLFTLSDLDKKYEYPTFNYRWVPSYFEDKIIAKKYYIEMFSKFKNENNIIIATDYDIEGELIGYNILRYVLNKENANRMIFSAITYRDIVRAFNNRKESLNFGYIYAGETRHIIDWLYGINLSRALTKSLFYYTRKFVLSIGRVQGPTLMLVFNREREIENFKPEEYYKVEALVIKDDKKLKFSYIKDKIKDKVEANKIKNDLGKYLIVSNVDKKEEKINPPHPYNLTDIQMDAYKYYKISPKRTLDILQSLYEKGYVSYPRTSSQRLPETINFKEILSNLSLINSYKKYIVLLLGKQILKPNNGSKDDVHPAIHPTGNIPEYLEYKEKLIYDLVVRRFIATFYDSAIVYKIKVITKENFVYDYYDIKYKGWLDIYWEKYKDNFVSLKFNVGEKLFIDKVYISKKKTKPPARYNKASLVKKMEELDLGTKSTRADIVEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1G313</accession>
    <name>R1G313_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="4" type="ORF">Nst1_184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42456">
        <property type="protein sequence ID" value="EOD42456"/>
        <property type="gene ID" value="Nst1_184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="120" mass="13977" checksum="4ECAE58B5CB4603E" modified="2013-06-26" version="1">MPNDWSYLVELQKNKPGTLAKILKNNAPKYVKEEVKRLIKEGKIKNIQELIEKAVSENKSLIKVLEEYGIKNKERKFGKGSVRCIICGSHDRVIRRYKIYICGRCFREMAKELGFKVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1G319</accession>
    <name>R1G319_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42461">
        <property type="protein sequence ID" value="EOD42461"/>
        <property type="gene ID" value="Nst1_189"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.183"/>
    <dbReference type="OMA" id="ERQRMTI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015005">
        <property type="entry name" value="DUF1854"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08909">
        <property type="entry name" value="DUF1854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="129"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="447"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="480"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="856" mass="99760" checksum="7275D08CAE499866" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G347</accession>
    <name>R1G347_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42481">
        <property type="protein sequence ID" value="EOD42481"/>
        <property type="gene ID" value="Nst1_210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="67" mass="7363" checksum="C0752C8D75F44A85" modified="2013-06-26" version="1">MATPSQLRTEIESAFKKGVSKEDVDKVAQQIANKLGKKPAVVKALITRYVNKGMIKEQGGKYVWAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G363</accession>
    <name>R1G363_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42501">
        <property type="protein sequence ID" value="EOD42501"/>
        <property type="gene ID" value="Nst1_231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="165" mass="20222" checksum="3CFECF36E55F364F" modified="2013-06-26" version="1">MNIYERLTKREIRNSKKFKRNSNINIIALESNTKDFVLDIINKIDKKFNMGFKINLNIYKKIEEIEIKENSILILPIEGVLLSFLLYNYKKEEKYKYLIQKKNKYFYNIAYNVSEYYISKYLNKEPYIFTDYKDMLNFIYEIVSMKEKYVFGIKNILDYLSKYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3E4</accession>
    <name>R1G3E4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase related to nicotinamidase</fullName>
            <ecNumber evidence="2">3.3.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.1" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42641">
        <property type="protein sequence ID" value="EOD42641"/>
        <property type="gene ID" value="Nst1_373"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.359"/>
    <dbReference type="OMA" id="IVYTKIT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="187" mass="21444" checksum="CA75A836A946A951" modified="2013-06-26" version="1">MEWYNKDEMKKLINKKNSVLVVWDVQEALVNSIFNKDEFLTKLKELINSARQYNIPIVYTKITPLPERFQPPYLKRRFNPGDIVKEVYPKESDIILNKNTTSIFVGTNFELMLRNAGINVIVFTGIATDIGVETSARHAQALGFLPVIAREAVSSSDKQAHERSLANMSKLMLVLDNKEIIERWSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3F5</accession>
    <name>R1G3F5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42656">
        <property type="protein sequence ID" value="EOD42656"/>
        <property type="gene ID" value="Nst1_388"/>
    </dbReference>
    <dbReference type="OMA" id="ALEIFPI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="428" mass="51262" checksum="63C8FB5F805FB5B8" modified="2013-06-26" version="1">MEYIPRVLLNEIIEYIDRREIIAIKGPRQSGKTTLLKMLKDFLINKKNIDEDHIIYITFEDNEILYKFSENPKDFIRKYITDNKRYYFLIDEAQYCKDLGKKLKLIYDLFENIKIIITGSSSLELKNETAKYLVGRLLEFELYPINFYEFLLYKDQKIAKIYREWNEKILNLLINNSDFEIKKDVDIYINDLLKYLNEYIKFGGYPAIVKAKSEKEKIFLLKNLINTYLDRDIVSFLNIRDIIKFRRLITALSSLNGSLINITQLANEVNSYFKEIIDLLDILEQTYIIRRIRPFHKNLVTELKKENKIYFVDTGLRNYLINNFNDIEIRNDSGTLIENFILNELYQYGKINFWRTKNKAEVDFIFEGKEIIPIEVKFSTIKKNILTKSLYSFIKNYNSKFSIIVTKNYWGERIINGNKIKYIPLVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3G3</accession>
    <name>R1G3G3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name evidence="2" type="ORF">Nst1_004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42666">
        <property type="protein sequence ID" value="EOD42666"/>
        <property type="gene ID" value="Nst1_004"/>
    </dbReference>
    <dbReference type="OMA" id="MNRPLIV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="208" mass="23812" checksum="C6353953DE881F7A" modified="2013-06-26" version="1">MMKLVVALPVRSLEDIKLVPTIDSDLVELRLDYLERPEDFDPSLIEDIKDRIIVTVRDPSEGGVKKVDEDWKASLYKKLHDMGVLYDVEARFLRKRNDIPFKGKIVSAHFFDRVPSIKEVEEIFEGFEEAWVRKIALTAKEGYKELLAHFARKGFAVMSMGSNPIERIAFTVLGSELIYASFDEGLETAPGQMNYKKVREILSCLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3G8</accession>
    <name>R1G3G8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TATA binding protein of transcription factor TFIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42671">
        <property type="protein sequence ID" value="EOD42671"/>
        <property type="gene ID" value="Nst1_009"/>
    </dbReference>
    <dbReference type="OMA" id="VYRMDEP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="197" mass="22636" checksum="F30D96BFE1A9B310" modified="2013-06-26" version="1">MVTWEISNAVVTIYFNVKLPLDKIANLIPYAQYDPETFPGLIIPLKEGGSKEENVKALVFNSGTINISGIKRLEDIEYVAEKLRELFKQIDIELPKNYKIKVQNIVVNGKFDYDNIDIVRLADEIPDSQYNPEAFPAVTVVFDVSENYRVKFNVFKNGKFVCPGLKGEFNSFDEIKQHVDYVLNSFQEKVIKKYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3H7</accession>
    <name>R1G3H7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42681">
        <property type="protein sequence ID" value="EOD42681"/>
        <property type="gene ID" value="Nst1_019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="95" mass="11365" checksum="A960535D46B3EDBD" modified="2013-06-26" version="1">MILVKKYKDNYGYVLVLCDKNLYGKRFEEGEFVLELNEFFKGEERESIDEKDFDDIYFIYAVGEESINILKEKKIIEEKDIKRIAGVPYTFVIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3Q6</accession>
    <name>R1G3Q6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase of the AAA+ class, CDC48 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42766">
        <property type="protein sequence ID" value="EOD42766"/>
        <property type="gene ID" value="Nst1_105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.103"/>
    <dbReference type="OMA" id="ENFRFAQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="248"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="535"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="794" mass="88838" checksum="91BF1A3439B1913A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3R1</accession>
    <name>R1G3R1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="2">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="4" type="ORF">Nst1_110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42771">
        <property type="protein sequence ID" value="EOD42771"/>
        <property type="gene ID" value="Nst1_110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.108"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="23477" checksum="09DA752CB52B0D77" modified="2013-06-26" version="1">MVLVDKKIREYIKSGKIKVEPFDENMIGPASLDIRLGYKFRVFKTLEKEVIDVKDYYDDIYTRVETKDYIIHIGKYSDLYILKNDNVPIIIHPGEFILASVYEYIELPNNIVGQIHGRSSIGRLGLIIHTSAGYIDPGYKGYLTLEIINVNKVPIKIYPKTKVAQIVFIETESSEVPYDKRKGSKYLNEEGATGSLISNDFNNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8M5</accession>
    <name>R1G8M5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42194">
        <property type="protein sequence ID" value="EOD42194"/>
        <property type="gene ID" value="Nst1_611"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.592"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="1272" mass="138574" checksum="149B2B77307F2A1C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8N9</accession>
    <name>R1G8N9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SSU ribosomal protein S7P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42209">
        <property type="protein sequence ID" value="EOD42209"/>
        <property type="gene ID" value="Nst1_626"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.606"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="5">
        <location>
            <begin position="51"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="201" mass="23296" checksum="0E13D6E78BE309DC" modified="2013-06-26" version="1">MVNNINDLKFLGRWEYEVDVEDETLRAFMNLKPYIVPKTNGRYQNRRFGRRNMPIIERLIGRLMTPGHYGGKHKFTSYYASGEYHKVLKILIKTFEIIEKETKQNPIKVLTKAIENAAPREEITNIEMGGARYPKAVDISPLRRIDLAIRHIVWGAYHGSRNKKDMASALAKEIINAYKNSIESFAIQKKLELERLASSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8P7</accession>
    <name>R1G8P7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42219">
        <property type="protein sequence ID" value="EOD42219"/>
        <property type="gene ID" value="Nst1_636"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.616"/>
    <dbReference type="OMA" id="AEHASTF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="135" mass="15566" checksum="F193B7547A128B3D" modified="2013-06-26" version="1">MKLVIKAKGNKLIKATHKSTLELTKDNYLTERGDCIIGISANYSVKDLPEDLKDHLLNEGKIKIVIKVDDLIDDIIAYGSRKLLLTNDRSIVIRKSNYIDDRTLAINSNKSAIDIDRELIERLKNEREMEFIIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8R4</accession>
    <name>R1G8R4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">Nst1_651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42234">
        <property type="protein sequence ID" value="EOD42234"/>
        <property type="gene ID" value="Nst1_651"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.631"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="67" mass="7986" checksum="B4A83BA6A34EB5E8" modified="2013-06-26" version="1">MSGKKDLKILKLYKVEDNKVVRLKKVCPKCGRFMAEHEDRYHCGYCGYTEFKQNIEKKYIKEIGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8U5</accession>
    <name>R1G8U5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42264">
        <property type="protein sequence ID" value="EOD42264"/>
        <property type="gene ID" value="Nst1_524"/>
    </dbReference>
    <dbReference type="OMA" id="HAKNDWN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="349" mass="41037" checksum="7DB14DCCF817D1C1" modified="2013-06-26" version="1">MKIALFSISHLSVNRGSEKWIIKVASYLSKKYDIKVITTNANKKYDLNNLNFDYIVINYKKRFGLLHDISEIKDYLKDIDITYAFYIGFGTQIDILKYSKKVVFGHHILLDEPIQRVYYSILENIIARKIKYSYHHFLTEYRANIYRKRGFKNIFVIPNFIELDKYKLKEKSYDKFKIVCPGAVSIQKGIDILIKVAEILKKYNDIEFYITGNRPIYENLPANVKYLGMLNEEEFINFISTANLMFLPTRYETFSFAVLENLAAGNPIVVSNLPDVISAFGEFESIYYAKLNNIKDYINGILKYYQIWKNSKDKYEELSKKAREIASKFDSNIILPKIEEMFKKVYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G924</accession>
    <name>R1G924_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DDW03_00810</name>
        <name evidence="1" type="ORF">Nst1_508</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000002">
        <property type="protein sequence ID" value="PVU68865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42349">
        <property type="protein sequence ID" value="EOD42349"/>
        <property type="gene ID" value="Nst1_508"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68865">
        <property type="protein sequence ID" value="PVU68865"/>
        <property type="gene ID" value="DDW03_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PVU68865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <sequence length="60" mass="6985" checksum="11CB9BE6F04ACB66" modified="2013-06-26" version="1">MATYICPRCHSTNIVPLFAKDNSWVCLDCGYQGPAQLINKDLEYFWNEYQKLENINKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G935</accession>
    <name>R1G935_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42359">
        <property type="protein sequence ID" value="EOD42359"/>
        <property type="gene ID" value="Nst1_518"/>
    </dbReference>
    <dbReference type="OMA" id="DWKAGLI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="203" mass="22574" checksum="85EB2C5BEABF5265" modified="2013-06-26" version="1">MGIDILYILIVIFDILISIWNAYNAGKALEYMKLNNIESDWPRMVAYSTLILSFAGAAYGNASLLSIVAYYLGYIDIYTLLGVLSFSFLVFGFLIILFGIVITVNSIIVASKTKSFFDIFIAIYNSIAVIWDIYTYIEGFSTAFNILKDQFGNEDRNSQGIFVLIIIAAVLIAVFMVYGAFKYGKASVYKVEGLSIQPSPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G986</accession>
    <name>R1G986_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein, containing PUA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42404">
        <property type="protein sequence ID" value="EOD42404"/>
        <property type="gene ID" value="Nst1_439"/>
    </dbReference>
    <dbReference type="OMA" id="IENIHYY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015266">
        <property type="entry name" value="DUF1947"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09183">
        <property type="entry name" value="DUF1947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="71"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="157" mass="18451" checksum="991A65D34FC7A915" modified="2013-06-26" version="1">MKSLDKKSRKNLIEILKNNYKIECEKLKNENIFLDEENNIYIYNNIPIAFIKDNKIYPTIFLINECETDMNYIKVNIGAKEKILNGADVFRPGIIEFSDFKKDEIILIISEDNKLLAIGRALYDSNDAIKMEKGKIIENIHYYGDKITKYYLNKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9A8</accession>
    <name>R1G9A8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ORF">Nst1_459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42424">
        <property type="protein sequence ID" value="EOD42424"/>
        <property type="gene ID" value="Nst1_459"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.444"/>
    <dbReference type="OMA" id="MDPYKVI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="86" mass="10118" checksum="E2EA493B3702129B" modified="2013-06-26" version="1">MDIKDVILYAELTEKDMYLLDKYNKVIFIVNRSSTKKDIKEAVEKLFNVKVKKLNTLIDYKGRKKAYVTLEKEYKAQDILSKLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9K6</accession>
    <name>R1G9K6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42504">
        <property type="protein sequence ID" value="EOD42504"/>
        <property type="gene ID" value="Nst1_234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="326" mass="36636" checksum="8E6042CC6C5B47CF" modified="2013-06-26" version="1">MTNYLIIIISTLIPLLIYAFLIYLSENIILKYIEKYSKYYSSWPEHYLLIYTAGIASALQSFLPGLSVALNGDPKLGYYFQLYNVVLDYTITLGSFILAFNFKKGMIDSNVLSLIMISIIAQVVVLIFKQINFFSGSILYLIFIIISIFLLYKYRKKSEKNIYIPKSSFYEYFKATVFSLEIALAISIIYIGGNILNNISNTLQGLNLSIPLIGYAISLILFTLPDILYGHFSWFKDKDLNISMASISGEEISAFTIFTGILGMISPIKFSSQDVIPIISAFLVLLISIIILYISSYKKGIPKWVGILLISLGILIGFIDGIANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9K9</accession>
    <name>R1G9K9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42509">
        <property type="protein sequence ID" value="EOD42509"/>
        <property type="gene ID" value="Nst1_239"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.231"/>
    <dbReference type="OMA" id="DENIGAH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="383" mass="44570" checksum="642C57BD83CAA971" modified="2013-06-26" version="1">MTYKLNKKVEELFFERFKDFNPIQKIAIPEILNGNNTLIVAPTGSGKTEAAILPVFSKILELKEKGVENQLLGIYISPLRALNRDLLDRIKWWCDNLGITVAVRHGDTEEKERARLSKKPVEFLITTPETFQILFLGKRLREQLKTVKYVIIDELHELLNEKRGIQLSLGLERLVNYAGEFQRIAISATIGDLDEAAKFIFGYRNYKIAYWYAEKKYHIEVYYPEIGEEDLKLSRKYNWNPKIAWSLRKIKEILDKHKSVIIFVNTREMAELLSSRFKVWLPEYKIEIHHSSLSREVRERNEKLFKEGKIKAIIATSSLELGIDIGYVDAVIQYNSPRQVTRLIQRIGRAGHRLHEVSIGYIITTDIDDYAESLAIKKFALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9T4</accession>
    <name>R1G9T4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">Nst1_329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42599">
        <property type="protein sequence ID" value="EOD42599"/>
        <property type="gene ID" value="Nst1_329"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.319"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="220"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="361" mass="38544" checksum="2C249E57572D0198" modified="2013-06-26" version="1">MAESNNKMEDEIIGVSPGEEFKLMPTIKIIGVGGGGSNMADWLYRMNIKGAEVIAANTDYAHLKMVKAHKKILLGKEVTRGLGAGGMPSKGMDAARASQSDLRKLLEGADMVWILLGLGGGTGTGAAPVIAQIAKEVGVPLTVAVATLPFYNEGVVRREKAEEGLAQLRKYADNVILIDNNKILQYAGNLPFTQAFGYANNLIGQMIKGLVETFDKASYINLDFADVKTVLGVGGASIVGIGIADDEKRAVTAAKRALELPLLDVDYNGAAGALVHVEGGADMTLNEINEAMEYIKQHLGEDALTIMGARQSEEMKGKIKVTVIVSGVKSPYILGKWKEEWESGELTKVRKDANLGIDVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9V3</accession>
    <name>R1G9V3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA m(1)G methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42619">
        <property type="protein sequence ID" value="EOD42619"/>
        <property type="gene ID" value="Nst1_349"/>
    </dbReference>
    <dbReference type="OMA" id="GVEKRCR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="1">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="252" mass="30037" checksum="10E6E3A5A7628328" modified="2013-06-26" version="1">MILEKITSKYINYITVRNYDKSKKYIGQDCIVKYLLNRKKLYKDNGEIIYKNFIEVKYNKDAKEEIDIPKEKILKDIENEKKFLIDNSLYNLLPNKGKISLKIQISQSLKVIREYLFDSNLILIGNIDYSFLGKNLVNIYKKQEDFDFYKYKAIILDPYGDEILNDKDLERYDLFILGGIVDIDLNWQYATRYLFRNVDLPHKRIELYGSIKNVPDRINILIKILLDSIYLNMPLEKSIIINSPKKFIKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Y0</accession>
    <name>R1G9Y0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42654">
        <property type="protein sequence ID" value="EOD42654"/>
        <property type="gene ID" value="Nst1_386"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.372"/>
    <dbReference type="OMA" id="WTQEMVI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="852" mass="98811" checksum="F0BC6E0D07C5867B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA09</accession>
    <name>R1GA09_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ORF">Nst1_028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42689">
        <property type="protein sequence ID" value="EOD42689"/>
        <property type="gene ID" value="Nst1_028"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.27"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="224" mass="25987" checksum="DFE92F27FE326133" modified="2013-06-26" version="1">MKLKPLKENKNIFIDERGKLYTKNLVPGKVVYEEKLVKYNNEEYREWITNRSKLAAAIKKNIGEVPINKGDKILYLGIASGTTASHISDIIDKNGIIFGVDVSSRILRDLVPILYDRSNIIGILADADKPWEYLHIVTKVDLIYQDVAQPHQVKIFIRNIEYYLKNKGYGFLAVKARSIDVSKDPREIFKEVRRELEDYGLKIIKEVRLEPYHIDHAMFLVQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA17</accession>
    <name>R1GA17_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42699">
        <property type="protein sequence ID" value="EOD42699"/>
        <property type="gene ID" value="Nst1_038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="348" mass="38238" checksum="0D94004ADC0D9B5C" modified="2013-06-26" version="1">MNAPLPNFNDLGEDSPLLVELNNGSLMMLWAGTPPTPSNFAIMNITSNTTSTSEILPILNNLTILLQASILNNNVWGPVINLTNNGDALSYASDGNYIYLVYEPTLSLTYNNTILEELTLSGNVIKSLNIPGILDILSANNGLVTVQFLNGTIALVNMNNGSIEFVNTTYIGFVGNSLYQFYNGVLTINQNLTLNLPIYESAFPILYNNGYVIIAWRPGLLSIYYWNGTELQPIINYTTQFTIIPKASILNNDLYLAWFGLNNISTGQGSIYMAITPLPYQISQYTNITTINITNNTINNTSNNSTISTSNTSYNSIQSTTSNKSLFSSIPIWVIIIVVGVVVFIILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA22</accession>
    <name>R1GA22_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42704">
        <property type="protein sequence ID" value="EOD42704"/>
        <property type="gene ID" value="Nst1_043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="314" mass="34780" checksum="189072BA43C07E95" modified="2013-06-26" version="1">MRGDFLRIIFDIIVLIVLAVLIYFIIVTFIGVAMGNEARYIGYLNAIASDINNPGNSGNGEVFINNYDYNYVFVLTNNNNAWYLQLYHCFPPNQVVGLLSVKVVYWNVSTTDNGNTIIFAPALAFCKLVKQESLNVNQININIQGLNDNAGLLAYSNNENLGIFQIFVNIIDNFFPGSSSFFLTIVNDTTITCNSNGCKFTSTINENGNTYQESGYIYCDPNPNVNTNNNNLPYNPADCVELSGFPQNPQIQLSNLEGEIISSETFTSLIQLFQTNFPLLYFAGSLPPTVMDIEVNSNGNTANINIYIGETVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA31</accession>
    <name>R1GA31_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative archaeal coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42714">
        <property type="protein sequence ID" value="EOD42714"/>
        <property type="gene ID" value="Nst1_053"/>
    </dbReference>
    <dbReference type="OMA" id="DESQACH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="286" mass="34739" checksum="B08684BB2A5A2AE5" modified="2013-06-26" version="1">MTDSDKIYRGIILTKKELIKLGEEKESLYSRKRVLYKERKELLEKLKELRSKKEEYSKILDNLMNERQKTLEKLEELKKKLDEIKQARKDIFKNKDIAKDINKYKKELETLEYVLQTEVLSYSQEKKIWNRIKYLRKLLGKYEEISSVLQEIDKLREEYNAYRSKLSIIGQNIRKNIDERKIVKEQIKQIKEKLTQIMDEYNKLKEQIKQIKDKIRELEDKLYEDLQRYISQRLQKQAVEISEEEKNKIIEEYSKIQQKIMNGSELSMDEILVMQKYELLKKKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA50</accession>
    <name>R1GA50_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42734">
        <property type="protein sequence ID" value="EOD42734"/>
        <property type="gene ID" value="Nst1_073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="102" mass="12343" checksum="55AC047652A3D83E" modified="2013-06-26" version="1">MEVKLILNGIGNNFLFSEQDIYKFFDYLIDKYKLVINNKKIIISDREKFSSFLLDTNKFTIALNYWERIDYCFIYISSNNFDLSNLVHDLLEYLKPKYFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Q4</accession>
    <name>R1E3Q4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein (Contains KH domains)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42283">
        <property type="protein sequence ID" value="EOD42283"/>
        <property type="gene ID" value="Nst1_543"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.526"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="173" mass="20798" checksum="7CE54389640C00A4" modified="2013-06-26" version="1">MYTYEFDIGDIKVSELENLLKEKNIKYNRNKNKIIVYYEDFYFIYKFDKFVKGLKAGFDIKKLSNILDNDWDILEIDLKQVFEKKMNHIIRIKGRIIGEEGKVLEELRKRTNADIIIKDKYIYILGDNISLQSAYEGIKRIINGEKHGTVFNYLDKYIKDLRNKDKEFARYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3S9</accession>
    <name>R1E3S9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42308">
        <property type="protein sequence ID" value="EOD42308"/>
        <property type="gene ID" value="Nst1_568"/>
    </dbReference>
    <dbReference type="OMA" id="WYDIGSA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="264" mass="30657" checksum="D6E5C7AD83BDDA17" modified="2013-06-26" version="1">MSLDTLILAGGFAKRFRPLSDYVPKPLFPVGGVPLIYYIIEKALETGSDEIIISTNKKYENHFRHILSALYSFYEPYQIGKIRLVIEPSNSEENKLGSIGGLHYAIKEMGINNNLLILLGDNLFSFNLNKIIKLGNENNSIALAIYDIKNPDDAKNYGVVKLKNNIIKEFYEKPQNPLYTTISTGIYYIPKEKLYLLDEYMNSNYSKDSMGNFFEYLIKRGEKLYGYVYNDDKEYWFDIGTTESYQRANNFANEKGLYRRWIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3T4</accession>
    <name>R1E3T4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42313">
        <property type="protein sequence ID" value="EOD42313"/>
        <property type="gene ID" value="Nst1_573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="220" mass="25566" checksum="4AA7A5B437113F86" modified="2013-06-26" version="1">MRGILRKSSIRDKILIFLIVFSIFMILASIIYRYLFYPVYSLKLPYVYNISDNETEIRYYELNLTTYDIIKMSINGVFNQKNLNFTNPNASVEFISEVDGYLLNNSLYMENYKLYYTKLNIIYPQYSFILCVGDSCGAFVFTNNGITNIPISYINNINNTLIIYLSYSISERILDYLKYENGNFVDIIKSGLENGEIKVINDNQLVQNILNIYNLNISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E409</accession>
    <name>R1E409_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42383">
        <property type="protein sequence ID" value="EOD42383"/>
        <property type="gene ID" value="Nst1_416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="106" mass="13147" checksum="45AA52E7FEFA799E" modified="2013-06-26" version="1">MDEINEYEKIIEDLENKIKNLKEELEKNKKIKDEIYDKYLKLKNIFDKNNEYNKLLDELKIILLEINLKLKDIDDIKKRLYNLELKYDMIKKEIDEIRKELLKSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1E456</accession>
    <name>R1E456_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="12" type="ORF">Nst1_453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42418">
        <property type="protein sequence ID" value="EOD42418"/>
        <property type="gene ID" value="Nst1_453"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.438"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="360" mass="41224" checksum="517FAF4CBAA6300B" modified="2013-06-26" version="1">MDVEELELQMLIEELSNYNGRATELISYYIPAGYDLAKVLDHLSYEYSTAQNIKDKNTRQHVMDALAKIINYLKGLKKLPERGLVIFCGNISNKPGDVDIRLWAIEPPDKLNIRLYRCDSRFVLDPLKELILPKQIYGLIVLDRGEASIGVLKGNQLIILENKQSWVPGKIRAGGQSSVRFQRLIEQDVHLWLKYLADEVRNYFEKDLDKLVGILVGGPGLLKEQFVNGDYLPYHLKQKVLGVYDTAYSNEYGLKELLERAKDVLEKTEYVREIELVKLFFEHLGKGTGLVVYGFDDVKKALEIGAVDTILISEDYKDKIKELMDLIKQTNAKVEIISKNHPEGEQFSNFKIGAILRFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E478</accession>
    <name>R1E478_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LSU ribosomal protein L10P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42202">
        <property type="protein sequence ID" value="EOD42202"/>
        <property type="gene ID" value="Nst1_619"/>
    </dbReference>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="RL10P_insert" evidence="2">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="287" mass="32574" checksum="B4434A2D8F3D9811" modified="2013-06-26" version="1">MVSQQKILYVNDLYSKLSNSKVIGIANVMDIPTNSLQVIRKKLKEMGIDVKVVKKNLFVKSLEKINDQNIKKMIDIIEENKRITVLLILPKEEINPFVLNKILEENKSYRAAKEGDILEEDVIIRAGPTNLTPGPVLTELKKYNIKTKVENGKIVITEDALVAKKGQKVDSGLVSLLQKFNITPIPVKIKLLLVYDGKTLYTYDILSTPLEEYINQLRSGYRKAISLAVEISYPTKENIKILLTKAYQNLVKLSLNTGIPTKDTIKDLLKITNRRSITLKEKLNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4C5</accession>
    <name>R1E4C5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42478">
        <property type="protein sequence ID" value="EOD42478"/>
        <property type="gene ID" value="Nst1_206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="109" mass="13074" checksum="B3B2EEB8B65AC469" modified="2013-06-26" version="1">MEKVSYIYNINEKYQIIYNQFMDGRVLIKKITEQYTNNICNLTSNNFDPSIMNNLANFPYEIIYENLSNISQEYIFSNDNITNMQNNYIEFNRVCYYDGSLFLVRVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4E1</accession>
    <name>R1E4E1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-phosphoglucomutase</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42267">
        <property type="protein sequence ID" value="EOD42267"/>
        <property type="gene ID" value="Nst1_527"/>
    </dbReference>
    <dbReference type="OMA" id="HSGEINF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="3">
        <location>
            <begin position="149"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="4">
        <location>
            <begin position="271"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="434" mass="49769" checksum="F4DDC6E1849FF9F9" modified="2013-06-26" version="1">MSGVFKLYDIRGIYGQDLTDELLYKIGYALGRYFNNYESIGIVRDIRLSSPRIRDILAETLVYTHDVLDFGIGSTPEAHYLAKVYNIPVLMITASHNPPQYNGIKPINSNGNDLPKEEIDKIEKLTYENVKPTQKEGMLEIVEGARDIYKKHLKEKFKGVSGFKVGYDPSNSVLTLMKDVLTDLGNEVVAINDNIDGTFPGHGPDPSKDENIKPLQELMKNRKDLDIGFMFDSDGDRLGVVDKYGNRIRMDKYLIPFIKKDRTYVLEISLPIYLRKLVEEKGGKVIIKRPGHTFIKFAGQQNRAYLCIEYTGHIYFAENDYIDDALFGALMLLKYMKKGIDINNLNIPEFTWLEKDIPRNNPNLIDKVKEYGKNNGFILNDLNGDLDGIELLKDNLRILVRYSETEPLYRVVIDSYDKNIDVNKIFEEIVKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4J4</accession>
    <name>R1E4J4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42558">
        <property type="protein sequence ID" value="EOD42558"/>
        <property type="gene ID" value="Nst1_288"/>
    </dbReference>
    <dbReference type="OMA" id="HNEEMAS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="153" mass="18358" checksum="025142C4D3257F85" modified="2013-06-26" version="1">MRGIYGKPVEKENFHITLKFIGDVQPNIFEKIKEELNNIKYNKFSIKIGNIGTFGDRVVWMDIYEGYEDIINLHNLIDEQLYKIKIDKDYRFSPHITLYRVKEILNKKEFRESIEKLSKYISDDILIDKFYIKQSILRPQGPLYINMAEYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4L0</accession>
    <name>R1E4L0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42583">
        <property type="protein sequence ID" value="EOD42583"/>
        <property type="gene ID" value="Nst1_313"/>
    </dbReference>
    <dbReference type="OMA" id="HSAIIGD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="PTHR10876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="zf-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zpr1" evidence="5">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="162" mass="19238" checksum="9CD459EA7690C89B" modified="2013-06-26" version="1">MIILTDSCPVCNSKNIEIKTIEYDFPEIGKSLLYTFKCNSCNYRTFEIIPLEDRGYIKIEYKIDNKEKARKLFLKSPYAKIILKEIEIEITPGIESKFEIRAIDDFLMNIKNNLERFKILYSDDKEKYNKIIEKINYIEDVLNNKKELTIIIEDEKGLSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4L8</accession>
    <name>R1E4L8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42593">
        <property type="protein sequence ID" value="EOD42593"/>
        <property type="gene ID" value="Nst1_323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="64" mass="7348" checksum="6ED32089DDAE0294" modified="2013-06-26" version="1">MAVRRRKTLKELLLELLKTPKTIDEVIKAVKSKRPRTRVRVIKALVSRLLKEGSIKKVGDKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4M1</accession>
    <name>R1E4M1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42598">
        <property type="protein sequence ID" value="EOD42598"/>
        <property type="gene ID" value="Nst1_328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="89" mass="10021" checksum="BB0A47CB9330FFF4" modified="2013-06-26" version="1">MFILPALIIAASIVATTQYLSTDIIHMDSNIIAYADCAQNMMNYAFIGQVYNFSQCYLNSINQTYVDCYYNSTNITCNINGTNYNYPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4M7</accession>
    <name>R1E4M7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42342">
        <property type="protein sequence ID" value="EOD42342"/>
        <property type="gene ID" value="Nst1_500"/>
    </dbReference>
    <dbReference type="OMA" id="HHVYYRL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019254">
        <property type="entry name" value="DUF2250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10007">
        <property type="entry name" value="DUF2250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="105" mass="12582" checksum="7E805AC64416CDFB" modified="2013-06-26" version="1">MSEEIKLLAKMLKDDPDYFKVLNHLKIANLDYAKNISKYTKIDINKVNKILEELKEIGLVEEVHSRTVKRSKARLKKQFEVRMHHTYYKLTLLGKQVYKYLRDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4R5</accession>
    <name>R1E4R5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42658">
        <property type="protein sequence ID" value="EOD42658"/>
        <property type="gene ID" value="Nst1_390"/>
    </dbReference>
    <dbReference type="OMA" id="VPAKIYN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="129" mass="15167" checksum="31E733AE01DAE6EE" modified="2013-06-26" version="1">MRENVELWLKQSLEDLDTAKVLLNNNKYYASTFYSHQAAEKCLEALLLYFGKDVKTHDLSKMLDIIKEEVNLNVEEIRKEALKLNPNYTISIYPDAANSLPYLLYDKKDAEEYLNMAEKIVNWVKKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4S9</accession>
    <name>R1E4S9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42387">
        <property type="protein sequence ID" value="EOD42387"/>
        <property type="gene ID" value="Nst1_420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="206" mass="23844" checksum="EA6E09B650D2A62A" modified="2013-06-26" version="1">MLENIINQILQIFNYDMLKIILISVSIIIIGYFIGKLIALILKIILKKVLGLDKWLHDKQIMTTYSLTDLIVNITKFFIYFYFIGFSFYIIPYVSNIGILIFDILNSLLIIIIVIIISYAMMEFILRSFLYPAIQNFKYVNFILGSIRFIVLFFILVLTLSYLNMLSPVLLYMFIILFGGIVISISIAIGIALGDILKEKIRDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4V2</accession>
    <name>R1E4V2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42703">
        <property type="protein sequence ID" value="EOD42703"/>
        <property type="gene ID" value="Nst1_042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="53" mass="5967" checksum="46335308A0652BEB" modified="2013-06-26" version="1">MEADNSINFLIFLIIAIVIIVLAIIFYYYMVSHSMQVNVTIVGYKILNQSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4W9</accession>
    <name>R1E4W9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42723">
        <property type="protein sequence ID" value="EOD42723"/>
        <property type="gene ID" value="Nst1_062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="207" mass="23799" checksum="3B0AE8A372A96E80" modified="2013-06-26" version="1">MDFISQLLLKIYQVIGEPILLYISNIQDYTTYFIIFIIFATIGYIIAKATIFILRIIFNYTKLNEIQKKNPELFYGINISNLTLSLVKYYIILYFLILGIVVDFPSYYYLFYILNLVYTAIIILLVGIIIGDIIAYLFNIKNNVAKIVKGTILYLFLIIALSYLGLNSTVLVQALYYLLLSAAISFGIMIGVIIALEYKDEIIKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Y9</accession>
    <name>R1E4Y9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42432">
        <property type="protein sequence ID" value="EOD42432"/>
        <property type="gene ID" value="Nst1_467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="139" mass="15688" checksum="E29841CB1F5CEBFC" modified="2013-06-26" version="1">MDISKIPKFVIWVGVAAFILIVLYAIYTYYVTSYLPPYLEYFTYNCQYSNGTSLIIITAKQNLENVTVYNFYENSTCNLGNISYGSMNACSVNNNIIILNAYVRVYYTVNGNQYEAILPCQIVESKGGILSGLFSLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1E517</accession>
    <name>R1E517_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42783">
        <property type="protein sequence ID" value="EOD42783"/>
        <property type="gene ID" value="Nst1_122"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.120"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="212" mass="24410" checksum="63F2CD12DBDDC3A3" modified="2013-06-26" version="1">MEDYIDFEEFRILGVGDKVPEFVIKVYDTVEKRFKEVNIYKDILSKGKFLVLFYYPADFTFVCPTELEDLAEKYDQIKKEGAEVIAMSTDTVYTHLAWHATEKLLENVKFPMGEDHTGTIAKMFNIYDYKSGVAYRATIIIDPDGTVVGMEVNNTDVGRDADELLRKIKAFKYVREHPGEVCPAKWGKDVNITLKPGENLVGRVYEYYKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E521</accession>
    <name>R1E521_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S8P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42457">
        <property type="protein sequence ID" value="EOD42457"/>
        <property type="gene ID" value="Nst1_185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="124" mass="14588" checksum="9A3A686CB803D5F3" modified="2013-06-26" version="1">MVDIINDFFSHATNCINIGRREVEFNYYNKLLLNILEKLKEYRFVEEYKTEGKILIARFSEYFNFGKAIHPRYPVSYKELEKYEKRYLPASGFGILLVSTNKGIKTNEECKREKIGGVLVAVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E572</accession>
    <name>R1E572_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SSU ribosomal protein S5P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42487">
        <property type="protein sequence ID" value="EOD42487"/>
        <property type="gene ID" value="Nst1_216"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.209"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="252" mass="28546" checksum="BB57F5AEF6F59520" modified="2013-06-26" version="1">MVEEQKEVEEVKKEQEALEKIGSQKFNLESWNPKTNLGKLVKEGKINSIEQVFKNGYKILEPEIVDALIPDLKYEYIRLSLSKGKYRRPKFVKMVQRKTAEGNKTSWVSVAVVGNENGYVGVGIGKSSDIALCMEKALRNAKLNIIPIARGCGSWECAFKTPHSLPFKVEGSYGSVRVVLLPAPRGVGLVAPEEMKKIFRLAGIKDLWMKSFGQTRRRYNFAMAVYNALRKTVEYRIKEEYAKYSGLKIGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E577</accession>
    <name>R1E577_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42492">
        <property type="protein sequence ID" value="EOD42492"/>
        <property type="gene ID" value="Nst1_221"/>
    </dbReference>
    <dbReference type="OMA" id="PEGILKC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="229" mass="26275" checksum="7DFE6E61FA3CBAB7" modified="2013-06-26" version="1">MFIFYNLKGVAIDLDGTLVNSLKVYDEVHKKILEKYNIKLDGSLDNFGMSPEEIIYDIVNRYNLSIPIDDLKKEFENMILNEYIEKIKFNPGAKQILNYFKDKKYKMAIFTSNTRRLTIEILKHLHIDNLFDIIITSDDVKQTKPDPEGYIKIIKGFSVLPNEILAIEDSIYGVIAAKRAGINVIGVASGVNKKRELISAGATMAFKNLKELYNYLIEEDNKNNQNNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5A8</accession>
    <name>R1E5A8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fen</name>
        <name evidence="13" type="ORF">Nst1_267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42537">
        <property type="protein sequence ID" value="EOD42537"/>
        <property type="gene ID" value="Nst1_267"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.259"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="11">
        <location>
            <begin position="143"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="10">
        <location>
            <begin position="339"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="349" mass="40203" checksum="CF69386C46D9592E" modified="2013-06-26" version="1">MGLAEIRELIKPVIKEVDFSYLSGKVVALDAFNALYQFLAAIRQPDGTPLKDSKGRITSHLSGLFYRTKNLIEYGIKVIYVFDGKHPEFKKKEQELREEQRKKMEEKYKKAIEMGIKGDLKKYAEFTSKLEFNMVDESKELLEAMGVPYVQAPSEGEAQAAYLVKKGIADYVGSQDYDSLLFGGLRVARNLTISGKRKVRGVEVDINPEIAELNDILNYLKLDYKKLIWFALIVGTDYNPDGIPGIGVKTAYELVKNNNDPEKLFKYVGWDKYYKEISWKELEEFFEDPPVIEINKEDIKFGEVNEEKIRKILIDEHDFSEDRVNKAIEELKNAYRKGSQKNILSFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5B2</accession>
    <name>R1E5B2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42542">
        <property type="protein sequence ID" value="EOD42542"/>
        <property type="gene ID" value="Nst1_272"/>
    </dbReference>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="137" mass="15928" checksum="4F89F0D9FE638C60" modified="2013-06-26" version="1">MKIYQKEVKIETKGPYDFIDITDKVNEILKESGIKNGIVSLFSLHNTACIIIQENDETIFKDIEEFFDRILPLNTKYHHNYEGNINATAHIKTNLLSQSLCIPIKDGKLLLGTWQRIIFLELFESRERKVFITIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5B8</accession>
    <name>R1E5B8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42552">
        <property type="protein sequence ID" value="EOD42552"/>
        <property type="gene ID" value="Nst1_282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="199" mass="23089" checksum="06DA58B669EDB372" modified="2013-06-26" version="1">MDENLSEFLNSLNIYSKITYISSILGFSSYLLLIILSFFSTYNSTISPFSLIFSPYLSLSILYIFLNLINLGTILVILIIISIISYFISIEYLKKIFRIIEKIINKEYYPNNLFSMIYIGILISIFITYPGLVIVGISNYLILKKLYNIVVHLNNQNINKYFRISMIGSIFPLLLILSFIGFYYINKELGKYNLNSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5C5</accession>
    <name>R1E5C5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42562">
        <property type="protein sequence ID" value="EOD42562"/>
        <property type="gene ID" value="Nst1_292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="116" mass="13991" checksum="7FC0C89F9ABD0F49" modified="2013-06-26" version="1">MSVELKDVWDVEIKTSFDVNNIIYEKKVLIIIKNHSPYIRRFEVGTKYINIEDQYEALKFRMRYNLISPVVISIDKYRKETIEVLIPKINHHLGDNIIFYVKNLDKNEEKEIQYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5I9</accession>
    <name>R1E5I9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Minimal nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42657">
        <property type="protein sequence ID" value="EOD42657"/>
        <property type="gene ID" value="Nst1_389"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.375"/>
    <dbReference type="OMA" id="NEEWENP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="118" mass="14009" checksum="028B14F15B441EAF" modified="2013-06-26" version="1">MKARSAIKSQKELLKKAIEVINDIKKEINIIDVYVVGSRARGDYLDTSDLDLVIISDDFKNLRYIERLEKLYKYSKGDIEFFAFTKEEWDNPKSLFIINMKKEAKRLEDLAKYYEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5Y2</accession>
    <name>R1E5Y2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42802">
        <property type="protein sequence ID" value="EOD42802"/>
        <property type="gene ID" value="Nst1_141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="100" mass="12069" checksum="74EB560D777A17C6" modified="2013-06-26" version="1">MLIGLYRLHAKKLFNKIQDNEAKMLLLMSFKDNDILNILEDIVDRKKIFDEYIRNNQIKKAYLVYKDIEYKYKLAESILYNRIEDLVKIRALDIVKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5Y7</accession>
    <name>R1E5Y7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42807">
        <property type="protein sequence ID" value="EOD42807"/>
        <property type="gene ID" value="Nst1_146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="24343" checksum="2A4697BD1DD56773" modified="2013-06-26" version="1">MYNRQSYKSYEKTYDLLEKNKKLELEYPIREIRGLFYLISKHIQENANLPKIERLTAVIDLYCNMHNEPTSCIYDTKMDIYNDKYKLIGCSSKKQDESYEIKCTNYNDISFIDLSNSPQITYSLEGIKYLILSAYNTLYPGILIDMSERGNQYIDIITKVSMNLNNSTNENPKMFVDNNLFIFNSDGFIIEIFWEFYHSPKLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5Z2</accession>
    <name>R1E5Z2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42812">
        <property type="protein sequence ID" value="EOD42812"/>
        <property type="gene ID" value="Nst1_151"/>
    </dbReference>
    <dbReference type="OMA" id="IMECHMV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="153" mass="17448" checksum="1702B728087E99CD" modified="2013-06-26" version="1">MKIDEKDKQLLSLLQKNCKLSLRELSQITEMRETTIFTRIKRLENAGIIKEYRAVLDPKAIGKNVLAFVLIKYDPSAGIKQREVAEKIANLPEIQEVHIIAGDWDMIAKVREKDVEGLGKAVLDKIREIKGVKETVSLIVFESIKETTFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSX3</accession>
    <name>R1FSX3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42225">
        <property type="protein sequence ID" value="EOD42225"/>
        <property type="gene ID" value="Nst1_642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="146" mass="17276" checksum="561F85BC4F558A9F" modified="2013-06-26" version="1">MEKWFWIIVTIIAFGLSLYLYFKFSSINNQTQLLYQDISSCQNLYTTIEKVCYSNNGTELYINIEINKYLNYIYANNNLLSCYIYNEYYNYTIPCNVIINTANNMIQYYTSGLFYELSYGYPNEKIPLLVEKTSPTEVTIYIENPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSX8</accession>
    <name>R1FSX8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42230">
        <property type="protein sequence ID" value="EOD42230"/>
        <property type="gene ID" value="Nst1_647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="196" mass="22470" checksum="D1654B1CC51A99AA" modified="2013-06-26" version="1">MRNQTEIIYVVLFLTIAILIILLSFYALTYNYNQNIVFNRFTSLSTLSNYFLGYLQTLLTQESYAESYLAGTNGWGKENWASYPYGCILPQSCQNAIQYYNNLLTSGYQTLLTFGEQYLTAYQYYYPYNVSFNFSNNYQAGIFGDCNNIISGEYNYNFPVYVQGLYINITGPSSGSIIPYASTSNITNNPAFYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT19</accession>
    <name>R1FT19_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="4">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.16" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42275">
        <property type="protein sequence ID" value="EOD42275"/>
        <property type="gene ID" value="Nst1_535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.519"/>
    <dbReference type="OMA" id="VAVWMTS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="193"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="402" mass="46304" checksum="1D08CC1F308D1A71" modified="2013-06-26" version="1">MNIEGYRDYIIDLYKKFIPVKSIGPDNNGEGEWERAKVLYNVVKDLFDEIKIIEAPDERVKEKSRPNIIAIKYGKNREKTFWIIAHIDTVPEGSLNLWKYDPFNVTVEGNKIYGRGVQDNGNGIVLGILLAKYFKDNNILPKYNYGLILASDEETGSKYGVKYILEKEPNLFKKDDWILVPDAGSSDGLDIEVAEKGILWIKFKVIGKQAHASTPDLGINSTKLGSILILQLYDSLHEKYDKENKLFNPSKSTFEPTKVEKNVDNVNTIPGEFIFYYDCRVLPDYNLDEVYQTIEYICKEFERNYNCKVDIEIVNKDYPSILENIDNNEFLNELKEAIKKYKNNEPRLIGIGGGTYAKYLREKGLNAIVWSTYNESAHMPNEYIDINDIINDVKILLEILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT51</accession>
    <name>R1FT51_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42300">
        <property type="protein sequence ID" value="EOD42300"/>
        <property type="gene ID" value="Nst1_560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pilin_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="166" mass="17718" checksum="F5062A041B976A1C" modified="2013-06-26" version="1">MKIKAVSPLIATIILIALTVALGAIIVGWAKGYVSNQVSNLGAQVEILQVNYNNSNGNISILVQNIGSTQLITNNLLVEFSSTNGKSQKCPLVLSGNAQGYLACYVYNITDPSSGNSYINGTIPQNSLFLINMTVNMNSFGITSLSGSTIYVYYYDNPISTGYTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT85</accession>
    <name>R1FT85_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42325">
        <property type="protein sequence ID" value="EOD42325"/>
        <property type="gene ID" value="Nst1_483"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.468"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="177" mass="20557" checksum="193F24D477A83B78" modified="2013-06-26" version="1">MPFEFEKLDLGLILIKPKVFPDNRGYFKEIFKESDFQKIGIPKPLQVNISYSKKGVVRGLHYQIPPKEQGKIVTVIKGKILDVALDIRKNSKTFGKYVSVELSEENHYMLWIHPGFAHGFQALEDSIVLYFVTNNEYSLQHERCIHYSIIDWPIKDIIVSEKDSKCPILDKAEIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTB5</accession>
    <name>R1FTB5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNase P/RNase MRP subunit p30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42350">
        <property type="protein sequence ID" value="EOD42350"/>
        <property type="gene ID" value="Nst1_509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="240" mass="29427" checksum="29699A43237F006C" modified="2013-06-26" version="1">MYDFCLPDDNEEELASEYYKNRIKNVVFCYEVFDKNDLRYFKLNNILYHKKLNIFYCALINNENFKKSLEIANELFYSDKYYNDLLFIIGRDLNYNDKILSKYFLNGLFDPIKYDKKYYFGGINYVNIKRIKENNLSILFSMKKLINDIEKFYTTKKFLEFAQKKYLNILIGSFAENKDEVPNRYQIYSFYKVLGIYYSLNYLNKIFEEQIIRIRLAKRKDYFTKGFYIISYPYQDCREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTH1</accession>
    <name>R1FTH1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ORF">Nst1_428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42395">
        <property type="protein sequence ID" value="EOD42395"/>
        <property type="gene ID" value="Nst1_428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="64" mass="7524" checksum="47CB895F3846B4AA" modified="2013-06-26" version="1">MGRILHGKFRREANKILEKYSNLFTTDYKKNVKILEVVAEVPSKRLRNMLAGYITRQIKKLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTH7</accession>
    <name>R1FTH7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="8">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysS</name>
        <name evidence="10" type="ORF">Nst1_434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42400">
        <property type="protein sequence ID" value="EOD42400"/>
        <property type="gene ID" value="Nst1_434"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.419"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="9">
        <location>
            <begin position="16"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="474" mass="56913" checksum="F671ABB17FB3D81D" modified="2013-06-26" version="1">MIYIYNTLTKKKEIFEPIEYPFVKIYHCGITPYDTSHIGHLRSEISLDIIRRIFRYFGYIDIAISNFTDIDDKIIKRARELNLLNNWQKIPEEYIKYHLEQIKRLNNLPFYINPRVTTHINDIVDFIKDLINKGYAYKGKYSIYYDIDKYPYYGQLSGTKKEQWEQETEFLEDKKHPYDFALWKFKKEDEPYWNTEIGDGRPGWHIECSTMSSKYLGPQFDIHSGGQDLIFPHHENEIAQSEARFNTHPWVKYWLHFGFIKIKGEKMSKSLGNIIPAKEFLDKYGEDITRFYIGSYHYREPIDINEESINQAKENYRYISSTIKTIVNEINSLDRTFYLDDNKIKIWKELLNYEKEFINSIKDDFNTREATRILLEATNYINKNVIGSETFTLYITSYNFYNIASRIYGLWEDIFYGKESRENLTNILLNIIIDIRNELRKNKNYELSDKIREELRKIGIDLLDQGNKTIYRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTM1</accession>
    <name>R1FTM1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42440">
        <property type="protein sequence ID" value="EOD42440"/>
        <property type="gene ID" value="Nst1_475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="212" mass="24920" checksum="90E0E6172927ED83" modified="2013-06-26" version="1">MPEISLLEKSTDKYAVDKDEKIYKLKLLIRDVTPNFLNVLRRAILEEVKTLAIEDVYIIENNSAIWDEMLAHRLGLVVLNTPENIKENEEIKFYLEKNEKGYIYGSDLKTDKKDVYVVYPETMIAYIDENQKVKLEAVAILGNGKQHAKFIPGHVYYYRTGELKLEGKLDEKELENLKLLGVEIKKNKIQIPKEKEYDRTFLDSIFRNRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTV9</accession>
    <name>R1FTV9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42510">
        <property type="protein sequence ID" value="EOD42510"/>
        <property type="gene ID" value="Nst1_240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="423" mass="49266" checksum="18BDFC97D8D1A138" modified="2013-06-26" version="1">MEGTKNINKKLITTIFTVLFLIGFIFSVYSQGTSEQNNAVSSLESNYIIQWIINSSASGYSTAGQYLANFLSINGVPSYIWTIIVFLMTILFFVAIYTYLFEIFIQRAKITESETMRKSKILFIFTLSLFSAIAIGYAIPFLFNLYGFILLILVLIALFFFGRATISYGKSFHHSIKSFAANIEKDLVEIEKELKKVKKDLSEEDAKYLMEGIEKINNDLANIRAKLDNAEAKFKNILSKLRDTYKTFINELISRYNGYLNTYKGRLQPNQINDLENLIKNLEHKRDSLNTDIPYIPSLSQLRDYTLREIWKLGLDNNDKDELKNILNNIYSNFYSQYQQILSEINDVAKEYNNVKILLIRFYQYEDAFKNDIGLRLKKLLHTPGDRKYEIGILSALDRSKVYIREMENLINERIKFLEKLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTX2</accession>
    <name>R1FTX2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB11 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42530">
        <property type="protein sequence ID" value="EOD42530"/>
        <property type="gene ID" value="Nst1_260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.252"/>
    <dbReference type="OMA" id="ELNLMHP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="149"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="515" mass="60389" checksum="C1249CF28191CB94" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTX6</accession>
    <name>R1FTX6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42535">
        <property type="protein sequence ID" value="EOD42535"/>
        <property type="gene ID" value="Nst1_265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.257"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="251"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="632" mass="76644" checksum="E1B17220033D52A4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTX9</accession>
    <name>R1FTX9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP cone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42540">
        <property type="protein sequence ID" value="EOD42540"/>
        <property type="gene ID" value="Nst1_270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.262"/>
    <dbReference type="OMA" id="GWKPYEL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="190" mass="22131" checksum="9638747B36932CC2" modified="2013-06-26" version="1">MVKVIKRSGEEEEFLEDKVYNSLINAGASEEVAKQIVKELKDWIKIEGVGKISTDEIRRFIFNRLRVLEPDVLESWQFYDRIFKGRITFSDGKVLVVDKGHLYLGRKVKDIGNKGLDNSEEVKEILEELKEDMKYGLSPKTVNARLYALFMGVLKKKDMPKEEKIKSIELINNFRKEMGCKPYELKQPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTZ5</accession>
    <name>R1FTZ5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42560">
        <property type="protein sequence ID" value="EOD42560"/>
        <property type="gene ID" value="Nst1_290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="120" mass="14457" checksum="1FBD56E8C6CBC709" modified="2013-06-26" version="1">MGDIDYDKIINNLLEFEKYNEVLFGFKKYLDSIKEDIDKLKSEIENSKAENKKIEDRLNLLEDKYNNISNDIKNIYNLLDEINKKITEISKRLNEEYINEKIDNYRYKLLLEKLKELDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU35</accession>
    <name>R1FU35_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L39E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42615">
        <property type="protein sequence ID" value="EOD42615"/>
        <property type="gene ID" value="Nst1_345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="41" mass="5061" checksum="CBE4917C27A2DC74" modified="2013-06-26" version="1">MVFKNYNVKIRKIKESKKFMRPPFWAAIKKFGRIVSLYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU54</accession>
    <name>R1FU54_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42640">
        <property type="protein sequence ID" value="EOD42640"/>
        <property type="gene ID" value="Nst1_372"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.358"/>
    <dbReference type="OMA" id="LHQRERF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="295" mass="32927" checksum="D5AEBD9A5CF18CB0" modified="2013-06-26" version="1">MVTEIKKKEEDIDRSPFHGLWTLTNRELKKWYKAPVILLLSIIQPILWIALFGKAMNLQALFSGTTISIPGLNIPKEIIDQIGQEILKQTFGTTDYFSYLAAGMLSFITLFTSMQSGMSMVWDRRLGVLDRLLTTPVSRSSIIISKVLSSVIRSLVQATIVLIVAVLLGMSFYPGINIFDFLGAYAALFLMSFGLSSLFLMIAIRASSWQSQMAVMNLVNLPLLFTSNAFYPINSMPSWLKPIAEINPLTYSNAVIRGMLLGIQTNLIIDFTYLIIFATVLSIAGIILSWKYISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU70</accession>
    <name>R1FU70_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ORF">Nst1_387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42655">
        <property type="protein sequence ID" value="EOD42655"/>
        <property type="gene ID" value="Nst1_387"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.373"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="221" mass="23753" checksum="127F1A048251AB80" modified="2013-06-26" version="1">MLVINLKSYIETIGKGGSELLEAAEKVAEEYGINIVIAPQFTDIYLLAKNAKKVKIFAQHIDPIEPGAYTGYILPEAVKEAGAVGTLINHSEKPMKIIDIEKAINIARRLGLITIVCANDEIVGAAVAKLNPDYVAVEPPELIGTGISVSTAKPEIVINSVKMIKEVNPNVKVLVGAGISNREDVKKALEYGAEGVLLASAVTKAKNFYEKIKELAEGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUE1</accession>
    <name>R1FUE1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42730">
        <property type="protein sequence ID" value="EOD42730"/>
        <property type="gene ID" value="Nst1_069"/>
    </dbReference>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="188" mass="21155" checksum="F5AE25DC4C2240DB" modified="2013-06-26" version="1">MFIILGTVPNIFIFESIFDSLGLDLNKKRYAINRAFLIAYILWLIIFLFGNWFLIILGINLIDFRIAGGIFLFYIAFEILTKDIPSHLNIKDNNESLEDIIATPLAIPLITGPGVITTTLIYTSENLNLIYLFLIMSLAFLISYIIIYNSTLILEKAGKKNLIILNKLGGLILLAIAIDIIISAIKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUH2</accession>
    <name>R1FUH2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42760">
        <property type="protein sequence ID" value="EOD42760"/>
        <property type="gene ID" value="Nst1_099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="266" mass="30618" checksum="BB76F2BEBD036457" modified="2013-06-26" version="1">MYDILIEKIRYNYFILFFLSILIIVFSTLLSLKSGPYGGILIIAISLVPFVQIYNKLIEKDEKISEKIKSKRNIFFRYKEYFIMSFIIFFASIIGFYIGYLINYNLFYPQIQAIEDIREHVIALSYGHAIYSNTFFTYILFNNMTVLLLFFAFSVIFGAGSIYLLLWNASIIGVFLGLRASEYVSNNIIYKFVLIPTVSLLEILPHGILEFLGYFLAALAGNILSIAFIKNLDRKTLEIILSDSLALFVLSILFIFIAALIEAYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUM8</accession>
    <name>R1FUM8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42805">
        <property type="protein sequence ID" value="EOD42805"/>
        <property type="gene ID" value="Nst1_144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="53" mass="6491" checksum="41218E24A2FC3F88" modified="2013-06-26" version="1">MKKFERFYIYLLKVRCKIALEYLMGLKMEINTFYNTNYKISIKIPSISNSIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUN4</accession>
    <name>R1FUN4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42810">
        <property type="protein sequence ID" value="EOD42810"/>
        <property type="gene ID" value="Nst1_149"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.145"/>
    <dbReference type="OMA" id="VDALYGH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="361"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Eco57I" evidence="4">
        <location>
            <begin position="608"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="1121" mass="128774" checksum="0B868D695CBF9053" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G291</accession>
    <name>R1G291_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein involved in tolerance todivalent cations</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42191">
        <property type="protein sequence ID" value="EOD42191"/>
        <property type="gene ID" value="Nst1_608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="107" mass="12691" checksum="7F432907B1ACFF88" modified="2013-06-26" version="1">MIVIFLSVKNGDGINISRRILERKYAISIDIKKVEALYLEKDNIKEEDRELLIIKTREELFDKIEELIKEIYKDNIIEMYSINVDDVNKDFLDLLEKETSIKKIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1G297</accession>
    <name>R1G297_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">Nst1_613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42196">
        <property type="protein sequence ID" value="EOD42196"/>
        <property type="gene ID" value="Nst1_613"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.594"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="357" mass="38159" checksum="5F5D16D1D9CA7BC5" modified="2013-06-26" version="1">MVNDTEIFDKELEEYLAQATKRIKVIGCGGGGSNTISTLYSMGIEGPELIAVNTDVRHLLITKAHKKILVGKQLTKGLGAGKDPKVGEEAAKESEQELKKAIEGSDVIFITCGLGGGTGGGVAPVVAEIAKKMGTLVIAICTWPFSVEGANIWDNALYSLEKLENNVDLLVIIPNDKLQALYPNIPLMQAFKVADSLLANALKDLTELLTKPGYINVDFADFRSIVAGSGYGVFGVGESNSENKATEAVQRALNNPLVDVDATGAKAALVRIVASPDVTPTDINKILDTVKSVLDPKAKIIQGITFEEDKKNYVRVSLTITKLKAPPSFVLGIKSGEKELKPEEQKKLESDLGIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2B7</accession>
    <name>R1G2B7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42216">
        <property type="protein sequence ID" value="EOD42216"/>
        <property type="gene ID" value="Nst1_633"/>
    </dbReference>
    <dbReference type="OMA" id="GKICPSE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="7">
        <location>
            <begin position="158"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="9">
        <location>
            <begin position="396"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="490" mass="56580" checksum="7C4F6C36A26AD73D" modified="2013-06-26" version="1">MEENDLLGVQLRSFEYFVDVEMTKIGRELGTFSPRLLAPGLRDLQFKIEKLWLEKADFMEKEGVSRLIYPMEARIRKLTYSGTVFMEFSVYENETFKSKYQVAIGRLPIMVRSKYCNTYGLSEEELIRIGEDPTDKGGYFIINGNEKLIILSEELGTNKFYVQRESGSIKYSGYLLSESLTQLKAHRMEMTKDGLLYLTFEKYKKIPLIPLVRALGLEKDVEINQLISEGEDFEEVYINLLEFQNIKTSEDAIRYLADKLKLTGSPEVKREKLLSILDNLLLTNIGTSPNDRLLKAYNLLKMARKLLLLAHGKIDEDIKDHFANKIVRTPGELIREYFLVALRTLMTDAMYQYERLVKRGKIPSYTSIFRSKIFTERFENVMAIGKWTRNRTGISQALDRTNKISVLSHLTRVVSSISGEAELLEARMAHGTHWGRLDLIETPEGHETGLRKNKTILAKISFEEVDKNELIRKLEDIGLRPIIKNISDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2C2</accession>
    <name>R1G2C2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42221">
        <property type="protein sequence ID" value="EOD42221"/>
        <property type="gene ID" value="Nst1_638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="656" mass="75663" checksum="6BAD13F50074BEDF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2K8</accession>
    <name>R1G2K8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42311">
        <property type="protein sequence ID" value="EOD42311"/>
        <property type="gene ID" value="Nst1_571"/>
    </dbReference>
    <dbReference type="OMA" id="IKHASIM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="111"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="418" mass="47603" checksum="2DEE5C8CE4456621" modified="2013-06-26" version="1">MITNAYNKKVNQKGLIERFIDQIFNVKDPLHYKEINVFGLYIKEDRFILYISILFAAIIGIFGIIFKLYENYIALSILIIVIYIIGGVPYLFYKYIEGKIYENISNNYTYFLSYLSESLSSGMTLLDALGYLSSVDLGYLSILVKKLYNWIAWGMSFEKAFMLFNMYFEELPNIKMINYVILETYKGGGDISKVLKRLYNDLESVKELEGLKKAYVSQQIMVLYAIFVIFIGLSISILNTIKPLIISQVSVSTVHTAFNFFSSQINYPWLKFITALSIIMVGISASIIMGIAETGKIRSSVKHLAINNLIGLLSIVIFVLPSFVSFNLQVFPTTAYVYTPINIQVYGYIDAQPISNAPLTIYVINSAGNYVYQNFPILQNGYYSQSIELNSTGTYIVEVILNYNGEKYIQEQSINVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2L3</accession>
    <name>R1G2L3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ORF">Nst1_576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42316">
        <property type="protein sequence ID" value="EOD42316"/>
        <property type="gene ID" value="Nst1_576"/>
    </dbReference>
    <dbReference type="OMA" id="ENIVTWT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="97" mass="10763" checksum="C6A5558616240330" modified="2013-06-26" version="1">MPRKVVSKVGEEGIRNAEENVVKENIVTWTKGYKAEVLDVVGRTGMRGEATHVIVRVLDGPDSGKILRRNVIGPVRKGDIILLRETEISAMPIEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2N7</accession>
    <name>R1G2N7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42341">
        <property type="protein sequence ID" value="EOD42341"/>
        <property type="gene ID" value="Nst1_499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="215" mass="26498" checksum="9760327ED03038BB" modified="2013-06-26" version="1">MFNNSEKCIYFMNPKNDLEKKHFYTYCINEKDYIKKGEKVELFIFYEYIEKTLNEFPKIDDEIFEIIRLFLINIYLLIAKPEENEKYLKYAVYIEEKAEQLEKIGREKIKSFIDFSDIDNEEIKKLNNLRINIRILEDLFWLVVKNKEIPDNGLYLVIPHFLNVSSKYIFYYIVVKYCDKLKPIKRLDIIEVKYNEEKYREYLNKYKNKRLDEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2P8</accession>
    <name>R1G2P8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42351">
        <property type="protein sequence ID" value="EOD42351"/>
        <property type="gene ID" value="Nst1_510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="676" mass="76634" checksum="5CD7FED7CD074484" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2U3</accession>
    <name>R1G2U3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42391">
        <property type="protein sequence ID" value="EOD42391"/>
        <property type="gene ID" value="Nst1_424"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.409"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="138" mass="16025" checksum="E3F938CCEA2DE7D0" modified="2013-06-26" version="1">MNNIDIIKEFLYTLLILFSVETFLDLISFIIYPSIFPNYINISVEIFLFIIFLLSIFSIYLIRKDNLYGYIISLFISILILFSAFTLNSNDIIDIAVRNVASNYGIYPNPIILFFGISIFLISIRKIIQLRKTKISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2V2</accession>
    <name>R1G2V2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 2 subunit gamma (AeIF-2g)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42401">
        <property type="protein sequence ID" value="EOD42401"/>
        <property type="gene ID" value="Nst1_435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.420"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="399" mass="44599" checksum="408E2D2F9ECBBCE6" modified="2013-06-26" version="1">MDDIIYPDLSIIILGHVDHGKTTLAKSLTGEWLSKHSEEIKRGLTIKLGYADFTIYKCEEHGYFTEKICPICNKENKPIRKISIVDAPGHESLLMVMLTGAAIVDAAILVIAANEPVPQPQTLEHLVAFKYLGNKPLIIVQNKIDLVTREEAMKNYKEILNLLDKLNIDKNKVKIIPISAINNININYLLEELVNLPKPEKDESSDPIFLISRSFDVNKPGTDIEKLVGGVLGGSLLKGKLKLNDEIEIRPGLFINNKWIPIKTRIISLKQGNSDVEEILPRGTAGIGTTLDPSVTKDDTLAGQVAGYTNKLPPQYDEIKVKYEVIKELFNENEKIQKGETIIVGLYNIISDGVVKNIEKGNIITIKLNKPVLGYKDDKVIILRNINKRWKIFAIGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G369</accession>
    <name>R1G369_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42511">
        <property type="protein sequence ID" value="EOD42511"/>
        <property type="gene ID" value="Nst1_241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="420" mass="48678" checksum="0902A1B91F4C02F0" modified="2013-06-26" version="1">MIKNYKYLIILTFILNSTNIYSQSNNYIYTWYNESIGTLYLDKQLLESSANILSQYLGPLAPIIIENLPYIVTFLALLFIFRRFLNIFNSLAPESQKFAISALMSLILTYLFWPFVMPILITAFIIKVFRIGKSKLESFKESLSKINPGLSGIFSRSTSDIRNFNRDTKGILRDINKLYRIINHPYIRNLLNPIEKDIETLNNIILYLLKETENERLTQHMLVASSSKFNMVYKDTIYKTEQLSRIINTMFSNISLLRRFGNRIFRTNKFTPKYLIVLRKILNDLNTRLNTTYEEGQKIFADLNRLLISAEAISRKYANEINNNLNINPNIAALLSLDNEGALKREIQIIKNTTNAIYENPSISSLKKIEILSTTLNSTKNLSKSLLNLRKFRGNPKGLLKYYKTAINLSKGILKNLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G374</accession>
    <name>R1G374_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42521">
        <property type="protein sequence ID" value="EOD42521"/>
        <property type="gene ID" value="Nst1_251"/>
    </dbReference>
    <dbReference type="OMA" id="LVFHADI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="254" mass="29850" checksum="BC3700E1F333CB41" modified="2013-06-26" version="1">MEIKIDTRKSIYENINEIYEKIKELKNKKQKIESLIKELEEKLNNIEEKIIIEKKKEEIKRNKKWYEKFRWMFTTNNFLLIAGKDSITNEIIINKYLEKNDLVFHADIVGSPFGILKNGRNASEIDIYEAAKFVGSYSRAWKNKLSSIDVYYVYPDQVSKKAPSGMYLKKGSFMIYGEKNYIKVNLEIALAFEDYNIIPGVPESIKDKYKRYVILIPGNKKPIDIAKQLENIFKVDYNIILGYLPGDSDILYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G377</accession>
    <name>R1G377_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger domain containing protein (CDGSH-type)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42526">
        <property type="protein sequence ID" value="EOD42526"/>
        <property type="gene ID" value="Nst1_256"/>
    </dbReference>
    <dbReference type="OMA" id="NGPYEIS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="58" mass="6644" checksum="F547EAE2881317D7" modified="2013-06-26" version="1">MVEIVIKGYENGPYEISVNGEVLYHLCRCGYSQNKPYCDGSHRKMGFQAKAFELKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G384</accession>
    <name>R1G384_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ala-tRNA(Pro) hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42541">
        <property type="protein sequence ID" value="EOD42541"/>
        <property type="gene ID" value="Nst1_271"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.263"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="234" mass="27140" checksum="41FB0C3B2ABFA93D" modified="2013-06-26" version="1">MTEKLFWQDQYLKEFEGKVIEIKGREVILDRTVFYARSGGQPGDTGEINGIKVIDTYYDDNGNIVHLLEKEPNFKVGDIVKGKIDWERRYKLMRLHTALHILSTVLNNIFGNVKITGSQIYEDKARIDFDLDKLDDELVKKIEEKANEIVNKDLPVYAKFINKEELEKMPQLKRLMDEKRYEKYDVLRVVGIGDIDIQLDGGTHVKSTKEVGKIKIIGRENKGKNNKRLIITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G388</accession>
    <name>R1G388_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42546">
        <property type="protein sequence ID" value="EOD42546"/>
        <property type="gene ID" value="Nst1_276"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.267"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_L34Ae"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="PTHR10759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="89" mass="10147" checksum="CED6613EEA9E8DBE" modified="2013-06-26" version="1">MAKTYLIRKTPSGGVSIIVKLKKGNIPRCAICGRKLQGLPALHPSKYRRLNLSQKRVSRKYGGYLCHKCLENLLKEKVREKIKILNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G394</accession>
    <name>R1G394_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42556">
        <property type="protein sequence ID" value="EOD42556"/>
        <property type="gene ID" value="Nst1_286"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.277"/>
    <dbReference type="OMA" id="TIPLWYG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="72"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="323" mass="36468" checksum="E3E7B0CE56741DDF" modified="2013-06-26" version="1">MFRTKKLMEIMKKISNTKFSKFLSISSLILGPILIALAVFFLFFGILTKTPTYAPALPGISYGPITLPIIQTIIAIFIAAFIHEFAHGILVYKNNLDLKSWGFFYLGPLIGAFVEPDEKEIEKLNKKEQIKIYSAGAAINIIAGLIFLFLFFFFTYIISMFNLATPYVKILYTLPNTYAYNVIPNNTILYSINGNQILYLNQIGEVLNNTKPGEYVLLNTSAGLFNIELTNKDGKPFIGIVAEQEYNYKVPVIDFIQSLLFWLFVINVGLGIGNMIPIYPLDGGKTMKSILEIFLDKKRSRIVNLSLSIILLALILYNISFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3A1</accession>
    <name>R1G3A1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminopeptidase, Iap family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42566">
        <property type="protein sequence ID" value="EOD42566"/>
        <property type="gene ID" value="Nst1_296"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.287"/>
    <dbReference type="OMA" id="YIREAFP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="310" mass="36462" checksum="0257092710BC611C" modified="2013-06-26" version="1">MDYKIIDIIKDLERFSPRNNEEAINKTIKYIKENLEKVGVDFFDQYFYVSIPFDEGSYIILDNGEKIIGKANSFVSGYFEEKNIYSSQNIKQEISVPHINYNQYYDAYSGVIFYDFPVINIKKSDLIKVINSEEIKVYVNVKRKLIKNENILVGNTKNPKNVIFTHFDTIFNGALDNSSGTATLLYAIINNKINLKENLIVFSGCEELSYDKPYYWGYGYRVFEYEYKEILEKSEKIIVYDMFGHSKPILTKEYIREAFPIMSEYLYEKSIQISESNNDWIKFYHSDADTIDKINEDYLKEGLELLLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3A2</accession>
    <name>R1G3A2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="ORF">Nst1_301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42571">
        <property type="protein sequence ID" value="EOD42571"/>
        <property type="gene ID" value="Nst1_301"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.292"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="176" mass="20406" checksum="040DE75BCF9FE17C" modified="2013-06-26" version="1">MNSNKNNIMRRIIIDKVTINIGVGKPGEPLEKAEKLLKKMFPDLKPVRTKAKKRVQAWGIRPGLEIGVKLTIRGKKAEETLKWLLKAVNNTLKESQFDKYGNFGFGIKEYVWIPGMKYDPSIGIYGMDVIVTVRRPGYRVMYRRIKRSSIPERHRTTKEEVIEYLKNNFGVNIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3B6</accession>
    <name>R1G3B6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane or secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42591">
        <property type="protein sequence ID" value="EOD42591"/>
        <property type="gene ID" value="Nst1_321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="709" mass="84062" checksum="F114F24ADDF1ACAD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3C2</accession>
    <name>R1G3C2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-specific transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42601">
        <property type="protein sequence ID" value="EOD42601"/>
        <property type="gene ID" value="Nst1_331"/>
    </dbReference>
    <dbReference type="OMA" id="ISMWDEM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="278" mass="31558" checksum="ACBEB26B78B3D4DF" modified="2013-06-26" version="1">MVISEELVEKIKSSFNLNTYEARIWLALLMKGVATAGELADIADIPRSRAYDVLESLEKKGFVIMKLGKPIKYLAVPPNEVVERVKRRYEETMSRRINELEKVKTSDLIKELDALHKSGAGSIDVSEKSGAIRGQQNIISHLESMLKEAQKHVNIVTTQLTFVRDAIALKPIFYELKERQIPVRIITPIDEGNAKYVQELMNVVEIYDAGDYRGRIVTIDSEEILMMLFDEKEVPSSMDVAVWLYAPALAKFIDEMIEVLLPKLKPAQQSLVEKKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3G0</accession>
    <name>R1G3G0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo3</name>
        <name evidence="4" type="synonym">rpoD</name>
        <name evidence="6" type="ORF">Nst1_393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42661">
        <property type="protein sequence ID" value="EOD42661"/>
        <property type="gene ID" value="Nst1_393"/>
    </dbReference>
    <dbReference type="OMA" id="NNTSVMY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="5">
        <location>
            <begin position="24"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="257" mass="29935" checksum="E6A73D903FAB18F8" modified="2013-06-26" version="1">MPEISLLEKSTDKYAVDKDEKIYKLKLLIRDVTPNFLNVLRRAILEEVKTLAIEDVYIIENNSAIWDEMLAHRLGLVVLNTPENIKENEEIKFYLEKNEKGYIYGSDLKSDKKDTYVVYPETMIAYIDENQKVKLEAVAILGNGKQHAKFIPGHVYYYRTGELKLEGKLDEKELENLKLLGVEIKKNKIQIPKEKEYDRTFLDSIEKASNEKIKVIPKDEFIFIIESFGQYSAEKLIPLAIKELQNKLNNLLEFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3H3</accession>
    <name>R1G3H3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42676">
        <property type="protein sequence ID" value="EOD42676"/>
        <property type="gene ID" value="Nst1_014"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.14"/>
    <dbReference type="OMA" id="TLIYNFR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="218"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="386" mass="46385" checksum="5BB145694964402C" modified="2013-06-26" version="1">MRNSYIIEIRPILEKYKLKQIMRKVRYLSHLKVHRVPHITLIYNFRPLVAPLKIMEVIKEVSNKYSNLEFYYYKYEIKKGKKGYTIALGIRPNNELFQFREDLYKSLKNYIIERSDSKFYNENFWFHAAISFHLSSKVVKNILNNKEIIQILSRFLYKAEVLRITLVNAGKIVYEYDVLNRKILNRREALSLVELEKTYKKYRENFLKIEVDPKNLDKIWFIADTHFGHKNIIKYSARPFVDVTTMNEYIKNKWNEMISNDDIVYIVGDFARRDFKKYFNSLNGKKIFIQGNHDPPAIGVKQLELQINNYKFIISHYPTNLNSYNTWLIHGHVHNNRLREYPFINSKKKTINVGVDVTKFYPVNLKWILDLIETESNYLYLPHKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3I9</accession>
    <name>R1G3I9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42696">
        <property type="protein sequence ID" value="EOD42696"/>
        <property type="gene ID" value="Nst1_035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="62" mass="6719" checksum="03DD152BFE9EBF4F" modified="2013-06-26" version="1">MKNSIAIDMVIIIVIALVILILAILFGYKIFLGGNTASNQSFSFINNSFNNVTNQSITNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3J7</accession>
    <name>R1G3J7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42706">
        <property type="protein sequence ID" value="EOD42706"/>
        <property type="gene ID" value="Nst1_045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="288" mass="34062" checksum="9DE688EFDB76ECDA" modified="2013-06-26" version="1">MRSLSLKDIIEYIAAAVVIIFAFFIVAILYALFNIESYSEYTYQQFTNSLLIDRLNYCLYEDTGNPLLLFYAPNPNIINEYNNVYQQCFMNVSGTLYYFINESNQSNEAIYTYLNLSYDDYIYFFFYDINNINYSYSYDPYNLSFENNISVNPYYVAYNIYNVSYTYENLPSLNQFLINYFYNYSLYIFNKTEYMYQNYQFINNTKILNTVANVKAGNYKTKYYYNEVYIQPIASYYITLPEYDSGEPVIVSLYGVGKLYMNGIYNETCNIIAGGQINISSCQINQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3K0</accession>
    <name>R1G3K0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="3" type="ORF">Nst1_050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42711">
        <property type="protein sequence ID" value="EOD42711"/>
        <property type="gene ID" value="Nst1_050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.48"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="395" mass="44540" checksum="B64ADBF6CA24BF9E" modified="2013-06-26" version="1">MAKSSPPYIKYMIHASVYIDGVVEKPDVIGAIFGQTEGLLGSEMDLRELQRSGKVGRIDVDLKVENDKTIGEIRIPTSLNRFETALIAATLETVTRIGPTHATIKVQKIEDIRKTKVQQILERARELLAKLINEELPDPKELLLYLEYSNNMKSLIEYGPEKLPAGPDVDKSEEIILVEGRADVLNLLRYGITNVIALNGLNVPKTIVDLSKKKIITTFFDGDRGGDLLVKECMLSGVDIDFVAKPEPGREVEELSGKEILKALKNKISFDQVRAYYEKLEGTTEDIKNIRNEKKIKDPILQKLKSYMNDVFKTDQALLLDENFNILNKVPVDKLGEIILKHNNLAYLVMDGILTRELLELIEKSTNIKYILCIDSIQKSSNKVKIYTISDLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3L7</accession>
    <name>R1G3L7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="5">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysS</name>
        <name evidence="8" type="ORF">Nst1_070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 6">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42731">
        <property type="protein sequence ID" value="EOD42731"/>
        <property type="gene ID" value="Nst1_070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.68"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="172"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="511" mass="59748" checksum="1C3472C42D7AD007" modified="2013-06-26" version="1">MENKDLLKTGLEIDIVDRLKVLEKMKEKGYNPYPYEFDKTNDVKEIVNDPDKFMDKYVKIAGRVYSVRKHGGIVFYDIKEEGYRIQVVIKKDITKNFEDAYEFIQRGDIIGVYGKVGRTKAGELSVFAEDWIILTKSLISLPDQWYGFTDVEERYRKRYLDLLMNDEVRRYFEIRFKTISYVRKYFENLGYIEVQTPVLQPIYGGANAKPFITYVNDLKENWYLRIATELYLKRYLVGGFNKVFEIGPDFRNESIDVTHNPEFTMLEAYEAYANRDKMMEIVENLIYGIAKDIIGKDYIEYNGKKISLKPPWRRLTMYDALKEYANIDVTKLSDEEIMEIMKQNNIQLELKEYNRGLAITALFEELVEDRLIEPTYIIEHPKESTPLCKLSRKDPSLVERAEGYILGVEVTNIYSELNDPILQNKLLLEQAKMRELGFEEAHLYDQDFVEALMYGMPPTGGIGIGIDRVIMLLLGIKSIKEIIPFPMVKKKTESEAVKILTKYTSNKDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3V9</accession>
    <name>R1G3V9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42816">
        <property type="protein sequence ID" value="EOD42816"/>
        <property type="gene ID" value="Nst1_155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="370" mass="42777" checksum="4C2DE8FD7F14BF9B" modified="2013-06-26" version="1">MQKNNIAFLNLRNNLNYLQQTPHVKNLSSTRTIYHNYIPSYAKDIKVKNYDGFYFAFFMFFYIFIFQFVNVPFKLPVFIILMSISLFLIIRGFKRYIIHNILNNTPFSKIHIATYGLNKVKGRFIPYGYQPLKSPISGQDCIYYSISTFYVHPGGNNNSTWISDFIDGFDVGIPALFTDGTGFLAVDLEKAPIVEVRTNIIEIIPNNSQDRKIKLSNFNDAKRISDEILQYIKYAANNNTQVNLYYIKNYKFTIKNNKIRNLKLYVDSTELCSSIIHTRIGEICKYDSRNMLYLVEQYIPINEDYTIIGGFADTGEMINMKPVKVTVPDMSTGILEVHLSNFYRNEFLIKAVAYITLGIVYLITGIVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3X9</accession>
    <name>R1G3X9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42831">
        <property type="protein sequence ID" value="EOD42831"/>
        <property type="gene ID" value="Nst1_171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="235" mass="26442" checksum="F9B17FED9BC62551" modified="2013-06-26" version="1">MDLVETYKKSFDLVKSHIIESLIYGIVFYILGGLLFLIPIVGAIIYSYFYPRLTEWYYTKVTGDNINPDYKTAFLSLLIPNLLASIGITIILAVLISILMQLGLNFTDILNITNLQQSLLMSLPNFSIFLYDLLGIIIGIIIMIIGGIIWILLLYSIYGSILGKVNKLSIYFEKSLILFAYWLVFYIVTDIILLIIGGIFSLILPGLGDIIVTILNIMIVYPASNLILLLKAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8T3</accession>
    <name>R1G8T3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42254">
        <property type="protein sequence ID" value="EOD42254"/>
        <property type="gene ID" value="Nst1_595"/>
    </dbReference>
    <dbReference type="OMA" id="PRDANEC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="398" mass="46745" checksum="71B47C9C6D7D32D5" modified="2013-06-26" version="1">MKILFLSWGVFPQKGGGLEKVTYYYLKYLDYFNNVVYLFILNLTDDVKSFWNNKLKNSKIFGLNMKLYQSYIDYFKYGSFTLYKRKIIDYKKAVIEYKDRILDILKKMKLDFDIIYAYDWLTALAGIEIKKIYKKPLVIHFHSLVYDRVGGNPDVLKYLYDYDYGIELEACKYADKIVVVSKREKDILVKYYNCDENKIDVIYNAPDDDFSIKEKINSKIKEKYKIVLYLGRMTMHKGPDYLLRAAKRVLEKRKDVLFIFAGTGEMLEQLIKMAADLNISKNVIFTGWVDDDLAEYLYSIADIFVLPSISEPFGLTPFEALKYKDFIIISKQTGVYEVLKNALAVDFWDVNKMADYILALLSYPKLGEYEIKLCLDDIKNLSWKNSVEKLISIFNSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8U8</accession>
    <name>R1G8U8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA methyltransferase, SPOUT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42269">
        <property type="protein sequence ID" value="EOD42269"/>
        <property type="gene ID" value="Nst1_529"/>
    </dbReference>
    <dbReference type="OMA" id="FPIHKDL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="260" mass="31237" checksum="D50CB18361C3CAD7" modified="2013-06-26" version="1">MRKLLLIPSTFTGEKRDQKIRIFLISQLARAIVNFGINEVGIYYDDDPKFNSHGLGRFILKVLKYLNTPPYIRKIAFPIDKELKYIGSALPLNVYYHKDRTRYEYVYILKREKDKFYLTNGEEKFYVNVNKKYRKTNILIYDKINKKLLYPHETEFYFGYEVFYYNKTLEELIKKLKEENFYLMATSRYGEDIKNAKIEKKDKIAIAFGSFARGIEDMIKDWKEKFDISINICPDQKLETIRTEEAIYYTLSILHYKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8X3</accession>
    <name>R1G8X3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42294">
        <property type="protein sequence ID" value="EOD42294"/>
        <property type="gene ID" value="Nst1_554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="264" mass="30416" checksum="C716088930570D55" modified="2013-06-26" version="1">MMNEDKKEVIFLLGATGGIGKLLAEELKNNGYIIVGNGRKEDVLISMKNEGKIYDYVVGDITKDEDRKRIVEKIKEYVNKGYKVSIFYNIGILYNYPGEFKNYTNKMIEDSYKTNVISIEEMDRELEENGFYLDTIYMVSISAFFRGNWDHEYQKTKAALKAHVEDQLLNSNGRRIIALFPDTIKTGEEGMGSKLKEYPKIPGEIFVKKIAEIINGKYKKYSGFIFEIDNNNIIKLYGINPSKITNAFEYLEKVFIEDVGKAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8X8</accession>
    <name>R1G8X8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42299">
        <property type="protein sequence ID" value="EOD42299"/>
        <property type="gene ID" value="Nst1_559"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.542"/>
    <dbReference type="OMA" id="QHLGGAF"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="343"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="391" mass="44239" checksum="ECFF776AAE94C1E6" modified="2013-06-26" version="1">MEIKSAKARVVLNSRGDPTLEVEINSYSEAAPEGASKGSGEVVYLDPKKAAELFNNELIDFLKTFDIASLDDLKEFENEFESIGGIKRYGGNTLIATEYAILRAWSNYEGKPIYQFFNKNPKINIRILANVVGGGAHAKGRSTNIQEFLVSPDTDNLPLSIFVASYIHKLLGKRLELLDDKFLYGRNDEGAWTTSLEDETVFNIIKMVFDEVKMDYNIKVDLGIDFAASQLYKDGTYRYKNKVFSREDQIRYVKFLIDTYDLFYVEDPLYEEDFEGFAEINNSTKSLIVGDDLTVTNIERIKKSLIYKSIKGVIIKPNQIGSVVKAYEAVKFCKENGLIPILSHRSGETESNILAHLAVGYEVPFVKFGIINGERIAKLNELIRIYESLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Y7</accession>
    <name>R1G8Y7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42309">
        <property type="protein sequence ID" value="EOD42309"/>
        <property type="gene ID" value="Nst1_569"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.552"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="909" mass="98107" checksum="EA4CA72C4546052D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G958</accession>
    <name>R1G958_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division protein pelota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42379">
        <property type="protein sequence ID" value="EOD42379"/>
        <property type="gene ID" value="Nst1_412"/>
    </dbReference>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="338" mass="40344" checksum="3F8127B56560A183" modified="2013-06-26" version="1">MKYEIIDKKTIKIRVEDEVDLLYLYKIVNVGDIVEGYDYRTLKFENEKEKKKIKIKIEVENIKFSEYKDSLRISGKIIDSNDKDSIGHYHTFDVRISTEFTLYKKEEIKKYEEKILEKSSRKKEEIFVISIDGNEIALGIINSGIKIIKEEYYKINKGDPEEKAKLHKIFSEFLNALKDYNIKFLCIIGPLFYPEEFYDYVKNKLNIKNIKIYKVSNGGINGIYEFVRRTEYYETLKSLEILEINKLIEEILYLMQKNMVAFGYDEVYNNAMYNNIEYVLISEECFKKMKEENNIDKIINLFNILDKIDAEIYFVNNNVNNFELIDRFCIVGKLRYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1G975</accession>
    <name>R1G975_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ORF">Nst1_427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42394">
        <property type="protein sequence ID" value="EOD42394"/>
        <property type="gene ID" value="Nst1_427"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.412"/>
    <dbReference type="OMA" id="QFNEGAK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="95" mass="10780" checksum="79C9D2517DEAC64F" modified="2013-06-26" version="1">MAEQTIIYIGNKPFMNYVTAVAMQFTSQDAKEVVIKARGRYISRAVDVAEVVRKKFMAGQVDIKSISIDSEERQVDQTGKKRRISSIEIVLVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9A1</accession>
    <name>R1G9A1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42419">
        <property type="protein sequence ID" value="EOD42419"/>
        <property type="gene ID" value="Nst1_454"/>
    </dbReference>
    <dbReference type="OMA" id="PYGFYRN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="11">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="230" mass="27623" checksum="F85D483EE51E5169" modified="2013-06-26" version="1">MKYREIWKVYGKVFDKNTLYYLDKLYKDHYIEDDLTLISEGKEAIVVRSGKFAIKIYKIMSISYKEQVNYLKADPRIYKFPRTKIGIIYTWVKKEYMNLRKMYKNLVRVPIPYLYKGNILVMEYVGYEKGPLLLHDSYDSIENKEGLFFDILDQYKKIYNKAKLIHGDFSEYNIIIFNNVPYIIDVSQSIPTDSPYSEEFLNRDLNNILNISKKLDLDYDMKYIREYIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9G5</accession>
    <name>R1G9G5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42479">
        <property type="protein sequence ID" value="EOD42479"/>
        <property type="gene ID" value="Nst1_207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="114" mass="13450" checksum="CB70E346AF257BF3" modified="2013-06-26" version="1">MRSFSISIFIELVVVIIVLYFILTSTYYSNFYIRGYNKEDLYASLISINYMDLNNTQQLNNSLYQIVTNILPYYYVEINGQVAFNNINLNEAKQGIETFYIINGSVDYVDIYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9J0</accession>
    <name>R1G9J0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSU ribosomal protein L10AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42489">
        <property type="protein sequence ID" value="EOD42489"/>
        <property type="gene ID" value="Nst1_218"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.211"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="4">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="185" mass="21742" checksum="1FB0657352BE19D6" modified="2013-06-26" version="1">MAKRPWRIFKEIERPYTRFSYSKSYNKIPGAPVSKLRMQIMGITNIPKDQWKYVGHLIALHNVQVSDYSLESVRTNILKYLEGEVKEFLFIVRKYPHHVVREHALVYGAGADRISQGMRHAFGRPYTRAAQVYYKDIVLSIYYNKPEFTNRISFYLDVARKKLSGKYKKYIGENKPEEVILSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9M1</accession>
    <name>R1G9M1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase of PP-loop superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42524">
        <property type="protein sequence ID" value="EOD42524"/>
        <property type="gene ID" value="Nst1_254"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.246"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="221" mass="26381" checksum="FF3316B794A16A8C" modified="2013-06-26" version="1">MKLAVLYSGGKDSNYSLYIASKYHEVSVLLNIIPKNNESYLYHYINNNLTELQSKALNIPIERFYINNNEEETLFEALKYLKEEYNIDGVVTGAIRSTYQGSRFQRICKRLNLWCFNPLWLKDEKEYLYELLKNNFQFIIVGWYTYPLDINILGKVVDENIIKKLIEYKEKYKINISGEGGEYETFVLYQPLFKKRIIIKDYEIKVEKNYAEYIIKNAYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9P9</accession>
    <name>R1G9P9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42559">
        <property type="protein sequence ID" value="EOD42559"/>
        <property type="gene ID" value="Nst1_289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="173" mass="20765" checksum="B2404FED5E0A6225" modified="2013-06-26" version="1">MIIRLHQALSSFITYIIFFYIFNFDKVSSIIISIIVGLICVIPDYDYKIYNWANKQYENINKSKILKYLLFPYYLFILFLLKLFKHRGFTHSIFPIIIFFLLGLFIMKIFYLFSLAFLLHIIEDSLTVSGITPLYPLSNYKFVIPILNNRKNRKVQEYLSYIIYIMFFAIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9R1</accession>
    <name>R1G9R1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42574">
        <property type="protein sequence ID" value="EOD42574"/>
        <property type="gene ID" value="Nst1_304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="180" mass="21722" checksum="81D08F18495342D6" modified="2013-06-26" version="1">MTWETIYKTRVRSKIKFIPQDFYEKFKKFLESDKWQGIFKKDRYEKYYFHRLTPEGLLFVEAKWEGYKNYWKEEPKIDWKIELTILINAYNINTAVGDLDISIETAHNVEEFKDFDISKASRTEKILLGLGFSKVLSSLKSNLEKVRGKKKLIDMSGRDLYEDSEKIKNFILDYFKLYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9W1</accession>
    <name>R1G9W1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42629">
        <property type="protein sequence ID" value="EOD42629"/>
        <property type="gene ID" value="Nst1_361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="140" mass="15164" checksum="F0B6754ADE2740B2" modified="2013-06-26" version="1">MTVAIAGLMYAWLSGMFSSLTTSTSQQVIQATQLTSFNVPKMFISNGNIYAIIYNNGNVPINANNMTITAQEFWASNNTYDGITYVCSASSGIITSGQQSTITLSCNPTSLVTNWNSGIYYYLFTFVYNGVSVQATLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9X3</accession>
    <name>R1G9X3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted or membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42644">
        <property type="protein sequence ID" value="EOD42644"/>
        <property type="gene ID" value="Nst1_376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="135" mass="16001" checksum="35DAD22D1911A49B" modified="2013-06-26" version="1">MKKEDIIIFIVLTVIFFVIFYIAFYKLFGKNIGTSKNMPINITFYPNPYQYNANYVNNTLYLNITDYQLPYINTSNFILNITENIYNLTCGKEIIYTNQSVLCYVKNIIIENNTMIQLLYPFNNVLYNIEYNITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9X7</accession>
    <name>R1G9X7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42649">
        <property type="protein sequence ID" value="EOD42649"/>
        <property type="gene ID" value="Nst1_381"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.367"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="707"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="937" mass="110854" checksum="C40D8EE729807F3A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Z8</accession>
    <name>R1G9Z8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42674">
        <property type="protein sequence ID" value="EOD42674"/>
        <property type="gene ID" value="Nst1_012"/>
    </dbReference>
    <dbReference type="OMA" id="EENYINT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="68"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="302" mass="34635" checksum="59B3C95092F8C408" modified="2013-06-26" version="1">MENEKEKTEENKEWNFNLNLEKSIIIGFIILAISIILGAYIIANSVSNIKVYGSSSSSSNELQTYLQTLPQAPLPNITNIDPVYGNPNNANVVVYEFSDYACPYCDIFYLQTFPQIKQNYIDNGKIAWVYVNFPLYSIHPYANITSQYLTCVYELYGFNTWEEFANWSWYNQMQNISWDTFSNQQDVYNVFNKEAQALGLNVNEIDSCVNSSEYYNQIYNEENYDASEYGIDGTPTFIIAVKTSSITFQTVQQVNNALNQLKQYGLSPSVYTTPDHNYIMFEFAGALPYSFFNNILQPLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA60</accession>
    <name>R1GA60_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase involved in DNA repair, SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42744">
        <property type="protein sequence ID" value="EOD42744"/>
        <property type="gene ID" value="Nst1_083"/>
    </dbReference>
    <dbReference type="OMA" id="PYVDVNI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="6">
        <location>
            <begin position="338"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="338"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="751" mass="89389" checksum="50D0D894C44EE00A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA91</accession>
    <name>R1GA91_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DDW05_00365</name>
        <name evidence="3" type="ORF">Nst1_113</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000002">
        <property type="protein sequence ID" value="PVU71642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42774">
        <property type="protein sequence ID" value="EOD42774"/>
        <property type="gene ID" value="Nst1_113"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU71642">
        <property type="protein sequence ID" value="PVU71642"/>
        <property type="gene ID" value="DDW05_00365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.111"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PVU71642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="246" mass="28597" checksum="302291BBCE593C68" modified="2013-06-26" version="1">MIDFYIVFVEPESEDNIGALARVMANFDFKNLILVNPKVNPYGDKVKIVAREKGWEIIKNMKIYNSLDEVIDLFDINYGTTGVSSKMGNEVLRNPLTPREFANSIYKYDGKIGIFFGRESKGFSNEELNKFDGIITIPASEEYPIMNITHSAAIILYELFISKNNPIRKVFKLINNQERKYLYKMFKDFVDVLPSQDYRKPFIYRGLRNLIGKALITKREYSLLMGMLRIAKENIENCRKNKNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAD3</accession>
    <name>R1GAD3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42819">
        <property type="protein sequence ID" value="EOD42819"/>
        <property type="gene ID" value="Nst1_158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="327" mass="39586" checksum="B40FFC96167B7DE9" modified="2013-06-26" version="1">MEKIYNEDLKLISREYDVRTLFNNEFERFIIEERIDPITNFKVRINKSIKSKPRSYGRIYSKKSKCPFCNPEKETPDFEFSKKIFIGDSVLFSNKYPYGKYHAVLVPNYKKHVKSFSQISYLDLYNSFMLIKEFYEKIPEKDYKYIFINLNKGFSAGASQEHLHFQILIEKEPTNYFRIYLDKSNKYFDKYKKFFIEDYFNFEKQLNERIILDGIIKLWSSFAPFRNNELIGYIDTFGIFFLSQNKFEEFIKTLYKILITYEKLYENFNLVIFDTTLLRESRSYPIIKISQRPLFDIGYMEICHLEYVVSSIPEETAKEFKENLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3L7</accession>
    <name>R1E3L7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Archaeal Lon protease</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent protease La homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Nst1_584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42243">
        <property type="protein sequence ID" value="EOD42243"/>
        <property type="gene ID" value="Nst1_584"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.566"/>
    <dbReference type="OMA" id="GLYFWNL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="440"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOD42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="620" mass="69094" checksum="ED4C7D925AACFBD6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3N6</accession>
    <name>R1E3N6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42263">
        <property type="protein sequence ID" value="EOD42263"/>
        <property type="gene ID" value="Nst1_523"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.507"/>
    <dbReference type="OMA" id="ATWWETA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="384" mass="43479" checksum="7797012F42153C33" modified="2013-06-26" version="1">MKILFALISTGLTGGFRYIFEVANGLKERGHDVKIVALTGDHSWFKNLKVDVIYKPLNLNMFRSAVYSLYKFYSHITLQNVRRTPYGVFRAISSKLLGVRPDSIIELADLIKDFDADVTIATYYLTAFSVWFSQNKNPFYLVQDPPELVEINEGKVGLNMFKLSLKLPFSFVAVSSYVKQLILDNNSTARVTIANPGVNLEIFRPKSEPKESNKKKVMVILRGYEYKGDKISLEVLKIVNKKIPIHAIIVGSKDLVKKYSKTIGLNFSYTVFSNIDDEKLSRLYSSSDAFLYTSYAETFGLPPLEAMACGTPVVMTDYKGSRDYAVNDFNALISQPGDVKSLVDNLLKVLQDDKLRDRLIENGLETAKKFTWEKTVDNFEKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Q9</accession>
    <name>R1E3Q9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42288">
        <property type="protein sequence ID" value="EOD42288"/>
        <property type="gene ID" value="Nst1_548"/>
    </dbReference>
    <dbReference type="OMA" id="MVKFCPK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="104" mass="12081" checksum="E9C124B5E746FC47" modified="2013-06-26" version="1">MKFCPKCGSLMKKENNYLVCPNCGYKEKIKDANSLLLTENINKSSEITIMEEDYKLYPVDNEVECPKCGNKGAYFWSIQTRAGDEGETKFYRCVKCGYTWRVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3R4</accession>
    <name>R1E3R4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42293">
        <property type="protein sequence ID" value="EOD42293"/>
        <property type="gene ID" value="Nst1_553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="279" mass="33539" checksum="4260A8739B91D519" modified="2013-06-26" version="1">MNINEYIKRANYNDIENIVEFIRRNIEENKFYFDFEENGKNSYKIYEENYVKRLLDKGDIILLYIENDQITGLSHWTSEYGIWYNLYTVVNEKNSKKGIAKKIYYYFLKQDIPVAADFVIYLPTSSKIFKIWENHGIKISGFASSFIHKDNKNNLYTTIIGYRSKDRILELKIPKYSEKFFKNLCILNNLDCKIYTFEYKRKENNEKYPKLIYTTNIKEYEEKGYYLTGFLYNNGQIIYAYSSKVDKNIREPIVKFFNDLGREDIKNTILEYIDNLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3V0</accession>
    <name>R1E3V0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42328">
        <property type="protein sequence ID" value="EOD42328"/>
        <property type="gene ID" value="Nst1_486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="357" mass="41575" checksum="328A9C853F4C22D9" modified="2013-06-26" version="1">MGLKDIFRKKLKEAHQLEKDYLDLANRYNLDYITGSDHFIILSNKRLSEDADRRKSDTSPWPGIKIHSPLSVKMYNILRSYDFTQMLKNEEIDGIKVYLYDDPSTKHKEVTIYISLGSMPNLGKLLNILEKNGISIQPALSSYYHQGYKMVLLNRIPIDSYTGVFVRYSTDFTGKMNIRDIENIRNSIMSNIDTKNINNYINQVKILQDYIIGKYIDKIDDRVWRSAADTSSPRIVAVPRGWLLNNQYNLDEILRNSYTSLKDFYYKLLRNSDPKELLRYSSTIYTFIKLGEIDGTIVAYPAIIISYDKNNNLLEAYDIFRAKIVKYNLSNEEDITAISRDPESELYEFLKYGTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1E479</accession>
    <name>R1E479_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.9" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42438">
        <property type="protein sequence ID" value="EOD42438"/>
        <property type="gene ID" value="Nst1_473"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.458"/>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008886">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="44"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="516" mass="58483" checksum="9A5FF8B3356468AD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E486</accession>
    <name>R1E486_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42443">
        <property type="protein sequence ID" value="EOD42443"/>
        <property type="gene ID" value="Nst1_478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="149" mass="17140" checksum="ADA04E25D067E81A" modified="2013-06-26" version="1">MLGNYKLFNIEDGPITAISADLYILKISGASYINIENLENPFKVIGSIYVPKYSYKKIINNLSNYNKKIFDSYRLEGTIFDISYIGPQYSKLEKYIKGKPVEILQDHDLDDKIEMITNDWNLYQLANIGKGVKMAVKISIFSNYQGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E498</accession>
    <name>R1E498_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42222">
        <property type="protein sequence ID" value="EOD42222"/>
        <property type="gene ID" value="Nst1_639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="94" mass="10957" checksum="164C567B1E663E31" modified="2013-06-26" version="1">MKLQQSVYWIIITFILIIAAGLFSFYYIYNVKNNLSGNNIQTINCQQLENLYNKSFQEIINIKVFLNENCTINGITIPAGYRIIYIYNGSINYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4A4</accession>
    <name>R1E4A4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42458">
        <property type="protein sequence ID" value="EOD42458"/>
        <property type="gene ID" value="Nst1_186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="83" mass="9836" checksum="55B074BE653ACEF3" modified="2013-06-26" version="1">MASDWKDSLDPVFRDFVKSLIEETKKYKDIYENTDNPSKVQIWIALGILYRKLLSIEGKLSEIESILNNKELKEKLEEYLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4C2</accession>
    <name>R1E4C2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome, alpha subunit</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42247">
        <property type="protein sequence ID" value="EOD42247"/>
        <property type="gene ID" value="Nst1_588"/>
    </dbReference>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="3">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="238" mass="26773" checksum="4FF1042CFB0B0068" modified="2013-06-26" version="1">METDIGQFGPMDRGWAIFSPEGKLILVEYAKQAAKAGSTAIGICTTDGVLIIADKKIPSKLIITDSIEKIMEIDDHIIGTFSGFIPDGRVLIDYAREIAQQHKLQYGKQIDIELLVREISDIMQSYTRFGGVRPFAVSLIIGGIDKDGEPKLFSLDPSGIFYRYKAVVIGEGEDKITPILEERYKEMDLNEAIKFGIDVLKEYLGNNFAYERLILSYVKKGEKVKTIENHEIRELYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4D2</accession>
    <name>R1E4D2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42257">
        <property type="protein sequence ID" value="EOD42257"/>
        <property type="gene ID" value="Nst1_599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="281" mass="32589" checksum="9E69C1BE6BB03B0B" modified="2013-06-26" version="1">MKAQRLYLVGLIILILLVSISIAIFFMNYTQQTGLELANLEITNLKNNYTNLQNQYKALQMQFSIIESNYENLKTNYTNLQNIYQNLQSQYESLQNNYSILQTNYTNLQDQYQVLQSQYNTLESNYQNLETNYTNLQNMYQNLQSQYKSLQEQYSNLNNTYWNILTFLGNGNNSAILQPNQFIYKEIAIPTGFSGTINIMISSSNPIEVFVFDLYNLIQAIEGNPYGYYLYNNGTYINTSVTLGPGFYIVFIYNPNNTTEATLSYEITTIYTTAPKLLTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4H2</accession>
    <name>R1E4H2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GMP synthase-Glutamine amidotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42523">
        <property type="protein sequence ID" value="EOD42523"/>
        <property type="gene ID" value="Nst1_253"/>
    </dbReference>
    <dbReference type="OMA" id="SDRCVQA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="175" mass="21013" checksum="578804924CF99AE5" modified="2013-06-26" version="1">MIGIIYTNKEELSKYEFLYPIINILKELNINYKVFSYKDKINEYFEKIIITGTAIMDFDYLNYIKNFEFIIENNIKTFAICSGSQILTKLLNYDFEDKELIGKYYVKIINKDKIVDKDFEAYFLITKIPKIDEKFYIIGKVENIPVLYKYKNIYFSLFHPEVLNKDIIINFLECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4I3</accession>
    <name>R1E4I3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42538">
        <property type="protein sequence ID" value="EOD42538"/>
        <property type="gene ID" value="Nst1_268"/>
    </dbReference>
    <dbReference type="OMA" id="GNALWKE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="144" mass="17130" checksum="920089C4ECAF8D21" modified="2013-06-26" version="1">MKDNAFLFDASALYKFLTVYKNYTNKIDYNYIYNIYILDLTFYEIGNTIWKNYYIFKRINNPIETSETIYEILKEFNVIENLSLSFTEIIKIAIEKNLTYYDAAYVYASKNFGLILVSEDKDLIEKGNAISVKEFIEKYLKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4K9</accession>
    <name>R1E4K9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42327">
        <property type="protein sequence ID" value="EOD42327"/>
        <property type="gene ID" value="Nst1_485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="288" mass="31474" checksum="5B0D47A3655AF622" modified="2013-06-26" version="1">MSSLELLAVGIGIAITVMMGILVAGWIISAIPIYFVAKHFNKNLSFPKVLGATILSEIVSFIIIPGSGLTIFLFISKLGPHLFWGILKALIIVTIINFIAVLIIYKLAFKVGWKATLVISILATIIESILNLSLPGIFYYVAFLIPILGPATSIVFTVNTPVGTLGIGIYGIIGYFIFGLILSAIFGYLVIKFSKINISFLETLVVNMFSGAISFIIIIISFLSSIMEENIVAFFIGGVLAYILSFIIYKYILNVSWKKAIPISVISSVLWFITGLTILPYSIYFMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4L5</accession>
    <name>R1E4L5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42332">
        <property type="protein sequence ID" value="EOD42332"/>
        <property type="gene ID" value="Nst1_490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="53" mass="6543" checksum="95C0058824CA4E77" modified="2013-06-26" version="1">MEKFILRDDNYVLKFNFNNGKKIYLNLLYLKNSTYYYKANKIINDFSSKYCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4N8</accession>
    <name>R1E4N8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42352">
        <property type="protein sequence ID" value="EOD42352"/>
        <property type="gene ID" value="Nst1_511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="605" mass="70099" checksum="1066F14E315F0846" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4P4</accession>
    <name>R1E4P4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42633">
        <property type="protein sequence ID" value="EOD42633"/>
        <property type="gene ID" value="Nst1_365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="125" mass="15096" checksum="B3C1A70FF4A15E1B" modified="2013-06-26" version="1">MVTHEIGHTVFRSNNEWKASVFEFLVYFYKNELYKYPEVYEIMERNMKICERFIQEKYPSPYSLGSCLANDFVYIYENLLNKDKQSPKLNIKDTIEKLKYFSKDDEIDATKMINTLTKILMLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Q5</accession>
    <name>R1E4Q5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S3AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42648">
        <property type="protein sequence ID" value="EOD42648"/>
        <property type="gene ID" value="Nst1_380"/>
    </dbReference>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="24244" checksum="F00A824B659FD097" modified="2013-06-26" version="1">MAYNKKYADWGKKVWVDIYAPVEIFNENKIGETPVNKDNIENVVGRTVDLNLAFILNNFKYQNYKVIFQINKISGLKAYTEVKEVMLYPSYIRRITMKGTSKIEDSFIVKTSDGYDVRIKPLVITKFKAHRSQRTEIKKVYRKYLEEKVSSLKYYELIEKVINYDLQNEIKPTLNKIFPVSNVEIKRITKINQVKQKIQQTLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4T9</accession>
    <name>R1E4T9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA biogenesis protein Nop56/Nop58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42688">
        <property type="protein sequence ID" value="EOD42688"/>
        <property type="gene ID" value="Nst1_027"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.26"/>
    <dbReference type="OMA" id="NMCAILG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="212"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="327" mass="38410" checksum="2B786347D374C308" modified="2013-06-26" version="1">MSYILLRYNGLYIFDDNLEKFQKIDLELNLDDLKEIYKNKLPEKVKNYIKENDIFIGQRFDGYKYTEDINIIRKALEKIGEEKINNKLFIDLLKEQISDSISKDEIIIQAISFLDDLNKSLNLFMERFREWYGLYFPEISQEIEDHEKFIRTIINSNREELMKKYNINKTMGGKIFEKEDLEIMNKISLKIKELYDLRKDLEDYIEKLMREIAPNLSEIATPKIGARLILLSGGLKELSLLPSSTIQVLGAEKALFLHLSKGIKPPKHGVIFNHPYLQKLPPKRRGAMARTLASKISIAVKADLNKKIIYQKLKEELDKRFKELSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4U3</accession>
    <name>R1E4U3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Cytosine-48,49-C(5)-) methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42397">
        <property type="protein sequence ID" value="EOD42397"/>
        <property type="gene ID" value="Nst1_430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.415"/>
    <dbReference type="OMA" id="PQDNDTE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="69"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="356" mass="41644" checksum="C1EA2851DB8C9CA8" modified="2013-06-26" version="1">MIIKKSFEEHFKELLGDKYELFLEWSFKLLKKSIRINTIKVKDNINFENLKEILLSKQDHLKEKELKEIFEKIDNLYNLKQNPFNLNINAKEVLSRLKEYGWEIERIPFYKYGFWIKGERRDIGNTTEFQLGYYYPQEAASMIPPLALDLKKDDLVLDVAAAPGSKTTQIAMHMENEGLIIANDVSIDRIKALSENLQKMGVINTIITMMDGRKLYKLNLKFDKILLDAPCSGTGAIRKSYKTLKIWNEDTISRLANLQKKLLLTAFDLLKDNGILVYSTCSVEPLENEFIIDYLLSKRENAKIEKIEIPNLKKSEIISEYNGYKLEHEEEIKNTIRLWPWDNDTEGFYIAKIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4X0</accession>
    <name>R1E4X0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ORF">Nst1_452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42417">
        <property type="protein sequence ID" value="EOD42417"/>
        <property type="gene ID" value="Nst1_452"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.437"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="141"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="426" mass="51213" checksum="8DB802E7A3CC73F3" modified="2013-06-26" version="1">MIDYNKILSKIKPSEEEKKKVYNIINEFFDILRSNNLEPFLGGSFAKDTWIKNDFDVDTFLLFKDDKNISNIVENVLKKENLDYIRIRGSRDYFKVSYKGLIFELVPILKINDIKEAKNTTDLSPFHVKYVISKLNEKMKDEVRLLKLFTKNINVYGAESYVRGFSGYAIELILINYGSFENTIKNVSNWRPKVIIDLEKYYKNYNEIKKNLSKDKIKSPIIIIDPTDKYRNVAASVSLQKFSEFIYYSKIFLLSEDKEKFFFNKIYMDYDEIKRLAEKYNVNMIYLKIEGDSNNKDIKNSKALSLFNNIKKWINNIGFKIFNYYYFFDENYLYGYVLYYPDKLPEYEIREGPLLWEEKDYNRFYEKHKDEELIIRNGKIYAVTKRKINDIYKALEFIINNYKNSIRKKVKYLYIKIGEKEIEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4X3</accession>
    <name>R1E4X3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
            <ecNumber evidence="2">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.-" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42728">
        <property type="protein sequence ID" value="EOD42728"/>
        <property type="gene ID" value="Nst1_067"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.65"/>
    <dbReference type="OMA" id="HIHISGI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="278" mass="32501" checksum="195725A72A191E2A" modified="2013-06-26" version="1">MVKHPKKLHFGPAGVPLSSKKRDTLNGIKYAYEELNLDGFEIEFTYGVKLKEDVANSINEYLKDKEFILTCHAPYYINLNSTEESKINKSIDMLYNAARLLYLSGGYSVVFHPGWYLNNSKEETYNVVKENLKKLIDKLKDESIDIYIRPETMELPKKFGDIDEVIKLSQDIENVLPAVDFAHLRYRSNRNDIDYFREILDKIENELGREVLNNMHIHMSGITLDKKGTHLNLEESDMPWKDILRLLKEYKVKGVVISESPNIEQDAIRMRDYYKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4X6</accession>
    <name>R1E4X6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S2P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42422">
        <property type="protein sequence ID" value="EOD42422"/>
        <property type="gene ID" value="Nst1_457"/>
    </dbReference>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="220" mass="25295" checksum="401D0AEC4DC909CA" modified="2013-06-26" version="1">MAQGEQEERKQYKMAQENIWLVSLEEYIKAGVHIGTKIKNKQTKKFIARVRSDGLAIIDVIKLDERLRLSTKLLSRYEPYQILAVGRRETARKPLQMLNKYTGINVYPKRYPPGLLTNPALDIFKDVDVVIITDPILDRNALLDAYRTGKITIAFVDTNNSLSYIDIAIPANNRGAKSLALLYYIIAREYLRNRGLLSKKGELPISYEEFMEKGLEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Y1</accession>
    <name>R1E4Y1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42738">
        <property type="protein sequence ID" value="EOD42738"/>
        <property type="gene ID" value="Nst1_077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="109" mass="12868" checksum="E5FB5C93551869E0" modified="2013-06-26" version="1">MSNDSTTIYIGDIKEELEELKKKGYTIKDILKKGIEYINIQENLPYNISELGQSIKELRSQVEMIKEFNLSILLLNKNINRLNKILKKKKKVKRKKKGLLRRLINFLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Z6</accession>
    <name>R1E4Z6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42437">
        <property type="protein sequence ID" value="EOD42437"/>
        <property type="gene ID" value="Nst1_472"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.457"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="249" mass="29196" checksum="FF1C9C6A00DEFCF5" modified="2013-06-26" version="1">MKIISWNINGLKSIIQKGLIDFIKKYNVDFYLFQEIKTKEIPLTFQLLGYNVYSFPAKRNGYSGILTLSKIKPNNVKYGIGIEKFDIEGRVITMEYDKFYLINVYFPNAGVGTLKRLDFKLEFDKEFEKYVLSLNKPCIICGDFNVAHKDIDIYDPINLKGYAGFTDQERQWFDHFLSLGFIDTFRYIKGNIRKYSWFSYSIIARKKNEGWRLDYCVVSKELKDKIVNADILDNVYGSDHVPILLEINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Z8</accession>
    <name>R1E4Z8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42758">
        <property type="protein sequence ID" value="EOD42758"/>
        <property type="gene ID" value="Nst1_097"/>
    </dbReference>
    <dbReference type="OMA" id="QDCLGWK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="186" mass="23000" checksum="4B4B0915D08A1571" modified="2013-06-26" version="1">MFEYIIKKYYSRLIDYAKRNKLLRKELILSIFFINMLIYSIPLFLFSYYYIVLPYNFLINYSEIISKILYYSHINFTLENNVVYIKNISFIIDQECTGFKSIFGIFALIFSTPILNIKKKIYYFIIFSPILFILNIFRLWSVFYFYYIFNINPYFLHNFLWEIFTTLFLIIFWLIFLIKNKKELFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E501</accession>
    <name>R1E501_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42442">
        <property type="protein sequence ID" value="EOD42442"/>
        <property type="gene ID" value="Nst1_477"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.462"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="323" mass="35006" checksum="FA0C4902B59E0470" modified="2013-06-26" version="1">MPISLSLSNVSNVENLDKEWDVIIVGGGPAGYTAALYCGRYRLKTLVITKDVGGTLNDANIIDDYPGLENFRGSEMGKLFKKHAEKYGAKTLLESVARIEKLPDGNFKVLTNLGKEFIAKAVIIATGSQRRKLGVPGENLKGVSYCAECDAPLFKDKIVGVVGGGNSAFHDAQVLAQHAKEVYIIHRRDEFRADPVEVEEAKKNPKIKFILNKVVKEIKGTEKVEEVVLQDTKTGEISSMKLDGLFVAIGLVPLSEIVKGLNVNMDESGHIVVDQCGKTNVVGLLAAGDVTIQICNLRQVVTSAAQGAVAAYSAFLYIKTKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R1E524</accession>
    <name>R1E524_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LSU ribosomal protein L3P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42793">
        <property type="protein sequence ID" value="EOD42793"/>
        <property type="gene ID" value="Nst1_132"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.130"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="325" mass="37218" checksum="214E943A0776C71B" modified="2013-06-26" version="1">MPQHGRHKPRAVSMQFWPRVRAKRICPIIKSWPSINNIQPIAFAGYKVGMTHILTKEGKYVPVSIIETPPLKILGIRLYKKDINKGYISLKDIISNNFDEYIKRRIKTLKPNEDLEKDIQDAEQILDKVSLIKLIVYTQPWLTTIKKKKPEIFEIPIGGNNIKEIFNYAKNLLGNQIKINDVFKEGEYIDVIGVTKGKGFQGEVKRYGITIQPKGNKRSKSVRHAGARGARGMKRVFPTTPMPGQYGFFRRTEYNKLIIKISDNYNEINPSSGWPHYGVVKNTYVILKGSVIGAKKRLLILRKAIRPPKNPEKIGIEYISLLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5C0</accession>
    <name>R1E5C0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L40E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42557">
        <property type="protein sequence ID" value="EOD42557"/>
        <property type="gene ID" value="Nst1_287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="65" mass="7342" checksum="0E981E8682FD6FA7" modified="2013-06-26" version="1">MASDLLPEIKARKFDRIFICRKCGARIRANPDKVRAGLVRCRKCKSTALRPKKSEITLVTGKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5D1</accession>
    <name>R1E5D1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L6P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42572">
        <property type="protein sequence ID" value="EOD42572"/>
        <property type="gene ID" value="Nst1_302"/>
    </dbReference>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="3">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="172" mass="19681" checksum="C93541057AF0F594" modified="2013-06-26" version="1">MIDYIEIPNGVNISIEDGKIHIKGPKGEKYRNINNRNIIIEIKESKIIFKAYFPSKKIIRDMNTMIAHIKNDIEGVTKGFVYKLKGISIHFPLKLKLQNNTLIIENYMGGRDIKEIEIPKGVKATLKENEITLEGHDIELLGNLAGLIENSVKPKEKDLRKFQDGIYIIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5E2</accession>
    <name>R1E5E2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HerA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42592">
        <property type="protein sequence ID" value="EOD42592"/>
        <property type="gene ID" value="Nst1_322"/>
    </dbReference>
    <dbReference type="OMA" id="RGYGKSY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="432" mass="49295" checksum="69DCD56D0550194C" modified="2013-06-26" version="1">MDIIIGRSLDDLEKYGLKGSIFIGKEYIKMENALSLANTVYLDVNLPHLILIAGKRGQGKSYTLASIFESLSDLEKDLLNNFSGLIFDTMGIFWTMKFPNYRDAELLEKWGLKPKSIKNCRIIVPKGLLDEYRNINIPIDDVFQLNPADLSGIEWVLTFNLDPTSNIALYIQKIIKRMKENNNGYSIQDIISYTEKLDIDSNMKNAITTYFENADSWGLFSEKAESIRNLTKPGYINILDISLYTAITGGWSIKNLVIGLISKKIFYQRLIYRKVEELEEIYISKELGTREFPLIWIAIDEAHEALPNDSITPATEPLIQIIREGRQPGITLVLATQQPGKMHTDVITQSDIVISHRVTAERDLKSLNEIMKNFTAQDIDIYMNDNLPKKKGAALILDDKSERIYPVQMKPRVSWHGGSDPTLIRKRLWLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5F2</accession>
    <name>R1E5F2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reverse gyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Nst1_337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42607">
        <property type="protein sequence ID" value="EOD42607"/>
        <property type="gene ID" value="Nst1_337"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.326"/>
    <dbReference type="OMA" id="RLVGYMV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03361">
        <property type="entry name" value="TOPRIM_TopoIA_RevGyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005736">
        <property type="entry name" value="Reverse_gyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034142">
        <property type="entry name" value="TOPRIM_RevGyr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43505">
        <property type="entry name" value="PTHR43505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01054">
        <property type="entry name" value="rgy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="634" mass="73821" checksum="5CE0297C1B0EA575" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5F7</accession>
    <name>R1E5F7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylmethionine decarboxylase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42617">
        <property type="protein sequence ID" value="EOD42617"/>
        <property type="gene ID" value="Nst1_347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="135" mass="15641" checksum="CCAC1014D9A10ED5" modified="2013-06-26" version="1">MNMEYKKISVKDVKRLIAIVKINKNENFIDVIGEFSNDLAKILNSKLLYHKIYLFPADFEGNKDITFTGILSTSHIVISSYTEDDGIYIDIDAAWCSGENLNKEKFGELLKKYFKNYEIKSFKIYNYLGEESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5H8</accession>
    <name>R1E5H8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42642">
        <property type="protein sequence ID" value="EOD42642"/>
        <property type="gene ID" value="Nst1_374"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.360"/>
    <dbReference type="OMA" id="AWRWKNQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="305" mass="36026" checksum="6D93349254B783BB" modified="2013-06-26" version="1">MYDPFYLDYYSIIKKYENLEELDYKKVLISGMGGSGIYGDYTKQILNDREIVVCKDYFLPKFIDKDWLTIFVSYSGDTEETLNCMNEAINNGNKIITISSGGEMEKIAKEKNLYYIKIDNNYPATRYTFPVILGIILSILDKKKYYELLEILKNYRERLKDLSIFVNDVKNPIMIYTDIKHEPVALALKMHLNEDAKWFSEYGIISEYNHHDLEGISKLNIDFILLKFNYYQRIEYRINYMKDLLEMYGNNVLLFDLRYRNLMEELVLGTLSLRTFTLKLAEKNNVDPYHSKNIAGLKAFLKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5J3</accession>
    <name>R1E5J3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42662">
        <property type="protein sequence ID" value="EOD42662"/>
        <property type="gene ID" value="Nst1_394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="43" mass="5265" checksum="D5A08B1D6E8CDDFF" modified="2013-06-26" version="1">MEYYIFNIYLDKGLLSIRRKIKEDKIIVYLKTTDIEYESSIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5P0</accession>
    <name>R1E5P0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42717">
        <property type="protein sequence ID" value="EOD42717"/>
        <property type="gene ID" value="Nst1_056"/>
    </dbReference>
    <dbReference type="OMA" id="TYPDRIC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="200" mass="22802" checksum="5944497B564885CD" modified="2013-06-26" version="1">MSLASLEEEIYLRGLTGYVAAKRIFDGYKNIAIIAYPDRICAALSSSLVSSLISKQGYKDKIARVYIYDENKLNDIAKDIVKNNFDAVFIAYGGEQKVSYVSEITKKTILALKNAGYKNSLLIHMRVWVATKQLSEILNDEIREYLKSLKKVRTFTGDLQNKLFLFHKVKIDDGVKLEKYAEEKITDEHVELIKKSVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5P5</accession>
    <name>R1E5P5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ORF">Nst1_061</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42722">
        <property type="protein sequence ID" value="EOD42722"/>
        <property type="gene ID" value="Nst1_061"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.58"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="328"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOD42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="555" mass="65298" checksum="E3BEE916272991DA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5U0</accession>
    <name>R1E5U0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein implicated in RNA metabolism, contains PRC-barrel domain</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">Nst1_106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42767">
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        <property type="gene ID" value="Nst1_106"/>
    </dbReference>
    <dbReference type="OMA" id="IWIISKA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="111" mass="12676" checksum="ABD08A115D71DE1C" modified="2013-06-26" version="1">MALNIRKISETTRSKVYTEDGYFLGEVEDAIISDNKIYGWKIKVLDQDLSRRGIKGIIAPHQLIKAMGQIWIISKAVYSVRSTSEKEGEEKSSKETKEEEAENKIEVEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5U6</accession>
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        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase III</fullName>
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        <name evidence="2" type="ORF">Nst1_111</name>
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    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42772">
        <property type="protein sequence ID" value="EOD42772"/>
        <property type="gene ID" value="Nst1_111"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="42"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="230" mass="27963" checksum="D8DE3C774D3008A0" modified="2013-06-26" version="1">MYESIINLIKEMDFQFWWPVDINYHNKNNGDWRIEIIIGAILTQNTKWNLVEKNIEYLKSKNFIFRLENINNLSINDIKVPLRLRKLETLKYLSNYILENYGNIDDFSKLEINKIREELLKIKGIGKETCDAIILYSFEKPIFVVDYYTKKFFNRFEEYDKLRIEIEKIVNDNFNEIYNLFLNKLKNIENKDLPFLSVYDLRKNINYEEKLTIIYKELHAMIDIKMKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5V2</accession>
    <name>R1E5V2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42777">
        <property type="protein sequence ID" value="EOD42777"/>
        <property type="gene ID" value="Nst1_116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="93" mass="11289" checksum="07DECC7C512ED7B9" modified="2013-06-26" version="1">MKYSLVIKITKNISLEGNDNLIWYIKNYTKDINDLESIFEALKKYKEKYRKKGKINIIVVGDIDKNIIERYKDYFNIFIENDMQRKITEFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E605</accession>
    <name>R1E605_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42822">
        <property type="protein sequence ID" value="EOD42822"/>
        <property type="gene ID" value="Nst1_161"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.157"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="132"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="445" mass="52768" checksum="5CD1226167BB98C5" modified="2013-06-26" version="1">MKTLFIKDILKEDFLGKEVSIKGWVYRMRDMKDKVFFVIRDSSGIIQAVVKKESVDQKTWEDATKFQIEGSLEVKGILRKDERAPGGYEIEVKEIKVYDYGKPFPLKGDEDVDTIQKYRHLWIRTRWFTDVLKIKHSLIVHLRDWFIKDGWYEVTPAILVGNAAENTTELFEVKYFEDKAYLSQSAQLYLEALIFALEKVYSLTPSFRAELSRTKRHLHEYWHFEIEAAWYHVEDIIKVMEESLKYSIEKTIEERKSEFEELKSITGRDISELKQFVEKPWKVITYKDAIKKLQDLGVNIKYGDDFGSDEERLLTEQFDVPVFVTHYPREVKAFYMYEVGDGTVKNFDLLAPEGYGEIIGGSEREWRYDILHKKIEEWGLDKFKVKVGNEEISAYEWYEDLRRYGSVPHSGMGLGIERFLRWICKLDHIRDTQPFPRLRGSWLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSU6</accession>
    <name>R1FSU6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FKBP-type peptidyl-prolyl cis-trans isomerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42195">
        <property type="protein sequence ID" value="EOD42195"/>
        <property type="gene ID" value="Nst1_612"/>
    </dbReference>
    <dbReference type="OMA" id="WVEIEYS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="192" mass="22455" checksum="3B0296D29EC37691" modified="2013-06-26" version="1">MVKWVEIEYSIYDQDNRLLEKTNEPVIMPLGYNILNKEIEERLINAEYGKEYSFLLKRPFGERDPSLIKIIPISEFYKRNINPIPNLVVNVDNMVGIIRSVNSGRVIVDFNHPYAGKDLLYVIKLNREVTDLKEKILGILSITYNISKNNIDVNIDENNKKISINVKDLNLSKEQKEIIKNFIPEIKEYNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSV0</accession>
    <name>R1FSV0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42200">
        <property type="protein sequence ID" value="EOD42200"/>
        <property type="gene ID" value="Nst1_617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="50" mass="5941" checksum="55D7E908BE0D03B8" modified="2013-06-26" version="1">MFDILSFFIGLISGIIISFIIIFLIIRHYIKKYFSSKKSIRDIIELFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSW5</accession>
    <name>R1FSW5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Nst1_632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42215">
        <property type="protein sequence ID" value="EOD42215"/>
        <property type="gene ID" value="Nst1_632"/>
    </dbReference>
    <dbReference type="OMA" id="YQKLYHM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_4" evidence="12">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_5" evidence="13">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="136"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="507"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOD42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="600" mass="68153" checksum="E74CC14855B996DB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT11</accession>
    <name>R1FT11_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42265">
        <property type="protein sequence ID" value="EOD42265"/>
        <property type="gene ID" value="Nst1_525"/>
    </dbReference>
    <dbReference type="OMA" id="HIAGMVD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="395" mass="47423" checksum="D6E0F86F8808E212" modified="2013-06-26" version="1">MKILLFHPWLKSKGGGERLVYEYFRRSKHKIKIMTWIYIREKTYDFGEKNVISLYDKKFEGIFRQYLVRGGLLFLDRLIRRFNIDDFDLLLISTAGIAELLLFNQNFNIPKVLYSHSILRASYKYDIYWNLKYRIPNIEVLPYKVALNVYNFLEKRMWKKIDFAIFNSELSRKRALDKNLIDINKTDVIYPGVDIQNIYNDNPEDYFLYVARFALPKRQHILVKSFAKFIKKYPEYKLYLVGGIENNKYYLKILRLIKEYNLQSNVKIFINVSDEKLRELYAKSLACAYIPYMEDYGIVPFEAMSAGKYLINVYPAGSYELLKNAPGIYWIKEKFYEESMTDEIYKALEYFVKNKDELLEKGKENRNYIKNIDISWDSFTKKLDNKLKDILEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT30</accession>
    <name>R1FT30_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42285">
        <property type="protein sequence ID" value="EOD42285"/>
        <property type="gene ID" value="Nst1_545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="462" mass="53942" checksum="AB5197C8C427BFF4" modified="2013-06-26" version="1">MLIIPVMLKIYSQQPIVGYPVVINNQINISNPNSYAVYEIDIYNPTNYIYYYDISPLSSQWFFIIGENNTMVSGYLYPGQLENIKVYIRPLGFINQIPEIVVYLHNLNVTSEFYSDIIQFTPILYYNQPTTSNSTITLPLSINFELSSSTVTQNSFIYLIGIINNPNNFSQNLSINISSDFNFSALYNEILSPGVNIYQIPIFISNNVSTGEHQLVIYSNNNVYYLNFTVFQLNTTPVIEITKKGLEYIINITNPYNYPINCTYYLQSYYGIFSTFYPNQYYTGNINGSKYAIYNVFLLPGQSYIIYENFNYLLLAEIIAVILIVLFIILYVFLRDNVEISKEILKIDLDKETIDITINIKNKSIFPLNQVKLIDRVNGPLKVKEYKIVEPSSVYKVDNNYILNWKFDNIRRNEEIVISYTLEAKDIKEYKNIEFPRAELRYRYLIWDKVKYSNGLIIRITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT58</accession>
    <name>R1FT58_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S6E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42305">
        <property type="protein sequence ID" value="EOD42305"/>
        <property type="gene ID" value="Nst1_565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.548"/>
    <dbReference type="OMA" id="DGFPMRP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="129" mass="14650" checksum="2FA1BD8454246133" modified="2013-06-26" version="1">MANKRKEIIFKVVVSDPKTGKSIQVQTKDESLVGKKIGDIIDGSVINLDGYKLRITGGSGFEGAPMVNYVEGMNKKYVWYNENKKVRVKKLVRGNTISPEIVQINTKIEEYGNKDFNQIYEEFKSQKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU02</accession>
    <name>R1FU02_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4e</name>
        <name evidence="10" type="ORF">Nst1_300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42570">
        <property type="protein sequence ID" value="EOD42570"/>
        <property type="gene ID" value="Nst1_300"/>
    </dbReference>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="7">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="243" mass="28613" checksum="9CDC1F593BE34614" modified="2013-06-26" version="1">MAHVSNKRHLRNITIPKTWPISRKKYYWIIRPSTNGYKFEYSMPILLWLRDYLKIVKNKKEAKYLLRNEKVLVNNKKIKDLGYSVGLFDVISIKDLNKNYRVVMSNNLKLKLVEIPEQEKDLKIIKIVRKNLVKGGKIQVTGIDGRNFIIDDKDIKTGDSVLFNTKENKIEKIIKMNKGNLIYIFYGAKVSTIGRLENIKIFRKPFGHTRFIEYINMDNNKKEETIFDYSVVIGEDKPLITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU85</accession>
    <name>R1FU85_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ORF">Nst1_008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42670">
        <property type="protein sequence ID" value="EOD42670"/>
        <property type="gene ID" value="Nst1_008"/>
    </dbReference>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005079502" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023260374" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="7"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="22968" checksum="323F3BB4969455CD" modified="2013-06-26" version="1">MTESSGTTIVAIKFKDGVLIASDKQATAGMMVYHKKVQKLYQITDNILMGAAGLVGDIQALVKILQANLKLKYLRSKNEPTAEEAASFLSTLMNYYKWFPFFTEVIIVGKDNDDYNIYEIDEAGGLEKFDNFISTGSGMMFALGVLETEYKENMSEEEAKELAKKAILAAIKRDLGSGYGIEIWTLTKEGLKKELYEVKEELQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU94</accession>
    <name>R1FU94_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 2 subunit beta (AeIF-2b)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42680">
        <property type="protein sequence ID" value="EOD42680"/>
        <property type="gene ID" value="Nst1_018"/>
    </dbReference>
    <dbReference type="OMA" id="FIRYYVV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="142" mass="16318" checksum="B90454F852551E67" modified="2013-06-26" version="1">MIPTYEEMLDEAYKKLSSMKVLQGSTLGSINIPLPKINYVGKWTSIENAGTICDVINRDINLLAEFLQKEFSVASKIEDKKIILQKKIEFDKIKAKIDKFVDIFVRCPICKKLDTRLEKRERVYIIKCLACGAESPVIYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUC4</accession>
    <name>R1FUC4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Nst1_054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42715">
        <property type="protein sequence ID" value="EOD42715"/>
        <property type="gene ID" value="Nst1_054"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.52"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="58"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="399"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="771"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOD42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="868" mass="103502" checksum="6D9581E48A9E518E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUC9</accession>
    <name>R1FUC9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42720">
        <property type="protein sequence ID" value="EOD42720"/>
        <property type="gene ID" value="Nst1_059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="70" mass="7992" checksum="F6681A57451171A3" modified="2013-06-26" version="1">MKGQMMTHGSAFMVALIIAVILLVGYSYFEYHNFTGGFSDFITLFQHYYIQVGIIFLIGFIFGYTQGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUF7</accession>
    <name>R1FUF7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease, SbcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42745">
        <property type="protein sequence ID" value="EOD42745"/>
        <property type="gene ID" value="Nst1_084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="379" mass="45257" checksum="7740870DB1F19E63" modified="2013-06-26" version="1">MKFVHVSDTHLGCQIPVEYGEIRKYDFLNSFKQVIEFAIREKVDFIIHSGDFFDDYFRIDSKYLLEILDILFKLKDNKIPLIFIKGNHDTKGLRQNVLEILKRLDLVYEANIKDPFIYKDVYIYGISEPQNLSYEQLRAYYKKNLSNLKFENNGYTIFMFHGAINIFPESILEGYSKEPRILSPEDFPKANYYAFGHFHKKHLEKHENIIFALPGSTERTEISKDEENIKKGFFYVRDDNIEFKELNVRPIYIYEDVINNDYALNKLKNDIYNKSKETIIKIKVRYKKDYYINIKNLLENLIESGYLILDDSYSLDEEIKLNNEVITIDNIIDSSFFVNDKHEVIKMFNYIKELFEEMYSGKNSDLDRIRETIFKQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUH8</accession>
    <name>R1FUH8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42765">
        <property type="protein sequence ID" value="EOD42765"/>
        <property type="gene ID" value="Nst1_104"/>
    </dbReference>
    <dbReference type="OMA" id="LGSWEVY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="9"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="240" mass="28129" checksum="7316EBBB04275B8D" modified="2013-06-26" version="1">MDNFSRYISQIKFFGFEKNKRIQETSVAVIGLGGLGSWLSEFLVRIGVKNLAIVDFDIVEEKNLNRQNFIIDDIGKLKIDSIEKRLKEVDNSVNIEKYKEINNKIFNRDIIFDCTDNIKSKYLINELSVYYNKPYIFASVVMDQGFVGLINPEQFCLYDIYKGKEDVLTCNITGVDFSAVIFAVSLMLKLFINYVFGNRDGILYHFNIRDKFYLEEIKVKSNNCKICKRKQFELIWNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2A2</accession>
    <name>R1G2A2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42201">
        <property type="protein sequence ID" value="EOD42201"/>
        <property type="gene ID" value="Nst1_618"/>
    </dbReference>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="217" mass="25310" checksum="E594FA58FDC33AA5" modified="2013-06-26" version="1">MDVKNIQSLIEKSKKRRFKQTVELIINLKKEYDLNKSENRFTEYVELPKGRGKKVKIAAVVGPELEKSAKEIFDFVLVKDKIKEIAENKREAKKLVRRYYIFVAQASTMADLGRYLGKYLSTKNRMPNPKYGMIIPDNANQDFLRSIYNRLQNMVRVVVKNHKTIGIPIGTEDMKYEDILENANHVLEYFINRVPGNKNSIKSVYIKLTMSDSIRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2D8</accession>
    <name>R1G2D8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42241">
        <property type="protein sequence ID" value="EOD42241"/>
        <property type="gene ID" value="Nst1_658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="412" mass="47055" checksum="0E143CC3DA6075B8" modified="2013-06-26" version="1">MRNQTEIIYVVLFLTIAILIILLSFYALTYNYNQNIVFNRFTSLSTLSNYFLGYLQTLLTQESYAESYLAGTNGWGKENWASYPYGCILPQSCQNAIQYYNNLLTSGYQTLLTFGEQYLTAYQYYYPYNVSFNFSNNYQAGIFGDCNNIISGEYNYNFPVYVQGLYINITGPSSGSIIPYASTSNITNNPAFYLYNLAYQFSQNGDFSECSYQDCSNALNNNPTYTCAQEFEQFSNDPNIQCNETIIPYQCVNIPLCQICLYPQEIACRVILKCSDNQYNVYYNGNTYPQTISITSIVFYENITNQYYLNCVYDCTEVYNSTSKQIISQSCTLENQQYSCTSQSGCGNLNTNQQNNEVIYTFQYYYSIPIQCYMCIIGGQQCPACLLGQCPNNPTCPENINFPNECVPQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2G7</accession>
    <name>R1G2G7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42271">
        <property type="protein sequence ID" value="EOD42271"/>
        <property type="gene ID" value="Nst1_531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="61" mass="7389" checksum="DD2735ADBB8177AC" modified="2013-06-26" version="1">MNKVKKILVGSRALFSSRRLIKNLYSSLYQYLILRKQNIELKLRNGETIYIYIYLDFFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2L8</accession>
    <name>R1G2L8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42321">
        <property type="protein sequence ID" value="EOD42321"/>
        <property type="gene ID" value="Nst1_581"/>
    </dbReference>
    <dbReference type="OMA" id="TIEMEFI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="179" mass="22143" checksum="85A084987053F32A" modified="2013-06-26" version="1">MKKIDESWHSEIFLTENGTIIKKFKDKLYKNYEKEKYFLNFLNNFGFVPKIISYNDKNLEIEMEYINGKKFEDLDIEEKKKYLDNILDILFLLDRLKIEKEEMRRPYEHIIIKDNKIYLIDWERARLKNNPSNLTQFIQYLIDEKIIDIDQELINLLREYKKFYSEDIFNKIKEKLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2P4</accession>
    <name>R1G2P4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42346">
        <property type="protein sequence ID" value="EOD42346"/>
        <property type="gene ID" value="Nst1_505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.489"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="328"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="466" mass="55512" checksum="AA6E03074248DD6A" modified="2013-06-26" version="1">MISEIEYKVLSILNDNWKNLDEISNELNIDKYKVLRTLGFLREKELIELREEKIKRYELSEIGKKYLKEGLPERRLLNLLKEKKELNLEELNEYFNKDELSFSLGFLRKNGAIKIENGKVIYIRDIETYERYLENIDENTIKLFKGRKGIIEEKEETIYYAKINDKGKEILKNYKPEEYIEKYTKEVIDKKIYKNKKFRPYDIRINIEEENIGRYNPYLEFLDKIREELISMGFKEMDKYSMIVSHFWDLDSLFIPQDHPAGDISIMDAFYIKNIQYIEDFPKDLFENVKNTQLKYFKIFDENISKRTMLISHDTAISAKTLLNAEKPGKYFLIEKVFRYDTIDAKHFIEFNQLEGIVLDDNLTFLDLLGILKELVLNVVKAKNVKFYPAYFPFTEPSVEVYAEHPKLGWIEVGGAGVFREELLRQFSIDYPVLAWGLGVDRLATIYLNINDIRELHTRNIKKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Y7</accession>
    <name>R1G2Y7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42431">
        <property type="protein sequence ID" value="EOD42431"/>
        <property type="gene ID" value="Nst1_466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="251" mass="29228" checksum="C59A77C2D2B2053D" modified="2013-06-26" version="1">MIDSNNKFKNFPTITFSMRYISSDKDLYGKIKGETLKIEEILKKIKEKRGMDKLIDEVDDSQYFIEEVLKKIKEKEGIDTPIDEVDKLKYFYKYIVGDILIKISTNAPQTAGKYVRLVEKLQELDICKSSLIKDWEALYQCMGEYYFKIGIIMGTRRYIELHGEFLSKPGELENFINGLETLVDGKVIKGLYKLYQEVKELNSKYLLDVNKYNHSVSQEDIIIMSYELASKFVADLIFSYLLGYISLETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G336</accession>
    <name>R1G336_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SSU ribosomal protein S3P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42476">
        <property type="protein sequence ID" value="EOD42476"/>
        <property type="gene ID" value="Nst1_204"/>
    </dbReference>
    <dbReference type="OMA" id="YIKKCGE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="225" mass="25287" checksum="5E4F1E3DB7B265DB" modified="2013-06-26" version="1">MASKNLEELLKEQKIQAILDKTLKNKFKGKLISKVEYFKISMGTKVIIYCARPRLVLGRANENLDEIKKIVENIANVKDPSIEVVGVENPLLDSEIVADLIASQIERYGNRAIRRIMQRVMEQVMQAGALGIEVRVTGKIIGDRSSTIREQKGYIKKSGELNKIIGKSIRHAKLPSGVIGIQVRILKPTDKLPDRINIKDISEIKPEELEKIDPSLLEKLAKQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3A5</accession>
    <name>R1G3A5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease M5 (Contains TOPRIM domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42576">
        <property type="protein sequence ID" value="EOD42576"/>
        <property type="gene ID" value="Nst1_306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="128" mass="15985" checksum="A01F144CEEB8698C" modified="2013-06-26" version="1">MYKIISFLYRLREKKDSIIVVEGRKDKEVLREFGFNNVYTIYELRKDDRIFLNYREAIILTDNDNKGRILYKYVRNLLESDGIIINDIERRRFFKYFKVREVEDLRKHVEEIKFYINYFENPEKILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3B2</accession>
    <name>R1G3B2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ORF">Nst1_316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42586">
        <property type="protein sequence ID" value="EOD42586"/>
        <property type="gene ID" value="Nst1_316"/>
    </dbReference>
    <dbReference type="OMA" id="ISTGIWQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="72" mass="8318" checksum="263A9D9AD092882F" modified="2013-06-26" version="1">MSHTKLLGPVARFGSRYGKGIKENLVEIEKKYRNKKLKCPFCNNISVKRLSYGIWYCTHCGKKFTGKAYSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3B8</accession>
    <name>R1G3B8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA synthetase</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42596">
        <property type="protein sequence ID" value="EOD42596"/>
        <property type="gene ID" value="Nst1_326"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.316"/>
    <dbReference type="OMA" id="CDKPVLL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="109" mass="12428" checksum="7318BA77012C0323" modified="2013-06-26" version="1">MDYITIDEFLKVKLVVGKVIDVQDHPNADRLYILKVDLGNEVRQIVSGIKQWYKKEELLNKKIIIVYNLQPKSFRGVESQGMLLAAEDGNGNLSLLTVDRDIKEGSFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3C6</accession>
    <name>R1G3C6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42606">
        <property type="protein sequence ID" value="EOD42606"/>
        <property type="gene ID" value="Nst1_336"/>
    </dbReference>
    <dbReference type="OMA" id="EYYKHEV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="6">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="92" mass="10340" checksum="56E42A5E133E5FBE" modified="2013-06-26" version="1">MGRYVVITLKISPNDVDIDLEKVNEKVKDIIKNFGGQYLSHEIQPIAFGLNSLNVKFLYPDQEFNEEELLNQINSIEGVSSSEVISVSLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3C8</accession>
    <name>R1G3C8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42611">
        <property type="protein sequence ID" value="EOD42611"/>
        <property type="gene ID" value="Nst1_341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="58" mass="6660" checksum="45DA7F963610DA95" modified="2013-06-26" version="1">MAKLVLLLDRRWNGGVSTHSIGLLLSALALKKNNRRKIRKSGSRIVFYCSRRGFFKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3D5</accession>
    <name>R1G3D5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42626">
        <property type="protein sequence ID" value="EOD42626"/>
        <property type="gene ID" value="Nst1_358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="372" mass="40313" checksum="892FFE9220E8E214" modified="2013-06-26" version="1">MNTNAKIKRILKYMLILILFIKIFNVTYSQYACGCFTSTNGCKYCYVLPTVCAETCTVTQTNTIYVTNTVTTTVTSTATSTIFTTVTYTVYNTVTSTTYNTVTKTATVTNTVSTATITSTITNTATSIIYTSTSKAYTTVTNIQTVTSRVSTLTVTYTVTSTSTIASGQTYTITSTVTTTSTIYSTVTNTQYTTSTVTTTSTITNYVTTMTTTTLIYNSIIYLQGILNINSINQTFYRSISFPVQSGNTIFYLNITNSGNATINNITLSFSVIGNSVILSYNNLPITTLNNITISSPLQPNSSLIIPFKMLVISPGLTDVVIKVYVNGQYIGYADYKFDVELGSSSSSLVVSENINYILISLAGILGLLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3E8</accession>
    <name>R1G3E8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42646">
        <property type="protein sequence ID" value="EOD42646"/>
        <property type="gene ID" value="Nst1_378"/>
    </dbReference>
    <dbReference type="OMA" id="YPNITRE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="440" mass="51315" checksum="90D44EFF9970E508" modified="2013-06-26" version="1">MNKRIILYYLIVLSIILLGFLLILYSERSNFSYSNEYSVYIPAVLNQSNNLSGEVTQFFLRTSPGSGNVYVSIPPISYEDYDLSYLFAKVAACNIYPNKCNNYDYYFSSNDVLFAEGFSGTAGLTLLVLEALSNKTAIVNYPVTGFMLPNGIIAPVEGIRYKLNATLQYFPYMVAPYYNNSNIVPVYTILDLEKIYFGEQFNSTYNVPQDYIDVMKNITYQICSGINNNTVNYYISLGDYYTAASLCFEQKVTNPKFYPNITREELEKDINDFYNYINNYQCFGNYECEEIKYQVISRLENANETLDNLQESYWRYYSAIGWAQFLSITNNIYKENECSLIDQQYTLMQYLYQYQLPLNLSCFEKIDYLSDLYYLYITNSTNYVSNDTIKSIEQLDYYYYNKYGFSITSYNYLQFGKDLINMGNINSGLYYLILSTEYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3Q1</accession>
    <name>R1G3Q1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphthamide biosynthesis methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42761">
        <property type="protein sequence ID" value="EOD42761"/>
        <property type="gene ID" value="Nst1_100"/>
    </dbReference>
    <dbReference type="OMA" id="TAGDPMV"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="245" mass="28973" checksum="F88373C4FFD49186" modified="2013-06-26" version="1">MFILSGLGQNKDEIPYGLIEEIKSADLIFLEYYTNFIDEETKEFLLNIRKDINIVDRNFVELELEKIILNNRDKKIILITSGNPLFATTHMYFIELCKKNNVEFKIINSPSIFDEIGKIGLFLYKFGRTVSISFHESTEFYDYIIRNYKNNLHTLVLLDLDPINNKYLDHKEAIKRLLEIDNKREKIFSENFKLIVCSNLNRKNEKIYYKEIKELLNINLDPPICIIIPSNLNKIELEFLLCMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3U4</accession>
    <name>R1G3U4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42806">
        <property type="protein sequence ID" value="EOD42806"/>
        <property type="gene ID" value="Nst1_145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="227" mass="26298" checksum="4ADEFB22632C6809" modified="2013-06-26" version="1">MIHSMDSPQLDERSNKLIDMLIEKTNNLLIKSYAGDLKELLDKLYRNVQKEGGISHPKEYQGTIELIQGKCKITIKVSSENMTSECYSKLEPLPDKMECTSHDTIVGSIYRQFNVSNSVHLMENIKDIITNMSKIIYSRVSTNIDNQNISISIAFVRYLTTNKENSKACELRKYNNIVTFDDGEFAFTIFHLDDLDKRIEENNLYSYKKHARTYFGDNISYNRGCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8R7</accession>
    <name>R1G8R7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42239">
        <property type="protein sequence ID" value="EOD42239"/>
        <property type="gene ID" value="Nst1_656"/>
    </dbReference>
    <dbReference type="OMA" id="SIPMPAY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="345" mass="41201" checksum="DE8C9AC539E56ED1" modified="2013-06-26" version="1">MGETIIDKLIDENKNINKHILILYLIIFPISILFFTNLYYILFGIFYFFALYYFLKNTKFNMIKILYLLIFILPILNIFNNILFKYFVYVFFSFILFYFFGNFVAENKLSINRKQIIILTISLIYVLFITSYNIMNIYSLFFISLLGFLFNLDDKKIYHLTSLNFLDKNKQIIFSIISLFLSIQLILSLIVQNILILFTISLFTILEFILMLMIKRIFNNKPEGFTAYILILIIFLFIFFTILFFLTKNNIIYIIQNIIIMFLFFFTAIHAYLFHRFPDSKKIILGIVSGIPFILMNLANYFYYINPGTIFNFPLFIILFSINLLILAIIGLVLIYIHLIYKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8S2</accession>
    <name>R1G8S2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42244">
        <property type="protein sequence ID" value="EOD42244"/>
        <property type="gene ID" value="Nst1_585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="321" mass="38396" checksum="92F8BE0682E33B9B" modified="2013-06-26" version="1">MFEYIKIDRRVIYYLMIIGFFLSFNHWDNLFIGLANLFFSIIYTIISYFILLFVFNLVSSFYGLYIYLDNVIAELKILFYKRESYAFFYYLLIILEIILFFIFRGNLFLYVMISLFVILFFYNYIKQLKIKSSKSEQLNFTYIHRYNLSYIITIVLSIVTLGLFVPIIFSMKPIVIEYRRLGKSKNVEVRNDELLRIFLISTIILWIIYSSIKYISSYSTILYGFTYYFFNFLFFFTYSSIIPIGILLSPYLSIRRGYVYSNKFIGDILILSNIPFYLASIITIALLPIFSIIFNPIEVLIFSLAVFSIIWIRKQFDVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8W7</accession>
    <name>R1G8W7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42289">
        <property type="protein sequence ID" value="EOD42289"/>
        <property type="gene ID" value="Nst1_549"/>
    </dbReference>
    <dbReference type="OMA" id="HENQAIG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="169" mass="19930" checksum="02CC51055FD56740" modified="2013-06-26" version="1">MIEKIKKFIVRIFFGDDYLSDILFLIFIFIVYFIIQIVYPPLFSVIVSPSMEHYYFNFQKYEQYNITQQEFFQFPYPNGLYVGDIVIILPINTQYLRIGDVILYKGISLYKNEDIFHRIVGYNNSNFIIMGDNNPGPIIFEGENNMDPNRIIGIGILRIPLLGYIKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Y4</accession>
    <name>R1G8Y4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit of KEOPS complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42304">
        <property type="protein sequence ID" value="EOD42304"/>
        <property type="gene ID" value="Nst1_564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="398" mass="45435" checksum="05C2F357EFB2027D" modified="2013-06-26" version="1">MIISLGIESTAHTYSIGIVDENGNIYSNERIIYKSEKGGIHPREAAELHSKENINILRNSVWKAGFIFKKLNGKFYIVDALYEIKNKLEESEEIFYDEPWNRKRYIIYNNNKIWVENNKIVSDNKELENSLNLYINNLNNFERKINLISYSAGPGLYPTLIQAYFSGKLFSKIFSSNLIGVNHLIAHAEIVKLYNKFIDPLILLVSGANTMLLSFEGNKYRIVGETLDMGVGNFLDKVGRLLNIGFPAGPKIEELSKKGKNLIKLPYSVKGMDIQLGGIYTYIKNLIKSKDINIYDLSYSIQEYIFSMLAEISERGLSLLDKREFGLTGGVSVNKRLQEILYLMCNERNVKFGTVPLDLGNDNGAMIAWTGILWYKNGINVIDGINPYWRPEDIEYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Z1</accession>
    <name>R1G8Z1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42314">
        <property type="protein sequence ID" value="EOD42314"/>
        <property type="gene ID" value="Nst1_574"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.557"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="197" mass="22404" checksum="CD63F8FA9AD7AFAB" modified="2013-06-26" version="1">MNGKHLIQKTLVVLKPDSVKRGIIGEIISRFEKAGLKIMGLKMIKLTREQAEQFYYADEKWLESVGNKTIARYKEMGLDPIKEFGTDDPKKIGSIIRGWLIDFITSSPVVAIVLEGVNCVEEVRKLVGPTEPLKAPPGTIRGDYAHVSIAYANWNKIVLRNVVHASETEKDAEREISIIFKPEEIYNYERNIEEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G901</accession>
    <name>R1G901_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42324">
        <property type="protein sequence ID" value="EOD42324"/>
        <property type="gene ID" value="Nst1_482"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.467"/>
    <dbReference type="OMA" id="FRHKGFP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="274" mass="31328" checksum="E276CF37024DF196" modified="2013-06-26" version="1">MKILIFGASGQLGLELSKILQGDLIKVYNSNEIKDGYKLDLTNFSMVEDFILKKKPDIIINTAAITDVDKCENEKDIAYKVNSEVVKHIVRAARVIEAYFIQISTDYVFDGQKGLYKEEDLPNPINYYGLTKLLGDTYALSYDDSLVIRTSGIFRNKGFPIYVYKTLKENKEVNAFKGYYSPISARKLAEAINEIIQYRKTGIINIAGERTSRYELALKIKEKYNLDGIIKEVDNVKNWIAKRPFDSSLDISKAKKSLSIDFYSLDENLNYMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G905</accession>
    <name>R1G905_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42329">
        <property type="protein sequence ID" value="EOD42329"/>
        <property type="gene ID" value="Nst1_487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="274" mass="31966" checksum="6E75D011DB07F67E" modified="2013-06-26" version="1">MSEDEYNLDYIIEKSFEEAIEYFNKNGIKVEGLKLIILESPELLIQKYGKDRINENIGGRYDSGTIYIIKSHIKNFADKVSKSMNESSIGNLFTISRNEVLWPVYKNDNDIEKAIAKADAESILIHEIGHRIVGNGEWKASVFEFLVYFYKNELYKYPEVYKIMERNTKRCEKFIQEKNQAFYLPYSLGFCFANDIIYAHENILNKNKESPKLNIKDTIEKFKHFSEEDGTKITKMVNKLLKDYVNIKSTLNIKANMLSCILEKLPNIMDNVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G912</accession>
    <name>R1G912_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate:ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="5">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42339">
        <property type="protein sequence ID" value="EOD42339"/>
        <property type="gene ID" value="Nst1_497"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.481"/>
    <dbReference type="OMA" id="LNPFPKN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="193"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="547" mass="62431" checksum="D08502188DA58089" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9B2</accession>
    <name>R1G9B2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42429">
        <property type="protein sequence ID" value="EOD42429"/>
        <property type="gene ID" value="Nst1_464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="204" mass="24572" checksum="2188418B92EF564F" modified="2013-06-26" version="1">MIDTFSYQNKSEIIEERIRWARQRAKESESPDMHGYAIILEVLYNLARERAPEVLRQLEKVVERTDAFTYDIQKLSAIRDYIRDHISPSEQENTRKQKIQYLKEGLEKLLDWDVEDYLYDLYKSIRSGDLIPLDFDFYLERVRDWAYFTGHRLDWETKIRYARKEAAYDRLSSHIKCLLSNPEGYMQHLKSGDLEKFVRELCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9C3</accession>
    <name>R1G9C3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42439">
        <property type="protein sequence ID" value="EOD42439"/>
        <property type="gene ID" value="Nst1_474"/>
    </dbReference>
    <dbReference type="OMA" id="VLAYDWH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="121" mass="13945" checksum="006049F55659D8E3" modified="2013-06-26" version="1">MKKIGDVELRLAKGPVPHYKELKELERSIVKVIIEEFGTEELIKRYSNPLWFNSLACLLGFEWNYSGMTTVTLKALKEISIEDNLPIIVLGGKGKDSKITEEIETKDIKDKLKDKIKVYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9C8</accession>
    <name>R1G9C8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42444">
        <property type="protein sequence ID" value="EOD42444"/>
        <property type="gene ID" value="Nst1_479"/>
    </dbReference>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="234" mass="26995" checksum="9B556B069E6A1CEF" modified="2013-06-26" version="1">MAEEILSEDDKKALKEMFDKNLKNPVEITVYLDEKNNKETSDFAKKIGELLMQINDKIKFEFLDAYDPKVEEEMKSKNLLIDKYGNRRGPIFVFKKYPGIIYYGLPSGEEFPIFLEDIIHVSNEHFDIDGATAKKLASINEPIDIYVFVTPTCPYCPYMTHHSHQFAMVKSNIRGIMIESYEFPEFAEKFKVYGVPHIAIINKDGNVLTEWEGAIGEMEIFANKIKESLEKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9F2</accession>
    <name>R1G9F2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <ecNumber evidence="6">6.3.5.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42469">
        <property type="protein sequence ID" value="EOD42469"/>
        <property type="gene ID" value="Nst1_197"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.191"/>
    <dbReference type="OMA" id="CECESKL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="271" mass="31310" checksum="BB0D3A450C508B12" modified="2013-06-26" version="1">MIAGLEIHQQIDTKEKLFCNCPTNLSDKYDYRTERKLRATLSETGKKDIAAEYETMKDKKYIYEYSKDYSCLVELDEEPPHLINIEALKFGILISTFFNMYIPKVLQVMRKIVVDGSNTSGFQRTLLLSLNGELKYKDKKISIGTICIEEDAARKIEEGEDYIIYRLDRLGIPLIEISTGPDLRDPKEVKEVAEYIGLILRLTGKVKRGLGTIRQDVNISIEGGEKIEIKGVQNLKIMDKVCELEVKRQERMLEWKKIMNERGIEGYELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9J7</accession>
    <name>R1G9J7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42494">
        <property type="protein sequence ID" value="EOD42494"/>
        <property type="gene ID" value="Nst1_223"/>
    </dbReference>
    <dbReference type="OMA" id="INPNYIS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="251" mass="28536" checksum="47D6D8D689E1A637" modified="2013-06-26" version="1">MAKVYTISSGKGGVGKTFFSINLSRALSLLNFKTLLIDFNLTTPNVSINLGLGNENNNIHKFLRGEIEINDCIKEYEDNFYIIPGSLDIKDLIYISTEKLHNGIMKIYDDFDYIIIDSAAGIGKEALEALKASEEVIIITNYEKSAMFDSYRVTKVLDNLDIKTFGIVLNKIKKDIDYVNAEKFFKKKIIGIIHYDENVQISMNKGIPLIDYNINSIASRDIIKIAEKITGKELKIKNSFIDNILKIFKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9K2</accession>
    <name>R1G9K2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42499">
        <property type="protein sequence ID" value="EOD42499"/>
        <property type="gene ID" value="Nst1_229"/>
    </dbReference>
    <dbReference type="OMA" id="VIYRSTM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="274" mass="31501" checksum="AAB84904CACF0317" modified="2013-06-26" version="1">MKEEIIDIFIIIVLIFLFYFVFNFSILNSIVTGIIVGIFPYLIYQTIINNIEKEKEEQFIRFSIDLIGLLKSGLSLPIALKQLEKNDYGRINELVKNLSSRIDWGVSIEDSFTEFAEESNSRMIKRTIQSLIDIYKEGGNLEQGLEAIINSIMEIRKIKEDKKAAIHENIIHSYIVFAFFLGIVFTFQIFLLPFLQISLPGQASNVNFNFINNLMYYMSIIQAVFAGLSMGKMYDDSYKAGAKYVAIFLFMVIILFNVIIPIVPKGMFLININM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9P5</accession>
    <name>R1G9P5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42554">
        <property type="protein sequence ID" value="EOD42554"/>
        <property type="gene ID" value="Nst1_284"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.275"/>
    <dbReference type="OMA" id="GFPNYFD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="3">
        <location>
            <begin position="137"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="373" mass="45486" checksum="81894E2C7278458B" modified="2013-06-26" version="1">MKIKEKPEDFVVKEIIDLDKKKEGETFRYFLMRKRNINTINAIKIIARKLHISKRKIYFAGEKDKNTISEQYIAIRNFNDFKDEYNFGNIYLKYVGSYDEPLKISDIKYNYFRITIRELSNEEINIFNKNIEIFDKYYFNYFDDQRFGNRGNNYIIGKYIIKRDYENAIKVFLTDYENEKNKDAIRARKFLYENWGKFKEALKMFPNYLDVERSILNYLSKEENYKRALKYIPKRLLKMFVHSYQSYLWNKLLSNYIKNNYGEEYFIETKIGKFYIIKDKKEIEKLKDMKFPLLGYDIKDNNIYKDILREERIDYEELKFEDKPSLTLLSTERDILSEIKNLEYNINNNIMIISFILDKGSFATMYIKHLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9S1</accession>
    <name>R1G9S1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42584">
        <property type="protein sequence ID" value="EOD42584"/>
        <property type="gene ID" value="Nst1_314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="66" mass="7790" checksum="11451AF4E1EBB06B" modified="2013-06-26" version="1">MKIIINIEDKDLIDILKFLESQEGIKIENNNIIINKKDISKARAQMNLIFRLLKIYDNLNRFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9S9</accession>
    <name>R1G9S9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42594">
        <property type="protein sequence ID" value="EOD42594"/>
        <property type="gene ID" value="Nst1_324"/>
    </dbReference>
    <dbReference type="OMA" id="EWQTGRF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="244" mass="28760" checksum="8AA6EDF842478C32" modified="2013-06-26" version="1">MDTKIKELINKSNILLEILDARFPKLCRIEYIEKYIKNKNKDLILVLNKSDLVSEDFLKKVVEEFSKEYITVYMSAIYRKGSRKLREAIKKVGKKYEKAYIGVFGYPNTGKSSIVNILVGRRSAGTSPKPGFTKHLQIIKLSRKYYLIDSPGIVETKNKYLLSILGAYDIDKLDHPEKAVLYLYKKIGKKPFEEYYNINIENIRDLFIKLREKYNIKKDSYWIKRVSKIILYDWQKGKIKAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9U4</accession>
    <name>R1G9U4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LSU ribosomal protein L7AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42609">
        <property type="protein sequence ID" value="EOD42609"/>
        <property type="gene ID" value="Nst1_339"/>
    </dbReference>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="8">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="129" mass="14210" checksum="8837E7552BE4FCC0" modified="2013-06-26" version="1">MTAPYVKWPEDVLNTFIQNYEAKVYELFERAKQSGKIRKGVNETTKAIDRGQAKLVAIALDVDPPEIVMHIPALCEEKGVTYVYVSSKQKLGQSCGINTQASAAAIIEPGEGKQIMDEIVKALSTLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9U8</accession>
    <name>R1G9U8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42614">
        <property type="protein sequence ID" value="EOD42614"/>
        <property type="gene ID" value="Nst1_344"/>
    </dbReference>
    <dbReference type="OMA" id="NRMIITC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="63"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="263" mass="30393" checksum="A199DC82797EFF39" modified="2013-06-26" version="1">MNKRDILYISIISVFSIFFIFLPININIFVKIGVIVLLYLIYSLKYLQEYLEYEEMVDNFPLFLRDLSHYLKIGQPLPVALKSVSNNYYGKRLNREIKYIISEMEYGKTFYDALNDSANRINNLEISEVLSNINNVLKSGGDLSNLLDTLSESIRNLEMIKKDRLSQLKVTTYTYYGLFFGVLLSIIAVYYLIINIKSFGLTFNKETYYELINIYRFLSFLLLLINAIFTGLVIGKLSKGTIKSGIIHSIILTAISIGFFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9V7</accession>
    <name>R1G9V7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted or membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42624">
        <property type="protein sequence ID" value="EOD42624"/>
        <property type="gene ID" value="Nst1_356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="401" mass="46543" checksum="935AFE148BDF6A7A" modified="2013-06-26" version="1">MNKKILLILLSFFIFLLSRNIFSYQIYYYNQSYIPNISITPYLYNSEFLAGQNITGYVLVQNNDPYYYPQIFLGIMLVNENSSFGTQVLFAELKMISNLFPYENYTVNFSYQIPENISSGNYELLFYLYTATKHIIGNPNNFSTPIYENIYLSNPNIGNYPWIAIVRNQTELTNNNGILNLNLSLYSLYNTNATINIKLAEWDALLYGAAYNNSLNVELNKGYNYIYDNINVSNLYPGIYYILIEVYSDNLLQDLYIIPYYVYGRALFFDGIYLNSNGTLLVILSTYPNDNKNHNLYNVGLTIYSDNQNFQDSINIGNLLYNSTEYIYIYDDVPMINGEDLCFNLTYQKEINGLTYLSSICYTYYLTNQTTSSYSNYNTEIKVLIVLVIVVGLVIYLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA12</accession>
    <name>R1GA12_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42694">
        <property type="protein sequence ID" value="EOD42694"/>
        <property type="gene ID" value="Nst1_033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="185" mass="22419" checksum="2256911150A76A87" modified="2013-06-26" version="1">MKEDYYLSFEKEKINEKIKLENEDPLFIINYNPSVYSLRYTFPLYLIFSIYFVTFSFSEYYNPNILSLVLLFFIISIVYYIALKYYEKAKNYYIIFTNKRLILIENENIRSIENSYINNIEIYQSLYEKIKKLYTIKIYTHTFLLNKSVSLTIELPLLKKEDMIKIRDIILNNIPKKPEQEKPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA35</accession>
    <name>R1GA35_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="6" type="ORF">Nst1_058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42719">
        <property type="protein sequence ID" value="EOD42719"/>
        <property type="gene ID" value="Nst1_058"/>
    </dbReference>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="5">
        <location>
            <begin position="125"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="248" mass="28136" checksum="7FFB1946A35EF918" modified="2013-06-26" version="1">MKVTFPQAKEIKNILPAIVSFLSEGTFKANKDGIFLSSLDPANVAVILLDMYPNMFTEYDIQDEEKFTINLEDLKKIMTKVALKNQISWEIDKEKNKFVLTVYGKAKKVFTLPLIESEGSFMDLPSLELPVKVEMDSKAFYDIIESAKVIADEIKIVADPDGPKVSFIAEGELKDMRIDLTPQDESVLSMEVPSKAMARYSIDYLYKLSKVARISDTLTFKLDSGKPIWIDYKSTDKFKFGFVLAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA69</accession>
    <name>R1GA69_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide kinase (CMP/AMP kinase related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42754">
        <property type="protein sequence ID" value="EOD42754"/>
        <property type="gene ID" value="Nst1_093"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.91"/>
    <dbReference type="OMA" id="VWEIDTT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="167" mass="19890" checksum="511D031EC0A7A350" modified="2013-06-26" version="1">MIICITGVPGVGKSTIAKRLAKEINAILIDINDFAIKNNLYEEYDEAEQTYIVDENKLFQEIDNYIRNLNSKYIIIEGNFAHLYDKGDLYIVIKTDPNILYERLSKERSYPYHKIFTNIWAMNLEVIEDELEEMKKEYYVFYNNKEDDIDNIIREIKRLIENKEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA74</accession>
    <name>R1GA74_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42759">
        <property type="protein sequence ID" value="EOD42759"/>
        <property type="gene ID" value="Nst1_098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="83" mass="9928" checksum="C24674153E420A85" modified="2013-06-26" version="1">MYESFDYIKEGIIYGKIKNIMKDKVIIEINGKDYSFDKSIDMNNLNSGDYVRFYIKNNNIIYIEKISQKLYENIKKILESLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAA5</accession>
    <name>R1GAA5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.021"/>
    <dbReference type="EnsemblBacteria" id="EOD42789">
        <property type="protein sequence ID" value="EOD42789"/>
        <property type="gene ID" value="Nst1_128"/>
    </dbReference>
    <dbReference type="OMA" id="YVEDRTS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="9">
        <location>
            <begin position="212"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="10">
        <location>
            <begin position="497"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="810" mass="96924" checksum="F19925776448DE3D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAC8</accession>
    <name>R1GAC8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42814">
        <property type="protein sequence ID" value="EOD42814"/>
        <property type="gene ID" value="Nst1_153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="124" mass="13250" checksum="10843E8E4BCA46B0" modified="2013-06-26" version="1">MDVAYALIGLALGLTVAAVIVLIGVGIVSVAGMSFYPLIYNSYQTVYNQLPSNATNIQNAVNTSFQNSITYVQQVSSYSVVAINTLRSLGSVLQIIIFIGAFLLILEILMRLAMPRTADAPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAE4</accession>
    <name>R1GAE4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42829">
        <property type="protein sequence ID" value="EOD42829"/>
        <property type="gene ID" value="Nst1_169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="881" mass="92618" checksum="1B34A6CE5EF27252" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3H7</accession>
    <name>R1E3H7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42193">
        <property type="protein sequence ID" value="EOD42193"/>
        <property type="gene ID" value="Nst1_610"/>
    </dbReference>
    <dbReference type="OMA" id="YVMFNNV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="218" mass="26223" checksum="0DFC7BCF3188E435" modified="2013-06-26" version="1">MIKVGTCGFPISRKKYYEEFNVIEINSTFYSIPDIEWVRKIRNEAPENFEFTFKAFQGITHDVNSFTWRKSKIKDYKELKGKVGYLRNTKEVFEFWEKQEEIANILRANIIIIQLPNSFKDTTENIENAYNFFNSIGKKYKIAIELRGWSKENREKICKEFDLIDIVDINVEEPVYDSDIKYYRLHGLHEGNKLIYNYDYSKEELNEIKEKVLKYNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3I0</accession>
    <name>R1E3I0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Preprotein translocase subunit Sss1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42198">
        <property type="protein sequence ID" value="EOD42198"/>
        <property type="gene ID" value="Nst1_615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="61" mass="7044" checksum="AEDFBA2809745801" modified="2013-06-26" version="1">MGIIDSIKEMREVYETANKPSWDEVKKLVYVTLLFFALVAAIVLPIFISLQYSIMICQYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3J0</accession>
    <name>R1E3J0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase, subunit A</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42213">
        <property type="protein sequence ID" value="EOD42213"/>
        <property type="gene ID" value="Nst1_630"/>
    </dbReference>
    <dbReference type="OMA" id="TPMMTVY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_5" evidence="2">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="364" mass="41925" checksum="A743CA0680B7A6B0" modified="2013-06-26" version="1">MELPEKIKKDLEKIEDEKLRKIVEDFSYKFIIDPGEPVGIVAAQSIAEPTTQMILKSFHFVGISAQQVSLGLPRLTEITDAKKKMKRKYMIIRLLDEYKNDLSVAQNVAKKIKELLLEDILSSITIDVFENKIIIVLDKEKLKKEELKFDEVFRILKKKIKKYKVENDKQNIYVSAPKLSAKELYLLKEMIKKILIKGIKGIKDVTIHKEDDEYVIYTIGSNLLEVMKIPEVDYTKVYTNDLREIERVLGIEAARAAILQELVKLYEQQGLSVDVRHFMLVADMLTWYGIYLGINRYGLHAEKESTLSKAAFETPVSIFVRSSMMGQSDKVLSGIDNVIMNQPIYLGTGLYDVYFVGNKREDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3K3</accession>
    <name>R1E3K3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42228">
        <property type="protein sequence ID" value="EOD42228"/>
        <property type="gene ID" value="Nst1_645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="537" mass="60890" checksum="8875D8C526E842F0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3M2</accession>
    <name>R1E3M2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42248">
        <property type="protein sequence ID" value="EOD42248"/>
        <property type="gene ID" value="Nst1_589"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.571"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="229" mass="27192" checksum="E76F0202D1BA68E4" modified="2013-06-26" version="1">MKDKDTEISIKYKKEGYNFEIIVYLRKAFEYKEGKIKDIKEVLAVEEIFKDSKKGERASTESLKKVFGTTNILEVAKQILENSEIPLPTEYKRELIEEKKKQIIEYIRKIAYDSKNNMPLTYERAKELFEIVRYNVDINKPVEKQAEEVLKEIRKKYPLKIEYKNIKLIVYPNRFRIIGIIKNKYKIIKENWGENYEAILEIPIGLLSEFYSDIGKLCGEDCIVEEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3P8</accession>
    <name>R1E3P8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42278">
        <property type="protein sequence ID" value="EOD42278"/>
        <property type="gene ID" value="Nst1_538"/>
    </dbReference>
    <dbReference type="OMA" id="MFQVTDP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="44"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="281" mass="32233" checksum="125483E77278C93E" modified="2013-06-26" version="1">MEEYSNMRQWTIFFILLLISVSLMKFLGIVGIIFGIFLLIYTLSGIRIIYNYEKAVIFTLGYYSGVLSGGLIYILPGFQKLIKVDMRIINYDLPEQVLLTADNVNITVRSTVFYRIVDPGKVIMNIRDLNRAILNYAQTNLRDIFGKYNLNDILQKKEEIGNELRDIIQKEIGEWGVDIIAIKIQDLIVPQEILSALTQKAIAERQRDAEILRAQGLAQAKVIESQGELQAAENFRRAAEILSESDYGIVLRFLDILRNSQNEKIIVIPPEIFDLFKKHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3U5</accession>
    <name>R1E3U5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42323">
        <property type="protein sequence ID" value="EOD42323"/>
        <property type="gene ID" value="Nst1_481"/>
    </dbReference>
    <dbReference type="OMA" id="KYFINDY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="313" mass="37713" checksum="58D015E90481C29B" modified="2013-06-26" version="1">MKASVVIIDYKRKKYILDALQSIKNQKGIDLNDIEVIVVKYYQDEKIDNYIKENFPNHKIINLDPNDPDHYVGRTFSEGIKAASNNLIFLLEDDDMFTENKISRIFEIVKKIKNYDEYLIIHKFIVTDESLKKLEYIERKDGSVVLNINNRIITLKYNNSSIILHVKDKNKLIDYLRKICYVADQALVCYFNKRIIKIDEPLTYYRRHEENVSGSKFDRKKLELELQDYQHIYEKTKCKNQIDGIIIYKIRLNILYNANYKISLKEYMEYLLLFDKSYIRRLLRIILYKLFKNYLKRRYMGKIYITDLNIQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3W5</accession>
    <name>R1E3W5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">Nst1_501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42343">
        <property type="protein sequence ID" value="EOD42343"/>
        <property type="gene ID" value="Nst1_501"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.485"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="205" mass="23811" checksum="B21A7EF72BE10A58" modified="2013-06-26" version="1">MPILCLIRHGESLWNKENRFTGWVDVPLTDEGREQAKKAGEILKSLDIKFDIAYTSLLSRAIETLEIIIRTLGYNIPVIKDISLNERHYGDLQGLNKDKVSEIYGKEQVKLWRRSLKVRPPNGESLEDTQKRTIPFFERAIKGDLELNKNVLVVAHGNSLRSIVSYIENLNEEQILNLEIEPAVPILYDYDIYNKKFYNKRILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E429</accession>
    <name>R1E429_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42398">
        <property type="protein sequence ID" value="EOD42398"/>
        <property type="gene ID" value="Nst1_432"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.417"/>
    <dbReference type="OMA" id="HRDEMRK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="197" mass="22995" checksum="E157294D3A609DE0" modified="2013-06-26" version="1">MIVIVVGVPGVGKTSVINEAKKYLKYEFKVINTGDIMFELAKEKYGINNRDEIRKKLTFEQQKEIQKEAIKRIKEMEKEGDIILDTHLVIESYEGYIPGMLREYAEILRPDGIAVIISDPDKIFVRRLKDIQIRGRDIENLKRIEIQQNLTIYFTTIFMFEYGTIVEVINNEEGLLEESAKKFAEFLNKLKESKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E488</accession>
    <name>R1E488_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42212">
        <property type="protein sequence ID" value="EOD42212"/>
        <property type="gene ID" value="Nst1_629"/>
    </dbReference>
    <dbReference type="OMA" id="IYLASNC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="3">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="90" mass="10519" checksum="3849648CA528BFA5" modified="2013-06-26" version="1">MVTFDDLRKKIVDEKKIIIGYNRTLKMVKRGKVEKIFLAKNVPENIKKDIEYYQKLGNFEVEVLDYSNEEVGLLLKKPFKISVISILKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4A7</accession>
    <name>R1E4A7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42232">
        <property type="protein sequence ID" value="EOD42232"/>
        <property type="gene ID" value="Nst1_649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="97" mass="11478" checksum="55E81FBEA8F156C5" modified="2013-06-26" version="1">MTYGLSFIIGYFSADYIIKKFSPEFFIEIRTKTREYRAKIHHMYLSIFGIISIIIGAITYLYELYILTTLFLGAALHDIILEIRKKLKKLDYIKQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4B4</accession>
    <name>R1E4B4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative archaeal flagellar protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42468">
        <property type="protein sequence ID" value="EOD42468"/>
        <property type="gene ID" value="Nst1_196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="159" mass="17310" checksum="B6C8B8DD7F019CF4" modified="2013-06-26" version="1">MKTQFGTILVEIILFIVAGIAAYIFVSTAYNNLNGISNAAIANSKSLESQLNTYITLDSCAYNSSTNLLYFYVTNRGSVVLNQNLTLLFINGELINNTKIYIANSYTGTSAWGPYDTIAIVANISVTTNFYQVRIVASTGAYTQDTIYVNTTASTCTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4F0</accession>
    <name>R1E4F0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42277">
        <property type="protein sequence ID" value="EOD42277"/>
        <property type="gene ID" value="Nst1_537"/>
    </dbReference>
    <dbReference type="OMA" id="YYNSINI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="192" mass="23617" checksum="2A8B8B6E1F4F0871" modified="2013-06-26" version="1">MEKNIEKLNNLLYFSLFSIYYNSINIILYLIIYYNPLILLNELYNIIFLLITIFLFLISIIMYLNFKHNSNVIILLLIYIITNFLLFFKYPFIVYNILFSIISFSYFLIYYLIYKDLYKILSFFKILKFYKIFNILNFLYFLINISKIFLRTFIINSLEYIIFLSIYSIILFIILYKNIYILIKKYSTYYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G3</accession>
    <name>R1E4G3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42508">
        <property type="protein sequence ID" value="EOD42508"/>
        <property type="gene ID" value="Nst1_238"/>
    </dbReference>
    <dbReference type="OMA" id="GNHDGGI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="221" mass="25368" checksum="77E7DCB8E050C94D" modified="2013-06-26" version="1">MLKFTGTEGLIFFDKILVISDLHIGIEKELYKKGINIPSQVNYYINKIKKIYEKYKIEYLIIDGDLKHNIPETSLQEMSDIPYFINEISQYFKKIYIIKGNHDGDIEELINGINNVKILKALKIKNVVFTHGNLNTKLNGKYYVIGHHHFAKSISTSIGESIYEKVFVIGYKDNKVIIILPAFSDLAGLWDTGEFQGPIAKGIKKYEVYTLDGILIEEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G6</accession>
    <name>R1E4G6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA-processing protein RRP4</fullName>
            <ecNumber evidence="4">3.1.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42513">
        <property type="protein sequence ID" value="EOD42513"/>
        <property type="gene ID" value="Nst1_243"/>
    </dbReference>
    <dbReference type="OMA" id="NWFVDIN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="199" mass="22909" checksum="C2D1F270156CFBD7" modified="2013-06-26" version="1">MILIPGDNLKKKDNNSYERENNYYSKYILLVNEDKTTKLFGYYMPEVNDIVIGKVIDVLSNGWLIDINSPYMGKLSLKDVGTDPNDIYTYGDYILCQIVKMTKNKLIDLDIKKREKLNDGLILKVDPARIPRVIGKNSSMLNLIKQYLKVDIIIGKNGRIYLNGDVNDILKAVDIIRFVINNSYKRGLTEKVKEILENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4I0</accession>
    <name>R1E4I0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">mRNA degradation ribonuclease J1/J2 (Metallo-beta-lactamase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42533">
        <property type="protein sequence ID" value="EOD42533"/>
        <property type="gene ID" value="Nst1_263"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.255"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="8">
        <location>
            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="442" mass="50721" checksum="324FE0C977064E51" modified="2013-06-26" version="1">MEIEVFPIGGYSYIGKNMSAIRIDDKIIIIDIGINVDKVSQFGEREDITNKPLKELYDLDIIPDDSILENYKDKVKAIILTHGHLDHIGAVNFIAPKYNVPIYASPYTIELIKQQEKEYGIILPNDLKKISPNSSIKISEDISINFINITHSIPQSLMIDIQTNKGHIIFSGDFKFDNFPIIGKKPDKEKLKKIGKEGVLLLICETTRVEENSKSQSEIIEKYMLYDVLHSIDTKGIIITTFSSHIARLKSIIELSKEINRKPIFIGRSLGKYISAAENINLYNFSKEAEVYFDPRDYKKVLERVEKNKEEYLLIVTGHQGEPGSILDRLARGEYNFDLSNTTVIFANNIIPHPINEANRKILEERLKRRKAEIIKDIHVSGHGKSQDHIMLLKMLNPEYIIPNHGDINKKASYYNIASDYGYTLGEDIFFLEDYQRKIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4J2</accession>
    <name>R1E4J2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42312">
        <property type="protein sequence ID" value="EOD42312"/>
        <property type="gene ID" value="Nst1_572"/>
    </dbReference>
    <dbReference type="OMA" id="FNMAGWL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="110"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="282" mass="32030" checksum="1CFB5660A2FB4D2C" modified="2013-06-26" version="1">MVDIFNQFFSGIEKDLLIINSKEDPFKYIYKAKIYSIGISISISILTFFFLLMYNIRVYGSFNPVSPIIFGITAGILGFFGSLLLFKKYPSIEKQNRARKIDNSLYYAVLYMASLVSSGATPKALFELLSKYSEFSEIKKEASDIIYLIDTIGLSLPVALERKAEYSPSKKWASILNGMKSIIVEGGNLEEYLYNEAAKLFEEYKRKIIEYSNNMQVFLEIYITLIIVGVIFIIILTTLMGSIAGTNFQYIEFLQLMSILIILPMGTAMFIILLKAISPFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4K1</accession>
    <name>R1E4K1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ORF">Nst1_298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42568">
        <property type="protein sequence ID" value="EOD42568"/>
        <property type="gene ID" value="Nst1_298"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.289"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="134" mass="14617" checksum="D55E445256F0AEF2" modified="2013-06-26" version="1">MKPISAKVTRGITVGTILKVADNSKAKLAKVISVVGYKGVKRRYARAGVADMVSVSIIDGDLSLVGKVMKAVIIRQRKEYRRKDGTRIKFEDNACVIIKDEKTGTPAGTIIRGPVAREVVERWPEIGKIASIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4K3</accession>
    <name>R1E4K3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42322">
        <property type="protein sequence ID" value="EOD42322"/>
        <property type="gene ID" value="Nst1_582"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.565"/>
    <dbReference type="OMA" id="QIDFHQP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="51"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="456" mass="54140" checksum="29D5F704E5944CF7" modified="2013-06-26" version="1">MEKDHIDIGDEMDILVKHDRRLEKLSRNFGDLLGKGLQLFSLGGGLTYYILSQILTDFHVKRGYYLVRTPFITNTLLYQISGHLSYYKQNMYVFNIEDEEFAIKPMNCPHHILIFINLLEKYRKIRLPFRTFELGTVHRYESSGSVYGLLRVRSFTQDDSHIFITPNLLEKEIEKLMDEMILLYEKVFNINLKASEFKVRLSLHDPNKMNEYSGSKEDWEYVEDVMRNVINKLANKYNFSTYEGIGEAAFYGPKYDFTLKIGEKEWQLGTIQLDFNLPRNFKLIELVKDYFGIENLYIIHRAYLGSVERFIGAYLESFKGRLPFVLTPIQVAILDIFTGDKEKDNKIKEYAMKIYNNLKNKEIRVVNIETTKTQLSNMTRILESTYKPYIIIYIGEKEANDNIYSIRYYNINSKNIEEKKMKEEELYNLIEELEKPLEELNNKKYRLFEAFNFIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4M2</accession>
    <name>R1E4M2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42337">
        <property type="protein sequence ID" value="EOD42337"/>
        <property type="gene ID" value="Nst1_495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="122" mass="13725" checksum="4A9BF5C3662A4C73" modified="2013-06-26" version="1">MEVKEIIGWIGMLLATFWAGVHMLVAGAVAVNVFPIFGAFVGMFVALSIISGLVFLLNWKKYYLPNIIFWIIMLLLLFVGYVQYIRGGNINALFTNVLAEITLIIDIVEILLAFAIWKVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4N1</accession>
    <name>R1E4N1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42613">
        <property type="protein sequence ID" value="EOD42613"/>
        <property type="gene ID" value="Nst1_343"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.331"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="362"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="461"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="760" mass="85282" checksum="6CB9A6F2232BF809" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4N3</accession>
    <name>R1E4N3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42618">
        <property type="protein sequence ID" value="EOD42618"/>
        <property type="gene ID" value="Nst1_348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="282" mass="33523" checksum="C73BB33ECE64B23D" modified="2013-06-26" version="1">MTKDLEAILSDAKYIINNANNLPNPEDYLPIISKFPDILSQSDASFYEEIKRERLPFGEIKGYIDLDSIIIEGCSTFGNIEITRILDHLEKHVSNVIDIACKDIKGTIEQKDKIIKYFEMKGYEYKFLPNNIYGYKLNLNGEELKVPNLYGIYFYIEVKLPNNRKLYIVIDTEGNILIRKSGLEHTLYFENFELFSIIYKFFRYKEKDIKDLEEYEKYRDKIKEIINKGFSERDINNSRSLFGEKYTKIIRNWYKYLEKHPGSIYESLNNVFDKLFGRINNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Q2</accession>
    <name>R1E4Q2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur transfer protein involved in thiamine biosynthesis</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DDW03_00535</name>
        <name evidence="3" type="ORF">DDW05_01310</name>
        <name evidence="1" type="ORF">Nst1_375</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
            <strain evidence="3">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
            <strain evidence="3">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000001">
        <property type="protein sequence ID" value="PVU68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000007">
        <property type="protein sequence ID" value="PVU71339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42643">
        <property type="protein sequence ID" value="EOD42643"/>
        <property type="gene ID" value="Nst1_375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68997">
        <property type="protein sequence ID" value="PVU68997"/>
        <property type="gene ID" value="DDW03_00535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU71339">
        <property type="protein sequence ID" value="PVU71339"/>
        <property type="gene ID" value="DDW05_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PVU68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PVU71339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="68" mass="7811" checksum="04B9900BD4F76DD0" modified="2013-06-26" version="1">MKKIRVFIERYYTENNIEFNGNTVKDLLNMLNLDPSRFIVVKNGEIVTEDDIINDGDYIKILDSVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4V0</accession>
    <name>R1E4V0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42402">
        <property type="protein sequence ID" value="EOD42402"/>
        <property type="gene ID" value="Nst1_436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="135" mass="16462" checksum="A6D361ED5C6D6D04" modified="2013-06-26" version="1">MKYKILIDTNIFFIPFYENFDVINELKDFLMKNNIEYEGFYTLRKNIIEIENKINSSKSEKWKKIYNLVLEYIKKSNINIIETKENYEKTDRLIIKTALSDKFIVCTLDKNLRMILKKLHIPVIFYSNKRLHIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Y3</accession>
    <name>R1E4Y3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome biogenesis protein, NOL1/NOP2/fmu family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42427">
        <property type="protein sequence ID" value="EOD42427"/>
        <property type="gene ID" value="Nst1_462"/>
    </dbReference>
    <dbReference type="OMA" id="ISEEPFG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="162" mass="19856" checksum="9FD80982181BA997" modified="2013-06-26" version="1">MKELNKKNIEEIFKKIEEYYNINIDKSIIKKYRFFINKDKIYMFNKNFPDFLDEKYIKKYGLYVIKIEKNNIYRFSIEGAQIFGINSNKIIEIKKENLFYKFYENIKLEKNYENGFYIAKDGNDILCSVYIKNNILKDFIPKERKINYSFTKDRPENTYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E506</accession>
    <name>R1E506_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42768">
        <property type="protein sequence ID" value="EOD42768"/>
        <property type="gene ID" value="Nst1_107"/>
    </dbReference>
    <dbReference type="OMA" id="FMGQAEA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="132" mass="15012" checksum="88AB3E340C589B85" modified="2013-06-26" version="1">MTIIVTAKRKTAIARAYIKEGNGKVTINSIPLQVYEPFLARLRISEPLVLAGEDYISKVNIKVKVKGGGYMGKAEAARIAIAKGLVKYFDDDKLKLLYLQYDPYMLKSDPRRKEQRKSPTSKARKHYTTAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E508</accession>
    <name>R1E508_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative permease fused to SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42447">
        <property type="protein sequence ID" value="EOD42447"/>
        <property type="gene ID" value="Nst1_175"/>
    </dbReference>
    <dbReference type="OMA" id="INREFIN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="424"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="575" mass="68734" checksum="B2E0881F63C57223" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1E515</accession>
    <name>R1E515_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase, subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DDW05_00070</name>
        <name evidence="5" type="ORF">Nst1_180</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000001">
        <property type="protein sequence ID" value="PVU71684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42452">
        <property type="protein sequence ID" value="EOD42452"/>
        <property type="gene ID" value="Nst1_180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU71684">
        <property type="protein sequence ID" value="PVU71684"/>
        <property type="gene ID" value="DDW05_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PVU71684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="93" mass="11020" checksum="6AE8DFC4042846AF" modified="2013-06-26" version="1">MKINKESETEMEIIFENDKATISMLLKEELDKDPNVIIAAWKENHPLIKDIYLYIKTDGKKKPREVLIDAIKRALDRLNSFEKEYNKIINEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E541</accession>
    <name>R1E541_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42472">
        <property type="protein sequence ID" value="EOD42472"/>
        <property type="gene ID" value="Nst1_200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.194"/>
    <dbReference type="OMA" id="HLADITI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="150"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="317" mass="38497" checksum="BFBAD3E9E7C769AA" modified="2013-06-26" version="1">MKYKFVEELLSSAFKRAKNNGNQFYDIKERNIVKLQTIYQYIDDKLEKIYNDIVLPENKFYKELYKLLFTDINIKKLRERIKYIRKIIKQVYLKYKNDIKLTKDKKLIERYRREFYGRISSILRRNWIIFKYYNIYLNRRKKVPNIKNLPTVVISGLPNVGKSTLLKNLTGSNVKIEPYPFTTKDIMIGYIKTPYFDIQVIDTPGILDRPIEEMNEIEKKSILALNYLANLIIYVFDLTETCGYNIKEQINLLNNIKRMFNKEIILYFSKKDLFTEKEEKILNEFIKNYNNTNIFYDYNELKEFLISYIKNKKEWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E547</accession>
    <name>R1E547_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42818">
        <property type="protein sequence ID" value="EOD42818"/>
        <property type="gene ID" value="Nst1_157"/>
    </dbReference>
    <dbReference type="OMA" id="MIWIYRE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="143" mass="15686" checksum="FE1A10EE72EC366C" modified="2013-06-26" version="1">MAGFGLLTLGIVGIIVAFIVIWIISSLSVYIAARIIGVQVPFLRTLFVTLIADIISFIINIVTVSYFLSTFNFAVLIIGLIISFVITLAIYKYLFDIDWIKTFIMLIIAGVIYFGIMVILGLILTALGFLVFGGIFSSLQAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5A2</accession>
    <name>R1E5A2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42527">
        <property type="protein sequence ID" value="EOD42527"/>
        <property type="gene ID" value="Nst1_257"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.249"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="734" mass="83074" checksum="DAFDF956806CCFFD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5E0</accession>
    <name>R1E5E0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ORF">Nst1_317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42587">
        <property type="protein sequence ID" value="EOD42587"/>
        <property type="gene ID" value="Nst1_317"/>
    </dbReference>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="169" mass="19472" checksum="92AA677C7D9A5C00" modified="2013-06-26" version="1">MVSVRDVNGQIFVERLAKYLFENYKDIIKPPSWAFFIKTGPDKERNPDFPADVDYNGGPGWWYYRAASILRKVYLYGPIGVSRLRRKYSGLRKRGMEPGKVVKGYGKLIREILHQLENAGLVMKVNEGKKKGRVVTNNGRSLLDKLANEIYKELNNENKNLIDYIKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5K2</accession>
    <name>R1E5K2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42672">
        <property type="protein sequence ID" value="EOD42672"/>
        <property type="gene ID" value="Nst1_010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.10"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="607"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="780"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="1073" mass="129150" checksum="845913DCA79498BF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5K5</accession>
    <name>R1E5K5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42677">
        <property type="protein sequence ID" value="EOD42677"/>
        <property type="gene ID" value="Nst1_015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.15"/>
    <dbReference type="OMA" id="FKIHTFS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="478" mass="51203" checksum="EE5676CA5C6142CF" modified="2013-06-26" version="1">MNSNNLALLVVILGTLMSAVDATIVILAIPSIAQDLHTNLYIIIWVIITYLLVIAVFTTQLGRLGDIYGRSRFYNLGFVIFTIGSILCGAAPNAISLIAFRGIQGLGAAMMQANSGAIIADIFPPNQRGKAYGYNSIGWNAGATLGIVLGGFITTFLGWRYIFYINVPIGIIAIILGLKYIKDRERRNTKLDIIGMLSLLASLSLISYGAADIAGEGMSLLNIYLISAGLIILLGFILIERRQQFPIIDLKAFKANRVFTYSLFASFLQTTGYLSTAFIIIMYLQGIRGLSPFNASLLLVPGYVLASLVSPFTGRLSDKIGARIPATIGLALMILAIFIYLQLSINTPLYVIIIASTIGGLGSSLFFPANNSAIMANAPRGFYGGASGLSRTLSNIGTLLSYVITISVSSVTVPRYVAFEVFLGTTNLIGGVASSFLTGLKSALYVSLGILSIALVLSALRGKEDRKQLLQVDQSNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5M9</accession>
    <name>R1E5M9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42702">
        <property type="protein sequence ID" value="EOD42702"/>
        <property type="gene ID" value="Nst1_041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="61" mass="6715" checksum="436A8012BD775CF7" modified="2013-06-26" version="1">MDKKTQVNTFLVAIILLVVALLLLAIFMYFYFKGGVNLFNSIPQTNGTSVVNNINSNNYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5N5</accession>
    <name>R1E5N5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Nst1_051</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42712">
        <property type="protein sequence ID" value="EOD42712"/>
        <property type="gene ID" value="Nst1_051"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.49"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOD42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="372" mass="42274" checksum="D74B439FE8366B6F" modified="2013-06-26" version="1">MTSSEKITISVLKADIGSLVGNSTIPEIFEETASDILDRYKGEKIFDYFVSHVGDDLNLILLHNKGENNREIHEIAFEIFKKNSEIAKEMNLYGAGGDLIKKEFTGSLIGMGPGVAEMEFTLRSPESIIVFAADKTESGAFNYPLFQMFANPFNTPGLVIDPDMRPGFRFEVWDLYNHKRIYLNSPEEIYDLLLLVGTSERFAIKRVYPRSDKYPKDEPVAVSSTERLYEEAGKYAGKDDPVMIVRAQKGFPAVGEILEAFSFPYMVNGWMRGSYWGPLLPVSLKNARATRFDGPPRVIALGFQVKKDKLYGPEDMFDDPAFDYTRNKALEIADYIRRHGPFEPHRVSYEDLLTTTAKPILDKLIQRFEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT25</accession>
    <name>R1FT25_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding TFAR19-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42280">
        <property type="protein sequence ID" value="EOD42280"/>
        <property type="gene ID" value="Nst1_540"/>
    </dbReference>
    <dbReference type="OMA" id="EPKIRFI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="86" mass="10303" checksum="CCD3E531CA56C0FF" modified="2013-06-26" version="1">MSKDDKKLKEIENIYKSILPFLTKEAIDRLSNIKVVYPEKFIQVVLILYQYIQSGKIKKVDDELLKNILLKLSENERREPKIRFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT37</accession>
    <name>R1FT37_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 1</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42290">
        <property type="protein sequence ID" value="EOD42290"/>
        <property type="gene ID" value="Nst1_550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.533"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="366" mass="44295" checksum="36A7ED29F0C8169F" modified="2013-06-26" version="1">MDKFYLGFSISSFQTEGNYNNQDWYYFIKNGKLPEIDNACNLWERYLDIIPILIDLNANAFRFSIDWARIYPSKNKIDYSSMKRYLEFTDKLIKNNIEPFITLWHYVNPLWFYNLGGWENKENIECFIDYSYFIIDTFSKLGVKYFISFNEPWVYIFSSYVFGKWPPFKKVNSIEDLKNAIVILDNIFYANKELYKITKEFNVYLIYTESLSLLKLPFNFLLKDIISSNIHLLFPKEVDFYGINYYGIFKDIKDIYERKPSFSVSILNNILKNLDKPIFITENGVNTEDEFLRVRIIKRYLNYFVKNRKKYNIKGYFIWSLMDNYEWDFGYNAKFGILNRNLSKKDSYYEIKEIYRKLNQKLNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTC1</accession>
    <name>R1FTC1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid-binding protein, PBP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42355">
        <property type="protein sequence ID" value="EOD42355"/>
        <property type="gene ID" value="Nst1_514"/>
    </dbReference>
    <dbReference type="OMA" id="PHEYVII"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="168" mass="19525" checksum="5C6F8B5D2F2FA478" modified="2013-06-26" version="1">MEILDIKIPDNAIKVNIYSSSFRDLEKIPKDYTCEGKNISFPIVIEEIPNNTKSMLLFVEDPDAPGGIFRHWIAYINKPIKSIPPGIKKERIVKIDDVQIIQGKNDFGKIGYDGPCPPKGHGKHRYYTIILFLNKELYIDGWFFEDFIRYVKEENIVGYGYFIGIYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTG5</accession>
    <name>R1FTG5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42390">
        <property type="protein sequence ID" value="EOD42390"/>
        <property type="gene ID" value="Nst1_423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="419" mass="49396" checksum="05D93906AACC257D" modified="2013-06-26" version="1">MSNYMSCLDEKSYYDYFQCIRNYVNSKNSFKGASYIIKTNSGTETISKYLIFYKIYGHAILGHHNLLDLPENSYLIVLLEKEDDVIEYIKEIGKRRQDIYVFDYYLRTKIPESILLRNSKNPEDIKKLIEARPYGFKTKRDIEKLKKSLDKRLVDIFYVPLSLSLILLLKNPEYFPNIYYISKLYTINTPYVFKILLGTSDIIKEPVKLFNDNLNFLSIIEFEKYPTIEPYSLGLNYNFELNYENLNKFEIQIKFDEFRHRFYDSIIKTSKAISTLKFSPADIEPYQIVMKNGKVIFIDIASGNIVPISQKGLEKIIVRAIKDMIEGIKESPLLKHCTKKENYVICNEKIKDSELHKIFVNDIERYLFYNNRTDNLIRNIKIGAQRLDDIIIQYKDDEFEENREILLGTTGLYLGSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTJ4</accession>
    <name>R1FTJ4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42415">
        <property type="protein sequence ID" value="EOD42415"/>
        <property type="gene ID" value="Nst1_450"/>
    </dbReference>
    <dbReference type="OMA" id="YNIGVNC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="135" mass="16117" checksum="4A0AE1F05DCA4B3B" modified="2013-06-26" version="1">MEECIFCKIINKEIPSYILYEDEYSIAFLDINPINKGHTLFVPKKHFERISNIDDEYIKNFYVSFTKFLKLFEERMSKDYNIIVNNGKKAGQAVFHAHIHIIPQYNENGYKNIFNWNTHKLSKEEAEEIIKKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTK8</accession>
    <name>R1FTK8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42430">
        <property type="protein sequence ID" value="EOD42430"/>
        <property type="gene ID" value="Nst1_465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="228" mass="26534" checksum="3EB6BB39802A65CB" modified="2013-06-26" version="1">MTDGHDIKNDIIIKYGLSHILFTELQQCGADFKNTLAEGNRQILYITIDVFEKMGTEMFYKADKTLRSSLDELMKAIMEWRKCKTPPNDYDSLIRCLTECRLTTGIAGAINEYLKEINATDFEKKVYNLIEAIEHLSRSYVLDALYERLKNKTNDEIYRSIDKLSRNSESKEGSTNYLEKTKKGVYEINHIFQKASQDVKEPIKILLKDPKKNIKLFYAIIGFNLYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTN3</accession>
    <name>R1FTN3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42450">
        <property type="protein sequence ID" value="EOD42450"/>
        <property type="gene ID" value="Nst1_178"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.172"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="66"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="323"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="585" mass="67551" checksum="321570699706DB40" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTQ4</accession>
    <name>R1FTQ4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42465">
        <property type="protein sequence ID" value="EOD42465"/>
        <property type="gene ID" value="Nst1_193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="310" mass="36986" checksum="46BA3F6944BAAE44" modified="2013-06-26" version="1">MLTRNLLEKISQKINQIKKDEENNKEEKINIEKLNLDNFEVKEKKKYGFIDSSHVNGIVGPYSYIYSRAVIVSDDIYESIEDIEFFETSFIRSINNENFDIQDISELLSKNLEYKLARKYSDRYIFIDGSIISDSILYAKFLDNFYNENIENRRKEFLENFEYLINNGNLLAVAKRILNLDIIKPGRSDLLTLMKVFPSEIFYTDINEKKLREFLGFEIPNCSFCNKKIYIIYFRARYNDHIYRLEGMEKVEKEKFKEIIKEVIYDQKSYPRGLKMAHNLCKITNREKTLLESYIKKILGFEKTVGWETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTT0</accession>
    <name>R1FTT0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42480">
        <property type="protein sequence ID" value="EOD42480"/>
        <property type="gene ID" value="Nst1_209"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.202"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="195" mass="23124" checksum="4723787BE3470F0C" modified="2013-06-26" version="1">MENSNENIKFGICPECKVREKDSSEKKLYQCPHCKNWFCEKHVEPKLVVTWNEIQGTKDPFLKEELYEEWKKEGHHPCSVWTVQYFENREIKEKEERERFLRALDKENIVITPYNRSSEVHKDEISPNEDSNKIEKIEKSNQYSKSSEVSKRKISPKDVAIILMLILLIYFIAVRNIMISIFILLVLALTAVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTW0</accession>
    <name>R1FTW0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42515">
        <property type="protein sequence ID" value="EOD42515"/>
        <property type="gene ID" value="Nst1_245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="213" mass="24885" checksum="B5D258CE7E03D83D" modified="2013-06-26" version="1">MDLSSFIYNLFSEYGIFTFVAPFLLVFSLLYGSLRKTGLFGKDNPNKEKLYAIISMVISFYYLYNISDVIFTSNFISFFFFEVLVIFFILMIIALMAGISEPYKGDEEFERYKQYSHNVIVGFITLTVLFAFLYASSTDFNGFGSTAQNIIIEIFLTLIYTGLLPFLIIIGFVIAAIYWVYHQEERPKKKRKVKYYIYGPMEALYELPEHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTW5</accession>
    <name>R1FTW5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="2 9">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Nst1_250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="2 9"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42520">
        <property type="protein sequence ID" value="EOD42520"/>
        <property type="gene ID" value="Nst1_250"/>
    </dbReference>
    <dbReference type="OMA" id="MISEFMF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dna2" evidence="12">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cas_Cas4" evidence="11">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="275" mass="33373" checksum="B57EE10361689903" modified="2013-06-26" version="1">MELNEIFVRVTDITDYIFCPRKVYLKRVLGYSEEDTEQKIFGSIVHSLFDKINEKEQEIIFNIKEFVEYEKILNLYNNFLTELLEESIKEFEEQIKNLNLDKNDIKIRAYSYVIKDIEERAKNVYNFMKDNDLYGIELWEFLEPKIKTELDVTSLKYNIVGRIDRLEIYKKYIIPYEIKSGFFRREHITQLYSYYLLLKDEFPNYNIEKGILLYAKDNRKMEIEFRNNNEIKKILDIKDKIIDMIDKKEDPGKKFSEKCKKCAFYNICWKNGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTZ2</accession>
    <name>R1FTZ2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein of the translin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42555">
        <property type="protein sequence ID" value="EOD42555"/>
        <property type="gene ID" value="Nst1_285"/>
    </dbReference>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="190" mass="23163" checksum="1187323F78D36B84" modified="2013-06-26" version="1">MIEKEYIESLKEKFREFENKKDKIIELGIKLNRTSKSIIYSVIRGDIKSANEYMVEMDKYKEEIDKIVREEPRLYNNALINYQEYAEAKIFYNFILNNKIPKNDELNVDEYSYVMGLMDFVGELYRKSIEEMLKNNLEFAEKAREIIYEIYKNMLYMEFKNYDIRRKVDYVGDIYNLLTDKIFMRKVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU21</accession>
    <name>R1FU21_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42595">
        <property type="protein sequence ID" value="EOD42595"/>
        <property type="gene ID" value="Nst1_325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.315"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="313" mass="35916" checksum="A4BD72D66F924D64" modified="2013-06-26" version="1">MDNVRDLKINKDMKIKDLIEQFKYIGGFQAQELYRGYEILKEMLNDKNTIKVLSFPADIIATGIRGVIKDIIKNKLFDIVITTTGTLDHDIARLTKDYYLGYFDSDDIKLREEGILRLGNIYIPEENYGIAIENTLRPILDDIFKELKNKNKNLISTYELIFEIGKRLEKFDKKEESIIYWSYKNNIPIIVPGITDGAVGTQILMKEYDYPEIQVSVWEDEKFLASKFFGEKKVGALILGGGISKHHTIWWAQFSGGLEYAVYISSANELDGSLSGAKTKEAITWKKIRKNAKHVNIWGDITIILPIIISEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU32</accession>
    <name>R1FU32_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42610">
        <property type="protein sequence ID" value="EOD42610"/>
        <property type="gene ID" value="Nst1_340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="346" mass="39277" checksum="927AE455A65532CB" modified="2013-06-26" version="1">MALAAYVNQTLDTLLNRYISEISRLKGLTTDDFAKESLDADIKTYSEIMGAMKEVSCQLEGQLDPKVNSDLKYVLENFVSKALKDNEDLSQLYRKILDAYNQEIFSKGDEALVILLSKIYWETLKILGNPDPINGQYYRNVSRQDRENAAKNKGIIEELLGEALLRHWTSRGKKITKGEIMNNLASRVVSFYKAWDGVKGKIVSDIEWLTPSIEVKDAVEKLVMELDKSYLSFIQGLIIAAYNKRSDPEHIITVLKYLNGKDFFKNVFSEIYNDIGSYINQLQPQIAQYLQLNQPAGQQQGQQGNQPQQPPQVQNQPMQPKISNLSSPLQKNNLNIPQPKVIKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU74</accession>
    <name>R1FU74_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42660">
        <property type="protein sequence ID" value="EOD42660"/>
        <property type="gene ID" value="Nst1_392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="111" mass="12213" checksum="0361B2AD0E229AEA" modified="2013-06-26" version="1">MDWKKVVLVSVFSVLVSFLSGIGMAVAISLLMYMLVKGMDKCIISNLGLALEFAGLLIYIMGTLLQPVYSNFQSIMQTGVYLLIGGLALFLVGMLVVMLVKNKVRENIYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUA2</accession>
    <name>R1FUA2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein containing archaeal-typeC2H2 Zn-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42690">
        <property type="protein sequence ID" value="EOD42690"/>
        <property type="gene ID" value="Nst1_029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="91" mass="10977" checksum="50CA20E6A2D72491" modified="2013-06-26" version="1">MLHAIREIDRNGREIFKCPLCGHVFVNSKKYSRHLMKSHLRNVTMNKRKWKKFMKQLLLVNIKEKSNIELTNYEKYLKIKSKLNNIKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUB7</accession>
    <name>R1FUB7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42710">
        <property type="protein sequence ID" value="EOD42710"/>
        <property type="gene ID" value="Nst1_049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="157" mass="18405" checksum="9E7026CFDB5E8FC7" modified="2013-06-26" version="1">MDREKIILNILFLVFSIPVIYLIYYSYSTYFVGNKMVNPENIYNLYISNFSVNGNYFSFNVNNPNNYSVEIYFSYLGLKNSYQTSSIITSGNFLQNIYIIQPESHITLQYNFELDDQTRLTILQWEKLGGILYLTLYYSSVENNSISGIINYQVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUE5</accession>
    <name>R1FUE5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HerA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42735">
        <property type="protein sequence ID" value="EOD42735"/>
        <property type="gene ID" value="Nst1_074"/>
    </dbReference>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="132"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="545" mass="62972" checksum="3566811F17BA762D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUF1</accession>
    <name>R1FUF1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease HII</fullName>
            <shortName evidence="10">RNase HII</shortName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnhB</name>
        <name evidence="13" type="ORF">Nst1_079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 10 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 10 11">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42740">
        <property type="protein sequence ID" value="EOD42740"/>
        <property type="gene ID" value="Nst1_079"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.77"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="12">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="215" mass="25242" checksum="575BA74860F53FF7" modified="2013-06-26" version="1">MKLILGIDEAGRGPIIGPMVIAGYCIEEEKIDLLRSLGVKDSKELTRKQREYIYNEIIKLTDKYKYIIIDPETIDYYVYRNKLNYLEFENMIKIIEEIKPDKVIIDSPLVNTKKVIEYIKNNLKINVEIIAENKADKKYPIVSAASIIAKVIRDREIDKIKEKINIDFGSGYPSDERTIEVLKKDYDKIKDYVRESWMTIKKIRKGEQKNILDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUG7</accession>
    <name>R1FUG7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, contains HTH and 4VR domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42755">
        <property type="protein sequence ID" value="EOD42755"/>
        <property type="gene ID" value="Nst1_094"/>
    </dbReference>
    <dbReference type="OMA" id="IWYINED"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="243" mass="28526" checksum="596F402AE0F23E5F" modified="2013-06-26" version="1">MEEKLLEVLKQNAYGLTISELSKILNINRITLSKHLEILKERGYLNYRVVGKAKIWYINEDVNFLEMIHGNTPIIRLIRKDKNEFYNISDIKFLIIPSEIFQVLYLQALEINNLNFIRDSGKRFGIIISTTYKMYSGIERVLNEEYLKEIIKLTEKFGFGKIEDIFIDIKALDFLITLNSSIESLILKDIEDILKEKNVEIKEYFMEGYFEGLLSTLFGIPMIAINKSTLYKDPKTEFVVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUK8</accession>
    <name>R1FUK8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42790">
        <property type="protein sequence ID" value="EOD42790"/>
        <property type="gene ID" value="Nst1_129"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.127"/>
    <dbReference type="OMA" id="YMRMAGH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="418"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="11">
        <location>
            <begin position="568"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="711" mass="83660" checksum="A57CE6BC2873777D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUL4</accession>
    <name>R1FUL4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prefoldin, molecular chaperone implicated in de novo protein folding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42795">
        <property type="protein sequence ID" value="EOD42795"/>
        <property type="gene ID" value="Nst1_134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="111" mass="13023" checksum="F47A0B86D628F3F3" modified="2013-06-26" version="1">MENSNELLEFLYTQLEAIQNKILEYELIKSFINELKKQEDTYINLGGLIFVRGSIKDDQNLLINIGRNIFIEKNKNDVLKLIDDIINKLNQDLNEIRTKINEISMKKTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUP2</accession>
    <name>R1FUP2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42815">
        <property type="protein sequence ID" value="EOD42815"/>
        <property type="gene ID" value="Nst1_154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="138" mass="15687" checksum="D1F76447E486F589" modified="2013-06-26" version="1">MITLSIDILEIGNTILSFIMFWIVYSFLFSIPVYLFSKLFLDEYISFPRILAATLVSGFASFYINGIIVYYSNYELYIYGIFLAFIIDLVSYKYIANVSWGAAFVIAIVAILLFAIFVFPFLLIMSGFAMGLKTFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2B2</accession>
    <name>R1G2B2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="5" type="ORF">Nst1_628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42211">
        <property type="protein sequence ID" value="EOD42211"/>
        <property type="gene ID" value="Nst1_628"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.608"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="142" mass="16081" checksum="EDDC71F079E117B1" modified="2013-06-26" version="1">MANGLFAAKKLIENRKKFRWSKKEWKRRILKLKEKYDPLEGSPMASGIVLEKVQIEKRQPYSGMIKCVKVQLKKNGKIVTAFAPGDKAIKYIDEHDDVLIVGIGGPKGRTIGSIPGVRYKVILVNGQPLELLRKGKIEKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2H1</accession>
    <name>R1G2H1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxycytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42276">
        <property type="protein sequence ID" value="EOD42276"/>
        <property type="gene ID" value="Nst1_536"/>
    </dbReference>
    <dbReference type="OMA" id="INEAWIQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="191" mass="22683" checksum="107D073F4A6A1089" modified="2013-06-26" version="1">MSVINGEDAKKFVKEYVKVNPAGIDIKPKKIYKIPVKKIRYILIDKDKRGYFFDYNLDYEDLLEIAINENKRKELLENSFKKIPNGFIEIKPKNNYWVLNRGLYYVVFPEVEIPNDMIAIALPRSTFNRLGILKFESALFDPGYKGEFTQTYYFPINAKININEAWIQLIFIKLEKESKEAYKGYWYGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2I3</accession>
    <name>R1G2I3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 12">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uppP</name>
        <name evidence="13" type="ORF">Nst1_546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 12"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42286">
        <property type="protein sequence ID" value="EOD42286"/>
        <property type="gene ID" value="Nst1_546"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.529"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOD42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="266" mass="29714" checksum="6FC3E17789D11F06" modified="2013-06-26" version="1">MDLYPIILGIIQGISEWLPISSKTQILIASNYLLNINPSIGYTFGLFMEIGTVLSALLYFRRDIYQILKDKKMLYYIIIATIFTGLIGAPLYIISDKLLENAYNTSIPMIILGLILILDGIYIYYTRNKIKIKDKKDLNLRDIIIIGTAQGLAALPGVSRSGITVSTMLLMKYDPKFAFSLSYILYIPAALGAFFLTILASKSNIMYVISNIGYYGILTAIIVSFIVGYLTIDILMKLAKSKKIYYIDYILGSIAIIISLIGLIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2I8</accession>
    <name>R1G2I8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42291">
        <property type="protein sequence ID" value="EOD42291"/>
        <property type="gene ID" value="Nst1_551"/>
    </dbReference>
    <dbReference type="OMA" id="CTSPAMG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="294" mass="34836" checksum="911FE5E138B7FACD" modified="2013-06-26" version="1">MLILYSKYLLYHNDPNHIENNRRLLVIKRLIKNNYKKIGKIRKDIYRYINYAHSWKYVKIIKRIWKNSYKNNRIIYLDSDTYISPLSIYSILKSVEGVLESIELNDKYIFIPTRPPGHHVPRNPLNNDKTLGFCIFNNIAIAGMYARKMYKNALIFDIDLHHGNGTQDIIENKKNIYYISTHAKNIYPNTGLESGNNYFNFPLDFNIDDNYYINLLKDKIFPLIEEINPEIILVSLGFDMHKKDPLSVFNITLKSYEYAFNYLKRFNKVIYILEGGYNERAIYNGISKLLKIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2J9</accession>
    <name>R1G2J9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ORF">Nst1_561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42301">
        <property type="protein sequence ID" value="EOD42301"/>
        <property type="gene ID" value="Nst1_561"/>
    </dbReference>
    <dbReference type="OMA" id="GRIENET"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="90" mass="10902" checksum="1CE54C07F52757F9" modified="2013-06-26" version="1">MNKYFLSYEFIGLNVEVYDCKIKGLKGIYGEIINETKNTFYIKNRDKIYIVPKNISKFIFYFNDYSIFLDGKLIDKRPWERLKINIKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Q4</accession>
    <name>R1G2Q4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42356">
        <property type="protein sequence ID" value="EOD42356"/>
        <property type="gene ID" value="Nst1_515"/>
    </dbReference>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="130" mass="15722" checksum="4D80900756D1E9AC" modified="2013-06-26" version="1">MENDQISKEQINDIIKELWNKGYTPSQIGRELKEKYGIKVKEILNKKLVKYAIKELNLKLEIPEDLLYLFKKINRMLKHLELHRKDIVTKKKLEELESRVKSLIKYYKKNKKLPQTFEYSRDIAKMYGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2T1</accession>
    <name>R1G2T1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42381">
        <property type="protein sequence ID" value="EOD42381"/>
        <property type="gene ID" value="Nst1_414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="118" mass="14108" checksum="2E9C823332BEB8A2" modified="2013-06-26" version="1">MPLIIPSPEYAKRRKILQIDNKIKKLEKERAGKITLVLKKEIDLNNLNESLKFISMLKELEERNFFEELYIVKSDKVLDYLDIEKGLDQKNIEKEKLIKLYDIISRLTNIIDKIKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2V8</accession>
    <name>R1G2V8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diphthamide synthase subunit DPH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42406">
        <property type="protein sequence ID" value="EOD42406"/>
        <property type="gene ID" value="Nst1_441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="225" mass="26209" checksum="57919107049A82A0" modified="2013-06-26" version="1">MDIINIPTKYKLKEIKNLDELKKYLPKKFALVSLTQYSEYAKKIYEILKNDYEIMLKEGLYGINVLGCYSEPANINDIDTVLLIGNGKFHAENIIRKLKKRVIVYDPMYGEINVYEPDYNFDKIIEFLLNKIKNSKNIGIILSIKPGQYYYLETLKVKDKLEKSGKNVYLFIGDTIDTLQLLNFPYIDFWIFSACPRLIDDVIDNNINGITIDILIKNLDKVVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2W9</accession>
    <name>R1G2W9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">radB</name>
        <name evidence="6" type="ORF">Nst1_451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42416">
        <property type="protein sequence ID" value="EOD42416"/>
        <property type="gene ID" value="Nst1_451"/>
    </dbReference>
    <dbReference type="OMA" id="GNTLEHW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00350">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02237">
        <property type="entry name" value="recomb_radB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="230" mass="26196" checksum="3445B7261A4B105C" modified="2013-06-26" version="1">MSKISTGIYPIDKLLDGGIETDIITSFYGPSASGKTNIAIITSYNVSRFGKKVIYIDTEGGFSLERLKQIAKEDFENAMKNILLYKPVNFSEQKKAIYLTYDYVKKNSNDIGLIVVDSISMLYRLERGDSNVNEVNIELAKQLQIFSEISRKYNIPVLVINQVYSLFDNRDTIGIVGGDLIKYWSKCLVELRILDNGVREAILRKHRYLPEGISIKFKIVNDGIIEYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Y1</accession>
    <name>R1G2Y1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagella assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42426">
        <property type="protein sequence ID" value="EOD42426"/>
        <property type="gene ID" value="Nst1_461"/>
    </dbReference>
    <dbReference type="OMA" id="DRLWHTG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="549" mass="63778" checksum="64B8277D021D7DDC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1G309</accession>
    <name>R1G309_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, PilT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42451">
        <property type="protein sequence ID" value="EOD42451"/>
        <property type="gene ID" value="Nst1_179"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.173"/>
    <dbReference type="OMA" id="FADMRMA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="261"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="600" mass="70047" checksum="23E64D78DC759A13" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G331</accession>
    <name>R1G331_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42471">
        <property type="protein sequence ID" value="EOD42471"/>
        <property type="gene ID" value="Nst1_199"/>
    </dbReference>
    <dbReference type="OMA" id="LILEMAV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="147" mass="17092" checksum="BE0B3164BC5A14F7" modified="2013-06-26" version="1">MNTDDFNDIYEEIRREFARQMKLLKKIFNRAKKGLGFNFEYEVPAADVIDKGDKYLIEIDLPGVDKKDINVTLVDHHLKIVASKKVEKEERNENYILSERAFSGYKRIIPLPEDADENSIKAKYENGVLRIEIGKKPGYEGKKINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G362</accession>
    <name>R1G362_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42496">
        <property type="protein sequence ID" value="EOD42496"/>
        <property type="gene ID" value="Nst1_225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="52" mass="6066" checksum="1DF6B5F06E9E7A41" modified="2013-06-26" version="1">MPDQLPIFTYLGLYKFGKEKSKIKLNRNKIIIFIIIFAALVYIANIYISCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G390</accession>
    <name>R1G390_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative intracellular protease/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42551">
        <property type="protein sequence ID" value="EOD42551"/>
        <property type="gene ID" value="Nst1_281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="177" mass="20710" checksum="ED99822B6648A44E" modified="2013-06-26" version="1">MNLIILSSKGFDEDDLFNFLDILDGRTYIAIKNRKIGIGKYKSKVLPDFDVHEIFLMRENHFDRLIYISDEGYKEFLNVDSQAIFTRFINSYRTVILSSLSQIAFLKSGLLAGRTITYNYDEYPQYLKYFPDFGVKLVTNADYVVDRNLITVKGRDSIYNLGEKLKEIEEELKRITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3B0</accession>
    <name>R1G3B0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin, chaperonin cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42581">
        <property type="protein sequence ID" value="EOD42581"/>
        <property type="gene ID" value="Nst1_311"/>
    </dbReference>
    <dbReference type="OMA" id="PPQVQAM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="118" mass="13919" checksum="A935A886EAC9145A" modified="2013-06-26" version="1">MVSEEEIASKYEEFENLRQAYLLIENKRQKVLQDLAETENALKELSNLPDDKKVYYMIGNVLIEKDKKELINKLNEDKEILKVEAEKLKKQSDIYKEKLNSLTKELNDLLKRSSLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3D8</accession>
    <name>R1G3D8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42631">
        <property type="protein sequence ID" value="EOD42631"/>
        <property type="gene ID" value="Nst1_363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="126" mass="15069" checksum="6AA96AB19729156D" modified="2013-06-26" version="1">MSSLFGGGGNAKNKKLKEEVERIDEDIKKLLEEFEKHPYNRDPKRIEEYIKLIEKILKEIEEHKKSLHELYGSRPNNFPELGWVEHYLRLYLNTLKAAEKRLDVIIPHGSLEIIADNWYKHRIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3I0</accession>
    <name>R1G3I0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42686">
        <property type="protein sequence ID" value="EOD42686"/>
        <property type="gene ID" value="Nst1_025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.24"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="514"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="626" mass="75623" checksum="BB928BD6B1649146" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3K5</accession>
    <name>R1G3K5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42716">
        <property type="protein sequence ID" value="EOD42716"/>
        <property type="gene ID" value="Nst1_055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="225" mass="27079" checksum="1321CF86C881367C" modified="2013-06-26" version="1">MTSYIYLRARVYHTTRDGSLYNIHAYVESNRGREKERKFFTLQTEKEIPKIIFEKYRKIKDDDKYYFPKVFIVPAPPIRKNETTIPFYDKFKLVIIYAKDPPYRIRLDKLFKVSNMEIYVKKDKLRRMYVEGSCEPDALDALINNNNLESKSYNIDLREANLDDLLKFIRYDVKYNSKNNQNNRNEEMEKTGPYIFIGKDKNLSCKQSYIAPRDIKILEIYRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3R6</accession>
    <name>R1G3R6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N2,N2-dimethylguanosine tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42776">
        <property type="protein sequence ID" value="EOD42776"/>
        <property type="gene ID" value="Nst1_115"/>
    </dbReference>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="360" mass="42122" checksum="BB0407F86F83B9A2" modified="2013-06-26" version="1">MNEGKAIINYNPDFLKKLSSKLPVFYNPLMKINRDFTIIILKSYYNIIKKKFDILDCMTATGVRSIRILKEIPEVVNKIYINDIKKEAIANIKENLKINNLENDEKIIISNKDCREILLKYKFDYIDIDPFGSPIGFVELLPKALKNNGIAGITATDISSLSGSKPKSCFRKYNTIGIKTDFYLEFGLRNLAKYIIIEGLKYDIALIPIFSYYYNHHYRIFVKKSNKSKDINYLMENVKEIYYCKNCGYKSLENGKCKVCNNDLIKLGPIYIGKLYDENILNNIRNNISLLNLDKDEKKIIDRILNCDSKIDLWYYYDIRKISSFYKNNLPKIEKILEINNGCRTHFTDYGIKTLYYPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3W5</accession>
    <name>R1G3W5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42821">
        <property type="protein sequence ID" value="EOD42821"/>
        <property type="gene ID" value="Nst1_160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="143" mass="17198" checksum="BA5251E0C3163BC6" modified="2013-06-26" version="1">MSILFYKAYRIFILDDNNLLDYERVKNNIKFWEKWIKDLKKELNNQHKIVLDRLESLKELRGKIERLRGEIKIGNLLIPLFSDRVNIDIRIIFSIFNNTNIIIVWGIDHHEKAYGKIIKHAEGFIKKHQKLILELLGIKTIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8M2</accession>
    <name>R1G8M2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DDW03_01955</name>
        <name evidence="8" type="ORF">DDW05_01135</name>
        <name evidence="6" type="ORF">Nst1_606</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 10 11" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AB-777_F03</strain>
            <strain evidence="8">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">SCGC AB-777_F03</strain>
            <strain evidence="8">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000008">
        <property type="protein sequence ID" value="PVU68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000006">
        <property type="protein sequence ID" value="PVU71407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42189">
        <property type="protein sequence ID" value="EOD42189"/>
        <property type="gene ID" value="Nst1_606"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68534">
        <property type="protein sequence ID" value="PVU68534"/>
        <property type="gene ID" value="DDW03_01955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU71407">
        <property type="protein sequence ID" value="PVU71407"/>
        <property type="gene ID" value="DDW05_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.587"/>
    <dbReference type="OMA" id="APLYRIM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PVU68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PVU71407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="75" mass="8185" checksum="7FFC211F4666FFD5" modified="2013-06-26" version="1">MAKRTTPIPVAPLYRILRKAGASRVGQDAKLAMVESVLQVAEAISARAVELAKHAGRKTVHEDDIRLAIRELRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G940</accession>
    <name>R1G940_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase related to tRNA (Uracil-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42364">
        <property type="protein sequence ID" value="EOD42364"/>
        <property type="gene ID" value="Nst1_397"/>
    </dbReference>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="369" mass="44128" checksum="4BD695E19E65592B" modified="2013-06-26" version="1">MLCKHFPKCGGCQIQNLLYDKQIEYKINRFIDIFKREPDEVIKSPKIIYYRNRMDYVVGPNYEVGLKEYGKWYSYVNIDECFLQSPESNIIRNKFREFIINKNLKPWDTKNYTGFIRYIVIREGKFTNERIVNIITYKTDNLEYYKNIFFEFYNEIKNYINSFYWTINDTISDVSYGNINYLLYGEKYIKEKALDNFYYISTNSFYQPNSYTAEILLKYVREFTDPNENDIIYDLYSGSGFYAIEIGKYSNYVYAVDNNKENFEMFNLNKEINNVKSVKFLLSNVENLEKINADKIIVDPPRPGINKKVIRKILESNAKKIVYVSCYPETQKRDIDILINKGNYKLENIILVDQFPHTYHMETIALLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G946</accession>
    <name>R1G946_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42369">
        <property type="protein sequence ID" value="EOD42369"/>
        <property type="gene ID" value="Nst1_402"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.388"/>
    <dbReference type="OMA" id="CENDYPY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005736">
        <property type="entry name" value="Reverse_gyrase"/>
    </dbReference>
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        <property type="entry name" value="Znf_Rg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43505">
        <property type="entry name" value="PTHR43505"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01054">
        <property type="entry name" value="rgy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="101"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="590" mass="68584" checksum="3CF8B979A9BFEC2B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1G963</accession>
    <name>R1G963_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42384">
        <property type="protein sequence ID" value="EOD42384"/>
        <property type="gene ID" value="Nst1_417"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.402"/>
    <dbReference type="OMA" id="FVLTRHW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="381"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="806" mass="94511" checksum="F5147DE7AC168893" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G970</accession>
    <name>R1G970_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA(Ile)-lysidine synthase MesJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42389">
        <property type="protein sequence ID" value="EOD42389"/>
        <property type="gene ID" value="Nst1_422"/>
    </dbReference>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="306" mass="36292" checksum="170008F2A4377927" modified="2013-06-26" version="1">MKCNFCNNNAVYKDIDGNFYCRDHFIKYFEEKTIDTIEKYKLIKSGERVGVGVSGGKDSNALLFFLNKYKEYFNIEVFGIHIDEGIKGYRDKDTEKLLEISKKYNLNVKIYRFSEYFNIRLDEAVKISKEYKSCTICGVWRRWLMWKAAKDLNLDKFATAHNLNDEVQTILMNIFEGNLKDLLKEGPYVGIVEGDFIPRIKPFYFNTEKENLLYSILNNLEPPFGECPFIVGEFRDIIRSKLYKLEDKYPGFHKNFLRNILEIIYKAKNDYKMRNKIRLRKCKICGYPTTREICRACEIKLRINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G979</accession>
    <name>R1G979_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42399">
        <property type="protein sequence ID" value="EOD42399"/>
        <property type="gene ID" value="Nst1_433"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.418"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="157" mass="17672" checksum="A543965C18647A59" modified="2013-06-26" version="1">MIKSKIGIILIIIFFIIGYFYIKSIFLGLLLASIYVKIFSCLYIILFSLNFALISFMIINYRKFYKGNILSFISAIFGFAGFQACLVGCGTGSFAILVATLAPIFGLNIFEFGEILLVVSDILFIVNLIFLLGLNKRKDIKKLKISKNNKEDSCCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9D9</accession>
    <name>R1G9D9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42454">
        <property type="protein sequence ID" value="EOD42454"/>
        <property type="gene ID" value="Nst1_182"/>
    </dbReference>
    <dbReference type="OMA" id="RGNYYSY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="410" mass="47837" checksum="EC57B1035C7070E8" modified="2013-06-26" version="1">MITNSIIDYFLADFEKISNKNNNIIIDGRYFEEDFVPYEIKFRDKEKEIILSNINLFLNRNTGSNLFLYGTTGTGKTLIARYLNKGISFYSAKNKLKVKVAYINCKQILSDDIDYYIFKRIYEELVNINIKSGFRKNDIYENIYKFIINNDYKLIIILDEVDNIFRKSENTEILYLLLRNYDINFLNRIRLILISNSPSFISQLDQRIKSSFSSIIQVRFSPYNYYELREILKDRAIKALKPGSISEEDINYISARVSKEFSGDARIAINVLRLSATIAYNKNKEKIDREDIDEAFSSVDLNILESIISTLNKTQKLILLALIKEQIKNEDFVTFNNLYEEYVNLSNNFGISILDKTVVYKNLKKIESIFGELIESKIISNGKKGVNKVLKIISDVDNLKKIYEKIKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9E8</accession>
    <name>R1G9E8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42464">
        <property type="protein sequence ID" value="EOD42464"/>
        <property type="gene ID" value="Nst1_192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="279" mass="33402" checksum="60C4A1E55FDE7865" modified="2013-06-26" version="1">MVVTKLKDILQKNMNPFRKPIDDRWKHLSINDRIEITEYLADHIDIIEKFLGHIDWKNEDDIYKILRHIETFSIYEQLLSQQPQPQQNYIDKYTVFRYITTLERLEDIIEDIKDGHLLSLPQYQNVAKPSRDHIMIVFGIKGRPKETLIEILERAIGGVMVRGYPAFYYDPARHNNADLPLIYYVQLNNDSFFTIFFIHSRRFPQKTTGYLFDELNRIIQSKRKSLILPSGRQYHIISDYLGRDFVAIDPDPNNPNTDPYIREYIRESARFFYGYQEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9L7</accession>
    <name>R1G9L7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42519">
        <property type="protein sequence ID" value="EOD42519"/>
        <property type="gene ID" value="Nst1_249"/>
    </dbReference>
    <dbReference type="OMA" id="EDMIDAQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="69" mass="7610" checksum="EB7F827D758A3EAE" modified="2013-06-26" version="1">MKIKTWINKDTCIGCGTCIAVAPEIYEFDSDGKSKAKIEIIEDPNLIEKAKDAEVACPTHSVKVEELNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9W8</accession>
    <name>R1G9W8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42639">
        <property type="protein sequence ID" value="EOD42639"/>
        <property type="gene ID" value="Nst1_371"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.357"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="331" mass="37332" checksum="6EEA82F803024909" modified="2013-06-26" version="1">MGEAIKAINLTKSFGKFVAVDHINFEVKEGEIFGFLGPNGAGKSTTIKMLTTVLKPTEGTAIVNGYDIIKEPAKVRNSIGVVPQEFTADEDLTGWENMMLMAGLYGIKKDIARERAKELLDMVELTQAMNRKVQTYSGGMRRRLEIAMSLISRPKILFLDEPTIGLDAQTRSAIWNYIMKLKKEYGMTIFVTTHYLEEADLYADRIAIIDHGKILAIGSPKELKESIGGDVITLNTSNDDEAIKLLQNLDGIIDIKKVENMLRIKVKDGEEMAPKILERLIKSGLKVLKMSITEPTMDEVYMEYTGRKMRDEEADSKEIFAMRRTLRRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Y5</accession>
    <name>R1G9Y5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42659">
        <property type="protein sequence ID" value="EOD42659"/>
        <property type="gene ID" value="Nst1_391"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.377"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="637"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="744" mass="89082" checksum="669E5826D6370363" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Z0</accession>
    <name>R1G9Z0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42664">
        <property type="protein sequence ID" value="EOD42664"/>
        <property type="gene ID" value="Nst1_002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="160" mass="19240" checksum="C0F861C99025BB5D" modified="2013-06-26" version="1">MFMIDYKISEFFYKKLMDRLDIVYTIDIISYLIGLYFISYIVFFVNFGYIFLFIISTTITYLLKLIFNRKRPYYFFDKRFAILVYENHSFPSEHTIIAILSFIITGNILALITPILRIITLKHWLSDAIFTIILSFVFYYFFSSIINFYGLFNSLINILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA04</accession>
    <name>R1GA04_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42684">
        <property type="protein sequence ID" value="EOD42684"/>
        <property type="gene ID" value="Nst1_023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="62" mass="6816" checksum="42E397387258A228" modified="2013-06-26" version="1">MKKSDAINFIILLIIGLIVLVLVIIFVAPQTLRIMSSQQNLSNTSNNALNQTFSNISNLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA45</accession>
    <name>R1GA45_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Adenine-57, 58-N(1)-) methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42729">
        <property type="protein sequence ID" value="EOD42729"/>
        <property type="gene ID" value="Nst1_068"/>
    </dbReference>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="243" mass="28335" checksum="6E25F3429F74C48E" modified="2013-06-26" version="1">MIIIHRKTGKKFYIEDKDKDFNTHFGIIKKEDLNKEPGSIIKSHLNEEFLILEDNFNDLVRYLKRGPQSIHEKDIGLLYSLVNISPGMKIVEGGTGSGILTSYLANSVRPNGKVYSYEIREDFYNIAKKNLEKLKLLDYVELKLKNINEGIDEKDIDLIILDIPDPWNTLDHAYNSLKFGGYLVSFLPNITSVLKLLYSNDKFLLIGVYENFYRKWIYEKGKVLRPRNLELVHTEFIVLFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA65</accession>
    <name>R1GA65_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB11 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42749">
        <property type="protein sequence ID" value="EOD42749"/>
        <property type="gene ID" value="Nst1_088"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.86"/>
    <dbReference type="OMA" id="YHDNWLS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="249"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="594" mass="69150" checksum="ACF8F217823791C3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA86</accession>
    <name>R1GA86_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ORF">Nst1_108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42769">
        <property type="protein sequence ID" value="EOD42769"/>
        <property type="gene ID" value="Nst1_108"/>
    </dbReference>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="148" mass="17357" checksum="8C8EAC10E2D0CDCA" modified="2013-06-26" version="1">MISIGKKYIDATDSVLGRLASRVAKYLLEGYEIYIFNAEKVILVGRWNNLVKYWNHKVNERGDWIKGPFYPKRPDKILRRVIYGMLPKNKRGRDALKKVKVFLGLPEEFKDVKLEKIEESLIQNRLKVGTVREYHYLGDISRQIGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA97</accession>
    <name>R1GA97_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42779">
        <property type="protein sequence ID" value="EOD42779"/>
        <property type="gene ID" value="Nst1_118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="92" mass="10891" checksum="31697A8E04EA5DC0" modified="2013-06-26" version="1">MVEVYVVHLPTQEKLEKFKETVNKIIEMAKNKKLPEGLKLKKLYFDEKNNIGLCEWEVDDVNKLLEAAKQLNVDWDIKIIENPKELYKKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAB1</accession>
    <name>R1GAB1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ORF">Nst1_133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42794">
        <property type="protein sequence ID" value="EOD42794"/>
        <property type="gene ID" value="Nst1_133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="98" mass="11727" checksum="979F7F9CC47D1AAD" modified="2013-06-26" version="1">MEVKIYRVEGLIFKTKILRNLKKKEGVLTKRKVVYKFTKELLGINEKDVLERIYSLFGSAYKVKRNKIKILKVEEISENDIRDKNLKKFVEYIKNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAC6</accession>
    <name>R1GAC6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ superfamily ATPase fused to HTH nad RecB nuclease domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42809">
        <property type="protein sequence ID" value="EOD42809"/>
        <property type="gene ID" value="Nst1_148"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.144"/>
    <dbReference type="OMA" id="YNEDKFH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="428" mass="51894" checksum="35E0FBCA93E7B29F" modified="2013-06-26" version="1">MLNKYLNSDKFEFIIIYGRRRIGKTELVLKATEKMKRIYYLALEKNNLDRFYNLCLNYFPELNKYKKDWEVLFDFLKDKVDVIIIDEFQNLIKEDKNILIIFQNIVDNILKNSRIKLIIIGSSISMIKSKVLGYKSPLYGRKTLSYKLKPISFFDLREFFPDKNILELIEIYGFADGNPYYLSKINGNFWDWLDKELKEKTFILDEVDFLMRYEFESPSLYKSILEAISFGKNTIKEIKDYIKVERTDLSPYLKNLIEVELIKRIVPIDQKINSRAGRYYINDNFIRFWFRYIYPNLSSIEEGIFDINDIKRDYNRYLGYVFEDIAKQFLIKSKLFKFTKIGKWWYKDKEIDLVAYNENTKDIYLIECKYYDNINTKEILENLKEKSEYINLDIKNKYYIIFAKSFKEKIKEDKTYLFDLKELENIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3K9</accession>
    <name>R1E3K9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps24e</name>
        <name evidence="7" type="ORF">Nst1_650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42233">
        <property type="protein sequence ID" value="EOD42233"/>
        <property type="gene ID" value="Nst1_650"/>
    </dbReference>
    <dbReference type="OMA" id="HETAKIY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_S24e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="94" mass="11192" checksum="CC4A72D85CD4CF01" modified="2013-06-26" version="1">MDLKIINRENNQLLNREEIIVLIDHKNEPTPKRDDIREKISAMIGKDKNLIVVEKILTEFGKQRSKAFVNVYQNEEDMKKLEPKHILKRNKIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3L3</accession>
    <name>R1E3L3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginase family enzyme</fullName>
            <ecNumber evidence="2">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42238">
        <property type="protein sequence ID" value="EOD42238"/>
        <property type="gene ID" value="Nst1_655"/>
    </dbReference>
    <dbReference type="OMA" id="VIETIAM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="276" mass="32631" checksum="58BA8C42FADCCF61" modified="2013-06-26" version="1">MFAHAQGEYDKSKWIIVGIPSEIGSLSHVKNYIEGPESIRDASYRIFSPIFGDINMEEIYDYGDIDLEDIKDLDKLYEKIYNEIKKIYRKDKKYIFFGGDHSITYPILKIVKENWEDFYLLYFDAHPDIHPDPYPNYQSFIYHLIKENYIEPEKIIFVGISNLSFEEKNIIKEWGIKYYNPLDVWDNIKEISKEISDILKNKNLYISIDIDVFDTGCGHWLEGIGIRPYHYFKIIKELRNINLIGFDLVELFSNEVCDNLASKIVIETIAMFNNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3M7</accession>
    <name>R1E3M7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 57</fullName>
            <ecNumber evidence="2">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42253">
        <property type="protein sequence ID" value="EOD42253"/>
        <property type="gene ID" value="Nst1_594"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.576"/>
    <dbReference type="OMA" id="GWRSPNY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="391" mass="47007" checksum="64BA9B263F003465" modified="2013-06-26" version="1">MTGIVFYFHAHQPRRIRYYSFFDIGSKNYFNDDLNKRILDRVVHKCYKPALEMIYDNIIKYDIKVSFSISGTLIEQLELYHPEILELWKKLVDTGNVEIVSETYYHSLAYLIDKDEFINQIKLHRKKIKEVFNYKSKSFRNFELVFNNEIGEIVYSLGYKVALTEGTEKILGNRSPNYVYKLKINNLRLLLRNYRLSDDIGFRFTNKNWSEYPLTADKYYLWLKSTPGDIINIFMDFETIGEHIWKESGIFEFWNKLFEYIGKEKYFETYNITEASEELDYKDELDIPELISWADIERDLSAWIGDSIQREALDYLRELYKKYKNDGKILNILRYLSTSDNFYYMSLKYNSDGDVHKYFREEAFATPYDSFISYMNILKDLELNETIENRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3N2</accession>
    <name>R1E3N2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5A_REDUCTASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42258">
        <property type="protein sequence ID" value="EOD42258"/>
        <property type="gene ID" value="Nst1_600"/>
    </dbReference>
    <dbReference type="OMA" id="WARIHLG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="196" mass="22762" checksum="A655770EDA19DD25" modified="2013-06-26" version="1">MIINYGIQEYLFLFIISEIIVGLVLPFIIIKEEREKIIELKLYSLVGFILYVLVGMTFIVILASIDYYYNFSLFNYNLGYYIGFILFIIGIILQGIAEATLGKYYLPSIGTVEGQKIVKDGIYKYIRHPGYLGEIIIFFGLGFVTYSLLGILGAFIVSLMVYVGEVIPEEKYMLEKFGKEYEEYMKETFRFIPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3T8</accession>
    <name>R1E3T8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42318">
        <property type="protein sequence ID" value="EOD42318"/>
        <property type="gene ID" value="Nst1_578"/>
    </dbReference>
    <dbReference type="OMA" id="DDILGWK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="335" mass="37856" checksum="73A942823541148B" modified="2013-06-26" version="1">MYKEILIAILPLILSFFVSYYLIKKWIPIAHREGYVGRDMNKYNKPEVAEIGGLYAIIGIIFGILLYIGLKVYILKTTEDLIEVFSILTLLSLTTILGLFDDILGWKKGLKPLQRVFLTFILALPLMIISVGNSYVNLPFIGEVNFGILYPLLIVPIAIMGTSNAFNMLAGYNGLEGSMGILLIGAVGLESYLTSNYYLAEISLITIFSIIAFLIFNWYPSKVFPGNSFTYGIGSLFGAIVILGNLEKFGLILFILYFLELILFIRGLLNHVYKENFGIPDENNNLKEPYDKIYSITHLAIRINRKIFKKATEKMVVYTIILLQIIITIFAFLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3X5</accession>
    <name>R1E3X5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein translocase subunit secF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42353">
        <property type="protein sequence ID" value="EOD42353"/>
        <property type="gene ID" value="Nst1_512"/>
    </dbReference>
    <dbReference type="OMA" id="TWLMNLG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="285" mass="32777" checksum="13138152359DB930" modified="2013-06-26" version="1">MSFIEKNYKKFLIISISIFVIFVGIILFNYFKYGYIINKSITISGGYVTLINNNYHITNTEIQNVLNQMNITDYVLYNTPNIIYIESEKQINETLLINLLNQDYNIKLLPTDISIQQYSSLVGNLIFNQFLFFVILAMILTAFIIFIAFRASKITLNIISTILFDVIGLLAILSITKYPIGANGFIGMLMILGFAIDNNVVLSTNIVKEKDKPFIERVRMSFRVGMLMEIIALYTLLLLYFIVPEPSVDEFAFVLSVAIILDLLYYLIGNIPLYKYFEVKKEQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E443</accession>
    <name>R1E443_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretory pathway, VirB11 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42408">
        <property type="protein sequence ID" value="EOD42408"/>
        <property type="gene ID" value="Nst1_443"/>
    </dbReference>
    <dbReference type="OMA" id="KPWTLPL"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="325"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="747" mass="86809" checksum="EBE6ABDDFD243893" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1E448</accession>
    <name>R1E448_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor E</fullName>
            <shortName evidence="2">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tfe</name>
        <name evidence="5" type="ORF">Nst1_448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42413">
        <property type="protein sequence ID" value="EOD42413"/>
        <property type="gene ID" value="Nst1_448"/>
    </dbReference>
    <dbReference type="OMA" id="FENDFLC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE" evidence="4">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="179" mass="21291" checksum="1A522A5E483C8589" modified="2013-06-26" version="1">MSKNLIGIMSYLLNENYLKILEYIADKKEFTEKEIKRQLKIKEEEIRKLLYILEENNIVYPISIINNNGKFDFRWGNRIQDKEKLFSLLINKEINRINEEIKNTPKTLYYCNECGSAYNFDEAYENDFICKECGSLLTEKENFRIIELENIIHNLQILLDKYSSKVAKKEKASRAKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E474</accession>
    <name>R1E474_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSU ribosomal protein L24A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42197">
        <property type="protein sequence ID" value="EOD42197"/>
        <property type="gene ID" value="Nst1_614"/>
    </dbReference>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NGN" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="145" mass="16349" checksum="96CC8809A14767E2" modified="2013-06-26" version="1">MPIYAIVVTSGREELVADILANEGKNGKYAIYSIMQIPGVKGYLFVETTNSLELQRAVLGIRHVKRVIPQEIPIEDLLKYFEEEKVKYDINDIVEVLSGAFKGTRGKIINIDEKKKEVTIELIDVPVPLQLNVPINSLKLIEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4A2</accession>
    <name>R1E4A2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42227">
        <property type="protein sequence ID" value="EOD42227"/>
        <property type="gene ID" value="Nst1_644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="275" mass="31640" checksum="246F1DE5656D4F28" modified="2013-06-26" version="1">MSLSHNKYLIALSILFFIILSYNIYSMRNPFAVYCEYGGGTYYINSTGSYCIVNGTYFNALQYYENNVPPQYSFCAHYGLIYVNNSYCEYPNGTLVSPYTLIPPSTYQDLILPTPPILCNSLLNCSNTPWYYQPCSNQIYPCFNPPYIPQSYLTGNTSYQTLLSTYQQEYQCGYCPENLSFEGDWFRCPYNYSLNQLYQEFLKQCPPPNIVYISCTGVFECVNQTEINLTNNTQQLIYPQPNISNKSNNVNLILPIAIVIVIIIIGLVILLYYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4A9</accession>
    <name>R1E4A9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42463">
        <property type="protein sequence ID" value="EOD42463"/>
        <property type="gene ID" value="Nst1_191"/>
    </dbReference>
    <dbReference type="OMA" id="DLAYHEI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="120" mass="14395" checksum="A9672B86D1DC4B7D" modified="2013-06-26" version="1">MLNFYKKDLNFINRLIEESIFPDLIFYEIGSYLRKYKEIKKVSNNKIKEMMELFNYIIGKAKIEEVRLNYEILDLSIKDKLSYYDAVYLYLARKYNLILISDDKDLIKEGAISSDNLLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4B9</accession>
    <name>R1E4B9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Icc family phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42473">
        <property type="protein sequence ID" value="EOD42473"/>
        <property type="gene ID" value="Nst1_201"/>
    </dbReference>
    <dbReference type="OMA" id="KKIMVTH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="193" mass="22322" checksum="BE245EC9C57E7665" modified="2013-06-26" version="1">MIYKIIELYRKERPDYIVILGDISELGEIERGLIKKLTEYIDPNKILIIPGNHETSEDIELLEKIYKIRNLDKKYIMKDNFVLVGFGGADVLLNVIDEKEFEEFLNEIKRKIKDKYIILLTHIPPKGSISSLDISGSYALTKFIQNNDKVILNVHGHMHETGGLEEIINKAKVLNVAREVKLVEIYDKKTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4C7</accession>
    <name>R1E4C7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42252">
        <property type="protein sequence ID" value="EOD42252"/>
        <property type="gene ID" value="Nst1_593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="104" mass="12489" checksum="AEF2D4E9F7F3109E" modified="2013-06-26" version="1">MIEVDDEKQAFITIDGQKLYSLQDLLIWLYNADQDKFNYHKNHFPEWIKNSLKEESLYEKIKEAKDKDEYIKIIGNFLKAHEIYVKKKFSKEEAEVKFSKLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4F4</accession>
    <name>R1E4F4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diphthamide synthase subunit DPH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42493">
        <property type="protein sequence ID" value="EOD42493"/>
        <property type="gene ID" value="Nst1_222"/>
    </dbReference>
    <dbReference type="OMA" id="DIEIYIW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="89" mass="10806" checksum="263BAD4717EFB436" modified="2013-06-26" version="1">MEIDFELDRIFETLDKKKYKKILLQFPDGLKPYSKEIYDKIKEKYKDIEIYIWFGSDFGGCDMPIYLDKYGFDLIIHFGHSKFYKLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4F6</accession>
    <name>R1E4F6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42498">
        <property type="protein sequence ID" value="EOD42498"/>
        <property type="gene ID" value="Nst1_228"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.220"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="288"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="459" mass="54540" checksum="FEC4BB0B0FDEEDAE" modified="2013-06-26" version="1">MINKNVLINLERDIEEIERYIDKLKNILKEIKRKEEMKKYFQKLYLNGYFDEKEYKRRLTIIEKKIKYLEKSKYLILYDLINLINNSQKIIEFLKNIEEKSEEENKNIQYYQMKINDTINYISKVYPEIFKKEEIKIGKRFIEASNILFRKKEEKKKKIKFKLKLTEERKINYYQEIKNILIRFSYKIFGGISRRILNSSPKLYFYLKYSLKEAYYNIEPDELLSIMFLFSSIIILTSTFISLYLLNIFYLVYGLVGFLSVVGLLVLYFNYKKQSIVEDINRNLPFAIIHMASLADAGIEVKYIIKIISETEEYGYLSKEFKKIYDKINLGEGLVESLRSVADDTLSKDLKDFLEELILTITSGRKISEFLILYSQQEMIRYNTFLKKVNQVMKTFSDLYVGMVLTIPMIIISVGVMLLSILQQTYNINIQGLLEIITYIGLPAINIGFIILFDKLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4H9</accession>
    <name>R1E4H9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42302">
        <property type="protein sequence ID" value="EOD42302"/>
        <property type="gene ID" value="Nst1_562"/>
    </dbReference>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="104" mass="11903" checksum="A9F6416F25335533" modified="2013-06-26" version="1">MKKKLFSGLPIDLENTTKEIEKEFQKIIVRAEKRSYGKIVTIIEGVDPSIAKETLKSLKQKLGCGGTYKDNLIELQGDHREKIKKLLLELGFKEENIEISNEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4I5</accession>
    <name>R1E4I5_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="10" type="ORF">Nst1_567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42307">
        <property type="protein sequence ID" value="EOD42307"/>
        <property type="gene ID" value="Nst1_567"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.550"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="591" mass="66999" checksum="B3A1ECCB7C935556" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4I6</accession>
    <name>R1E4I6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42543">
        <property type="protein sequence ID" value="EOD42543"/>
        <property type="gene ID" value="Nst1_273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="148" mass="17323" checksum="2366AD26ED09BAFD" modified="2013-06-26" version="1">MSDNLDERIKNAASNNMRVEYKIPNIITYVIAFTKTYEEYCHTSLPELEIIDKVGEKLGIAHPFTGKLSSYLLEEPILNEIEHMSEVQRELLRMLAAGYVLSVIEDYNEGKCIEKGKEKDILSEYLYKFIKSEIISKQREGLFYRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4N2</accession>
    <name>R1E4N2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Minimal nucleotidyltransferase fused to HEPN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42347">
        <property type="protein sequence ID" value="EOD42347"/>
        <property type="gene ID" value="Nst1_506"/>
    </dbReference>
    <dbReference type="OMA" id="QERRMES"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="248" mass="29149" checksum="73B6330B187D04B6" modified="2013-06-26" version="1">MDNNPNDIILNFSKDLIEKVDGLVKSIVLFGSYAENRENEKSDIDLLIIVDDIYANDLNITVPFYFDNLNKLLADEKYKKIHVTTLTLSKFWEMIINGDPLVLDILRKGEAIIDPAGIFGSLKKMLENGLIKTSPEYLEIMKKRAEEGINYANLMLIKAFESLYNSVVTISQYYLIKNNINIYGPEDILNKFEELKRKRKISSEVYNYYKEIFEYMKKIEHREIKNIDLDLLKEFLEEFEKYKEKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4N6</accession>
    <name>R1E4N6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42623">
        <property type="protein sequence ID" value="EOD42623"/>
        <property type="gene ID" value="Nst1_353"/>
    </dbReference>
    <dbReference type="OMA" id="ICSREPR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="291" mass="32467" checksum="BC7BD81C165B5E91" modified="2013-06-26" version="1">MSIFDIKSVAIVGASNKEGKVGNIILKNFIKRFPGKIYPINPNYDNLYNLKCYKNILEINENIDAVVIAIPAEGVPEVVKQAGEKGVKLAIIVSAGFSEVGRKDLEEKILEYSKKYGIRILGPNGMGVYDPYNGIDTFFVDDKRLIRPKKGKIVLLSQSGAIALAVMEWLSSKNIGVSKIISYGNKIDLDEVEILKELKDDQNSKAIFIYMEGLREGRGKEFLEVASQLNRPVIVLKSGKTKRGSVAVSSHTASMAGDYEVYRNLFKQYNIIEAKSMGDFMIYLKTLTFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4P7</accession>
    <name>R1E4P7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42638">
        <property type="protein sequence ID" value="EOD42638"/>
        <property type="gene ID" value="Nst1_369"/>
    </dbReference>
    <dbReference type="OMA" id="ERKYDIM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="74" mass="8775" checksum="846405FFA1724139" modified="2013-06-26" version="1">MILFGSIVRGNYRIDSDIDVLIILPNINDNFERAEIAAKIYKKLGMEDPIELHIISEEEYKNWYSKFIDKYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4P8</accession>
    <name>R1E4P8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42362">
        <property type="protein sequence ID" value="EOD42362"/>
        <property type="gene ID" value="Nst1_395"/>
    </dbReference>
    <dbReference type="OMA" id="KGPGIDH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo" evidence="1">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="141" mass="17446" checksum="D81DB60B374BB86D" modified="2013-06-26" version="1">MKRVLYKDNVFLSEDKILYFYEVIYLLEKNEIEVYDEKNNKLDINYFLKDEKIKLYYDIYKYFREKGYYLGTGLKFGGIFRIYEDINQHSKWVAIPININEKIDIYDFLAKNRVAHSTKKRILYCVKDNNYRFLEIRWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Q4</accession>
    <name>R1E4Q4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase activator SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42367">
        <property type="protein sequence ID" value="EOD42367"/>
        <property type="gene ID" value="Nst1_400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.386"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="447" mass="51446" checksum="DF1827EBAFCE82C1" modified="2013-06-26" version="1">MQEITIRGPLNEEKIKKISEILNEPDWMTNIRLKGLDYFNKLDLPKFGPEIKNIDFDNMIYYRSITKENKPKRWEDLPEDIKNRIEKLGLRKEFEREFLSGLLYQHDSSSIYKEIKKYLDQEGIIFMPLSQAVKDYPEIVKEYFGKVISFGDNKFAALNTAVWSGGVFIYVPENVKVDFPLQAYFWIGTENLGQFERTLIIADKNSKVTYIEGCTAPIYNVSSLHAAVVEVFAKENSEVTYATIQNWSKNIYNLVTKRAKVYKNAKIKWISAEFGSKVTMLYPGLILEENSTGEIYTMSIANENQIIDTGGRILVNGKNSRGYIVTKSISINGRAINRIDIKIFSNSENSKVISKCDSLIEGNGTAESIPRMEIYNNKNYYNHEAKTEKIDDQKILYLQSLGIDKKKAKRLIYMGFADDILKNFPPSYQMRIKKLLEIELEEIGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4R7</accession>
    <name>R1E4R7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42377">
        <property type="protein sequence ID" value="EOD42377"/>
        <property type="gene ID" value="Nst1_410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="91" mass="10217" checksum="6C1A9346EACEA43F" modified="2013-06-26" version="1">MKRGRAKRSSSGLIFLLILIILVIAVYLYHNQILGYLGNNTIFQNIKNSTMQFINESQQAYNTVQNALNGNINNLTSTYTSNNQNNTNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4R9</accession>
    <name>R1E4R9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42663">
        <property type="protein sequence ID" value="EOD42663"/>
        <property type="gene ID" value="Nst1_001"/>
    </dbReference>
    <dbReference type="OMA" id="TGHRIEN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="105" mass="12784" checksum="34C898D8AFE828A4" modified="2013-06-26" version="1">MENLVAIELKRREKEFYYWKEYGKSEGQEVDFLIKENNIIKELIQVSYINNIDEIDRREIRSLIKASSLLNCNDLKIITWDLEDKIIKDNKEIKLIPLWKWLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4S4</accession>
    <name>R1E4S4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ORF">Nst1_006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42668">
        <property type="protein sequence ID" value="EOD42668"/>
        <property type="gene ID" value="Nst1_006"/>
    </dbReference>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="202" mass="23827" checksum="9EFCE2BC50B92FAE" modified="2013-06-26" version="1">MIKKYRYIAIDGIDGSGKTTIANLLYNELSKRYNKVILLKEPYDNDLSKKIKEIILKEHEKNLDYGYLLALLFTADRSIKNIDLKKYLNNDYIIISDRSIYSTFSYQILYEGIDIEWLKCVSKYIIRPDITFILDVDPKIAVERINLRGKNITSYENIEFLGKVRENFLKLKEIFPNDNIIYINGEEKPEKILDKILNIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4V9</accession>
    <name>R1E4V9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSU ribosomal protein L12AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42713">
        <property type="protein sequence ID" value="EOD42713"/>
        <property type="gene ID" value="Nst1_052"/>
    </dbReference>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="102" mass="11384" checksum="635F83FD7EBD7DC1" modified="2013-06-26" version="1">MGLEYIYAVWLLHEAKKEINADNIKKVLTSVGIEPNDAMVNAVLASLQGVDLDKIKEESLSVAPAQVAPQQVEQKKEEKQEKKEEEKKEEQALEGLSSLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Z3</accession>
    <name>R1E4Z3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42753">
        <property type="protein sequence ID" value="EOD42753"/>
        <property type="gene ID" value="Nst1_092"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.90"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="553" mass="59867" checksum="09D018A61010F622" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E520</accession>
    <name>R1E520_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family mebrane associated serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42788">
        <property type="protein sequence ID" value="EOD42788"/>
        <property type="gene ID" value="Nst1_127"/>
    </dbReference>
    <dbReference type="OMA" id="FILLAPW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="48"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="210" mass="24145" checksum="A0C6F4A7C85108F0" modified="2013-06-26" version="1">MNKVYKFLGLPITIWLIIILFIVYIIELMNPSILNLIAFYPHYAIKYPWMFITSIFGDYDLSQLFFDGLALFFLGLLFEYLYGSRDLLILFFLSGIVGNIFFLIQYYNNPLVSGIGSSAAISGILGALGILRPKEKVIIFPIIIPIDMIYAAIFWAIFNLIGIFYPFIPLGFSAHLGGTLFGFLYGYILKKYKRKTSIDNIFDNQERIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E548</accession>
    <name>R1E548_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42477">
        <property type="protein sequence ID" value="EOD42477"/>
        <property type="gene ID" value="Nst1_205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="191" mass="22071" checksum="68EAF8F7AF7A3F25" modified="2013-06-26" version="1">MDSKLVSLLKENKKIVTVSSTNLPVSRKDSEMVGRFIKYLTIPYAKKYLEMVIEKKIAVPYYRYHKKQAHHKNVMGKVPYGRYPIKVSKYFIKLLNSLENNAKNIGLDPNKVVIVSVNVSKGNKFPGRLRVVKIKTGPNGIRRALITVHKKTSHIKIYGLYLESLDTSKKLKRKGLKQIVKQILEEWHQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R1E564</accession>
    <name>R1E564_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl19e</name>
        <name evidence="8" type="ORF">Nst1_211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42482">
        <property type="protein sequence ID" value="EOD42482"/>
        <property type="gene ID" value="Nst1_211"/>
    </dbReference>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="7">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="156" mass="18340" checksum="4FC7BB170367B823" modified="2013-06-26" version="1">MDLSLQRRLASEILGVGKDRIWIDPNKIQDVSKALSRSDILDLIDKGIIRVKQVKGQSRTWANYIKEQKKKGRRRGAGSRKGGRKARLDKKENWIKRIRAIRNLLRELKEKNIIDKKLYRDLYKRAKSNEFKSKRAILIYLKDSGILKNEKEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E580</accession>
    <name>R1E580_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB11 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42497">
        <property type="protein sequence ID" value="EOD42497"/>
        <property type="gene ID" value="Nst1_227"/>
    </dbReference>
    <dbReference type="OMA" id="TGHDGCS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="135"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="497" mass="58819" checksum="20A0F63D05889BCA" modified="2013-06-26" version="1">MINIKFINDIKINVPKNKFETNITYPIVEPFSYAHIYFDRSTYDLVYEIIEPKLTENEEKIYKNIIFYIEKLLYIKLSEINNLNDAISYLQRLYDFVLNDLGIQLGQSSYEKIFYYIFRDLYGYNKVDSLLRDPLIEDIECSGPGYPIFVVHRYFGNLRTNIILNDKEIRDLIEKFALRAGKHISYAEPILDATLPDGSRVNATYSQEITTHGPTFTIRKFREIPWTPIELIRLGSATPEIFAYLWLAVEFRKNIIIIGGTASGKTTMLNAISMFIPPNARIVSIEDTREIRLYHPNWIPSVVKYSSDKNREIDMFELLRMSFRQRPDYVIVGEVRGEEAYVMFQGMASGHSSLSTMHAESTKALISRLTTPPINLSPSLIELLNIVVIMQHDNFLGTNLRRIKEINEIIKYNRFNIAYKWNPFKREYLENPKKYLFRLIENDYGIRYKELYEEYIRRVKLLYRLSELNISDFQTFSKIIQMYYYNKENILRYYNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E585</accession>
    <name>R1E585_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuine/archaeosine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42502">
        <property type="protein sequence ID" value="EOD42502"/>
        <property type="gene ID" value="Nst1_232"/>
    </dbReference>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="11"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="402" mass="47428" checksum="71EE41226CA8D8A3" modified="2013-06-26" version="1">MFEIKYRDGAGRIGIIRYKNKKLETPLLLPVINPYKNILPIETIKKYRINAIITNAYILYRRKFDGDIHKFLNFDGIIETDSGSYQMLHYKKDLEINNREIIEYQIRINSDILNVLDIPTDIDKSKEEAENELNITIERIKEGIKLKGDRLINGAIQGGIYIDLRKKAAEYVKNLDVDIFAIGTIVPYMIKYNFYKLLELAIEPKILLPFNKPIHLFGMGHTLIIPLSIYLGFDIFDSASYILFAKDKRILTPYGTFRYDEIKNFYIETKNNIYHIEEIKDYNNKELIKILAEHNLYNLIKEIEITKDAIKNEYLTDLILIKAHTHYSLYKATKLILEKYYNYLKSLEPIRKRSGIFYGGELNEIRVDVKRALERINERVDKKDIEDIFDYAYPFNSFKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E588</accession>
    <name>R1E588_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl35ae</name>
        <name evidence="3" type="ORF">Nst1_237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42507">
        <property type="protein sequence ID" value="EOD42507"/>
        <property type="gene ID" value="Nst1_237"/>
    </dbReference>
    <dbReference type="OMA" id="SKENQHN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="L35A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_L35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="114" mass="13042" checksum="B5087F09B88FE857" modified="2013-06-26" version="1">MKGVILNYRMGRHHIYPNQVIVKFENINNKYEASKYIGKHVIWVSPGKKIFIGKIVDVHGNKGNLRVRFNKGIPGQALGDIVLLIDNIDKVKEIREKIKNAKDINQIRSILINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5C7</accession>
    <name>R1E5C7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S17P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42567">
        <property type="protein sequence ID" value="EOD42567"/>
        <property type="gene ID" value="Nst1_297"/>
    </dbReference>
    <dbReference type="OMA" id="KKYERYE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="111" mass="13177" checksum="C54148DF55D29F53" modified="2013-06-26" version="1">MVQKTHVKDIGIEGINPPEKVCDDKKCPWHGEIRIRGLLFEGKVERVRRRIALITFYRYYYVQKYERYMIRRSKIKAHVPKCLDIKEGDEVIIGETRPISKTINFVVISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5D4</accession>
    <name>R1E5D4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA primase large subunit</fullName>
            <ecNumber evidence="8">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Nst1_307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42577">
        <property type="protein sequence ID" value="EOD42577"/>
        <property type="gene ID" value="Nst1_307"/>
    </dbReference>
    <dbReference type="OMA" id="FRAPYSF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="460" mass="54629" checksum="5A2FA9D22F6BF470" modified="2013-06-26" version="1">MLNNLIKFYQNNREILEDMVKISQNREVGYLLSNNNFGHRPSKIETEDDIINYIKKGAISFHISIERWIDLNILSEKVSKKDLNEYRLGWDFIIDIDAKSLDLSKVTARIIVDYLKEKNINPIYIKYSGGKGFHIAIPWEIFPETINIYKKDNFVEEETRKLFPDLARILALYISKNIEEKLKKIILLKFSEDELKEYGVNDIERFNPYDIIEIDTILISSRHLIRCLYSINEKTGNLSIPIKENYIEKLNPEDSNINNYSYEGIPYLTEDLERKESGELKELINDSLLWKIKNEVEVVKFSRLAENYKNREGIEETKKDVEEIKKRKIEINEDLFPPCIKNILNNKEIEDGRKRSLFILINFFANIGWDWDKIEKYIKEWNESLQDPLKDRYIEYQLEWHKKLYKNNKRYLTPNCNNEIYYKDIGVCTPDNICSLIKNPLSYPIKKIKSTKSSQDSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5F5</accession>
    <name>R1E5F5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42612">
        <property type="protein sequence ID" value="EOD42612"/>
        <property type="gene ID" value="Nst1_342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="485" mass="56937" checksum="797EFF02384D2A21" modified="2013-06-26" version="1">MYFIAQEGDFSKFYKGDFDQLYEKYLEGNIKEIIKYVTNNIYKKPSNKISLDRLIDELSRDDIDFKIFGNLGSFLFNSLGEKQNLDKILNRGNFVISAHSEFAGDLLTDIYEAIVLNPYASKYVSIETRKKIEDLFKRRLEKGYTDEYVAKEVIWVLNDLLYGNDIDSIIFNVKKGFLEDEVKKYINLISKLKEGYTIFPTHILYEQTNNLLKSLNNLGLNLFIRNHIVMHEPMYMVTLERVYSEEVNIYKENYKEIYKDTDKVWLLYSGRISIERGSNELLKLYEDLIKEGKKIGLIIISDNIHEDSEFYKKILELADKYKGVEVHLYGKGFGNSLHEDPLYYIGLLKSLGELKNTVYVNPTYLESYGLATLEALIFGNLITIYRDTSGLRELKEKGYLNYKLSFKDYQELKNKIIEVIEDIKNSKYDSYINKDIIEELKKEVDPEKIAEKYAKIIYRYLEYLESESTEKEIIENKNEEALAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5R8</accession>
    <name>R1E5R8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42747">
        <property type="protein sequence ID" value="EOD42747"/>
        <property type="gene ID" value="Nst1_086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="133" mass="14046" checksum="8EE2C50416CC07D9" modified="2013-06-26" version="1">MVKRTQSLPLNTIILAIIAIIVLVFLILIFTGGIGKFVTQTNQVSGANQTASAQCSEYASQIQTQMGTATDPNAQLQMLASSQYVTSGCSTTYQYSFTLYNGSEVVCGLGSSYSLQISNGNGNSISIPGCELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5W8</accession>
    <name>R1E5W8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42792">
        <property type="protein sequence ID" value="EOD42792"/>
        <property type="gene ID" value="Nst1_131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="152" mass="17175" checksum="07F5CE14DA1719D1" modified="2013-06-26" version="1">MRSDFLTTLVIIFGIILGITVILYLFVPPQVILKLLGKNTQSSNSVSFKISYMYYTSNSIYAIIYNGGPDIDLSNMQITYTYSQNSYQTGTCNIVVNNYTLPSNSQEIIELNCTNEDLIINNLMLNKGSYEFSFKYGNTIQQAPLPFKISNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1E612</accession>
    <name>R1E612_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA-processing protein RRP42</fullName>
            <ecNumber evidence="4">3.1.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42827">
        <property type="protein sequence ID" value="EOD42827"/>
        <property type="gene ID" value="Nst1_167"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.163"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="263" mass="30051" checksum="A0350415213D9F7C" modified="2013-06-26" version="1">MDIDFEENITDYIRKIIKENYRIDKRGLLEYRDIKIIKNYVKNAEGSCYLELGKTKVLAGVKLEIAEPFQDNEDSGILVTTVNLSPVSDVNVDIGPSEESIEYSRVVDRVLRESRFINDKELVIEPGKYVWSVLLDIYVLNNDGNIIDASTLASVCALMNTYFPELIKENGEYKINPKNKTNKKLPLNKNIPLMVSFAKIDDKFVVDPNKYEEEAADMIVHIGLSDKINALQTRKSGSISLEEFNNLLSEAEKFKDYLLKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSY3</accession>
    <name>R1FSY3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42235">
        <property type="protein sequence ID" value="EOD42235"/>
        <property type="gene ID" value="Nst1_652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="87" mass="10519" checksum="B39100BCD91C4DD5" modified="2013-06-26" version="1">MFQLPKENTIYILDLKKDVEDGFVHTFFCLKPLDIYLYNSNFELVQYSKKLKPFKIIIPKKKFRYIIEGLDINEDMLNYTIDYLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSY6</accession>
    <name>R1FSY6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42240">
        <property type="protein sequence ID" value="EOD42240"/>
        <property type="gene ID" value="Nst1_657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="215" mass="25305" checksum="4AC6809B8517CA7C" modified="2013-06-26" version="1">MKEQFSIVFITILTVLFLVGMIILLAIFSNVNLTNYQEQTSFSYEQDIIYDLFSPNCLGYPGYPIYFTTLDKIEEFNQTYYNELPNCTIFPYTFRAEIDNYSFGIINFNGNCNTYTYPISVYYSLDYIKLTICKNYYSDFYYFLYSFCLSNENTSNQTFVFLFPTNLSGNVTCTENTNGDIICNYIPCYSVNNITFYQLVTAYLERINQTYFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSZ2</accession>
    <name>R1FSZ2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42245">
        <property type="protein sequence ID" value="EOD42245"/>
        <property type="gene ID" value="Nst1_586"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.568"/>
    <dbReference type="OMA" id="RMWQRRM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="308" mass="34647" checksum="B9167E6A748FEC83" modified="2013-06-26" version="1">MVQKLIKNPELKCPVCGSTEFIYNEKTAELVCAKCGYVIEEVPYLGKEYRTINSEDAEKLSRTGSAMRYTNIPSMISTEIGKAESKDEDVTLSRKLKKWQQRSTSSYERNLKLAQQELRRISSFLQLPKQVEETALKLYLDAVEKGLIRGRSVETVIAACTYIACRIHDVARTIDEIVKASNIHKKELGRTYKHLLQALKIKIQPIDVTEYVHRFSSLLGLPPEVISTAIEIVNKAKESDITAGRGPAGVAAAAIYLACVKHGIQKTQKDIAEVAGITEVTIRNRYKEMLEKLNLKDIEAKMNSAEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT16</accession>
    <name>R1FT16_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA synthetase, ATP-grasp containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42270">
        <property type="protein sequence ID" value="EOD42270"/>
        <property type="gene ID" value="Nst1_530"/>
    </dbReference>
    <dbReference type="OMA" id="FGHAIMF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="194" mass="23021" checksum="A487F29E055F91F6" modified="2013-06-26" version="1">MLSEGFELLEKYGIKIPKYWVNEIPLHSSFPLVIKADLNHKTDLGAVKLNIQNYSELKKYYEEFRKKFNTNIIIQEQVIGEFNEVIIGIKYDKIFGDICLIGIGGIYTELLKDFIILSLPFDINILERRLRDLKLYPMLNGYRNRPKVNINLLYENIIKLYELYKKEKLLEIEVNPLLINERESYAVDIRFVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT44</accession>
    <name>R1FT44_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein Nst1_555</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42295">
        <property type="protein sequence ID" value="EOD42295"/>
        <property type="gene ID" value="Nst1_555"/>
    </dbReference>
    <dbReference type="OMA" id="YHYDHHT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="288" mass="34014" checksum="39E26783704C0E5A" modified="2013-06-26" version="1">MIILPIAYDSFSTRSMATIIKTDIKIFIDPSVAIAPYRYNLKPHRIELEELKNKKKEIIELSKDVDLIIITHYHWDHCPNPKEEHFKILYNKKLIIKDFNNYINNSQRRRGKMAYEKIKNKSEIIIGDNKSFKFNNTYIEISPPLFHGIENSALGYVIGTYVEYKNKSLFFGSDIQGILTDFTLNYIIEKNPDYIILSGPPFYHVKWDISYNEIFYKNIEKLLENTKVSKIIIDHHMARSLNYKEILDNLNEIGKNYGTEFLSAADYLNIKNVQLEANRELLYKYYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT65</accession>
    <name>R1FT65_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42310">
        <property type="protein sequence ID" value="EOD42310"/>
        <property type="gene ID" value="Nst1_570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="228" mass="26762" checksum="0E78EE782C0729EA" modified="2013-06-26" version="1">MKSQSWIEVLITLAVFLYIIIYIYQDIVSGLSQYSTGLYKISEYQKLYLSSFYFSQFYDSQIVYNYINYSFSYYYTPDVIFLSTNPFICNNCIEFFYNMSSNNIEIIQNSNINVSSILQVYIYGTTQNISIANNSAYYNCNNYLSSSFFSVYTRTFLYCSFNLIGNSSIYINTSKKFLIINNYNTILYLYNGDKIVGLPNILMNIYPTVHLNYFQYFNGSIDYISLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT72</accession>
    <name>R1FT72_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L24E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42315">
        <property type="protein sequence ID" value="EOD42315"/>
        <property type="gene ID" value="Nst1_575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="3">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="59" mass="6985" checksum="AF37C6B3EB455AD2" modified="2013-06-26" version="1">MVVKNKCSYCGNEIEPGTGIIYALNNGTVLYFCSRKCIRNWEMKRDNKKLKWTIFYNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT78</accession>
    <name>R1FT78_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase, ribokinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42320">
        <property type="protein sequence ID" value="EOD42320"/>
        <property type="gene ID" value="Nst1_580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="247" mass="28801" checksum="3FFF61A207341E83" modified="2013-06-26" version="1">MKQNSIISLPDLFLDIITKKIDINKNTGNINQEIRLKIGGNAANFSIALGKIGIKNKLIAGCNKISELIFRQYIKDKKLKIRFLPIYIDISITISLEDNDRIMITDPKGIQIGINEIKKYEKLLKKTKYIFFGNWNNNKKSNELLKYIINLNRDAKIYLDIGDPSINIENLNELIKILKENRIWVLSLNEYELEYLGNFLKLDYENLLDLANKLYKILNVEHLDIHSPDFVYSLPSNIYIKLRKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FT92</accession>
    <name>R1FT92_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42330">
        <property type="protein sequence ID" value="EOD42330"/>
        <property type="gene ID" value="Nst1_488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="334" mass="39178" checksum="A64A58C4B45FEC4B" modified="2013-06-26" version="1">MTTDKYGLYDIIKEAHKEFKEYLKRTGIEIKGVRLRILESSKLLSELYYMIKTYKKDKLKQKLNTIDKILLEQISNYDNIYIINEKNLKEFYIGEIYLLKQIYNTDDINELNKKILEDIIHSIENSKPLAIGVPETKEIYIIKDRLEKSIDETLYRVDLININRPSIIRLGSPIFDVASAPLYTDGKNIKKDIAKAIAVNVKIHEEEHFIFNIEELANPELSVSALQYITYIDMYNLLEHSKTYEIIEENIIKCKNYIWNLATMDYFAAMGNFPKRLLKDYINALRRASYDLGYCYASIIIDRNKESLCLNIKDVIKEVRNLSTLDAVTKIAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTE2</accession>
    <name>R1FTE2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication initiation complex subunit, GINS15 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42370">
        <property type="protein sequence ID" value="EOD42370"/>
        <property type="gene ID" value="Nst1_403"/>
    </dbReference>
    <dbReference type="OMA" id="WKTITMI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="199" mass="23260" checksum="820AEE9C250A5BB6" modified="2013-06-26" version="1">MDISDIITYLQKEKERKTLQNLQKDFYVKVSELLKKYKKQLEAYKSDSKEYREVIATIDRLKESLSELINIRISKIINNTVLEVKEDLNIISEDFLEEEEKLLYTLIKKILKSYKENIQNKIINGEEIDINKFFSDINMNISLYQNKIDKKIVIIKNQLPKIVGPNGKIYGPFKVGDIIILNNNFAEKLENTGIGKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTE8</accession>
    <name>R1FTE8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 2 subunit alpha (AeIF-2a)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42375">
        <property type="protein sequence ID" value="EOD42375"/>
        <property type="gene ID" value="Nst1_408"/>
    </dbReference>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="258" mass="30731" checksum="08194FE88B6D08D0" modified="2013-06-26" version="1">MYKRKDSPKVNDYVICTVKNISDVDVKVSLDEYENFNGIIPIDELSNKRITNPRILVREGKKIVCLVLDVDEQNRLVTLSLKRVDKNKQKAKIFEYKREMVAYNILKIMSEKENIDMNKLEKDIIFKIVPENKLYNVFLETYINGKSVLDKYKISKKYSELLYKYIIDYLNPPKYEFTYIMQAYCLDGDGIYKIKEFLKKIKDLNIMIKYLGSPTYMLKYVTTSPSDLQKKEKEMLELIDKEAKNYNIVYEINKYERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTF3</accession>
    <name>R1FTF3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42380">
        <property type="protein sequence ID" value="EOD42380"/>
        <property type="gene ID" value="Nst1_413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="316" mass="38554" checksum="9AA48076AA006CDE" modified="2013-06-26" version="1">MIILLYSSYQDIKYKSVDDIIIYILLIFNVFYFLYLIIQNIYPENLIFSYFILLFFVLLYLFRLLAIGDLYIFFSIFFLLSFFSLYKMLLFLFYLVLFGFIFHNIEAIKIYRENRKKYYISIINIILILISIYFINLFILYFNIYYLLISLIFVYIPYFLFRYISKDMEEKLTFIRNVNELVEGDWIEDGIEVNNIKKEDKEILVKYFDIYENENKYILKFKRNNKLINSIIILFIIIIPLIFYFLNEIFFYYSVILIIIFYHIFQNKLFIGRFGLSKEEINILKKLGEYNDIKVKVKEGAPFIPPIFLSLILLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTI2</accession>
    <name>R1FTI2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein, predicted to be involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42405">
        <property type="protein sequence ID" value="EOD42405"/>
        <property type="gene ID" value="Nst1_440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.425"/>
    <dbReference type="OMA" id="PVGVWQI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="2">
        <location>
            <begin position="283"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="381" mass="44642" checksum="54DA5453F0C97A17" modified="2013-06-26" version="1">MIDVINAKKLAEKYKKLYGKSIILKKDINGYTPPSNLISSINYPKLSLGILTSYDENIELYDNPIYWAKNNIDVEEIIKSRISLINAKKVVDANLPRKNDKLYNEVLDSMLSIKSINLEIYFNKISENMRISKIIGLYGYSGIIDKIKINENPKIPKEIYKIEEMKAEDSIYYLYKSGMSDYYLSRLFSMGFFGYKINRKLVPSKWAITAVHEILEKRIKEEIKDYSKINDKYYLFYYSLYGNDFYGVFFPGNGNCELIETLIPGSVYNLNSKYSIIGRDDESGGYSALKLSFAEFMRNYKMIGNLVVFRFVTREYKVPLGVWVVREGTKYMLNNLVEKFDNYNELISYLNNKFMNKYNVSVYKLKKYSNLLKQKSIFNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTI8</accession>
    <name>R1FTI8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42410">
        <property type="protein sequence ID" value="EOD42410"/>
        <property type="gene ID" value="Nst1_445"/>
    </dbReference>
    <dbReference type="OMA" id="AMHEEEI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="234" mass="27254" checksum="BC5192B9AAAE5E13" modified="2013-06-26" version="1">MRSLLGLFSKKGNKDQSDQQNLDNLFQDFNSPIPQNNGPFNQFQQSNNINPIANNYQNFSFGQTNQQMPLQQNISSQFNQSWNLPPQPTPSPSLNQFQPQQQVQSQPEFGQSNFSIDDRLEQYINNTINDILKDKLNEVHDELSQIKIWKEKVEYLINKMQEQIDKLDNKITEINNLATKKLEEYDKGMQEATTEIQALHRLIRTMIPAISESTKELRETVEELKSLRDSIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTL4</accession>
    <name>R1FTL4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase of polypeptide chain release factors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42435">
        <property type="protein sequence ID" value="EOD42435"/>
        <property type="gene ID" value="Nst1_470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.455"/>
    <dbReference type="OMA" id="FIDINPV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="219" mass="26225" checksum="D1BAA3A7D1B8B48C" modified="2013-06-26" version="1">MDFEYVKHNDLIIYYKIYDLECYPPKEDSFLLNDHIKEFARGKRVLDIGCGSGIQGLEAYKYTKNVSFSDISEECLKISKINFYINYIDNNSDLDYLYKNIEKMNLPVKFYLSDLFNNINEKFDLILFNPPYLPEVSYEGVKVKRWVSGGKFGYETIDRFLYQSITKLNNFGEILIIMSSITNPQYILNKYSKFYDYRIIDNKHFFFEDIFLIYLKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTN9</accession>
    <name>R1FTN9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuclease of RNase H fold, RuvC/YqgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42455">
        <property type="protein sequence ID" value="EOD42455"/>
        <property type="gene ID" value="Nst1_183"/>
    </dbReference>
    <dbReference type="OMA" id="NDNHERD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="337" mass="40323" checksum="D72178C083BE4994" modified="2013-06-26" version="1">MLKSLIVGIDPGTNLGLVVIDDNGNIIDKLSGKNIQNEDIIKYISNLKHVVLIATDKKDIPKTILDIASKLNIGVYNPKEDISLEIKNKYYKDDNLKKIFENNHEFDAYISAIEALKKLKEIFEKAKRVSENQDEYIKILRYILKNRKVEAISAKNNLIKKEKEIKEKKKRRKTKIDKRDIEIIKVIIKNEKDKEEKEKIIEELNKKYIELLNDYNILSKILTERLKNNDNIIPKISFLYLNKIYYNRIFIDEFKEEYITYYKSKDVKFFVKRENLIEAKNIFPKFYIVDEFKELKNFIIVEKFHEEKSNIIENDIDEERLKKILKNYREHRLQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTU7</accession>
    <name>R1FTU7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42495">
        <property type="protein sequence ID" value="EOD42495"/>
        <property type="gene ID" value="Nst1_224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="150" mass="18120" checksum="9AF203E783F9D28D" modified="2013-06-26" version="1">MPNLEENLEYNRRYKEVLHIFNVSLKNNKGLETVRSFIKAVIEYYDYAIELFFKKLYENKKIDEIPDSPMKRYKKIIEITKDKELEESLKYYKLLKLALNSDARIINEYRKSMIIKFRTLSGEEFEINIKTLKDILESVKKFSTIINKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUG2</accession>
    <name>R1FUG2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42750">
        <property type="protein sequence ID" value="EOD42750"/>
        <property type="gene ID" value="Nst1_089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="126" mass="14712" checksum="1FAA4B9EC1C05957" modified="2013-06-26" version="1">MPVNAIEIVLITLILFFISQSMILYFNHITNPSNYDKIVLNYIGSNVEFCIYYSYLYDANLFCQPSQNYKFSISAINNFVYISYNGNLLSINLNNNSYFHPIYGQGFNSFFLQYKNYSSNSILYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2A8</accession>
    <name>R1G2A8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42206">
        <property type="protein sequence ID" value="EOD42206"/>
        <property type="gene ID" value="Nst1_623"/>
    </dbReference>
    <dbReference type="OMA" id="AMFVVET"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="298" mass="34352" checksum="375E0A5D563C6162" modified="2013-06-26" version="1">MMNYSFYFYTYIFLIAATILLLIGIEIALALSFFINNDLYKKYENLFLSMWEITGTSIVFFVVQYEALLPSLLIPIAYSFYPLIFIILFLFIFRNIGIGFFEGKSINKEYSKRDILIYLFGTLIMAILLVSILSTAITGYGIKIINGNIVWGLSIIFNYFTLLLLLSTILFVLGILGYIFNVKKFKIYGLMGYLLVLLDIYLYENTIPYLFIFPLIVLLILTFVNLKDLVQRILFIIVHYLNAIILATLLFPYIFGTININSLLSQSMPLLSAEFIISIIIIIVVIGIYYFEIKTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2C5</accession>
    <name>R1G2C5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C1A subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42226">
        <property type="protein sequence ID" value="EOD42226"/>
        <property type="gene ID" value="Nst1_643"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.623"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="499" mass="55769" checksum="2623CD7757691A95" modified="2013-06-26" version="1">MKRYQLNLLSVAIILVIISLAFIIYYQYSMNVKEQQENLIFENFINNLQNLENTINSIQGTYYIKVNIPNGIILYANGPKLIIQYNNNNYTIDFQNKTVVLYNNNQNVNFLYPNNHIYIVSTNNTIFVTTNLQNSITILNEYLSNGNLVYINPENINNNNEGNNQGNNNNNINQNVQCLFQYNGQANFFWGDVNGNNYLPPIGDQGECGDCWAFASANGIASIYMIRNNQPNDGLQLSPAYLAIECNNGYPNTPNYCNSNEGCTGGVVYPALLFTSQYGIPPDQGWNYYNSTLANCLENNNQNYPGDVCNYNYNGPNSPLYYSQGVIFLTQNGPLTDQQVIQDLLCYGPLVAAGFLGGSGGSNPNINPQQPILNTGHAMLLVGYTTSNTIYSQLCQEVYETPNCWIFENQWGDNSACIVLTTSGVPVPGPNNPNQCGELYQNYQDCNNYLQLVLKVPGVSCGGVYWMQDGYLLVPFDQSSYGQTFPYYIVAIQNVTLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2D4</accession>
    <name>R1G2D4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42236">
        <property type="protein sequence ID" value="EOD42236"/>
        <property type="gene ID" value="Nst1_653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="128" mass="15077" checksum="18E708F83FA987FE" modified="2013-06-26" version="1">MDNIQDLENQLLTQIRNLLSQINNYVLQLQSLNEYEKNISGNPYNLYNYQMQEINNLISSMKLLISILESIKDYITLYYKEISGNPYITPNIKIEIIGQINNGIKEIKSMIDRLFVEIEILTNNLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2F1</accession>
    <name>R1G2F1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with SCP/PR1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42256">
        <property type="protein sequence ID" value="EOD42256"/>
        <property type="gene ID" value="Nst1_598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="166"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="455" mass="53016" checksum="38DFF8243040E2DE" modified="2013-06-26" version="1">MWNRIIINSYLNHKDNILSAIIIDLVDNKYLIKENYLQIIAGNFKILISKMFLNIKKIIRSLIIVYTRHRHHRNHNRFHRHKHWYDDDYYYNNVSGSKPKRSRIIKIIARIIIISLIILIVIYNPSYIKQILKTLQTSINNISTTIQSAILSTQPTINSTWVFQFFNIVNQYRQSTGAPPLQYCPWLDNYAHIRFETMIQNPEISHYGFDQDFNEYFSQYQDLLVSEEVLYPDGYTPDEYVQDMQSEAPIHWEGLLDSNYTYYGYYIGYGPTYAIIGSCPVTEIVGSVNVPQYFQSYGCSVELENSTWLVIELSNWCSGPTTITVSTINEDLSPQYYIYLPIQYNLPTNEEYVKLVVNITSTSPVELFLFTPDQFTYFESLYQQEAWSFTGPAYYYGGISTTFNTEITLNTYQLANGGYYLVISNVLPDAQYTYVNGNITIVYTPTTPNILSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2F7</accession>
    <name>R1G2F7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nuclease (RNAse H fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42261">
        <property type="protein sequence ID" value="EOD42261"/>
        <property type="gene ID" value="Nst1_603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="161" mass="19414" checksum="EE88A7141183D10B" modified="2013-06-26" version="1">MILGLDLSAKENNKTGYFYFNKKPIFGILNKNEEILNLIENEKFKYIFIDAPLSYEHPYRIEERLLYKYGFKPLPLSLKSMKLLYERANLLKNKIIEINNNIEIYETFPRAVEKILKLKYQYFSKIFKYKDIYDAYLSYLAGLFFKLNRYEKFGNLILPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2G2</accession>
    <name>R1G2G2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42266">
        <property type="protein sequence ID" value="EOD42266"/>
        <property type="gene ID" value="Nst1_526"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.510"/>
    <dbReference type="OMA" id="CERANDW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="148"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="322" mass="37879" checksum="E902739B58474D5E" modified="2013-06-26" version="1">MMNKIKKILIAPKAVYNSRKLIKNLSLSLYQYLILRKQNIELKLRNGETIKVSRSLYPGIIYYYYLGYIKNINKDDIYFKVDNKTFQVPLKEIEFTKFLRMVSLGWLYYKNYWEKNNIKFKHVYLQTYEVFEEENYKFLNVEDKNILDIGAFVGDSAIYFILKGAKKVYAVEPHPDAYNEMLDNIKLNNMEDKIIPINMGINYEKDYVSINIVDINNVGGSFFNSNNTGIKIPAGKLSDIIDKYNIDAQVLKMDCEGCEYDIILKDYDTIREFDEIGFEYHAYNTKIPVSKLLEKLNKDFECKFIKGGINEKIGILHCIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2M7</accession>
    <name>R1G2M7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42331">
        <property type="protein sequence ID" value="EOD42331"/>
        <property type="gene ID" value="Nst1_489"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.474"/>
    <dbReference type="OMA" id="VTSIDEW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="47"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="401" mass="47573" checksum="7BD70A63683BEF9E" modified="2013-06-26" version="1">MNDELLYYFNPWYINQKDIVIERWENMKMRWIPEWLKDISLEPFSLNFIIGPRQVGKTTGIKLLINKLLENKDPWAIFYYDCSNLTNFEELKKVIDYYLKIKEKRNIKTSYIFLDEITYVNDWWRTIKLYIDIGKFKDDVITITGSSSIKLKGEVELFPGRRGNGKDIYVYPLSFREYLNIKGIKINKYENILEGMNNLSGLEPKIFEEFENYIETGGYPLSINGYKDTSLQIISSIENEILRSRRNLELSKAIISTILSKAPSPLSFSSIGNEVGVSYKTVEDYIEIFRRLFILDYALFKEKQIIWRKERKFFILDPFLAKTLSIWTNTEFLESALYEWIVQSHLKRRFGEVYYYRNSYEIDVIASNLKIEIKSKRAHKNYPKDVIILDESNLPLFLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2N2</accession>
    <name>R1G2N2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42336">
        <property type="protein sequence ID" value="EOD42336"/>
        <property type="gene ID" value="Nst1_494"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.478"/>
    <dbReference type="OMA" id="TRVTWVD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070193">
        <property type="term" value="P:synaptonemal complex organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022285">
        <property type="entry name" value="CHP03879_regulat_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026676">
        <property type="entry name" value="SYCE1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15233">
        <property type="entry name" value="SYCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03879">
        <property type="entry name" value="near_KaiC_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="212" mass="24250" checksum="EAB92FD56D238C04" modified="2013-06-26" version="1">MVDTISTQSEKIDIDFKSIPLNPLGKNDIKKLETFLIIGTLYRPEILELIKDPNERSTWIDSLAIAAAAYARYKAGMPISLIADELGRSEETIRNHISGKTKAGSLIIETYEKIKSGQLNLILSFNSSNKELDELKNQVKNLKEEIEKLKGERDELKNIINNKEETIKSLQIEIGRIKSDLDKISREKEEIINKYKLLQSKLLEIKRILENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G325</accession>
    <name>R1G325_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42466">
        <property type="protein sequence ID" value="EOD42466"/>
        <property type="gene ID" value="Nst1_194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="521" mass="57495" checksum="09F038AE0F59B878" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1G356</accession>
    <name>R1G356_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42486">
        <property type="protein sequence ID" value="EOD42486"/>
        <property type="gene ID" value="Nst1_215"/>
    </dbReference>
    <dbReference type="OMA" id="KIRRYAW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="54" mass="6402" checksum="8AFC164960B83E91" modified="2013-06-26" version="1">MTRLGGTNKVNHVICRRCGRKTYNPDKGYCSHCGFGRSSKIRAYVWSYKFKRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G367</accession>
    <name>R1G367_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Minimal nucleotidyltransferase fused to HEPN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42506">
        <property type="protein sequence ID" value="EOD42506"/>
        <property type="gene ID" value="Nst1_236"/>
    </dbReference>
    <dbReference type="OMA" id="YILTDFW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="3">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="576" mass="68039" checksum="CD90CD748DC6C8A5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G371</accession>
    <name>R1G371_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42516">
        <property type="protein sequence ID" value="EOD42516"/>
        <property type="gene ID" value="Nst1_246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="201" mass="22429" checksum="09FD2469BBC4EE99" modified="2013-06-26" version="1">MINPLPQINFNPVNFNQLLSQYGFIDFVLPFLLIFSLVFMILELSNLLKVSPDDPVGRKLSALFSFGFALLSIYNQNLVKWLLSFIPSATIAIIGFTLIVIVLAITNKKIPSWLRALFAFLVIGIILWLAINSLSIAGPSSSPIASLLSYTINYLIQSGILELLIVFGLIFLVLMWLVGGGEKEEEREEEKRNSPVLLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G383</accession>
    <name>R1G383_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan phosphorylase</fullName>
            <ecNumber evidence="2">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42536">
        <property type="protein sequence ID" value="EOD42536"/>
        <property type="gene ID" value="Nst1_266"/>
    </dbReference>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="533" mass="63148" checksum="EA8B971C82E03561" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1G396</accession>
    <name>R1G396_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ORF">Nst1_291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42561">
        <property type="protein sequence ID" value="EOD42561"/>
        <property type="gene ID" value="Nst1_291"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.282"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="117" mass="12931" checksum="94B6CA3D21951309" modified="2013-06-26" version="1">MVYKLVIVVRKDLDIGKGKLCAQVAHAAVEAVLNQLEKDKDIVKKWREEGAKKIVLYVRSLDELMSIYNQSISLNLNTVLIKDAGLTQLEPGTITCIGIGPDIEEKINKVTGSLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3D0</accession>
    <name>R1G3D0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Wybutosine (YW) biosynthesis enzyme, Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42616">
        <property type="protein sequence ID" value="EOD42616"/>
        <property type="gene ID" value="Nst1_346"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.334"/>
    <dbReference type="OMA" id="HRCLQMT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="54"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="342" mass="40293" checksum="4AB6C1FDDCE34A67" modified="2013-06-26" version="1">MNENIEKWKIHDLKTSKQLEKAGYGIYNHSAVEICHWTKESIINGRTCYKNKFYGIDTAGCMEMTQSVVWCTNRCIFCWRPNTKFEPYYNILPEDLVDKPEETMEKLRELRKKLLIGYYGNPKANKELLDKFIDKPTHVTFSLSGEPLLYPYVAESILYIKKNWPWIKSIFIVTTGQVPEALERLIEKNALPTQLYISFTAPNKEMYKKISVPIHKDYWERFIKSLEIASKMKTRRVARITLIKGVNDDPKYFDEWAKLIEIYNPHFVEVKSYSFLGYSRLKLKFENVPSMEDIRNFAKGLVEKLPGYEIFKEDVDSRIVLIKNRREGMDIDPIIKNVEPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3I5</accession>
    <name>R1G3I5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42691">
        <property type="protein sequence ID" value="EOD42691"/>
        <property type="gene ID" value="Nst1_030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.29"/>
    <dbReference type="OMA" id="IGKKLMW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="179" mass="20852" checksum="B1E4BDDE79BE1E2E" modified="2013-06-26" version="1">MDKREEYAIVIYYLPGGDPTKNIKEPVVYTVGRDYFTLLLLTLKPGVTVNLFEELYIGNKQRDKVRSILKRLSFDELPEIAKANLEKAIKDLIAKNEKKFVEFFNNAGPLNIRLHTLELLPDIGKVTVQKIIEERQKKPFESFKDIEGRVKGIKNIRDIIYERIIRELSGKEKIKLFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3J3</accession>
    <name>R1G3J3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42701">
        <property type="protein sequence ID" value="EOD42701"/>
        <property type="gene ID" value="Nst1_040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="48" mass="5272" checksum="1114DB65BB2C2F7E" modified="2013-06-26" version="1">METGELLKIILALIFIILILIFVFIVLGPKLGLNINIFAQYQLIGGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3N5</accession>
    <name>R1G3N5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exosome subunit, RNA binding protein with dsRBD fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42746">
        <property type="protein sequence ID" value="EOD42746"/>
        <property type="gene ID" value="Nst1_085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="154" mass="18682" checksum="876FD923EA2833F2" modified="2013-06-26" version="1">MKISFVLLRVNIHEWDDKNKILNAIDLLLKDIDRKKIEINNYKDKGLISNIIEVYEIKINKKNSIDIFFRNLISLGLNFEDIKNNCNFDENYNIYLRIDKDELTLNKIIKLHYTEDSFLLKISFDHYKKDKEIVLNYLREYLENINKKFLYNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3P5</accession>
    <name>R1G3P5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42756">
        <property type="protein sequence ID" value="EOD42756"/>
        <property type="gene ID" value="Nst1_095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="210" mass="24634" checksum="994D56FD333B28DB" modified="2013-06-26" version="1">MKREKVINLLILVIAFIILVLIITIKSKIINYTNNINNSQTYVYTNPNNITIAGPYNITQLEFIPIYSNTSLYNSLNNYKYQLFIFDPTLSGYYNAEILYILLYLLKYNKNLVYACSFYYNGPGCKYFLENNSINNNYIFLYTLYNNNENLTYILPKNETLLIYLLPTNDSYGIIFNSQNNTVIIYNNDSIIAEEMAEKFILYYYGIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3S6</accession>
    <name>R1G3S6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate synthase</fullName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42786">
        <property type="protein sequence ID" value="EOD42786"/>
        <property type="gene ID" value="Nst1_125"/>
    </dbReference>
    <dbReference type="OMA" id="SQSAHIY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="4">
        <location>
            <begin position="247"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="472" mass="55640" checksum="394F69908639669A" modified="2013-06-26" version="1">MLEKDILIVNSKSNISIATLWAKKDFIFNLLPENVKNKVNIIGTLYTVNGIKYLIQTLGENPQINKIILYGPDLTQSGQALVDIFNNKDKDTVKRYNINLDYDEIKEILNTTNIIDMRKDFWNKNISKLEEIIENNYKPNIIFRRKIDIKIEEEVKTNYGYIIPLPPAFIYEESLFNAWVRILTEIKMFGILKGSEYNEKQLERLNIVVSLGLYGRKYQLEKEFDEFIKLEEFEKHLKGYFINKKPEGVDYTYGERFLNYNNLNQLQYIINKLSNNPETRRAIMITWNPNIDMHSNDPPCVISIEGIIQGKYLNLTEYIRSNDMFRGWPLNMYALIKIGEYIVNEINKRTNDGYELGIVTTISASAHVYEHDFPYIEKVLEKYGYRIRSFVPDPKGNFIIYNEDNKTFVEHRSYDNTILDFKFGSENANEIYNKLKGLPFFTSYDHAMYVGREIYKADEFRKTGKKYVQDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3T5</accession>
    <name>R1G3T5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 6 (AeIF-6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42796">
        <property type="protein sequence ID" value="EOD42796"/>
        <property type="gene ID" value="Nst1_135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="209" mass="24089" checksum="D2A8547B82234943" modified="2013-06-26" version="1">MIVKKADYISIPSIGIVMHIFEDFLIASKSEKNNIERMNIDIKKYYIESPIVSPYFIEHDNKIIISSNAPEELKNILKNHFDIIEIDFIENLIGNIFLIGKNGIIYSYGKDSDVKKISEKLSLPAYKIKTKYLFGSISKLYNNKLLISQELNDKIIEKVKEITGYNLDIGSINFGSPYLRYGIEINKEYLIIGKYSTGHEIVKVEEFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3T8</accession>
    <name>R1G3T8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42801">
        <property type="protein sequence ID" value="EOD42801"/>
        <property type="gene ID" value="Nst1_140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.138"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="424" mass="49676" checksum="5FEFE91E232702D7" modified="2013-06-26" version="1">MMDKNIIKLLLWKKPAIEVLNEEKANKINNFRHYIGYEISGYVHLGTAVVSGYKLIDFMNFAETEVFLADWHSVINNKLGGDPEVIKRIARGYFTEAMKQTIKSLGGDPDKVKFVLASEIYNNDYWAEVIKIGKNTTLNRLLRSITIMGRKYEESMPSANLIYPLMQAADIIFQKINIAHAGIDQRKAHVITIEYADKINYDLIAVHHQLITNLQLPYETFQKLKSGNIKEAKEELSELKMSKSIPGSAIFVHDSPSEIIDKINKAFCPQKELEFNPIWEIVEYLIFRDQEGYGIIKYLYENNLYKIENIEKINYDIYEELKNNNKINWNEIYKIIDKESNELYKYSYKDIEFEIINEKTGERKVYNNLWDLRKDWIEGKIHPLDFKKAVGKWLANKLEPVYKYFTEGSGKKYKEELDSVKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3X3</accession>
    <name>R1G3X3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase, subunit K</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42826">
        <property type="protein sequence ID" value="EOD42826"/>
        <property type="gene ID" value="Nst1_166"/>
    </dbReference>
    <dbReference type="OMA" id="HNRYEKA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="66" mass="7485" checksum="787B58D09CA97F7B" modified="2013-06-26" version="1">MNDISKFALARLIGARAIQIAMGAPMMVKLSKEDLERIRYNPVKIAEIEYEKGVLPLKAVFKKIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8N0</accession>
    <name>R1G8N0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ORF">Nst1_616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42199">
        <property type="protein sequence ID" value="EOD42199"/>
        <property type="gene ID" value="Nst1_616"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.597"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="159" mass="17444" checksum="338FA1E01ECDFDCE" modified="2013-06-26" version="1">MGKEVIELLVEGGNAKPGPNIGPKLSQLKLNVGEVISKINEATKEFKGLQVPVKIIVDTETRKYEIEVGLPPTSSLLKREANIEVAKRTKPDEVVGNVTIEQIIKVAKMKMKDLNTNNLKSAVKMVLGTALSMGLTVNNRNPKELIKEVDQGLYDNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8S8</accession>
    <name>R1G8S8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42249">
        <property type="protein sequence ID" value="EOD42249"/>
        <property type="gene ID" value="Nst1_590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.572"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="222" mass="24801" checksum="D484DEF17298ECC2" modified="2013-06-26" version="1">MTSFADFIINVVNILGINLIFVFLFYFGILYFLLKFLMDSMVKAGEKGEKKDEGGSKKDINSTLAFIISISASLLLTTFTGFVSYTQYFVAFVVSMILVFFFFILLGALLTNGKIFEVIEKRLFSTEGKPSSARYIPIIIVVFIILFALLSMYYAYQKYFLSITFGTSPQAQNYIITFNPYILFAMIFFILIGIFLIFSGTGVGSEGGKGSEKQGGDKGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8T9</accession>
    <name>R1G8T9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42259">
        <property type="protein sequence ID" value="EOD42259"/>
        <property type="gene ID" value="Nst1_601"/>
    </dbReference>
    <dbReference type="OMA" id="PTYLNDK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="698" mass="80665" checksum="E6ABF65F5431F1DF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G909</accession>
    <name>R1G909_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42334">
        <property type="protein sequence ID" value="EOD42334"/>
        <property type="gene ID" value="Nst1_492"/>
    </dbReference>
    <dbReference type="OMA" id="YMINIIM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="340" mass="39167" checksum="B1CA7A0DAD4F65B4" modified="2013-06-26" version="1">MIDKDRRGFLKLIGFGLAGFIVGTTLGTLIFKYGINNSLNQNISNNLNNPQYIFWNVPWGPGNGTYKLLNSYFQSNSPITEGVIVTFNDNYTHSLDQILYLYENNKNKKPIYINLFVTTNRDNITNLSQYDQNIREFLEYLSNITNGGENIVIGFSEIDKAPIEQLAYYYSLMKNYLPKANLFYYVDMGNSTRIVELYNYLLNNYGIKLDMIGLEVYGNYIYNNGNISMNKYMINIIMQYKQFADENNIKFFIGELGFRNGDLEGYISSEGLGYWNGPSEQGYQATIKYYEAIINQLHGMGIDIIGIYDWNGANGDPFGLWSNPYVNELINYMINNYNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G918</accession>
    <name>R1G918_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein S26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DDW03_00835</name>
        <name evidence="1" type="ORF">Nst1_503</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000002">
        <property type="protein sequence ID" value="PVU68870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42344">
        <property type="protein sequence ID" value="EOD42344"/>
        <property type="gene ID" value="Nst1_503"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68870">
        <property type="protein sequence ID" value="PVU68870"/>
        <property type="gene ID" value="DDW03_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PVU68870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <sequence length="70" mass="7850" checksum="B164D9A5C115B9F6" modified="2013-06-26" version="1">MVRLDKAIKLTISPKLKPDVSGEQSPTLILSSPIKIYICPACARYRGISKKDIKNKNKEQEILKKLGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9E4</accession>
    <name>R1G9E4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">Nst1_187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42459">
        <property type="protein sequence ID" value="EOD42459"/>
        <property type="gene ID" value="Nst1_187"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.181"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="198" mass="22958" checksum="F11F73108D807943" modified="2013-06-26" version="1">MATGPTYLVKFRRRRENITDYRKRLKLLKSKKPRLVVRRFLNNILAQIISYNENGDKTLLTIHSKILEKKYGWKGHRGNLPTAYLVGLLAGLEAKKKGIEEAILDIGRYRSTKGNALYAALKGAIDAGLKIPYNEEILPSEERIKGEHIKNYALMLKEKDPEKYNKQFSRYLKNGLEPEKIVEHFEEVKNKILKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9N7</accession>
    <name>R1G9N7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42544">
        <property type="protein sequence ID" value="EOD42544"/>
        <property type="gene ID" value="Nst1_274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="55" mass="6179" checksum="FABF00F446CFFACA" modified="2013-06-26" version="1">MESKMLSSIFIIIGTLVELYLLWNPSFFSNEYVKFAAGSIVVLDVLALLEILLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9P0</accession>
    <name>R1G9P0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AP endonuclease family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42549">
        <property type="protein sequence ID" value="EOD42549"/>
        <property type="gene ID" value="Nst1_279"/>
    </dbReference>
    <dbReference type="OMA" id="PIMENAN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="686" mass="80065" checksum="863E030F28FD61A8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Q6</accession>
    <name>R1G9Q6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl24</name>
        <name evidence="4" type="ORF">Nst1_299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42569">
        <property type="protein sequence ID" value="EOD42569"/>
        <property type="gene ID" value="Nst1_299"/>
    </dbReference>
    <dbReference type="OMA" id="KICVEGI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="174" mass="20717" checksum="4655CA4EB081C369" modified="2013-06-26" version="1">MVLKIKNIDYKDWSSSWKSSESSRKQRKYIINAPLHIRGKMISSMLSKDIKNLIKINSLPLRVGDYVKVLRGKYRNTEGFVIHIDRKRYKVYIDNVKFTNKANREVYRPIHSSKLLILRLNLKDKKRIEIIKRKMKAKNIEENKIEELINQLVNNFAVKEDELAKVTELNKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9R4</accession>
    <name>R1G9R4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="5" type="ORF">DDW03_02445</name>
        <name evidence="6" type="ORF">DDW05_00950</name>
        <name evidence="4" type="ORF">Nst1_309</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 8 9" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AB-777_F03</strain>
            <strain evidence="6">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">SCGC AB-777_F03</strain>
            <strain evidence="6">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000012">
        <property type="protein sequence ID" value="PVU68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000005">
        <property type="protein sequence ID" value="PVU71465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42579">
        <property type="protein sequence ID" value="EOD42579"/>
        <property type="gene ID" value="Nst1_309"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68415">
        <property type="protein sequence ID" value="PVU68415"/>
        <property type="gene ID" value="DDW03_02445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU71465">
        <property type="protein sequence ID" value="PVU71465"/>
        <property type="gene ID" value="DDW05_00950"/>
    </dbReference>
    <dbReference type="OMA" id="VDRCPYC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PVU68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PVU71465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="67" mass="7786" checksum="4661A5FA7B0930E9" modified="2013-06-26" version="1">MAYRKPKRKVCRNCKAIIDKDVDRCPYCGSTDLSEDYSGFIIIVNQENSEFSKKLNLKEGKWAIRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9T9</accession>
    <name>R1G9T9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42604">
        <property type="protein sequence ID" value="EOD42604"/>
        <property type="gene ID" value="Nst1_334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="104"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="306" mass="37439" checksum="676C558C6B6096BC" modified="2013-06-26" version="1">MELCNFPFIIYSMNNNYNTLLITEKGLENITIEEIEKILSRNIDYNIIEKKNKILIYTNLDFEERLNLLFNSRTIDNILYKKKDKYKYFLLKNLYERGYQLKKIEKLKSTLVNKIIYHSNIRENEEILNIMDDGSFSIEQGIYIKNILPIFWRRKEISEYMNYFEKYMNIKKKVNIKIYCVNKDKNKLLLIERNSENALVNDIIFFRRLDIEWIDLKFKEGSIDKIFTFRIKKDSELNIKDKYIFYHSDKLLKSNGKLYLLLYNYDYKKILDNIKNYIKKYSLLYIDSFYLYNYNKRLLLIVLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Z4</accession>
    <name>R1G9Z4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent RNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42669">
        <property type="protein sequence ID" value="EOD42669"/>
        <property type="gene ID" value="Nst1_007"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.7"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="181"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="408"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="616" mass="70940" checksum="13CB391B2FCC8A85" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA26</accession>
    <name>R1GA26_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ORF">Nst1_048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42709">
        <property type="protein sequence ID" value="EOD42709"/>
        <property type="gene ID" value="Nst1_048"/>
    </dbReference>
    <dbReference type="OMA" id="GKWHHYA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="198" mass="23892" checksum="34A2DD77F9246EB4" modified="2013-06-26" version="1">MDEFNKLKIYHMKKLEEAKEKYLADQPIYYIIDFINSLDFFFTTSSCAGRIILLKIPKSGKKFEAEFLFKSHYYVNFYYIWNKLLEVYKNYDEKIYFKQEPFILHVSSKNIERAYELLNIARKSGFKHSGIFLINNKRVMVEIVGNEKIETIVSKNKKLLVSKEYFYNLVKEANEKLKNVRKRINIFYKNLLSYYITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA40</accession>
    <name>R1GA40_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42724">
        <property type="protein sequence ID" value="EOD42724"/>
        <property type="gene ID" value="Nst1_063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="147" mass="17010" checksum="4AD35F2EC238F1CA" modified="2013-06-26" version="1">MKTCELCGKSTDKLYKVYIEGTILNVCKDCLKYGKPVDENGNIIKENKLEIKEIVGEVVDENYNKILIKYREDHKLKQEDMAKLLGIKESLYKSIENKKIIPDINLAKKIEKILGIKITKKEVLTEKINNKDKKSYITVGDILEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA54</accession>
    <name>R1GA54_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="2">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truB</name>
        <name evidence="5" type="ORF">Nst1_078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42739">
        <property type="protein sequence ID" value="EOD42739"/>
        <property type="gene ID" value="Nst1_078"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.76"/>
    <dbReference type="OMA" id="GPFKEDE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DKCLD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="3">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="339" mass="38710" checksum="8DE05DA1366C22FD" modified="2013-06-26" version="1">MVEYCKLPYENEKYEILIKKEEETNEKYGYDPWKRPINELLDFSIINLDKPRGPTSHQVSGWVKNILNKKAGHAGTLDPKVTGVLPIGIGRGTKVLKLLLTAGKEYIAWMHIHKDIDENKVYEILNKFQGKIVQKPPLKSAVKKVPREKNVYCIKVLEVDGRDWLLQIATEAGVYIRKLIDDIGKALGTKAHMQQLRRIRVGELKEDSEKYPLSTLQDIVDSIWFWRNENNEEYIRKVFLPAEVAAEHTKKIWILDTAVDAIAHGANLTVKGISRLYSNIKEGDLVTIFTLKGEIVAYGTALMDSEKILNSEKGIAVDIDRVIMKRGLYPKVWKKSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA80</accession>
    <name>R1GA80_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA (Guanine(1405)-N(7))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42764">
        <property type="protein sequence ID" value="EOD42764"/>
        <property type="gene ID" value="Nst1_103"/>
    </dbReference>
    <dbReference type="OMA" id="NIENEGW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025981">
        <property type="entry name" value="rRNA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07091">
        <property type="entry name" value="FmrO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="277" mass="33907" checksum="F41422FBE43EE930" modified="2013-06-26" version="1">MELFEIINEIKNKKELRNISDKVVENILKRELRKKQYLYEKLSSIKSIKQLKNDEEFYLLFKEVRRILHELYGLYTPKEDKEIDKILFNDEITLEQKIIELLMLTRSTAERLNFYKEIYKNIFIEKPLEILDLASGLNPISIYFSDQKPKKYYYVDISEKILDINYQILKELNIENEGWLIDLLDPDDRIFGHYQYIFFWKIFPILEKYDFYAPRNLLSKLDFDYLIISFPQKSLGKKRNLGLAWRYKIKRFVTYKLKYKVVKEFDIPYEYFVIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAA2</accession>
    <name>R1GAA2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42784">
        <property type="protein sequence ID" value="EOD42784"/>
        <property type="gene ID" value="Nst1_123"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.121"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="128" mass="14446" checksum="9FCBC3521EFF9E09" modified="2013-06-26" version="1">MYMDLTTFMILFEIYTFILVLIILSKLLGRKSSIFIILLMILPLLIILLASLSGLSIIQSLFLFIIILLFIIEALLYYLFDLSLSIVAIIMLASLLISSIAYSLIVSPMYVYSASSQLLPIIIQSPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAB6</accession>
    <name>R1GAB6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase involved in biogenesis of archaeal flagella</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42799">
        <property type="protein sequence ID" value="EOD42799"/>
        <property type="gene ID" value="Nst1_138"/>
    </dbReference>
    <dbReference type="OMA" id="IVKYNNA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="234" mass="27201" checksum="55787940E06FC007" modified="2013-06-26" version="1">MVEYINVYLDRDEFSNRIGGGIPKGSIFIIEGENGTGKSIICQRILYGALSNNHTATYISTELSVVDFIKQMESLGYDIKDYLLNQKLLFIPTLNLFNRIKEKENLIFELTKEKSRKLLENELIILDSLSYPLINGLDKMDSIRLIEFLSKIKNLDKTIILTYNPSEINRFFVRNIRRIADIYFNLRFSSIGESSLLKMIEVKRFRYPMSIYNTLIPFRVEPNIGLIIEISSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3H4</accession>
    <name>R1E3H4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42188">
        <property type="protein sequence ID" value="EOD42188"/>
        <property type="gene ID" value="Nst1_605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="125" mass="14591" checksum="4BA64F7BC5073370" modified="2013-06-26" version="1">MEYSERKPIDFKKERPQLFKMKGISAKTVEEHLKIYEGYVKKFNEITQKLNNLTDEDYNAANVTYSLIRELKVEWTRAFGGMINHEIYFSHLGGEGGKPGSSLGSQIDRDFGSRDIFNSFKYFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3J5</accession>
    <name>R1E3J5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione synthase/glutaminyl transferase/alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42218">
        <property type="protein sequence ID" value="EOD42218"/>
        <property type="gene ID" value="Nst1_635"/>
    </dbReference>
    <dbReference type="OMA" id="NDWRANY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="95"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="283" mass="33884" checksum="7697908BFD1371BC" modified="2013-06-26" version="1">MGGIAIFTKTNLQDYRIIKLKEEIKNYNNISIIDIEKENIFPYSEKILNYELYYFFVGSNFLSDIHFLAKYLEQNGKEVINKIHVKESIISKTLFYSILNKYIKIPEFVKIYSIDNIEYVINKIGFPMIIKHQFIHRGEFVHKIDNEKELYDFLEKYLLEKKINIKNLIFQKYIPYEKDIRVIFVGKPIGAMERINKNSFKANISQGGYGKEYKLDEEIIDIGYKIMEKCELQIFAFDLLLKDNQYYLIDLHHIFQYEGFDKYLNKNITKEILKYLNEISNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3J9</accession>
    <name>R1E3J9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42223">
        <property type="protein sequence ID" value="EOD42223"/>
        <property type="gene ID" value="Nst1_640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="159" mass="18385" checksum="4BC5B5CD95452BCD" modified="2013-06-26" version="1">MKNDIAIDTVFIIIIAIISVAVILDIIYTKFFYNSQAYYCQSLISQGGFSPSCEKYYPSAINIIYTNESKDTIYSDITGLILNCYNNNVNTNKLFNICYDIYIDENITLHSSTLIQYIQTYTSFNPNNVIFHLNNSDGNIYPYNSIFIIYNNSYIVIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3P4</accession>
    <name>R1E3P4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42273">
        <property type="protein sequence ID" value="EOD42273"/>
        <property type="gene ID" value="Nst1_533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="312" mass="37643" checksum="4FF10A430007272A" modified="2013-06-26" version="1">MVKLGIYGTVYNSADTIRTTIEDLKKKLKYDFVISVCDNFSKDGTFEILKEYDFIDAFQRKSTRGLGRQYALENLIKNHPDVDYIFYIDFDVIFPDYLNELIDGIIKIYKENEIIGFGGFASLSTYKKILIKVRWRDMNVTEDFMYSVDIIHKGFNLYFLGLPISFNQERPKRERKYAKGLKYINRLFKIYFKDYALHKLLATWIKFNSIRDSERILHTHLKDILIPPELYLDKNLLFLIIPYHPGYLKKMIKKLSLYYDYVYIYIIKRKNKVKYYLIIYYDYKTIEKYLMNFLRYVNKTFDPNKVIKINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3W9</accession>
    <name>R1E3W9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Nst1_507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42348">
        <property type="protein sequence ID" value="EOD42348"/>
        <property type="gene ID" value="Nst1_507"/>
    </dbReference>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOD42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="238" mass="28935" checksum="ECE1AF4B4393CDA7" modified="2013-06-26" version="1">MEYKLIGHGAEAKIYLIESDKKENNKYIFEFNKDFLNKLEIDSEEFKIENDKNKIVLKYRYKKKYRNELIDKEFRKYRTRVEAKILEKLYNYINVPKLLYKNEENGIIVMEYIEGYNLAKYLEKLNYEEILYEIGKYIGLIHKNKIVHGDLTTGNMIYNNGKIYFIDFGLSFFSNRIEDYAVDLHLFKELFESNHWRISDKFSLILEGYKESFLEKYEEVFHRLKVVESRGRYKSILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Y7</accession>
    <name>R1E3Y7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42363">
        <property type="protein sequence ID" value="EOD42363"/>
        <property type="gene ID" value="Nst1_396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="283" mass="30455" checksum="B1DBD0BC0A8D73B9" modified="2013-06-26" version="1">MVRAQFGLSTLIILIAIIVTAAVAAGVIIYTASSLQSKALQTGAQAEQRITTGMQITQVFGYQYDPSSGQLNNYLQKVTVLGPVVSLMPGSNPINFEYVSTLITDSNGDVYSYAPSQYEPTAIYGVLQGGSFIITGFMFNNQVNVQNVTIDNSQVCSTLNNFTNQYIYTNFTYVNGTLVSCTVGLNSSIIGYPLSVNQLFQILQSMNEAGIQNPYAIIGLSVSQESVYLTTGELYEIMYYLPNGLSVNENYNIQITPVNGYTSQYGGAIPAVLSQSVVSLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E404</accession>
    <name>R1E404_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted or membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42378">
        <property type="protein sequence ID" value="EOD42378"/>
        <property type="gene ID" value="Nst1_411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="350" mass="39985" checksum="9AB13441E1ABC0E2" modified="2013-06-26" version="1">MKKLQTTGLGIFFILLGIVIFVYWAILPYQYKQYLLQQLINGTNITLYSSSNSSYTNISNQYVFQNIQLSKSQNYYYIASNYTIGSYTPVYYINLGTLNFETNIFYGTVSKSLYFYYSNNYNGINITAYSTCNNGNFNIYVNNYELYSGCQNGDISIFVPPNYLYNGDNELKIEFSPSSIIFNGNGVLNNININYLKFSSLNFNYYYISGDVYMFYDFCPYSPQNVELIVNGLSIPLSSCSNLFYLTPYLNVGENSISLISSYPVNINNLYIESESNIFYIAFPDNLTNYILDIIVGQGSGEVILNNNCIYNISSSVGAYAINIYNCLLPENLLEIKTNNYLKIDYLQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1E467</accession>
    <name>R1E467_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ORF">Nst1_463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42428">
        <property type="protein sequence ID" value="EOD42428"/>
        <property type="gene ID" value="Nst1_463"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.448"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="408" mass="47172" checksum="C848DDBB8326C921" modified="2013-06-26" version="1">MVEPWIKKYAPKHINEIINQSEAIGKIKSFIEKYPNVSKKALLIYGPPGVGKTSSIYAIANDLDYEVVELNASDNRNARVIHEKLGEAIKGKPFFKKGRIILVDEVDGLAGFQDKGGIGALVKIVEESRWPIILTANDPWDPKFKKLRDSCDMVEFKKLSNTDIIRQLKRICTNEKITIDDNALSALVERSSGDLRSAINDLQALATMTNHITLKDLEVLGYREREITIFRALGQMFKANTIMGATLPFADVDMDPEEIKAWVEENISNEYENIKEIYEAYNWLSLAVVFYGRIYRRQYWDLLKYFTTLMYAGVALAKEKRYNKFTKYRMPQYVKKLSQNKEIREKIEELSKNLQKKVHTSKKRIREVYINTLIVLMKENEKIGKEYAKILGFNENEISYIKEAVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E472</accession>
    <name>R1E472_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42433">
        <property type="protein sequence ID" value="EOD42433"/>
        <property type="gene ID" value="Nst1_468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="85" mass="10576" checksum="A0654AA040E81D52" modified="2013-06-26" version="1">MPYNIEYEFKIPKYIIEGILDEYYSENMYKNGDIMIKRLIMDYILNKYPDLFDIDNKKYEEIIKNMKIEDRGNKYIYVYIYVDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E483</accession>
    <name>R1E483_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquinol oxidase subunit 1 apoprotein</fullName>
            <ecNumber evidence="12">1.10.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Nst1_624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.10" evidence="12"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42207">
        <property type="protein sequence ID" value="EOD42207"/>
        <property type="gene ID" value="Nst1_624"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.604"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="453" mass="51140" checksum="ED0D4AFDA4AB232E" modified="2013-06-26" version="1">MLPVYDIDRVVFASSLAIHIIIASITIGMPFAIGTLELYGILKKDENIKNLAQRISTLILVLFAIGTLSGTIVAVEMYTLFPKFMQIVSNTAIISLYIEILAFFMESLFVGIYFYSFKKYNNSVLHPIFMYIIGIFATMSGFLIITLNSFMNYPVGIEYLDGQYIDINPYSIFFTPIEFIEVSHGILASLEFGLSMFVLFISYKILKEKDIENIKIYGKALKLIIPILFLSILLLGIFGINSIDTLAKYQPVKYSILEANLNGNISNAPENLFGIVTNNYTLIDSIQIPNLQSLLLYESFNPNTIVPGIYVNESYIPSPNDITIAHNSFDIMAIFGFLIFFISLYGLISLIISKEDKKDKKFTLNPKYTFYMNKLLLYGLILLSILSLISLETGWIAAEVGRQPWTIYGILLTVDAANLNPGIVPIAITFELIYIALFVLSIWAIKRYFIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E491</accession>
    <name>R1E491_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42448">
        <property type="protein sequence ID" value="EOD42448"/>
        <property type="gene ID" value="Nst1_176"/>
    </dbReference>
    <dbReference type="OMA" id="CARAGIN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="336" mass="40515" checksum="67B3A7CB41142CB7" modified="2013-06-26" version="1">MINYFELKKWYNDNAEKINNSIVKNIYNIEDGVVFELYKPGLENRFLYIIPGKIIFLYNVKEREEINNFTLKLRKDFNETKINIEIDNNDKIIIIKNNEKKLYVELFPNGLLIVTDYNDIIIYANQYKNFGVRKIFRNEKYTKPPGSVNIINNIDDFFERVNSTNKKDVVRFLAVDLSLGGKYSEYIIKKANIEKNKSPKELNKEEIEKIYNIYNEIVNSRILIDENGNIIEDINKYFINLYLNSRENKRIRKLNEEKEKIKRIIEEQKKYLEEINKEINELEKIGEFLNIYSWIFKDYDENNIIKNFREININIDIKRDNKYLIVNIDDKYLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4D6</accession>
    <name>R1E4D6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative archaeal coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42262">
        <property type="protein sequence ID" value="EOD42262"/>
        <property type="gene ID" value="Nst1_522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="470" mass="52872" checksum="23B01E3786A9C080" modified="2013-06-26" version="1">MKSLEKILFPKNEKSFNLRQLFEKTEEIIRSKIKRIGEYAEKASEYVINIENEVKHGVESLEKDIKGYLETAKYVIPSVLASSTTLGRLGYIGSTLLICGTSKGGIGGNWYSKIPPIVSSLLSIVSLIIGLYDFHQYHELSQELQDIKNNNNVSLIAIREQLQNINATLAELKNNLNDMNTNYNTTITNIQRQLEEINATIIGLENNYQTSQEQIQNLINQVQTLEQQLQALENYYTLEGILFGNNNNSYGISVIQINSVQIENETAYVQGTVSSSGANVILEIPVDYVEKVNVNIQEFVNDVQRNGWNPYLIIDRVDLQYMTLLNNQNGTYVISIQPNEPVKIGIAATPADPSAIYNVLNNKNNYYIVIQDSYPVYNSPLALWGYKSGNSVVVDFSNNYQYNLAENMISIADQIINSPGNQNPTSKGIIYTYSIFNGSVSTYQNYPEYIVGQTYIPLIVLEPEEGESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4E5</accession>
    <name>R1E4E5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42272">
        <property type="protein sequence ID" value="EOD42272"/>
        <property type="gene ID" value="Nst1_532"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.516"/>
    <dbReference type="OMA" id="IMLENIM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="82"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="256" mass="29718" checksum="580DFF79538BE2CD" modified="2013-06-26" version="1">MDINKNEIKIKLDDKLYSIPINALYSDDIGGILTFIKSNWQYKNNYWEKNGIKFKYAYGSISEIFDNEDYKFFNVKDKNVLDIGAFVGDSPIYFVLKGAKKVYAIEPHPDAYNEMLENIKLNNMEDKIIPINMGINYEKDYITINTKDVAHVAFSIFNSNNKGIKILAGKLSDIIEKYNIDTQVLKMDCEGCEYDIILKDYDTIKEFDEIGFEYHAYNTKIPVSKLLEKLNKDFECKFIKGGIKEKIGILHCIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G0</accession>
    <name>R1E4G0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LSU ribosomal protein L41E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42503">
        <property type="protein sequence ID" value="EOD42503"/>
        <property type="gene ID" value="Nst1_233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="38" mass="5185" checksum="6ECD0EC8B4B90430" modified="2013-06-26" version="1">MRRSSRRWKKYLRSRWKWQRRRIREEKRLRKIARMRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G1</accession>
    <name>R1E4G1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42287">
        <property type="protein sequence ID" value="EOD42287"/>
        <property type="gene ID" value="Nst1_547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="261" mass="31043" checksum="524991B4122269B3" modified="2013-06-26" version="1">MIRNYILSLILYIESSIALYFSYIYFLNLINNLLYSTINYDILFFLSISLLSFLITFYLGTYFSMKIKNKAFYLIIGIIYYIVGLILFHNFINLYITISLFFIIKIIEREYSFFAMIIYFLSILFIVLKNPIFFNIVSQFIHNKLENLYISNINDLYQIYEYQLLNTYIGGYETAIYVLENEGDTNGAYILYNNLTYVNQTFFNSLNSTINGYLNQYNQTINYELDNIINNFSPEINISIALFLITLFRIFLEINKKVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4G8</accession>
    <name>R1E4G8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA sulfurtransferase</fullName>
            <ecNumber evidence="8">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiI</name>
        <name evidence="12" type="ORF">Nst1_552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42292">
        <property type="protein sequence ID" value="EOD42292"/>
        <property type="gene ID" value="Nst1_552"/>
    </dbReference>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="11">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="8">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="435" mass="50804" checksum="0B08DCBE943A6621" modified="2013-06-26" version="1">MIGIDEIWTKSEKVKKQMINMLINDIKNRINFDKIENRRGRIIIWDYKDEWINILRNIPGIKNIYPAIYFETSIENIKKYSLEFFNNFIGNISRFKVSTKRVDKNFPYKSIEVNKIVGEEILNKYKLKVDVKNPEKILYIEIHKDYTFIYDKIISGPGGLPEGSQGKGILLFSGGSDSSVASYIISKRGLKIDFLFINIAGDIYLQYVYNVYNKLKDYFPNSKLYVYDLDIGYLFNVREGYRQILFKAIMYKIAEKFAKKNNYDCIVTGESLGQVSTQTIDSLKVLDSIVDILVLRPLIGFNKGEILDLSKKIGIYNIRAPEICKIENHPVTKPKIDIIISELNKLNIDLDKEVEKIKEINNINIEEFNLKIPDKKDLIIVKSEEFSKYNFEKGKRYLLICKKGILSKYFAKRLRNIGIEAYYMDEKTAKMLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4H4</accession>
    <name>R1E4H4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">8-oxoguanine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42297">
        <property type="protein sequence ID" value="EOD42297"/>
        <property type="gene ID" value="Nst1_557"/>
    </dbReference>
    <dbReference type="OMA" id="VKMFGYA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015254">
        <property type="entry name" value="AGOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09171">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="236" mass="28726" checksum="405244FE8A1543FE" modified="2013-06-26" version="1">MDLIDILSKFSIEEILYFEENYDLQYRYLRFLYKNIKNQNLFLKLIVINSLLAFQLSYKGEKFWKIFSIYFSKHNDNIYNNFLSFIDLYNRRFKEIKIKRLNKIYNWIKDKDLLIYKDDLVKFNSEIAKVMGQNIYDKTIVFSTKIYGYGLRIIGYKIIYPFEIFIPIDNRIGKISKDKNYWIKLSKEINIPLLHIDSLIWITMGLNKDKIERIKNEELKNKIKLLKNYLDNIINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4T7</accession>
    <name>R1E4T7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42683">
        <property type="protein sequence ID" value="EOD42683"/>
        <property type="gene ID" value="Nst1_021"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.21"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="48" mass="6267" checksum="84B02A5A9996803A" modified="2013-06-26" version="1">MDWEDLKRKVEELKMMAPKESEDWDEEWEEDWDEGEEDWEEDWEEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4U4</accession>
    <name>R1E4U4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl21e</name>
        <name evidence="4" type="ORF">Nst1_032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42693">
        <property type="protein sequence ID" value="EOD42693"/>
        <property type="gene ID" value="Nst1_032"/>
    </dbReference>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="107" mass="12279" checksum="0F629F06F685A61D" modified="2013-06-26" version="1">MTARKGKGLRRKTRDKLSLHVREHGKIKIRKILQEFNIDDKVVIKIDPSYNKTMPHPKYHGMVGKILGKRGECYEVLVNDKGKEKIIIVHPAHLEKFKGQVSPVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4W3</accession>
    <name>R1E4W3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42412">
        <property type="protein sequence ID" value="EOD42412"/>
        <property type="gene ID" value="Nst1_447"/>
    </dbReference>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="241" mass="28507" checksum="03D158681FD8E73B" modified="2013-06-26" version="1">MRYIDSHCHLYKFNEIEIKRIIKNKDITILSVSEDLESSLKNLILSQLNENVIPAIGIHPWNIEKVNENTFKIIEDIIKDNKIKILGEIGLDKKFKPETFEKQKEIFERFLNLAKEYDLNLNLHTPNASNDVYDLLIKYDIKKAYFHWYSGDEKLLEEIIDKGYFIGINVATIVNEKYRKYIEITNIKNIITESDGPYNYKGVILHPDMLKDLYKLISDIRKIDLEELSNIIQNNFARFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4W5</accession>
    <name>R1E4W5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42718">
        <property type="protein sequence ID" value="EOD42718"/>
        <property type="gene ID" value="Nst1_057"/>
    </dbReference>
    <dbReference type="OMA" id="ELPVAPC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="103" mass="12140" checksum="248F4E3598D958F5" modified="2013-06-26" version="1">MIRFRFHQPKYEKFIREFNNIYFMARGERGIPMAVVERILKQKGEQAGVTRVSDKAIRYLKQELEDIALEIAKEAVSLANHGKRTTVKREDIQLATKQIFKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Z0</accession>
    <name>R1E4Z0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42748">
        <property type="protein sequence ID" value="EOD42748"/>
        <property type="gene ID" value="Nst1_087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="212" mass="25207" checksum="BBCC8B54D55C8940" modified="2013-06-26" version="1">MIDKNYVSSILGISKTKLQELINEKIKQYKNLIDEETAILLILKERGLTLEDLYNIKVKNLYPGLKVKEIKLKINKILIKKDNLIILEAGDETGLIKLIIKDYKWKRKKNLLKENNNIKVKNGVVLNDFVLSIFINDVDLIEKINEEIDLNQNYISYRYIRLLKEKEDNYIVLTDNFNVLYLEKTIQLEYNKTYTIKFYNKRPIEIIELKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R1E511</accession>
    <name>R1E511_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspS</name>
        <name evidence="8" type="ORF">Nst1_112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42773">
        <property type="protein sequence ID" value="EOD42773"/>
        <property type="gene ID" value="Nst1_112"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.110"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="150"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="415"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA discrimination" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="444" mass="52281" checksum="E298EE83CE432914" modified="2013-06-26" version="1">MDIYNYNKGFELLKNRINIKDLEKIEYDREVILAGWIINIKNIGNISFIILRDQTGDVQITIKKDIFNDLEFIKEFSLHTFIVVKGKYVKGIAKKYKEVVAEEIYLISEPADRLPIDENSYFEKRMNYRWIDLRDPKKSLIIKLTSYAVKYIREYLYNNNFIEIFSPKIISTASEGGAEVFELKYFDRKAYLAQSPQFYKQMAICSGFERVFEIAPAFRAEPSFTSRHLTEFTSFDVEIGYISSHYDVMKVLEEIIKYTNKKIKENFEDEINKYYNVDIFVPENIPKINMEDVYEIVGKNNIKENGDITSEGEKILGDYVKKSYDNEFVFIIDWPWTARPFYHMKGEPMKNGIITTKSFDLLYKGLEISTGSQREHRYKILLEQIKEKGLNPDNFKYYLEFFKYGAPTMGGFGFGIARYIKQLLNIENVKEAVLIPRDPNRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E533</accession>
    <name>R1E533_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42803">
        <property type="protein sequence ID" value="EOD42803"/>
        <property type="gene ID" value="Nst1_142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="73" mass="8623" checksum="1FBA2F26AD10AE6A" modified="2013-06-26" version="1">MEEELYATKYELYISLIITLIVIAIIANTLINLPYKNLYYMSTLIILILIVIDVYVYLSYKGKIPLYKVKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E542</accession>
    <name>R1E542_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42813">
        <property type="protein sequence ID" value="EOD42813"/>
        <property type="gene ID" value="Nst1_152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="438" mass="51127" checksum="0B414043F98ADEC7" modified="2013-06-26" version="1">MVDIKNISDIEGLTSTDILNLFKETRAFKLLSTKAWNNRTDIFVNPIAFLRDISNDITDSISSAFDTDYWLLILGGSGAGKSTLSMAIYKHIMKNLGYTDEQIKNSIYLDFCYLPYDYLGRIMLHEKQIQEKGKSFPHPIILDDAYHLFGVFNRGITGTTRKLLDKIWEIGEYRLAHIVNNQFSLQLAQRAIMRMHSLIILWKEPISIGSNETPNMEETYLSYVKNLLNKSQETNSNNKDVDFLWGAFYGKDKAYKVMGYITKNQGNIGEVDILAKFTPDYIFPMLLTLHEISDLRKAYKDIKDCSLSIIDYYRNAEKLKIKGSHKCLFLRILIELNKNFDRITDKVDSKGFYKVNPPLDFKIRNKKDFDALQDIGDIHLEPPIKQTRKIYKDSTYIKETYSESPKIKIYSINSYIYYFLKNCHETLEKRSQLYERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1E552</accession>
    <name>R1E552_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42823">
        <property type="protein sequence ID" value="EOD42823"/>
        <property type="gene ID" value="Nst1_162"/>
    </dbReference>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="89" mass="10312" checksum="1EE8987897C61299" modified="2013-06-26" version="1">MKAVKIIIYGKVQGVGFRNFVFLHAKKLNIRGYVKNNPDGTVEAVFEGDEDNINRMIELCKKGPERARVDKIDIKDIEINNYQDFKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E555</accession>
    <name>R1E555_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42828">
        <property type="protein sequence ID" value="EOD42828"/>
        <property type="gene ID" value="Nst1_168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="31" mass="3520" checksum="5D11ECE0C59B1D1E" modified="2013-06-26" version="1">MDEDIKEAAKDLIILIISIGLVIFAYWLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E561</accession>
    <name>R1E561_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42833">
        <property type="protein sequence ID" value="EOD42833"/>
        <property type="gene ID" value="Nst1_173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="114" mass="14036" checksum="FD1F19CDCA1FDDA3" modified="2013-06-26" version="1" fragment="single">MKNDYIYIFLISFIPQLIILLLSPPILLWDEYSYLDNVKHILLNTPYFEYYRFPLLWWILIPISYITNFNIFFIKLFLIFIFSLSTVFLYKILEDYNNKYINYILILFYSLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E595</accession>
    <name>R1E595_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42517">
        <property type="protein sequence ID" value="EOD42517"/>
        <property type="gene ID" value="Nst1_247"/>
    </dbReference>
    <dbReference type="OMA" id="YAIMYSI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="164" mass="17787" checksum="CF1811D4F9E6E7CE" modified="2013-06-26" version="1">MYGILSKYKILGDPFAEGDRGRVTRSLISIVSAATGFFIVGSANVVLSLRTLIPYIVLFLLTVFFLILAISPFLQREEKSGEIQIGNRTRMILLASSIIIFTLIVIFILGLYNYIASAASASSSTLSSLQPFIETIVILAIMFGIAYWAIKPSKGQGSGPSQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5A6</accession>
    <name>R1E5A6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42532">
        <property type="protein sequence ID" value="EOD42532"/>
        <property type="gene ID" value="Nst1_262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="172" mass="20549" checksum="9AC17ADF3B5951CB" modified="2013-06-26" version="1">MKSIHIYIEYILIILLSVFTFYFVFTWWNNNKIYAINFYNQNKFQYESKYIENVLNNLEDDLYFNINFNLNGYDIYCLNNLTLIKSNNFCKTTLNNITYQGELIYSYGNYYVYDPKMNGYYLLENNNNITLYGCFEDYLSLIILTNNCTGVCYGNCNLNIVKNQTSIYSIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5B5</accession>
    <name>R1E5B5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OxaA/SpoJ/YigC translocase/secretase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42547">
        <property type="protein sequence ID" value="EOD42547"/>
        <property type="gene ID" value="Nst1_277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="207" mass="24231" checksum="1179BCDADE4904DD" modified="2013-06-26" version="1">MIDLIFFYVLFLVILVNIVIKIIEKKTGIREHQKKLQEIQKKYIESFKSGKLEELNNIMEDLTKIYSKIMKHTMIVSIFGIIILIFIIFGFQSGFYVANINNTTSVLITNPILYNQDFAIYYNNSFLGFYHANYNIINLNGTYEPKLLSVNVITNTLPFRLPIININWLNPLLLYIILYILAQISLLIFNIIYSRFIKKSKIDNKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5E9</accession>
    <name>R1E5E9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42602">
        <property type="protein sequence ID" value="EOD42602"/>
        <property type="gene ID" value="Nst1_332"/>
    </dbReference>
    <dbReference type="OMA" id="GMERKPF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="201" mass="23214" checksum="3C57DFFA832CB4A1" modified="2013-06-26" version="1">MELKDAIRNRRSIRKYLDEDISYEDILEILSLGILAPIAGNISHYYFIIVKDPEKISKISELAGQDFIKDANTLIVIISDDNKLKSLYGGKGQIYAIQDTAAIAENILLSATDKNIGTCWIGSFDEENIKNLLEIPKDKNIHIIISMGYPNEKPKESIRPNLYDIIFFEKWGNKVYKPQFYPLFKNIKNITDYFKRVFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5H4</accession>
    <name>R1E5H4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Minimal nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42637">
        <property type="protein sequence ID" value="EOD42637"/>
        <property type="gene ID" value="Nst1_370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="102" mass="12415" checksum="6DEA8DD5AAE810E4" modified="2013-06-26" version="1">MEYCEEFLSKIIKSEYLQIYDNLDLEKMKKIINENIDYLIKLKGEKAIEEMINNDKLIEYFQWLVKEKTILYIQKEFLTYIYSIKERFGGKVLENLISMLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5I1</accession>
    <name>R1E5I1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42647">
        <property type="protein sequence ID" value="EOD42647"/>
        <property type="gene ID" value="Nst1_379"/>
    </dbReference>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_3" evidence="5">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="170"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="382" mass="45783" checksum="DE8DE5AB0E418816" modified="2013-06-26" version="1">MQYEIEVGERVKREIKKGRQVFSVNWIKKIEAEPGELVKLKYNNNFLAWGIINPKDQYHYIRIFSYNEDVDIHNDIKEKIKKAKEYREKTINYKNHYRLIYSESDFLSGLIIDKYNDIFVIQNSNAFFDKNINIIKDALIDVYGKDITIYEKSIGKQRERSYLKPIERFIYGNKYETEIEEVNKKFYINILKGQKTGWFLDQRENRKIVNQLYGDRILDVFSYSGSFGIIINGEEKYFIEKSKESISMLYKNLKLNNIENYNVINGNAYRILKQFYLEKRKFDIIILDPPDLLAENYEKGIRSFILINSIALDLIDEGYLITFSCSQDLNERKFYSLIRTLIRRKNKKFEILYKFNQALDHKVIFPHKELSYLKGFLIEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5J8</accession>
    <name>R1E5J8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42667">
        <property type="protein sequence ID" value="EOD42667"/>
        <property type="gene ID" value="Nst1_005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="272" mass="31449" checksum="6189A980FA1C976B" modified="2013-06-26" version="1">MLGNSSAEARIEYYKKIVTYLSVAVTKYIFDGLVREPRVSLNEETGEINMYLKGVSSSLIPMLRPARGDSFRGVVEVLYDFGGLASIKDDKLKLELARRRVLEKREDYGVVIIASEYESRKNGLYYLRKLSKMDEMLPFAIWLLGEELDVKGVGEEKRIDIEYDMLTGDLKIELCGDDIIESLKGRKNTHINKLYSLIHGYQDLAGRKCIELEGKKEQAGIWLNTKYIIEKDSIEHEKYIIDRNTYFLEKEKIPEVLNIILSEETLNRKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5L1</accession>
    <name>R1E5L1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMD protein affecting ribosome stability and mRNA decay</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42682">
        <property type="protein sequence ID" value="EOD42682"/>
        <property type="gene ID" value="Nst1_020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.20"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="171" mass="20634" checksum="9A326EFA729100EC" modified="2013-06-26" version="1">MKRICPSCGKEVEKLYDGLCYDCYLKINKKEEKREKVYICKYCGRVKYHNKWYNNFDIDNFEYEYTICPRCKGLNRKANLILQIRGYNKNIEDEILKIAKKNKDIIKKVDEINEKDIDIYLYVGKNRVKDYYNILKKYGEVKLSKKLFGYDKEKGNRKYIVTILLRNDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5M4</accession>
    <name>R1E5M4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42697">
        <property type="protein sequence ID" value="EOD42697"/>
        <property type="gene ID" value="Nst1_036"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.35"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="869" mass="97900" checksum="466DF7CE59CCA5D6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5R0</accession>
    <name>R1E5R0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="9" type="ORF">Nst1_076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42737">
        <property type="protein sequence ID" value="EOD42737"/>
        <property type="gene ID" value="Nst1_076"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.74"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="187" mass="21872" checksum="6C9497877304984F" modified="2013-06-26" version="1">MWRNRKTWEGPGHPWQKDRIEEERQLLKQYGLKSKREIWKASTIARRIRFYVRYLNAKKAAGVDVSKEEEKLKNRLVKLGLLNKNSDISEALNITVKEILERRLQTIVFRKGLAKTIKQARQLIVHRHIVIGDKVISSPGYLVKVDEEDKIGYNPYSNINKEKLLGQNINKEENKESAVQEVNQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5R3</accession>
    <name>R1E5R3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0273 protein Nst1_081</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0273 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42742">
        <property type="protein sequence ID" value="EOD42742"/>
        <property type="gene ID" value="Nst1_081"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.79"/>
    <dbReference type="OMA" id="FSQQFLW"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01076">
        <property type="entry name" value="UPF0273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022475">
        <property type="entry name" value="UPF0273_KaiC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03877">
        <property type="entry name" value="thermo_KaiC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="283" mass="31974" checksum="EC74DCD73E4E4943" modified="2013-06-26" version="1">MIYKVRTYIPGFDEILYGGIPERNVVLLSGGPGTGKSILGKQFLYNGLKNNENGVFVALEEHPVTVRRSFKNFGWDISKYEEEGKIAIVDAFTGGTGTAAQREKYLVRDLDNIHELLDVVRQAIKDTNAKRVVIDSVSTLYLTKPAMARSIVMSLKRLIAGLGCTAIFVSQISVGERGFGGPGVEHAVDGIVRMDLDEVDGKLYRSIIVWKMRDTKHSLLRHPMQIDQNGIKIEWDKYIRIGINNVKIDNIPQEMIEEINKAMQEVEKYSEYKRSNFQEFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5T0</accession>
    <name>R1E5T0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA modification protein, contains pre-PUA and PUA domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42757">
        <property type="protein sequence ID" value="EOD42757"/>
        <property type="gene ID" value="Nst1_096"/>
    </dbReference>
    <dbReference type="OMA" id="DYQFGRG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="152" mass="17324" checksum="3AF134A169EDA1DB" modified="2013-06-26" version="1">MELSIVRGILNYQFGDNIGNKIIEKYKEKIKIEKSKKTGRIRRIYIDDKLFGTIEPTTGFIILTFYGGLIVKELLKFPKYRIVVKDEAAKFIKEGKSVFNKFVENLDENILPKDIVLIVDKNDNLLAIGESLLSGKEIKDFKIGVAAKVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5V9</accession>
    <name>R1E5V9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eukaryotic-type DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42782">
        <property type="protein sequence ID" value="EOD42782"/>
        <property type="gene ID" value="Nst1_121"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.119"/>
    <dbReference type="OMA" id="GRFQVMG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="448" mass="54028" checksum="FBC2AC6DD75B4522" modified="2013-06-26" version="1">MIEWSEIKNYYMNEYVTKEIIDYSKNRWIALETNRLDQRIFIRYDKDKKPLKIENEDEYKSLFTKFSYLKFRTIYATINLYNQISEDKLKDTNNIKYVTPIFDIDGTLEDFDIIKNVAEIIVSYLEKYKIYKSVYLKWSGRGIHVHINERAFSENILNKYHPLNIAFAIVDFILKKAKDDLEKEISKAKGKSREFKVENKIDIQRVFTVPLSFHRFLDYVCVVFKPNDIQNFDLSWANYKNFKHSEKWREYEPGEGDYLAEISLKETKNYIINYLNKNTLKQEKVSIKRENLGNVGRFQVMGLLQAARYYILYNDINKAKSFGLNRAIFYAWAKYYRPIYKRSKEKIFHPHFKEDKEIELIKVGNEEAPYNKNTGYFHIGDKDQTPEDYDKEIKDKINSIVDYNIAWNFALEYIKKFPKEVLLDQQEFYKKVYEPIRDKFFEELLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5W4</accession>
    <name>R1E5W4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42787">
        <property type="protein sequence ID" value="EOD42787"/>
        <property type="gene ID" value="Nst1_126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="79" mass="9443" checksum="062CFF4DF2887CA7" modified="2013-06-26" version="1">MEAKFENTNEKLIKEIRTKLATLSTNTLLRYYEDIKSKIIPSNLSYYSQYLSYEELLDNVERELILRGALKRIKKLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5X6</accession>
    <name>R1E5X6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal flagellar protein D/E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42797">
        <property type="protein sequence ID" value="EOD42797"/>
        <property type="gene ID" value="Nst1_136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006752">
        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009205">
        <property type="entry name" value="FlaC_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05377">
        <property type="entry name" value="FlaC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arch_fla_DE" evidence="2">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="244" mass="28081" checksum="2A95B7CA9EDF5648" modified="2013-06-26" version="1">MNIFSNIFRKKNNDKNVQNINVIPQQNIVNQNYTSEIKNIVNSIEGLAKSVRELENKVSEISSNISTISSTVESHQNEINSIKNNLEKVFSIYEMLIKSYNPFVEEEKKEESNVQVINENKIENSENNILPLSKLDDNPTVSSIIIGWLAYLVKKSNIEEVDDALDYYESINWITEKVKIKLKEYLNGLKSVEGENKRLLPMDHIVSLYIISKLAQINSSGNIERLKDLYNELIQKGYISPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5Z9</accession>
    <name>R1E5Z9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42817">
        <property type="protein sequence ID" value="EOD42817"/>
        <property type="gene ID" value="Nst1_156"/>
    </dbReference>
    <dbReference type="OMA" id="YNNAVQA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="188" mass="21729" checksum="9D4F2B6E615C0FAA" modified="2013-06-26" version="1">MEVLLIILVVILILIVGFFIAMYNSLIALKKNAEKAWSDIDVILQKRHDALAKLVETVSSYLTYERTVLERLTQMRTQYMNLPSNDIQSKINLSNQITGAFRYLFAVMENYPQLRSNQNVIQLQQAIMELESQLADAREFYNEAVTLLNTRIQQIPYNIVASIAGIRPMPLYKVPEEEKQDVSTRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSV6</accession>
    <name>R1FSV6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42205">
        <property type="protein sequence ID" value="EOD42205"/>
        <property type="gene ID" value="Nst1_622"/>
    </dbReference>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="279" mass="32217" checksum="A2DB1B5F8E954DAA" modified="2013-06-26" version="1">MNEIIEEYKVWLEIQGKSKNTIKTYSGIVKKFLEFLINNGIIITDTKSINDSLGKNLILKFLAEIKVKKKLDSNSLRLYVRAISSFLKFLDNESLAKQIKAPKVDKRLPKFITYDELNKLLENAENYRDKLIIKFLFYTGVRVSELIKIKKNDIIFEEGFVKVYGKGGKERIVPIPKELLNELKDYINKINTENIFSLSSRQVERIIKNTAKKAGINKKVTPHVLRHSLATTLLSKGVDIRYIQEILGHSSLNITQIYTHVVPNQLKEIYNKVFESQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSX1</accession>
    <name>R1FSX1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42220">
        <property type="protein sequence ID" value="EOD42220"/>
        <property type="gene ID" value="Nst1_637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="253" mass="27735" checksum="54B2CCC552E3BA86" modified="2013-06-26" version="1">MKRRGIDMAVQLIFVIIIMLVVAVIVIKLFQQQSSKISQISNTQIQQAVSDCSSYCSSPYTFCTKYENIGNGLVEVSPGYYVCSNAVPCSVALQLYGGSSSQCQYEGFTITPLDCMYLECQNYIDNLYYDPLAATSYVFGNYSSTTYFNATTGQENIQISSPSQILNPGPVQCSAQLPTWITNQVFGALLKIINYYDTADNCNLNLTVINGALMVTGNCTTLGINNNVNGMPLCQFLLQVPYSQLNNIPSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1FSZ7</accession>
    <name>R1FSZ7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42250">
        <property type="protein sequence ID" value="EOD42250"/>
        <property type="gene ID" value="Nst1_591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="PTHR10176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="539" mass="64674" checksum="C2F25119E1386DDB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTC7</accession>
    <name>R1FTC7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH superfamily phosphohydrolase/exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42360">
        <property type="protein sequence ID" value="EOD42360"/>
        <property type="gene ID" value="Nst1_520"/>
    </dbReference>
    <dbReference type="OMA" id="MEYFRIT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="357" mass="41645" checksum="21E05AEFCFB18A59" modified="2013-06-26" version="1">MDFSDIAKEIKDSNEEILIVADSDLDGKMALSLMKIILEKLNKKYMEYFRITGENNLDLIRILDGIIFNKKTINTIIFLDTPMDDKYLINFSKRHEKIKIIYLDHHKRRVPKILPNNLIYFDVRALFNLEICTTSISYRIGKMIFGDEFSKYSLLASIGAIGDFMLENDKELLKDLLKNYKGFYNGKYFYIPYIIYFYLFLISHPYEISKNIDKALNIEEFIKEFDLKKLKNRAINYYDGLKSAKKIYESEKLLVFKAKKSSIISTILSSFYPEKIILVLSLREKLFGRLFKGKHKRYSISLRNQSGKYDLGILMKEFAKKYGISGGGHPKAAGGLIYEKDIENLIKFLEEKANGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTD4</accession>
    <name>R1FTD4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42365">
        <property type="protein sequence ID" value="EOD42365"/>
        <property type="gene ID" value="Nst1_398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="202" mass="22064" checksum="460D58A6E8559EF1" modified="2013-06-26" version="1">MKGQAFQSLFFFIFLVALAAISTYIIVDVYLKSAGYSITKLQLNQQQSAVPQFTIHDVEYSEYGSVATVSFTLYNLGPTDIPLNGWFIDFTTPNGDIICTTPIFESIADAANIGIAESVYDATYNETLTYGQAIPAHSVANVNLTIIGGPCLNATINYSVSNLQMGFRVIIPPTQYYDIMQCSVNPNTGYSSCSSLGYQAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTG0</accession>
    <name>R1FTG0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ORF">Nst1_418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42385">
        <property type="protein sequence ID" value="EOD42385"/>
        <property type="gene ID" value="Nst1_418"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.403"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="377"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="480" mass="53736" checksum="12FA9C193137A0FE" modified="2013-06-26" version="1">MDIKLRKVSENIYEIPQEKGMNVPVRVYANDKLIEKMKEDKTLIQGKNVASLPGIQKYSIVMPDGHEGYGFPVGGVAAFDINEGIISPGGIGYDINCGVRLLRTNLKYEEIKPKLREIVNEIFRNVPAGVGETGKIVLSPGQFKDAVEEGLEWSYREGYAWKEDLEHVESYGRLKDASIEHVSDLAIRRGIDQLGTIGSGNHFIEIQIVDKIFDKDIANKLGIYEEGQVTILIHTGSRGFGHQIASDYIDLGLKKYREEINKLPDKELVYLPFQSEDGNNYWKSMSAAANFAWNNRQIITYFIRKSFQKVYNHPVEDIGLNVIYDVAHNIAKIEEHKVDGKKKKLVVHRKGATRAFPPGSEELVEDYKNIGQPVLIPGSMGTASYVLIGSEKSMELSFGSSAHGAGRNMSRAAARRSFNYNEIIKNLEEKGIYVKSTTKEGVVEEVPEAYKNVDEVVKVTDELGISKMIVRLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTK3</accession>
    <name>R1FTK3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LSU ribosomal protein L4P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42425">
        <property type="protein sequence ID" value="EOD42425"/>
        <property type="gene ID" value="Nst1_460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.445"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="272" mass="31945" checksum="CA896C3660AAA3A1" modified="2013-06-26" version="1">MIPVYDKEGNKIKEIELPEHFKYEIREDIVYKVFRAYMLSHRVPYGSYKYAGMEASAWTSKRRYTYRSSYKRGISRVPRSIFAKIAGNFIWIARVIPGSVKGRRAHPPKPEKNWYKKINKKEKRLAILSAISASSNLDYIKNRYIKSFIYLNESINTFGLPIVISNLEELKKAKEYRDLFNKLKIINFIEYIKENKKQRAGKGKMRNRRIKKYRGILFVLSSDSQLPKVSIDGVEFSKVDQLNIEKLAPGGKLGRFIIWSEKAIEDLRNLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTM8</accession>
    <name>R1FTM8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42445">
        <property type="protein sequence ID" value="EOD42445"/>
        <property type="gene ID" value="Nst1_480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="223" mass="26551" checksum="69C9D26093E9200B" modified="2013-06-26" version="1">MEISDEKSNMTIINQKMSIKEQKVRRFHWININYFDDSQIGFGSNTKTLNLSSKESEELRKNILEIINDERIEKIKEYIIRLKSYQNKNNTILKYINKENNDYIFYQELPYYLKIPDKIYWKALEINRTVENFKDLLFIKGFGPGLLRALAYTAKIIYGSELSWKDPIIYTFAHGTKVGKPYYVKRTLMLEEAELLRNAIEEAKVNNNFKLRSLRKLNELINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTP9</accession>
    <name>R1FTP9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42460">
        <property type="protein sequence ID" value="EOD42460"/>
        <property type="gene ID" value="Nst1_188"/>
    </dbReference>
    <dbReference type="OMA" id="KIFLHNT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="75"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="349"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="508" mass="60062" checksum="51030002F0E0830F" modified="2013-06-26" version="1">MIMIKYNIYNIKYCYNIMDIDILKNYLERRIQYTERLALKYTTDDNNKPLPKRHIFSRIKKHIDNFLEKNEKINRLIIMPGLRGTGKTTLLYQIYLYLIRKKNIPRERILFISVDDLKSLNFDLRSCIEVYESKILFEDLVTSEKPVFLLLDEVNHDPNWALTLKVIYDKYPNIFIIATGSSALELEKETSADLARRAKKEYLFPLNFIEYLKISKKIDKYYKTKIIKNEILKLLNDNSLIPEFAREFYNNNEIIEIYKKIKLYSFEIEDFLKFGGFPFTALYKKDSEDLLLETIKKIAYLDISKISIIESSSIEDYIKIIDDTIKIINYLAGSEKTSIENISKGLNIDRDRVRKILTYLEMSSLIFSIKPLGSEEKISRKAWKHYFITPTIRFMIKDYLGTFKESDIGFLLEEYIASVLYKIQITHNVLNTKVFFDPNKNSADFLIKTSNNKIIPIEVKYGKSQKGEKQVRNSMKRYNSEYGIIIGDCDLEFKDNILYMPRELFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTR0</accession>
    <name>R1FTR0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42470">
        <property type="protein sequence ID" value="EOD42470"/>
        <property type="gene ID" value="Nst1_198"/>
    </dbReference>
    <dbReference type="OMA" id="FAGSWYP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="267" mass="31633" checksum="670BFCE387CE982D" modified="2013-06-26" version="1">MDKRYGPGYIPKNIKKEKNIISGIVPHASYEYFLPVSIKLYKELYENFDFDTIIIIGPNHYNFGQKINLIIDDWYTPFGIIKTDVEFARKILNSYDSYENPILSRYEYSIEVQLPILRYLFKDKVKIVPIIVKDVELEVIKDFVKLLKELSRELNRKIVLISTGNLYHHGEFYGNIIYKEDISINVKKESEKIIEYILNLDSERLYKLEIDSKIFCGKYPFLFFIEYTKLYKGKIELINHILSSEINKDEKNVVDYASLLSYKSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTU0</accession>
    <name>R1FTU0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42485">
        <property type="protein sequence ID" value="EOD42485"/>
        <property type="gene ID" value="Nst1_214"/>
    </dbReference>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="236"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="352" mass="41188" checksum="1F1BA88DF5C9DF3A" modified="2013-06-26" version="1">MNIDISIIIPTLNEKENINELVKRIRESLNDIKYEIIFVDDGSKDGTIEEIEKLEIKYKNIKIIERGYRKGLSSAFLDGVKHSNGKYIVLMDADLQHPPELLRKMYEKALEGYDLVIASRYIKGSKIENWNIIREFISKTAIFIAYIFLPETLKVKDPLSGYFLIKKDLLNNFKISDPFSYKVLLDILVKVNYNKLIEIPYTFKERKHGKSKLGKRIIFSYLKQVFLLFNISQFIKFYLVGLSGIVINLLSLYLLIFYFPFYISSFLAILISIIWNFILNDLFVFKIKKRKLLERFLLFFGGRGLLSKPVQYLSALLFYYIFGINYLISQLIAIFIAAIINWVFTKGIVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU10</accession>
    <name>R1FU10_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="7">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltX</name>
        <name evidence="12" type="ORF">Nst1_310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42580">
        <property type="protein sequence ID" value="EOD42580"/>
        <property type="gene ID" value="Nst1_310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.301"/>
    <dbReference type="OMA" id="MRFAPNP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="96"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="417"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOD42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="570" mass="68126" checksum="6E2B486AC44EBBAB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU17</accession>
    <name>R1FU17_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42590">
        <property type="protein sequence ID" value="EOD42590"/>
        <property type="gene ID" value="Nst1_320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="106" mass="12831" checksum="882F4EE01B74279D" modified="2013-06-26" version="1">MRSWIILVELAFSIILLTFFFLYTYYGKASNYNIYNFNPNDFIYLNSSCNNNLYIYEIINLTNNNITICYFGKQVNSTYIENYEPIFEYLYAGQNYFNPYILIIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU38</accession>
    <name>R1FU38_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42620">
        <property type="protein sequence ID" value="EOD42620"/>
        <property type="gene ID" value="Nst1_350"/>
    </dbReference>
    <dbReference type="OMA" id="APRTAFI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="415" mass="45117" checksum="4B4BAA9D1F9F5733" modified="2013-06-26" version="1">MDNKRDIILIILSGIFRSIATGSLGIITGLYLYNVLHLSFTLIGVFFGVGAFSVPLMSIYFGRLGDRYGRKKILLIVLLFLPLSILILLSTSSYPFLLLSAALGGFGTAGALASGSAGAIAAPIMNALLADKTNEENRTKVYSLFFLSLSLAGAVGALLSHLNYRNVFIIALILSIASPIIILPVKDEYSNNLRIARNSSMYNSNNLNNPNESDKKVIKRFIATGALNGLGQGLVTPFLPLIFEVLLKVPKGEIGNIFFLGGIAAAFVSLLTPLITSRLGFVKTVILTRSISTIALILLPFVNMFSPILSYDLMFALALYIIYIMFRVISLPTQSSLMMNLVSQDLRSTATGMNQAARLFPSAIATISSGFIINYLALPIPFFLAFIVNIANIYLYKKFFKDIETSKGMKSVLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU43</accession>
    <name>R1FU43_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42625">
        <property type="protein sequence ID" value="EOD42625"/>
        <property type="gene ID" value="Nst1_357"/>
    </dbReference>
    <dbReference type="OMA" id="ARVTRTC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="225" mass="24597" checksum="2BC2899EFB4BDC12" modified="2013-06-26" version="1">MLYKNNFIMHNKGRNKGSILYKLYKIIVGFIIVFVYLLSLYYIYSRDFVCQCVSYEYTTQTIVVATVTSTVTVTSTYTDISTVYTTVTNTVYNTVTSTTYNTVTETTTVTNTVYTTATSTVYVTNVVTQTVYGISTTTSTLTTTSTSTVSVTATNTITTTSIVSTTITTTTSSTSTVWSTIYTTTTNTITTTSTVTTTSTVYTTTTSTITSTVTADQTYYTLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU98</accession>
    <name>R1FU98_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42685">
        <property type="protein sequence ID" value="EOD42685"/>
        <property type="gene ID" value="Nst1_024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="72" mass="7482" checksum="FBFBE68AC7D11BF2" modified="2013-06-26" version="1">MVKKGQSLPINTIIILIIALVVLVLVILFFSGTFSKGVVGTNNVINPAINQTNQTGQLISNISNQANGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUD6</accession>
    <name>R1FUD6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42725">
        <property type="protein sequence ID" value="EOD42725"/>
        <property type="gene ID" value="Nst1_064"/>
    </dbReference>
    <dbReference type="OMA" id="FISHFIP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="193" mass="22369" checksum="A64507DE8AC5CD6E" modified="2013-06-26" version="1">MNIYYILYIFFESFILNSFPLFGAPFTLLSIPILSIIGINIYNIILVSIILGIGAATGKFVMYIIGILLSKPLKNNKNLLFIKRISNSKNFYIIFFFLTILPFIPLDDLLFLSFGIEKINILKYYLISVLGKVLKSFLELYAEIFILNKVSYISNIPLLQLSIISSIAFILLSIIFFKLDWEKYFNKWISKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUI4</accession>
    <name>R1FUI4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl18e</name>
        <name evidence="6" type="ORF">Nst1_109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42770">
        <property type="protein sequence ID" value="EOD42770"/>
        <property type="gene ID" value="Nst1_109"/>
    </dbReference>
    <dbReference type="OMA" id="WRLERPR"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="121" mass="13797" checksum="32C33CF78A9F5439" modified="2013-06-26" version="1">MVKRTGPTNIYLRKLINLLKKEGKKNNSKFWLYIAELLSRPTRRRVEVNLSKLNKYTNDGDIVIVPGKLLGYGMVNKKITVAAWKYSLNAKEKLEKSGIKILTIEDLLKANPKGSNIKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUJ1</accession>
    <name>R1FUJ1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42775">
        <property type="protein sequence ID" value="EOD42775"/>
        <property type="gene ID" value="Nst1_114"/>
    </dbReference>
    <dbReference type="OMA" id="EFHIKIN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="113" mass="13698" checksum="6FBEEDE379D06859" modified="2013-06-26" version="1">MPEETQLVQTENVQQNQQVQQTQENVEKKENIQEFHIKINIRKWILKTPLKRRAKKAARVIREIIMKRYKSKNVLLTVRLNNYIWSRGIKKPPTKYKLKIIKKEDKIFVDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUM2</accession>
    <name>R1FUM2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB11 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42800">
        <property type="protein sequence ID" value="EOD42800"/>
        <property type="gene ID" value="Nst1_139"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.137"/>
    <dbReference type="OMA" id="CLEYGMS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="188"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="557" mass="64867" checksum="4DEFF7FC08DCCA33" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUQ3</accession>
    <name>R1FUQ3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase, ybaK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42825">
        <property type="protein sequence ID" value="EOD42825"/>
        <property type="gene ID" value="Nst1_165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="103" mass="11932" checksum="B369F095DF1E2035" modified="2013-06-26" version="1">MGKNLLDEKYLENYLNKLGIKFQIIKYEKPVISTKNAEQQINGIIAKSILLICDNKPLLCFLLGKDLIDLNKIKKYFNCNEVRLAKAKEVKEITGYDIVLYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2E3</accession>
    <name>R1G2E3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase P/RNase MRP subunit POP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000006">
        <property type="protein sequence ID" value="EOD42246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42246">
        <property type="protein sequence ID" value="EOD42246"/>
        <property type="gene ID" value="Nst1_587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="92" mass="11190" checksum="45797D72B9E1FCC0" modified="2013-06-26" version="1">MVILPKALKIKNRYILLDFFDEEKLKKDFIKYFGYINYYDLHLNKIEINKRIILAVNKKHLYKIIFLLYLQNIKNFKIFKTLKGAKSFLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2M3</accession>
    <name>R1G2M3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase</fullName>
            <ecNumber evidence="2">2.7.7.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42326">
        <property type="protein sequence ID" value="EOD42326"/>
        <property type="gene ID" value="Nst1_484"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.469"/>
    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="230" mass="26148" checksum="4CF2F670646E7184" modified="2013-06-26" version="1">MQAVILHGGQGTRLRPLTHTGPKQLIKIAGKPVSQWVLEQLRDSGIKDIIIILGNNNPNRVTEYYGDGSKFGVKIYYSVEEEPLGTGGAIKKAMRYIDEDIFIVLNGDIITNISIKPLIENINKDVIASITLVQMRSPYGIIQIDKENYITEFKEKPLLDYLINAGIYVFNKEIYDYLPDKGDIEVHTFPVLAKERKIKGVIYKDIYWKSIDSIKDLEEVSKVIDQIYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Q8</accession>
    <name>R1G2Q8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2341 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42361">
        <property type="protein sequence ID" value="EOD42361"/>
        <property type="gene ID" value="Nst1_521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2341" evidence="2">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="81" mass="9617" checksum="F1A590350230B287" modified="2013-06-26" version="1">MTDYQILVNLNRRSLILQDKIRSDFVDIGFNDFNGNMLLNYWMKSDKCNVINTKVWIIVLIIALSFIKTMYFLYRDLDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2R5</accession>
    <name>R1G2R5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42366">
        <property type="protein sequence ID" value="EOD42366"/>
        <property type="gene ID" value="Nst1_399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="197" mass="20453" checksum="A34CC00247AD035C" modified="2013-06-26" version="1">MKGQGGSGFSAMVLFIAAALTAAIAALVIIGATTSAQGHAAAAAQQTVQTSGTTVEIVRVEGINVNTTSQTVQEFLVYTRLAPGSQPILFNQTAVILYTPAGREIFAYGGAVANSSLVTGYTGYYYIDQKDSVDNSGLLYNGVLGPNDLAALLIYANVSLGTSQTWEFSIIPPNGQPYDLSGVTPAAMIYPTVILYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2Z2</accession>
    <name>R1G2Z2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42436">
        <property type="protein sequence ID" value="EOD42436"/>
        <property type="gene ID" value="Nst1_471"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.456"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="253" mass="29890" checksum="72A72BA5838043B8" modified="2013-06-26" version="1">MIADDHAHLFLYNNVDEKIRENVERNVKYIIENSIDIESINKVIEESRKYDIIYYALGLYPEEIEKMNDNDIEKVFEFIEENKDRKFLAIGEVGLDFSNVDENKIKKQKIYFEKFLELADRLKKPVIIHARKAEKDVLDILTSYNNKKVLHTFWKPSLVDKAIEINCYLSIPAIVYRDPGFQKIVKDVPLEFILTETDSPYLDPIEKGKAVNNSWKIIYSLKKISEIKDIDEKELEEIIFNNFVKVYNINNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3D3</accession>
    <name>R1G3D3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42621">
        <property type="protein sequence ID" value="EOD42621"/>
        <property type="gene ID" value="Nst1_351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="32" mass="3778" checksum="703855812D70DA09" modified="2013-06-26" version="1">MKNNINMINKLILKNKVASKIYIIYISELLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3E3</accession>
    <name>R1G3E3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative antitoxin associated with PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42636">
        <property type="protein sequence ID" value="EOD42636"/>
        <property type="gene ID" value="Nst1_368"/>
    </dbReference>
    <dbReference type="OMA" id="YVNKWIE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="74" mass="8806" checksum="4122516680F3FE3C" modified="2013-06-26" version="1">MSTVISVRINEKIKEELEKHGINISQEVKKFLEELYIKVKAKEYVNKWIEELKDIKPSEEGFSTKSIREDRESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3F1</accession>
    <name>R1G3F1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42651">
        <property type="protein sequence ID" value="EOD42651"/>
        <property type="gene ID" value="Nst1_383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="142" mass="16776" checksum="75D2707DA429568C" modified="2013-06-26" version="1">MSLDDLYVGIKSEKDILGVIKKVKRNIYLQLYDVLHDIKNHEIKVQRLDKLLENAKSIKDIIDELLNLLPEIKDIEELYKEINSEELNKVEIKEKKKVRKKPKVEVAKEENKEGNNQIRKELDDISVELEELKEELKKLIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3K8</accession>
    <name>R1G3K8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42721">
        <property type="protein sequence ID" value="EOD42721"/>
        <property type="gene ID" value="Nst1_060"/>
    </dbReference>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="866" mass="103045" checksum="F5E34F568224C684" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3L3</accession>
    <name>R1G3L3_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein Nst1_065</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42726">
        <property type="protein sequence ID" value="EOD42726"/>
        <property type="gene ID" value="Nst1_065"/>
    </dbReference>
    <dbReference type="OMA" id="LRLAHMI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="193" mass="22645" checksum="727BBC6674F1E6C3" modified="2013-06-26" version="1">MDIKREIRILGIDDGYFDRNKDKYTIIVGVIMRGSLQIDGILSNKIEIDGFDINDRIIEMIKRTKHYDQLRIIATNGISFGGFNLIDFEYLYNELEIPIISFVRKRPNINKFIEAIKHTKDYEKRLEIVKKYPEPKSYKTEYGTLYFQYYGLEYNDVINIIKLTSVHSRIPEPIRVAHLIAMGITKGYSRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3P0</accession>
    <name>R1G3P0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42751">
        <property type="protein sequence ID" value="EOD42751"/>
        <property type="gene ID" value="Nst1_090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="280" mass="30943" checksum="DC74184A5F6ACC7E" modified="2013-06-26" version="1">MKLQSQLISYLLLGLIVVGLSIGIYEWGVPLIQKSQIRSTVNDIQSQLISLAEAIPPVVQSRGSQTVTLNLPKGSLNIYNNLIQYSFQSPAIYYNPSISVIPINYNIYIPCNVNNTISIPSSGYNSIQLCGIPNLIVEVNSSNIIIQDVNNNTLILPLVSTNNVITQYFDFNIKVQNNSILFIPQYNTGIAGVSYYPECLLSATQLSGVIQYQITCRPMYNPQNGQCEWIIIEPTGETSTTTNGNSVNVNLQYNGLNIVNNPNSTVCNQLVYYYVQASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3V2</accession>
    <name>R1G3V2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42811">
        <property type="protein sequence ID" value="EOD42811"/>
        <property type="gene ID" value="Nst1_150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.146"/>
    <dbReference type="OMA" id="HSMILHK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="91"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="310" mass="35910" checksum="7AC6E4E2A83F9D8B" modified="2013-06-26" version="1">MAVEEMISHLKEMGPILRIQTVVLKEMQSFMVGRGFVQLLPIVTSVFTDPLAPDPASSIVFTPSFEYYSQKLVITQSMILHKQLSLIAADKIFIFSPNVRLEKSERAKTGRHAFEFTQMDFEMAHAKMKDVMDLVEDLVIHVIKKVKEECKEELDLLGRELKVPSKPFKVYRYSEVLEKYGSDEALSEKEKDPFWIIDIKREFYDKEDEEHPGHFLNYDLILPEGYGEVLSGGEREYKYERIMERIKELEKEGRDYSSYKAYLEVAKMGLLKPSAGGGIGVERLLRFLTGKKHIREVQLFPRIPGEEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8N4</accession>
    <name>R1G8N4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42204">
        <property type="protein sequence ID" value="EOD42204"/>
        <property type="gene ID" value="Nst1_621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="218" mass="26268" checksum="B23D76C5776AB75C" modified="2013-06-26" version="1">MLNIEPRKSYKLSNRIAIRNLERILELLDDVEPVLIGKIAVVAYEHYYGLRYNRIFKYIEIAISKRKKKHIKEILYDPTYTEETKYIEEIIFYDHNIKIIYEKGPSIIILFKDKKIPYNEIELKIGNRKIKLRVAKLEYLYVDKIFTYLNEKDKQGDFYSIKVLGYLMKKYGYDKGLLDKIFDEYSKEYKKYSLEAKNIMEKILKDIKESDILELDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8P2</accession>
    <name>R1G8P2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42214">
        <property type="protein sequence ID" value="EOD42214"/>
        <property type="gene ID" value="Nst1_631"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.611"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012758">
        <property type="entry name" value="RPO1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02390">
        <property type="entry name" value="RNA_pol_rpoA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 8 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="210"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="889" mass="102569" checksum="37CAE3515BE58551" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Q3</accession>
    <name>R1G8Q3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42224">
        <property type="protein sequence ID" value="EOD42224"/>
        <property type="gene ID" value="Nst1_641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="137" mass="15182" checksum="2BFF8D1F3DBDDDBB" modified="2013-06-26" version="1">MAIKSQELPINYTFLIIIGIIVVSVITGIIFLLKGNITSYISNTIPKYNNTQTVVETNVSSVQDVAMDVVACYYKKAQGLCYLINYQGSPFTCQDLINNVSSIDPNVVMQNCNYNINPGEYILVYSAGNYVYINVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Q8</accession>
    <name>R1G8Q8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42229">
        <property type="protein sequence ID" value="EOD42229"/>
        <property type="gene ID" value="Nst1_646"/>
    </dbReference>
    <dbReference type="OMA" id="YFFRTMS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="402" mass="47370" checksum="FF216E73859EDD02" modified="2013-06-26" version="1">MVKKEDKILFLIYLILFLLFIYISNFNINIIIFGTIYLFLLSFILKNSKNTSLIYKLTFLYIPIGIFGIYTNLPLPFPFPSIFTYVVNYWIFYFIAFSLGYYLFENNFYISKKSLIFYIISIILYIILFFFELIYNSVTTDLDVSVGNIIILFLIFVSLYLYIFKIIYSSLFIIFAIFLFLVAYFNSNEILIVKTKIYEKISKIYKYKKYIFLLIFLIIILQIIIAINKLLLYNGLIIESSTGKYIIYEYESLIFLSIYEFIIYFLVYRNLRYNNYTSYFLLFTMVLIIFFGELYLSNVDFTSAALHTRYLIAMLFFFMGIHHKIYKNSKRVITKALGISIGILILLQNITGEFLESVLFGGPSSIHLVSIPNILIALGIIHGLVTPILILTFIYLHIKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8V3</accession>
    <name>R1G8V3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42274">
        <property type="protein sequence ID" value="EOD42274"/>
        <property type="gene ID" value="Nst1_534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="2">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="296" mass="35057" checksum="DC2BC5ABF58A0B16" modified="2013-06-26" version="1">MVGIFDLAKLMTGFNLFKKVPQENIEYSKELIENAKKNLSDSYDLYNKKNYNLAIYYLEQSLYSSVKSLVLLFQMVKLKDVKDKNYNSFEDFVNKNKIFDKLKKIVNQNSTMYEVLLSEENKKKFKEDYEKYKKEVDEFLKKLKDKNERKNIVRYNENDLNNLFSINELINKYQMSEEVIESLINFAMNLFSRMGGKANNVLNTGMARSLIKRELEKNKDTLNIFGNILILTGILMLHERSTKEYDKDLDFSPDNYNQDLGVVKLYNKMYDMVNGLIKFNENFVNVLENKDNLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8V8</accession>
    <name>R1G8V8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42279">
        <property type="protein sequence ID" value="EOD42279"/>
        <property type="gene ID" value="Nst1_539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="48" mass="5667" checksum="C7F15766E3FB6FF5" modified="2013-06-26" version="1">MNEYDKGLLKFFIFLILVVVFLILKEFFGIVGIIFGIFLFLLYVILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8W3</accession>
    <name>R1G8W3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate:ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="6">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42284">
        <property type="protein sequence ID" value="EOD42284"/>
        <property type="gene ID" value="Nst1_544"/>
    </dbReference>
    <dbReference type="OMA" id="FNNNIYG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="50"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="5">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="286" mass="32264" checksum="34186A034867C5DF" modified="2013-06-26" version="1">MEDLRTGYQITWCPGCTNFGIYTAIISTLKELESEGKIDRRKIVFASGIGCAGKIHNYLNLSSFSGLHGRALPLGVGIKMGNPELTVLVFQGDGDTYNEGMDHFISSCKENVDVKLFVHNNQVFALTTAQHTFTTEEGYYSKSLGMKVFEKPLNPIALALLSGATFVARGYALWVDHLKYIMKEAILHKGFAFVDIIQPCVVQHDTRKYYETHMYKLEDVGHNSTNFDEALKKALEYDYTLREDAKIPVGIFYKGSRITLHEGLKLQPFYKINRELNLDVLSQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1G8Z6</accession>
    <name>R1G8Z6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein, Mvin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42319">
        <property type="protein sequence ID" value="EOD42319"/>
        <property type="gene ID" value="Nst1_579"/>
    </dbReference>
    <dbReference type="OMA" id="IYYRTDM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="596" mass="70648" checksum="03EEC6D2211BF411" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G951</accession>
    <name>R1G951_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="9" type="ORF">DDW03_00020</name>
        <name evidence="10" type="ORF">DDW05_02015</name>
        <name evidence="8" type="ORF">Nst1_407</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 12 13" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AB-777_F03</strain>
            <strain evidence="10">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">SCGC AB-777_F03</strain>
            <strain evidence="10">SCGC AB-777_O03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000001">
        <property type="protein sequence ID" value="PVU68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFH01000013">
        <property type="protein sequence ID" value="PVU70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42374">
        <property type="protein sequence ID" value="EOD42374"/>
        <property type="gene ID" value="Nst1_407"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68907">
        <property type="protein sequence ID" value="PVU68907"/>
        <property type="gene ID" value="DDW03_00020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU70969">
        <property type="protein sequence ID" value="PVU70969"/>
        <property type="gene ID" value="DDW05_02015"/>
    </dbReference>
    <dbReference type="OMA" id="FRIRKCP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245908">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PVU68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PVU70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000245908"/>
        </source>
    </evidence>
    <sequence length="58" mass="7013" checksum="81B04A8DC4755E7A" modified="2013-06-26" version="1">MKEIRKCKNCKIYTFKEICPICGNKTSRIIPPKFSPDDKWGDYRRKMKKETLYKNNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G991</accession>
    <name>R1G991_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42409">
        <property type="protein sequence ID" value="EOD42409"/>
        <property type="gene ID" value="Nst1_444"/>
    </dbReference>
    <dbReference type="OMA" id="RINNFEN"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="120" mass="14249" checksum="31220830203960F2" modified="2013-06-26" version="1">MNDPETLRRLKYLEEKISMFNNILQTIDVTTRSSLDDFKLEIENIKKEINDIKQEINDIEIKIKAIMDELSNFATTDQLKIINSILDYINPFDFVTKKELDKLVKEKIMEYLDNLYNQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R1G997</accession>
    <name>R1G997_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Archaeal Glu-tRNAGln amidotransferase subunit E (Contains GAD domain)</fullName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Nst1_449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42414">
        <property type="protein sequence ID" value="EOD42414"/>
        <property type="gene ID" value="Nst1_449"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.434"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAD" evidence="6">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="383" mass="45755" checksum="BFFC785694F1F3AD" modified="2013-06-26" version="1">MIFKVKIYDLTEIFKETKSKLVKTNIDNGAKVYGIKLDKMKGMIGFEILPNRRIGTEFSDIAKRFGLKGILHSDELPNYGISEEEVKNVKRMLNCSDDDAFILLISKDYEVTKKVFSLIINRINESIKRIPKDTRQANEDGTTSFLRPQPGSERMYPETDHPYIYINKDIIENNEYNIIRYYINYGDIKETFDIYYLKKFDRDLYIKLLNEGKTILNSIDPEFIKQILKSFGYNDKQIENIIWSEYIYDIIKISFDLDPNTVYYLFFQMIGDTENLFKEKIEKFDLDFIYKIKDYLKDKKIVKNAIPIIYYHYVKYNKDIEDIIRENNLYKRNREELKKEIEEYLKSINTNDKKVIFSNVFSKFKYVADSEDIKRVLEEILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9B7</accession>
    <name>R1G9B7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ORF">Nst1_469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42434">
        <property type="protein sequence ID" value="EOD42434"/>
        <property type="gene ID" value="Nst1_469"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.454"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="322" mass="36937" checksum="CE86E91DC6BD066E" modified="2013-06-26" version="1">MPENEIWTEKYRPKRLDDIKGQDEIVKRLKAFVENKNMPHLLFAGPAGVGKTTAALALARELYGDKWEQNVLQLNASDDRGIDVIREKVKEFARTKPIGDFPFKIVFLDEADAMTRDAQQALRRIMEEYSSITRFILACNYSSKIIEPIQSRTVIFRFKQLDKKDVFDLLRSIAEKENLNISDDALEAIYYISEGDMRKSINMLQAAALYSKDITPELIYEVASVAKPQELQEVLKLAYEGKFVEAREKLIDLMIKYGLAGEDIIKYLSKEVYSMNIPEKEKLDIIYYAGEVEYRLLEGSDPIIQLGALLAYIGLRGLQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9D4</accession>
    <name>R1G9D4_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42449">
        <property type="protein sequence ID" value="EOD42449"/>
        <property type="gene ID" value="Nst1_177"/>
    </dbReference>
    <dbReference type="OMA" id="TAYCVKC"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="51" mass="5803" checksum="0F58AAB64A1DA479" modified="2013-06-26" version="1">MAEQYMAYCVRCKKKVPVQNPQKITLKNGRTAIKGTCPYCKGTVYVFVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9I2</accession>
    <name>R1G9I2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="7">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisS</name>
        <name evidence="9" type="ORF">Nst1_213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="7"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42484">
        <property type="protein sequence ID" value="EOD42484"/>
        <property type="gene ID" value="Nst1_213"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.206"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="429" mass="50902" checksum="B7AAF078955B1DD5" modified="2013-06-26" version="1">MYNLPSGLRDFPPEIKILRNKIFSKIEEIFKRFGFDPIETPTIEYWDTMKGKYGEEAENKLIWRFKLPYSDKEYALRYDQTVPLARFFSNHRPNLPFKRYVIDKSYRYENPQKGRYREFYQADFDIIGSKEPESDAEILNIVNFIFKEFNFSNYKIIINDREFLRFVFEKNLNINEEKIRKVYTIIDKLDKIGIENVKRELNTVVGELSDKIVEIISLRNQEVIDYLSKYEEISKEINYFNNILDLLNDKGRIEINLSLVRGLDYYTGMIYEAVVEKPRIGSLSGGGRYDNLLKLFTNEEIPAVGGSIGVERLIDAGIELGIFKIDKKTYTEICVIYFEDTFKDAWNICNKLREIGLNCYIDLMRRDFNKQIKYAVDKDIRFLLIVGKKELSENSVLLQDRYTKERIRISINNLEDIYRIVKNIINNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9M5</accession>
    <name>R1G9M5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flp pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42529">
        <property type="protein sequence ID" value="EOD42529"/>
        <property type="gene ID" value="Nst1_259"/>
    </dbReference>
    <dbReference type="OMA" id="MNSYERF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="106"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="277" mass="32873" checksum="099B0E2C469881FD" modified="2013-06-26" version="1">MNFLVKKLYPYFKDKKYDIFYTQFKTSIEDYIKTTLKYSFLTFILSFISLSLIFIFYLNFYNIVLFSVSVLFGIIVGFLTFIYFYIYPSLAKADYVKDIEDNLPFFALYFYSYSGSQMNIIDIFKLLNKEKRFGAINKEISYLLILINNFGYDILSALLELARKTPSEKFKEFLYGLISVIRSGGSLKDFARIYAKQNLEEYEIQLKEYNEKVNLWVTLYAFFFITFPMVLLILAFLFSIASGNVNILNSLLFFFIVIIPFSYITYLYMIHIYQPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9M9</accession>
    <name>R1G9M9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42534">
        <property type="protein sequence ID" value="EOD42534"/>
        <property type="gene ID" value="Nst1_264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="819" mass="88592" checksum="E288EFD540445497" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9N2</accession>
    <name>R1G9N2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHH/CopG DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42539">
        <property type="protein sequence ID" value="EOD42539"/>
        <property type="gene ID" value="Nst1_269"/>
    </dbReference>
    <dbReference type="OMA" id="SEDEWIT"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="76" mass="8886" checksum="B2CDE151EBEFF03F" modified="2013-06-26" version="1">MGKTDVISVRIDKNLKEKAKELGINIKEVVEKALKEEIAKRKAEKIKKLAEKLSELMKDVTPEEFTRLVKETRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9S5</accession>
    <name>R1G9S5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane or secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42589">
        <property type="protein sequence ID" value="EOD42589"/>
        <property type="gene ID" value="Nst1_319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="146" mass="17297" checksum="4EA3DC6266A4EF40" modified="2013-06-26" version="1">MKSQYILLATIAIIIILSFITYYNLSPIKNINPNLIGKNFEDQIIYIYQNFGYNYISNYTSYFENYTNEINYNFSFICISSYNLSIPKCSGSNINCCYYFKGFFVVNQSILKYCNESFILYNPPNWVCFCYNVNNSNSYYINFFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1GA02</accession>
    <name>R1GA02_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing OB-fold-like and PCI domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42679">
        <property type="protein sequence ID" value="EOD42679"/>
        <property type="gene ID" value="Nst1_017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPA_C" evidence="1">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="201" mass="23812" checksum="87B623D63E2FB331" modified="2013-06-26" version="1">MYLPVFSKDLKNYKDKKVCLIGKVIDIQEEKKVIRLKLLDTFGFFDVVLFDVYNIKLFDTLLILGSVSEYNNNFSVIARYLSILNGDDEILWRKFFIKKIKKNKKKNNKENKMEEKDIVENNNLEEKDIKKEIYEEELPEEVKLRKQILEFIRDNDKGDGVSLKDIKDFFDISEEKLSNIIMDLLSSGEIYESSPEKYKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAC2</accession>
    <name>R1GAC2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42804">
        <property type="protein sequence ID" value="EOD42804"/>
        <property type="gene ID" value="Nst1_143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="45" mass="5594" checksum="D953F3B0D6069725" modified="2013-06-26" version="1">MIVYFPNQYNYIYLDNIFLILFLKNKYNNVRIILFIILVSNTVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1GAD9</accession>
    <name>R1GAD9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42824">
        <property type="protein sequence ID" value="EOD42824"/>
        <property type="gene ID" value="Nst1_164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="245" mass="29106" checksum="DC0B5FA08AAC384B" modified="2013-06-26" version="1">MDELLARIHVKSYESNQPILQTVIENDSILSLLMKISKGQLSKNDIDLYYSTILYLIRQNFIIKENNGYYLKDNSKAIIEKIKYELELLKNINNENLDGIDTYSLLEFACENIVEINRSKKIKYPFSYIIFRHYNQQDPFTSYFIGRNGIILISLYSLSCKNRECYNWWYPPKQIKKFLFNDIPKCYDILRNKLDITPLVKFGLVYQRVGGNDRSRYKLSEEGYNVTKFILKNLESAIVYQQKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3I2</accession>
    <name>R1E3I2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42203">
        <property type="protein sequence ID" value="EOD42203"/>
        <property type="gene ID" value="Nst1_620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="200" mass="23441" checksum="0FB379A79EB12FC0" modified="2013-06-26" version="1">MSPQNDYKLTDKATIKNLESILKILGDVKPVLIGGIAVAAYAHYYNIDYDRKTRDIDFIINESKKIDTKVMIYKKLSDVSIKEGQIFGYDGIEIEYRDGPSISILFKDKEVPYNEIELKMGKRKVKLYIAKMEYLLVDKIFTYLDRGEEKDLKDIEILSYLMKKYGYDKGLLDKIFDEYSKEYKKYSLEAKNIMEKILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3S0</accession>
    <name>R1E3S0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42298">
        <property type="protein sequence ID" value="EOD42298"/>
        <property type="gene ID" value="Nst1_558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="90" mass="11542" checksum="54A659229CB238BF" modified="2013-06-26" version="1">MEINKEEFFYYLDREYKKLELIFKNIKFLDNRFEDFLISYYKDLKYFYEKKDFVKAFELENYIWGILDTLINLRLIEVPEEYKKWFKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1E3Z8</accession>
    <name>R1E3Z8_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal enzyme of ATP-grasp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42373">
        <property type="protein sequence ID" value="EOD42373"/>
        <property type="gene ID" value="Nst1_406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="265" mass="30783" checksum="230D6CF812535C6E" modified="2013-06-26" version="1">MEFIIDKEKIKNMNNIVFLYSIGGGYGNLSKIVGKKLIETYKGKVVGRIITDFFPDVVKINKDGYISDNISYKLYSVPIGNYNFLVLYGDFQIMILEDPGLSLYFRYKFMNRLFRIISKFNLLEISIIGGIGSHQLEPENPNYLFALNKYYDINKIKEKLGELNLYKSNNVIGMSGLFLYYSQLFKKPAYLLLVETYLSNQINGYFGASKALEILGKLYDFQVDTNDLKEKGKKLKERIEKDLNMIKKLEEENKKREKSSGYYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E417</accession>
    <name>R1E417_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42388">
        <property type="protein sequence ID" value="EOD42388"/>
        <property type="gene ID" value="Nst1_421"/>
    </dbReference>
    <dbReference type="OMA" id="DEAHESK"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="338" mass="40063" checksum="86FEBBA55091E474" modified="2013-06-26" version="1">MNDIEMLNFFKLKDNPFKLEVILETFVGYNLERTKLLNSINNKEKIILVSGPTGAGKTTLLLWIYNNLKTKNKVYIYRPFEKMEEFEKYFIEKLSFFERIIYKFKKFNIVEYLNKKNLIIFLDEATFCDDNILEWIKVISDQTNCTFILAGLPELEERLLKQHRTLYERIITKIYLKSLDPESGKLLIKKRLELAGNPNLFTEDAIEEIYNLSGGLPREILKYSYEALLIAYREKKNIVDKDIVEKIYEAKKPPTDLLKLTEKQRYIVELITKYGPKTVNELLKLFKERYSDTTIHAISNILKRMTESKILIRTKVKGKFIYDVVPAIKDYFIREINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R1E424</accession>
    <name>R1E424_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase, probable translation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42393">
        <property type="protein sequence ID" value="EOD42393"/>
        <property type="gene ID" value="Nst1_426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.411"/>
    <dbReference type="OMA" id="QIDCACA"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="400" mass="45521" checksum="2DBB8D6AACF68955" modified="2013-06-26" version="1">MQIGITGKPNVGKSTMFKAMTLQDVAIANYPFTTIEPNKGYGYVRVEDVGPEFNVKSNPRYGFIKGKYRFVPIEILDIAGLVPGAHEGRGLGNKFLDDVRQADALIHVIDISGSTNEEGQYIGPGNYDPIKDVKWYEEEIDWWFYGIIKKNLEKNIRKIKNEHLQLDKELAKLISGLNVKEEHVSKAFNELKISQEDYDIINDDKRLFELASKIRKIAKPIVIAANRVDINIDIAKKNLERLKKEYPDKVIIPTSGYAELILKELDKQGKIFYIPGENYFEIKGDLNDKEKKALEFIENYIFKEFGSTGVQNILDITVFDVLKYVAVFPGGVDSLADKEGRILPDCFLMPPESTVIDFANKIHSDLAKNFVRAIDVRTRKFLGKDYILKHRDVIQIVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1E462</accession>
    <name>R1E462_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LSU ribosomal protein L2P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42423">
        <property type="protein sequence ID" value="EOD42423"/>
        <property type="gene ID" value="Nst1_458"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.443"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="5">
        <location>
            <begin position="93"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="243" mass="26674" checksum="6462F18DF5B78812" modified="2013-06-26" version="1">MGGNTILQQRLGKGKNIYKVPDFYSIGEFYFRPLDEKEMKDKVKGIVVDIIKDKVHYAPIAKIKFETGETILVPAVEGLYVGKEIYAGVNAPVENGNILPLKVIPDGSSVCMVEISPGDGGKIARTSGTSCILVQKTDKYAILKLPSGKTKMVNLYSRAIFGIVAGGGRTDKPFVKAGNKYYFKKAHHRNWPISKPTARNAADHPLGGKHKRNKGGMTPLPKHGYPIKYGKYGSRRTGRKKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E463</accession>
    <name>R1E463_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42187">
        <property type="protein sequence ID" value="EOD42187"/>
        <property type="gene ID" value="Nst1_604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="196" mass="24170" checksum="BB88DFF208C9AE5F" modified="2013-06-26" version="1">MKCNDKYYIFNIIEWKENGYYKKIIYLVDLKEEELYKIEAICKEIEKSPSKFFDKLFNKFDNRDKYKDKIDYDFPFLSLLRKNKSNYEYIIIININSNEIYKPNIYKFLLERISMEMSSYLSKNSYITTIIKIYKNGKFLRDFLIFYNDRINKYEILENIDGKIISEHMEYNIRELFEEIFERIKNVSRSKISIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R1E470</accession>
    <name>R1E470_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42192">
        <property type="protein sequence ID" value="EOD42192"/>
        <property type="gene ID" value="Nst1_609"/>
    </dbReference>
    <dbReference type="OMA" id="YEMIRRI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="5">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="254" mass="30654" checksum="3B477B1DFA831F34" modified="2013-06-26" version="1">MHNYLLRIKYNGENYHGIAYQKNVKTISGEILNYFDIKEFKLSIVSRTDKGVNAEENYIVISSDKNIDFSNFQNNDIKILNVYKLKEFINIRKFSRGKLYEYKLPKKLFEKKYIPKYLINNEKILIKSEEKEFDINKYIEASKYFVGIKSFHNFAKGKLRDPICNITKFEIIEDKDFYINYIEGNRFLYEMIRRIITFLISIGYNLFPLDLIEKVFIYNLEPKPFPSDPKYLTLKKVYLDWKELYKYIEDIIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4B2</accession>
    <name>R1E4B2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="APJZ01000007">
        <property type="protein sequence ID" value="EOD42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42237">
        <property type="protein sequence ID" value="EOD42237"/>
        <property type="gene ID" value="Nst1_654"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.634"/>
    <dbReference type="OMA" id="RPWLIAE"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="204" mass="24025" checksum="D17CC1E5FB4EFE34" modified="2013-06-26" version="1">MDKEKMIEELNNQILKCTRCPLYKFKTNYVPGDGNPNSKILFIGEAPGREEDKQGKPFVGRAGQVLTENIKNILNMDRKDVYITNVVKCRPPENREPEEEEIKACSIWLEKQLEIIQPDIIVTLGHYSTKWIFDYFKLKFSSITKLRGKIFKVNKWGKNITIIPTLHPASTLYHKEWREYFDQDFKTIKEILNKDKREGILKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4D9</accession>
    <name>R1E4D9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="7" type="ORF">Nst1_212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42483">
        <property type="protein sequence ID" value="EOD42483"/>
        <property type="gene ID" value="Nst1_212"/>
    </dbReference>
    <dbReference type="OMA" id="GYVFHAD"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="6">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="148" mass="17246" checksum="F0E1EFF065869457" modified="2013-06-26" version="1">MVAHRKRKYRKYLGQRYARRGYNDRNRGKGNKGGSGFSGWRFKKQKYIKLIKEYPERFEDKKGFTSIKYNIEKSIINLGDIEEYFDYLLSEGIIKNDGEYYIIDLDEIGVDKLLGAGKISKKMKIYVREASEGAIEKVKNIGGEVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4E9</accession>
    <name>R1E4E9_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl30</name>
        <name evidence="4" type="ORF">Nst1_217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42488">
        <property type="protein sequence ID" value="EOD42488"/>
        <property type="gene ID" value="Nst1_217"/>
    </dbReference>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="156" mass="18068" checksum="9060A1E4FF6115D5" modified="2013-06-26" version="1">MGLLAIVRIKGTVKANEEVKDTLYLLRLRRNNYAVIMKDTKDIRGMIKKVEPWVAWGEIDKETLKELLLKRGRLEGNKRLTEDYIKQTLNMDIDTFVEKLLNNEIDLDSIPKIKKVFRLKPPSGGYPRKGIKIPYNQGGAYGYYGKDINILLKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4J1</accession>
    <name>R1E4J1_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Nst1_283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42553">
        <property type="protein sequence ID" value="EOD42553"/>
        <property type="gene ID" value="Nst1_283"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.274"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOD42553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="383" mass="45696" checksum="A5C3B81188CC86CA" modified="2013-06-26" version="1">MNEYKDIINIYDANIKEEKDYEKLIKFFGVKEIDDIILNNLKYITGDLHVLLRRKFFYAHRDFDILLNKYNEGKRFFLYTGRAPSKSKMHIGHLIPFLLTKWFQEKFNVNVYIQIPDEEKYWEKKADNYEEIREYALEDAKTIASLGFDPDKTFIFIDSEYIKNMYKAAIYVAREINLNTAKSVFGFDDNSTIGLPFYIALQIVPTFFERNIPLIPCGIDQDPYFRLQRDIAEKFGYYKASTILSKFVWGLQGPYTKMSASDPKSAIFIDDDYDTIRYKIFKYAFSGGRGTLEEHRKYGGNPDIDVSYFWLSVLFEEDDNKLKEIREKYIMGELTTGELKEYTAKKIWEFLSNIQERRKNINIDKFMYDGRLAREMWEWEFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4L4</accession>
    <name>R1E4L4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42588">
        <property type="protein sequence ID" value="EOD42588"/>
        <property type="gene ID" value="Nst1_318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="156" mass="18113" checksum="55DD4209FFCEF5C8" modified="2013-06-26" version="1">MKGISLWVEFLIYTLFALSILSLVIYFVHLTIQNQQDELNLKYIVNLLTNLNYQIETIGSCYSCNYKVYDNLPPKTIIYIYPGEIMCVYYSTVNYSLQVPPYINLNITQLSSYDYQYNFTINTIPFNILNSSNLTITDNLCLLLDKNESGLYISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4P1</accession>
    <name>R1E4P1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA-specific exonuclease RecJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42357">
        <property type="protein sequence ID" value="EOD42357"/>
        <property type="gene ID" value="Nst1_516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="460" mass="53972" checksum="AB543B042A654674" modified="2013-06-26" version="1">MNNRFLSYIEEISNRINKSIENNQNFLIISSLNPDGISSSIFLLKYLYEKNSEVHLTFLDYISKKEINNLFLGESGYEYDNIIFLDTGSIFSDDIIKLNKDLNKKIYIIDHHFLTIKDIELNNVVNLNPNIFNLDGYKELSTSNILYYLYQSLNPYDKNILYLSLIGNLYDFNKLNNEILNELIDREILSKYTGINLPGIFTKPLYKVLSSPFNFYIPNITGSDEKALELVKELNIKDKGTAGIFYRDLFEEDIKKIVSNIIKLKLKYNLQRTDDLIGEIYKINKSEEIGDLLELLYNIEGLIENNKIEGILYFIKKYNIDILRESENNLRLQFSKLLYDIINNNVQIKDENGLKIITIEKNYGKGYFLSLLLNLLIRENIINGKVIILLYKVNNFYRGIIKTNKDENKKLINNILKKLFDNNIIYYSSFDNFGGFLLDINNYEEFIKKLKINLRQENII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4R1</accession>
    <name>R1E4R1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42372">
        <property type="protein sequence ID" value="EOD42372"/>
        <property type="gene ID" value="Nst1_405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="156" mass="18261" checksum="C93AA30F460761FD" modified="2013-06-26" version="1">MKSKLYFEAFSNDKDKLIEILNKTFEEVSKFKNFQIIDKKIADPITRDIKTPDGKTINVWSSYLEIYADFKDFDSLIDFVLFYTPSRIDIEDIKEMKIITKDKEIKYNKEQINLLLNRIPQAINTKISALLSIYLAQIKKNSKGPDNQSLTNLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4V7</accession>
    <name>R1E4V7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42407">
        <property type="protein sequence ID" value="EOD42407"/>
        <property type="gene ID" value="Nst1_442"/>
    </dbReference>
    <dbReference type="OMA" id="YILMQRP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="669" mass="77032" checksum="F240171278C45E60" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R1E4Y6</accession>
    <name>R1E4Y6_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42743">
        <property type="protein sequence ID" value="EOD42743"/>
        <property type="gene ID" value="Nst1_082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="113" mass="13149" checksum="2EB7B7202448A2F5" modified="2013-06-26" version="1">MAKYLILLTKDDKNTLEMALEFSKILKMSGAEDIKICFILAGIRALNKENEEYNLIISKHLGDIKNLNINIYACEKCMLKFNIPEEKLIYKDKIFSYEEMNKLVDQGYAIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E503</accession>
    <name>R1E503_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42763">
        <property type="protein sequence ID" value="EOD42763"/>
        <property type="gene ID" value="Nst1_102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="114" mass="13564" checksum="BF2582B51BFE6125" modified="2013-06-26" version="1">MGSNYKIGYYYEQKVRKMLEKEGYDAWRTPGSHSAIDIIAINKEGKVKLIQVKKNKRDIDINNINYIDLYELYHLAEKYKDSNNVDIELWIFSNNKLKKYNKDDILKLKDIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5D7</accession>
    <name>R1E5D7_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42582">
        <property type="protein sequence ID" value="EOD42582"/>
        <property type="gene ID" value="Nst1_312"/>
    </dbReference>
    <dbReference type="OMA" id="GVDEDWI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="131" mass="14990" checksum="087122A1E8C3ED93" modified="2013-06-26" version="1">MVSLRNIFKSKKEETSDQYVEVIPTQKAEEVKIYVRVFRIKDPSEVKAVVDSLRERNYIVFVDISGLNTGKDLVEVKRVVSRIKSVVDAIGGDIAAVNKDWIIATPPYVRIWRGHQMSAVEEVKQQEEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5G9</accession>
    <name>R1E5G9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42632">
        <property type="protein sequence ID" value="EOD42632"/>
        <property type="gene ID" value="Nst1_364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="290" mass="34658" checksum="C54BE3CB1F43DC57" modified="2013-06-26" version="1">MEYMNDVVYNVKEVFSLNDDLDKINLDEIIKREYKKVIESLRKFKIIEYIKRKYGINYKIPELEIVEDDPSIIGKYLPLENKIRISKKSIEREIDNYLEFLGYKKRSISDIPDIDYLNISYKSKFLFPFYVNKRNIRKTIAEVIILLTILHEIWHSIDLNILNKLKNDSAIKDNDYSTFLKNFELRASAFGFIMYYLVNGFYKDEKGYMAAYKNIPECRNYIEKIDKIEKNDHILYDLGYCYGNIIVATNKELLKENIYNIIEGIVRLDKEKAINIINLYENILRMSLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5I6</accession>
    <name>R1E5I6_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">Nst1_384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42652">
        <property type="protein sequence ID" value="EOD42652"/>
        <property type="gene ID" value="Nst1_384"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.370"/>
    <dbReference type="OMA" id="IWLTHIS"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="326" mass="38639" checksum="B349EC0201431839" modified="2013-06-26" version="1">MKRIIILGTSSSMPTKSRNHPGIFIKFNKRGILLDCGENIQRQLRIMKISPTDIDYILITHWHGDHILGLPGIFQSLSSMNYNKKLNIIIPKENIENLKGIIEDFIIPINFDINIIEAKEGLIVDEEDFQIYGIKTKHSTISYSYYIIEKDYIKLDKDLLNKYNIKNKELIKKLKEGKEIEINGKKISYKDIGYIKKGIKITYITDTMFFDKLIDFAKDSTILISESTYFFQPDLAKKNMHMDFLEVREIFNRSNSKILLLTHFSQRYEEEMENIRKDIEEKNENTYILDDFDEIYIYKDKIELKLKRKEIIYKYDEKTGNLLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5L5</accession>
    <name>R1E5L5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42687">
        <property type="protein sequence ID" value="EOD42687"/>
        <property type="gene ID" value="Nst1_026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="97" mass="11598" checksum="8E1DB1A4441AC67F" modified="2013-06-26" version="1">MWGTDLKTMNQFTNQLLKIIEQLGIEKRGPVNLPTKIIRVPTMRTLGKRGTKIYETYQIRIYRRFLDVANDERFFKNYFINMQIPSKGFRISLKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5P9</accession>
    <name>R1E5P9_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit SecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Nst1_066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42727">
        <property type="protein sequence ID" value="EOD42727"/>
        <property type="gene ID" value="Nst1_066"/>
    </dbReference>
    <dbReference type="OMA" id="IRWGIDI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOD42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="500" mass="55191" checksum="D5B088E04F789108" modified="2013-06-26" version="1">MDIKSLIKNWRILIFIIIFIIALVFDAYALTNNKVEVTSSTILPNGTYIYSINGCQVNSISSYYTCIYNNINSSFLQISTSNGNIVLEPYQYQLLINETNITQTSLISYGIDIAGGYLLILNSSKPLTSKELSIAAQVIENRLNSFGVKSINIYPTSAGYIIVELPYSEGNLIPYIISQGEFYAKIGNTTVFTGSEIKPLFGGQYSGLLGCSPVGNQYVCTYYFTLLLSPQAANNFAQATQNLSVVLENGGAYLSEPIVFYLDNQNISTLLIAANLRGSNTQQVSIQVSGTGNSMAQAQYNAYQQAYNLYIILENGQLPSKFNIVQESIIPPIFGYYILKSFELVLLLIFIGIFAILYLTYRNIKIPALVTLILTSEFLIAFAIGIAIHQTYDIPAFIGIIFGTATGIDDQLVAAEEILRAKKEGNNEVKMDNIERLDKAIKKAMFIILLAIILETLSVFPAFVAGLSLYKGFAVMVIITVWIGYLLTRPAFINLAKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1E5S5</accession>
    <name>R1E5S5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42752">
        <property type="protein sequence ID" value="EOD42752"/>
        <property type="gene ID" value="Nst1_091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="183" mass="21046" checksum="1C4CB3B89D81441E" modified="2013-06-26" version="1">MPSAEYELMPTDPVEKLVEEIENLKDDLAKLKSELKNNIEEIKRQVSIPSETNPIIKKEAQAQVYYAQSNIDTSFYKEIVNSLIKSNIDLQAKISELVVVTNNLYKEIKNLFDIFKEAALLRPKEKETNENNIELLKRIENLEKANLKVAELLDNLKKQIDNIKGNQSISYTSSSIQSYSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FTX0</accession>
    <name>R1FTX0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42525">
        <property type="protein sequence ID" value="EOD42525"/>
        <property type="gene ID" value="Nst1_255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="188" mass="22101" checksum="C828A93490941A63" modified="2013-06-26" version="1">MRSYFYTIILGIISILVLFFILLLNNVNFNNNYILEKTNITIDNQNISVYLLNLYGNGCYLYNITEGYFIIKNKGPGINYIIPLVEYINTTSFVFCNQTFYYNITIKECSPIIECSVISCPVPSCYNITYYINITYPIVIVNRDVFLYNNNVYCYSENYCNIIYQKLPENYLYNLIYNLISSIPKHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU28</accession>
    <name>R1FU28_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein with a function in translation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42605">
        <property type="protein sequence ID" value="EOD42605"/>
        <property type="gene ID" value="Nst1_335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="57" mass="6400" checksum="B67A6BFBECA082DC" modified="2013-06-26" version="1">MDITELEKTNVLKNLIVSDTVVKFTCPNCGQGIIIRSNKEKKWGLEWKCPVCGYTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU60</accession>
    <name>R1FU60_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42645">
        <property type="protein sequence ID" value="EOD42645"/>
        <property type="gene ID" value="Nst1_377"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.363"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="290" mass="34485" checksum="34F553893817C739" modified="2013-06-26" version="1">MYHHHGVSILEILIGDLETKKNKPNYDSSYLKRLEDFLENKIKEEYGNIPVVAASLLVKLNKKENNEISKENRWYVSNKVFAKYFEELLRSKTKSKIYPLISVEYFNGYPILIVGEPDGLSFEGNKAKIYEVKSFNLTDFIDHVRESREDILNREIFKLIKINSIQLMLYQYLLKRTQEFGLFNNIDKINLYEKIYIYSENIEYLDWARETIEQNFNTIKMIAKGYNTYNLSLKDNLSLEYIGTININNKRIYYFEIDSRVGYNQKIVKYYLKNLDGIIKSSNRVDNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R1FU90</accession>
    <name>R1FU90_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 1-alpha</fullName>
            <shortName evidence="5">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor Tu</fullName>
            <shortName evidence="5">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tuf</name>
        <name evidence="7" type="ORF">Nst1_013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42675">
        <property type="protein sequence ID" value="EOD42675"/>
        <property type="gene ID" value="Nst1_013"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.13"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="443" mass="48626" checksum="B52F1D992F4B38EC" modified="2013-06-26" version="1">MAREKPHINLIVVGHVDNGKSTLVGRLMVSLNLIDQKVLEELKNIAKELGKETDYLAFLMDKSIEERKRGLTIDVAAIKIPAKKYSLTILDAPGHRDFIKNMISGTAQSDAAILVVSAAPGEAETALGPEGQGREHLLLLRTLGIPQIIIAISKMDAANYDQKRYEQIKNMILTLAKQIGYTEKQIKAIVPIAAYSSDENVTQKSQKMPWYNGPTIYEAFDLLDEPPRLVDKPLRIPIGDVYNIKGVGLVPTGKVESGRLKPGDKVIFLPSKKPNGVVGEVKSIEMHHEKLDEALPGDNIGFNVKGPESGDILRGDVCGKLGEPLPKLAEEFTARIYVLYHPSAVAVGYTPVIHIHTAAVACKIAEIQSKIDPRTGQEVEKNPQFLKTGDAAIVKFVPTKPLVVEKFEDFPNTSLGRFAIRDMNKTIGIGQVLSVKEKQIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUK1</accession>
    <name>R1FUK1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42785">
        <property type="protein sequence ID" value="EOD42785"/>
        <property type="gene ID" value="Nst1_124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="517" mass="62376" checksum="45E3E777BF3BE095" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R1FUR0</accession>
    <name>R1FUR0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42830">
        <property type="protein sequence ID" value="EOD42830"/>
        <property type="gene ID" value="Nst1_170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.165"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="225" mass="25429" checksum="62894CD26938D3EF" modified="2013-06-26" version="1">MIEIYKKAFDYMRKNFVDSILFIISSAVLWTLSIAIPILGVIIYSYFYPNVVAWYYTKVTGDNINPDYKTAFLSLLIPNLLASIGIIYLFYGITSASIGPSASAGYINTFGLTNYQYVSYNPTLIIVELVIIIISIILSILLMYTFYGSILGKVNKLSIYFEKSFILLSYMLLYAIIASIILFIIYIIYALIISISYGMLIFFILLTIFVVPTVTLVALLKAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2H8</accession>
    <name>R1G2H8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">top6A</name>
        <name evidence="8" type="ORF">Nst1_541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42281">
        <property type="protein sequence ID" value="EOD42281"/>
        <property type="gene ID" value="Nst1_541"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.524"/>
    <dbReference type="OMA" id="NWGEARF"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="7">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOD42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="372" mass="43241" checksum="FC2CE3AE8066DCE2" modified="2013-06-26" version="1">MVQYIEKLSKEEVLSRIKKLADEIYNEFSSGNPSIKLAVRGNIKNIEYDEKRDIITLKEKIGSREFFNLGHVRRFMQTLLVASLAKKLVEKDKTASLREVYYQLKHTIPILNVNTLEEQEESDAVIEDLERAIKAIREQFHIKAEGRGAIYGDIYLRDRKRGDEWNCSKLGRGGWSVPSTIEDIEIGDVNADFVLVVEKEAMFDRLIEERFPEKQGAILITSKGQPPRGVRRLIHRLRKEKNLPVYVFTDGDPWGFYIYSVIKRGSMNLSQFSELLATPDVKFIGMTIDDIDEYDLRKKGAVIKLNQRDIKRINEIANYPWFKKSKDWQRQFRKMMDYGIKVEQDALAANSLEFVADTYLPDKLEHPDKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2J2</accession>
    <name>R1G2J2_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42296">
        <property type="protein sequence ID" value="EOD42296"/>
        <property type="gene ID" value="Nst1_556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="154" mass="17902" checksum="921CAA514AFCA8EB" modified="2013-06-26" version="1">MDILGIGIKLSLEEGKVTIKKEKEKMILEYNNKTITSSNYKDYKKNWQATLLIKDNKIKLIDSNINLYVYNFNDLNDKNKTYSLNQLIYLGYLLKKSEEFILKYDKYLLSPTEKISIGNGKIGSDFDSKLINEEKMARDILYVTDGLLIINNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2K4</accession>
    <name>R1G2K4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000005">
        <property type="protein sequence ID" value="EOD42306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42306">
        <property type="protein sequence ID" value="EOD42306"/>
        <property type="gene ID" value="Nst1_566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="157" mass="18739" checksum="BCD7EE4ED10556EC" modified="2013-06-26" version="1">MRELLHIEQNDEFPNLFNGIILNLPNTNAISIIDYDLNINTYINLKVSYPFYFGFIPRTFIDNYPLFFSFFSDKKFDILSLLRLEPLYFFKIPKDITINIIYSKLPSQNINIDKESIENILKDFFDIDNIIPLSKPSHILENTNREYKRKFSKIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2S0</accession>
    <name>R1G2S0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LSU ribosomal protein L44E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42371">
        <property type="protein sequence ID" value="EOD42371"/>
        <property type="gene ID" value="Nst1_404"/>
    </dbReference>
    <dbReference type="OMA" id="RYSRRPI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="104" mass="12052" checksum="6048C04BDE9F4E50" modified="2013-06-26" version="1">MKLPKTVNKYCPYCRKVTEHKVFIIKSVKARTGLVWGSRRAREGKKGRGNKGKYSKRPLSQRKRGNIKSSKGVDIRLECNICKKQTIWKIEGRYKKVELSTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2S5</accession>
    <name>R1G2S5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42376">
        <property type="protein sequence ID" value="EOD42376"/>
        <property type="gene ID" value="Nst1_409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.395"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="324" mass="35635" checksum="1883A48996D6DF96" modified="2013-06-26" version="1">MRSGKFIYMLPILFAGTTLFYFSTCPIGNIGSGNSGFFNSGNSNLYQPSWALNQPGNIYLYIQAPSSLNYSESNGLNYNLPVIYVNNIYTMSNSQLEVSYYIYSYALSSPYSGNFNAEPAVYNSSSNQLVPSNSTIGNIEVSLGPGLQAVPTQIPIVVEYNISNVITNILIPLQLNYSNSQITLSEPVYYSSSPITPEYSSINVNETNGNVYFSIAFQDSVGCFNNVYSSNQATFNLNAELDIIAANQIDIPNGEEGFSCTPTQNVPINSSTISCSINMQQLAQNNPEIKNLLNSNLVLQAYVLMNLSYNCYEEDIYNIPVTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G2U7</accession>
    <name>R1G2U7_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">Nst1_429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="APJZ01000003">
        <property type="protein sequence ID" value="EOD42396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42396">
        <property type="protein sequence ID" value="EOD42396"/>
        <property type="gene ID" value="Nst1_429"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.414"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="171" mass="19812" checksum="A0A52BBCBD884322" modified="2013-06-26" version="1">MKAGKQPPEDINVFIEIPKGSNIKYEFDEEEKVIKVDRILYTAMFYPFNYGFIPETLEEDGDPLDALVITYESFIPGVLIRARPIGVLVTEDEEGVDRKIIAVPHEKIDPRFSNIKDIKDLPEAILNQIKHFYEHYKELEPGKFVKVKEFKGKEEALKIINEAIGRFKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G357</accession>
    <name>R1G357_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Nst1_220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42491">
        <property type="protein sequence ID" value="EOD42491"/>
        <property type="gene ID" value="Nst1_220"/>
    </dbReference>
    <dbReference type="OMA" id="RITRDHP"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOD42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="346" mass="40258" checksum="4D2BF07616C48FF2" modified="2013-06-26" version="1">MIKIREQIRDIIINNYIKEGKDPFDSIIGQENAKRQILSSLISGRNILIIGPPGTGKTTLAKNIAKLLPEIDFPEGIPLWAYEEFPFVSEEYRKKWREGPFIKIRGEDRFIRIQGSYDLSVEDLIGDIDPSKALKYGIHSLESFIPGKIFRAHHGVLFFDEINRAPPKVQNSLLELLEEKKITIGTYEFQIPLDIIFIATMNPESYYGTEKISDVLLDRFDIINLDYPKDIEEEKKIILKYGKSLDVNFPEKLLELTIEFIQKLRKDDKLERKPSVRSTIGIYEKAQALAIIDKKENVEIQHIFESLLSILPHRIRLKPSYKMEINEEEYVKNQWNSFIIGKDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R1G378</accession>
    <name>R1G378_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Nst1_261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42531">
        <property type="protein sequence ID" value="EOD42531"/>
        <property type="gene ID" value="Nst1_261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOD42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="79" mass="9399" checksum="2B5F81FDFD38D63D" modified="2013-06-26" version="1">MKTQLLLEQVLFIFLVLLFISGSLIFYYNYLNNLNYRNSIIKNQIYNLTLEDAKLNNQSNLLYYQGYYYPVGTIIIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3M2</accession>
    <name>R1G3M2_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="7" type="ORF">Nst1_075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42736">
        <property type="protein sequence ID" value="EOD42736"/>
        <property type="gene ID" value="Nst1_075"/>
    </dbReference>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOD42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="170" mass="19710" checksum="533252FE3C7C278D" modified="2013-06-26" version="1">MPGALKLIIPEGRTLKDVIRIVGVELDGHKPIIIELRKVPGVNWRFANAICNVLKINKWQALGSLTDEELEKLEDCLKRPQNYGIPSWMLNRRKDPRDGQDKHLVGPDEEIQVKMDIKREIELNTWRGNRHMYNLPVRGQRTRSHHRKGSTVGVVKNKELRAQQKSENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3M8</accession>
    <name>R1G3M8_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Nst1_080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42741">
        <property type="protein sequence ID" value="EOD42741"/>
        <property type="gene ID" value="Nst1_080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.78"/>
    <dbReference type="OMA" id="SHEAVMH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="407" mass="46202" checksum="730137B6775A5764" modified="2013-06-26" version="1">MLILLIGIFAGIEGSITGLGGGAIISPILTIFLDYPLYLTIGVSLLSTISTSLSSSLSYIKKKIANDNIAISLLTATTFGDIFGFLLNNYLYTHNLFFIVYIIFGVVLLLSSIFLIIKNLKEKYYPSKPDESTYFFNLFGKYEENGKIIYYDGVRWVYGWIVMLFAGFVSGLLGIGSGILKVLGMDLIMNLPIKVSTTTSNFMIGVTADTSSILYFKAGYIDFILLPFLTLGVLIGSRIGTRLLMKLRDNTIRFIFITFISYLGARLLLEGLNINNILYSLLVAFIISLISFILLKKVKFKEKEEEINFEKYIKEDDIFISKMYKFQKIAFIVLFILNILAIIYYLLTENILLSYIYYFILISIPFIEVLMELKKYINEKNTLYIALSTIIIINLTLGMFILPFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3S1</accession>
    <name>R1G3S1_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane-associated trancriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42781">
        <property type="protein sequence ID" value="EOD42781"/>
        <property type="gene ID" value="Nst1_120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="404" mass="45695" checksum="2E9D02E01212B2C4" modified="2013-06-26" version="1">MVTAILVTNITYADYLVANVVGHIYKLPVYTVYQDQGNISSTVQMLVNDNITNVIIIGGPAVISNLLLQELNQSNISYLWIWGTTRYDTSAYVALYFWNSSSGAVLITRDLVNGHVSPNKLQLVTEAVQYAEENDEPILIVPNGVLPESTLYALEKLNVSNVVIFTGGSSSLGNITDQLSSLNISYEIYSNNQPPLNCQNYLYVNITSNTSWEDIREIFTGEINGVCIVPMVVNNNVNITQEKDELKQEIENDYEMNRNGELNLTEIVERHINRLLEHQLLLLDKFEVLCNYTNNSLPICNILPQLNQTLTLTMQEVMNGNISALLDTQYQLENYNWEVIRDIGEYNEEEIIGEHMRHFRREIENEDQISIENNNETLNINGQSSVTINNESITINGKGSMNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R1G3T0</accession>
    <name>R1G3T0_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wybutosine (YW) biosynthesis enzyme, Trm5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Nst1_130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000001">
        <property type="protein sequence ID" value="EOD42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42791">
        <property type="protein sequence ID" value="EOD42791"/>
        <property type="gene ID" value="Nst1_130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.128"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOD42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="315" mass="37451" checksum="8B4AD8C384D6108D" modified="2013-06-26" version="1">MSYDIVGDIVIIKKPLKYDEEEYVKRILEKHKFIRTILLQETDVLPPYRIPKYKILYGENKTETINVEYGLRFKVDVARCYYSPRLSNERYRIAKQVKENEEVLVMFSGVNVYSIYIAKYSKAKIIYSIELNPFAVKYGLENIKINKVNNVITLLGDVKDVSKYIGYLENGDGIIKNDKEYIKDIIDSELEINNLYIYEYDEIIKNIKYKKLRYISELENLEKFNKKFDRIIMPLPKESHTFLEYAIPLIKDNGIIHLYQFFEEEKIREKAIDLLEKYSNELNFKYEILNILKVGDISPGNYRVCIDFKVIKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R1G929</accession>
    <name>R1G929_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Archease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Archease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DDW03_00785</name>
        <name evidence="6" type="ORF">Nst1_513</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2015" name="Appl. Environ. Microbiol." volume="81" first="7860" last="7868">
            <title>Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus Distribution across Yellowstone National Park Hot Springs.</title>
            <authorList>
                <person name="Munson-McGee J.H."/>
                <person name="Field E.K."/>
                <person name="Bateson M."/>
                <person name="Rooney C."/>
                <person name="Stepanauskas R."/>
                <person name="Young M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26341207"/>
            <dbReference type="DOI" id="10.1128/AEM.01539-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2017-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song R."/>
                <person name="Chenine A.L."/>
                <person name="Ruprecht R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">SCGC AB-777_F03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000004">
        <property type="protein sequence ID" value="EOD42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QEFP01000002">
        <property type="protein sequence ID" value="PVU68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42354">
        <property type="protein sequence ID" value="EOD42354"/>
        <property type="gene ID" value="Nst1_513"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PVU68860">
        <property type="protein sequence ID" value="PVU68860"/>
        <property type="gene ID" value="DDW03_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000245509">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOD42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PVU68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000245509"/>
        </source>
    </evidence>
    <sequence length="152" mass="18093" checksum="7BD0405439BE98AE" modified="2013-06-26" version="1">MTVLREYEYEDHTADIKIVGYGNTPKRAIEALILGMFNIIYDNEKVEKKESKQFVIEGKNILEIIYNVARICLEEVFYKDKFAVRDIRVKNLKKVRVESKKYKWVCRFEVYGEKYDKEKHGFKKEVKAVTLHDINITKIMKTYWSAEIVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9G0</accession>
    <name>R1G9G0_NANST</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Nst1_202</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 11"/>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="R1G9G0"/>
    <dbReference type="EnsemblBacteria" id="EOD42474">
        <property type="protein sequence ID" value="EOD42474"/>
        <property type="gene ID" value="Nst1_202"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1294122.7.peg.196"/>
    <dbReference type="OMA" id="PLYPFES"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="642"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="12">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOD42474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="1299" mass="151188" checksum="2C0AAD775EE46D36" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9L4</accession>
    <name>R1G9L4_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein containing two CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Nst1_244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42514">
        <property type="protein sequence ID" value="EOD42514"/>
        <property type="gene ID" value="Nst1_244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOD42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="368" mass="43005" checksum="CD2476EAA41B4FED" modified="2013-06-26" version="1">MAVFISKDKKIGDIVEYIKKGEDIIVTDNNGKPFGVLENSKAIRYLYRPDTKIEKIVNKIKPLKTNNIIDIVEKLISSNSRVTFVREDGQIKIVNIYDVLKDILNDKDILEKMNLNEIINEAYTIYEDENIKKAIGIMKDKGISRLIVLDKNNKVSGIISLTDILKYMLIDNSNNIRTPNEKDFDIKIKSIMSSKLIFANKDDNIEKIINLMIENKVFSLPILDNGNLVGIITAKDILINYLQHKKEKEYNLVVHGISLDEIDIGYIKKLYEKFYKKYRNVLGENIRLLIHIKKVNEDRENKKIYYQIRAKLIYNNGKFSIDDHGYDLYSTIKDIFSILENEAEKIKHKNEEKYMLESMFKNDIIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9Q3</accession>
    <name>R1G9Q3_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42564">
        <property type="protein sequence ID" value="EOD42564"/>
        <property type="gene ID" value="Nst1_294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="340" mass="39734" checksum="F24F3DC74CAC45DA" modified="2013-06-26" version="1">MGEDGIEPDGYKKISLDEILRIAKGNDGELKFMFARQIAPYQIETKSALSYIEKIIDEARDDVKKEILDILQWGDDKFSLKNIEKGIFVEPQMLDGKKYYIAAQSKSQLKKDIKIRDVYLDIKEISKMIKETGFEYMEKALGYLMQREKVTKIKVNADKGKVIEKDVVNILDFWGLATLYYIGEISKDIFGIDKYEIKEFKDKIKLANGDEFDISGYELTFKYNGKELKFRVYDASHIYKEESEKYKKEEKMNSYITLALLSGSRYILLEEDPGKPSVDQKIRDFYKEAKDKTGYDILLLETDEQKLIERGIIGKDDYVKLIDKDKTKYIMDTIMETYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R1G9W5</accession>
    <name>R1G9W5_NANST</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Nst1_366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nanobsidianus stetteri</name>
        <dbReference type="NCBI Taxonomy" id="1294122"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nanoarchaeota</taxon>
            <taxon>Candidatus Nanoarchaeia</taxon>
            <taxon>Nanoarchaeales</taxon>
            <taxon>Nanopusillaceae</taxon>
            <taxon>Candidatus Nanobsidianus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into archaeal evolution and symbiosis from the genomes of a Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.</title>
            <authorList>
                <person name="Podar M."/>
                <person name="Makarova K.S."/>
                <person name="Graham D.E."/>
                <person name="Wolf Y.I."/>
                <person name="Koonin E.V."/>
                <person name="Reysenbach A.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="APJZ01000002">
        <property type="protein sequence ID" value="EOD42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EOD42634">
        <property type="protein sequence ID" value="EOD42634"/>
        <property type="gene ID" value="Nst1_366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053279">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOD42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053279"/>
        </source>
    </evidence>
    <sequence length="69" mass="8179" checksum="4D45E885A29AD730" modified="2013-06-26" version="1">MPEDRYNLDLFIKNSFEEAIEYLDKIGIKIEWPKLRIFESTELFRGFGVGEYEGQANEVHIIKSELIKK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>