<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL15</accession>
    <name>A0A087RL15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose-1-phosphate uridylyltransferase protein</fullName>
            <ecNumber evidence="5">2.7.7.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galT</name>
        <name evidence="5" type="ORF">AAA799O18_00779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000050">
        <property type="protein sequence ID" value="KFM14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.664"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="4">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="169" mass="19436" checksum="13468EF45B70BBEA" modified="2014-10-29" version="1">MGEMRKDYVIERTVIVPQKINKIANSKKCPYCPGNESMTNPSLLSLVAKDGMLQRLQDSEDYFVKDWSVRVFESSRPVVSTSAENSYSDRPLYSEPAYGYHYIVVASNKHNDSLATIDIEQWSNLLVVIQDRFRWLYTQKGVTYVSIFVNYGKEAGSVVDQFFKYTTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL19</accession>
    <name>A0A087RL19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000049">
        <property type="protein sequence ID" value="KFM14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="38" mass="4234" checksum="5FF149D3A42646A4" modified="2014-10-29" version="1" fragment="single">MRAKPKTGLTGFPNARNSETKVWLSDPSCAHYWGPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL31</accession>
    <name>A0A087RL31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000043">
        <property type="protein sequence ID" value="KFM14185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="138" mass="14987" checksum="78A78E0785B40A8A" modified="2014-10-29" version="1">MTLPAKPKTNFIQKKILVCCGIGGIAITIASVIFFAFPSSTTYDNYSILVDPTKEQQSLFIIARVLIQNTSSESLTNLAIDYGEGDKDFIGTLKPGQTIILSPPDGNPLQYVTVTADNDIYVFKAYREPVAMPGMMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL33</accession>
    <name>A0A087RL33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000043">
        <property type="protein sequence ID" value="KFM14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="167" mass="19394" checksum="55890EECC228E37F" modified="2014-10-29" version="1">MYVMSVLMKKEIAVDRIIAANYEVFKALDDPIRGKIVQLLNKKQLNVVQITRRLKKLGYKKAVTTIRHHVEILKDSGLIEIIKIEESRGAITKYYGSSIRLLDFTLPSDFDENYSKIISKTSSKLDKIISPILKNFSKTRKIQQINYNNYIVMEIMNRSITNLLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL36</accession>
    <name>A0A087RL36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="66" mass="7177" checksum="8CC9D1A97CC24260" modified="2014-10-29" version="1">MGISLVSAKKKSYLLITFLDFLLSADNFASSSSFITWSAFAFFALIPISPDAITHTNADLDIFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL39</accession>
    <name>A0A087RL39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.649"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="74" mass="7809" checksum="9EF2312DE1F48A2C" modified="2014-10-29" version="1">MGDTQNISAIVTGGEATAGPPLGPALGPIGINIMQVINTINEKTSEFKGMKIPVTVSVDSDTKKWEIEQLQHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL48</accession>
    <name>A0A087RL48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000040">
        <property type="protein sequence ID" value="KFM14202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.641"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="106" mass="12024" checksum="4441FB107019C3B8" modified="2014-10-29" version="1">MSEIVPYVIKQIVDNGNAVQISLTEDVETEPLSQKQLIMENVSKKLDTETKEQVMPLLEAILHSQPTIKVKSYAQTNITITMPKNKYDKMGRPQVGEKLQVDLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL53</accession>
    <name>A0A087RL53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S8e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps8e</name>
        <name evidence="5" type="ORF">AAA799O18_00743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="121" mass="13572" checksum="809D0588B2A72D80" modified="2014-10-29" version="1">MENLSTSKITGGRRKPSRSRKKYELNRFPNEALLGEQITVTRKVRGKNNKTAIKTINFVNLVIDSNVKRVKIVKVLENATNNDYQRRGVISKGAILETTEGKSRVISRPGQHGTVNAILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL56</accession>
    <name>A0A087RL56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="35" mass="4072" checksum="B1704111999759FD" modified="2014-10-29" version="1" fragment="single">RGSGVYGHLKELRQLDFIKNQNIFLMLFVMDMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL64</accession>
    <name>A0A087RL64_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine hydroxymethyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyA</name>
        <name evidence="8" type="ORF">AAA799O18_00732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000037">
        <property type="protein sequence ID" value="KFM14218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="12"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="246" mass="27215" checksum="A2513CE62B43FF3D" modified="2014-10-29" version="1" fragment="single">MTNNSPNKDAYDDVFTSLEKHNKWFENSIPLIASENIPSPAVREAIISDFGNRYAEGWPGERVYAGCTYIDEVEIQCMDLAKRLFKAEFADVRPISGVVANLAVYSAFSNPGDVMIAPSIPAGGHISHGKKEHHGTAGFVHGLEIEFFAFDSDEMNLDVDKTKTKVEELKKQGRLPKIAMFGGSVFLFPHPVKELADFLKGYDIHINYDAAHVAGMPKKITNSKITLINTALEIEKTEIDAKINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL79</accession>
    <name>A0A087RL79_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CdvA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000032">
        <property type="protein sequence ID" value="KFM14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041461">
        <property type="entry name" value="CdvA_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18822">
        <property type="entry name" value="CdvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdvA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="186" mass="21117" checksum="3FF6A9D6647D6BDD" modified="2014-10-29" version="1">MKPDAELIHETYKSKLRNLDEAEVKIKTQLTTRLDELDSQAKTVKMILFDTSVQFKSEEITELTFESVQKHCNNLLERLSHEKDEVSNVQRRLDDLSVECIEVIKTPKEMIQESAVSYLDTSGHTITESGNYQPSASTTVDSEPESTLPEPPVENIEPPIQESPNDSNNSECQTESESDWLSRMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL90</accession>
    <name>A0A087RL90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="46" mass="5335" checksum="B55C25F07DA4B498" modified="2014-10-29" version="1">MIKKEEVKADDKEKKEEVKADDKEKKEEVKADDKLIEGKKDESEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL94</accession>
    <name>A0A087RL94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle 54 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp54</name>
        <name evidence="5" type="ORF">AAA799O18_00702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.609"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="3">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SRP_SPB" evidence="4">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="214" mass="23734" checksum="F794834937E45E7C" modified="2014-10-29" version="1">MFCSGRSLSQVPVGGIIITKLDSSAKGGGALAASAATGAQVMYIGTGERIDDLEIFSPTRFVGRLLGMGDIQAVLDLAKRLENESDDVRMKRISSGKMNMEDFYYQLEEVTKVGSFQGLLESMPGLSGMVKEDQIDQMEEKVDKWRYIIQSMNKDEKDDPDLLNASRVKRIARGSGFPEHDVKELMKNYKNSKSMMKASKGRQMQGFLRKLGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA2</accession>
    <name>A0A087RLA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="56" mass="6204" checksum="B5B663CB240FFF1B" modified="2014-10-29" version="1">MGSLSNRWSKPQKPGISERLNSVLRPKGALKPRVETAIKKLQVQISKLDTMLSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA9</accession>
    <name>A0A087RLA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">7-carboxy-7-deazaguanine synthase protein</fullName>
            <ecNumber evidence="7">4.3.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">queE</name>
        <name evidence="7" type="ORF">AAA799O18_00694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="227" mass="25581" checksum="7F8A5D0830BCB353" modified="2014-10-29" version="1" fragment="single">MCLKTRLFEIFTSIEGEGILYGTKTLFIRFAGCPYSCFYCDTLDALPLDSGKEYSISEACNLIDKNLQENTYKVNFTGGEPLIQYESVNQLAKHVKTKGIPTYLESACFDSKKFLFVLPSIDFVKIEFKTIDSQFVDTKHYPNLIKNSLECLQASIDAKKTTYIKIVVSSKTEISSFNDLIDKIFKIVHKETISGVIAAIAIYIGRIIITKSVLVRGFSKLDRKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB0</accession>
    <name>A0A087RLB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="95" mass="10848" checksum="1C8E5043537BB72E" modified="2014-10-29" version="1" fragment="single">KNPLILKVSSKTGKGVTEFVTELKKIMGKRKKEKKLSEKQRLAIELDDIILNNINQKVATMLHSNKTYTGYLKKVQDREIDPFEAADKISNSVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC1</accession>
    <name>A0A087RLC1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purN</name>
        <name evidence="5" type="ORF">AAA799O18_00661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.572"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="206" mass="22867" checksum="36A1B1296DA50C01" modified="2014-10-29" version="1">MLKLAILISGRGSNMKSILEAVKKQNIPIKPTIVISNKSTAKGLKIAKKLGVQTEVVESKEFQGTRTEYDHKIIHILSKYDITPKNSLICLAGFMRILSPEFIKKFKNRILNIHPSILPAFPGLDAQRQAIESGASHSGCTVHFVDEGVDTGPIIVQKMVKIKNDDTEETLSKRILSKEHKAYPEAVRLIAEKKISVIGKKVKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD5</accession>
    <name>A0A087RLD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018747">
        <property type="entry name" value="DUF2299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10061">
        <property type="entry name" value="DUF2299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="146" mass="17426" checksum="6F68B7D8BB6B60E2" modified="2014-10-29" version="1">MKNLHESVERWLVQENYSFNEIKTEDNFKIIIKNADAFNNNLEIFEPKQQSNVLVIGVKIPLKSKQMIRYLKLNQKEKENFEKKITDFCYSIKAINKFFDEDGMKKVGVYIVLDKKDQLNQPNFIKILTKIIEMSDKTSQFLYKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE1</accession>
    <name>A0A087RLE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl5</name>
        <name evidence="6" type="ORF">AAA799O18_00643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.556"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="4">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="5">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="117" mass="12835" checksum="B87C45250655712D" modified="2014-10-29" version="1">MSQQTENIMKKIHLNKVVLNMGVGKSGEQIETAKAALNQIIKGKVNSRQAKKSQRDWGVRKGEPIGVAITIRGNDATSLLKKLLEAKGNQINERTLDNEGNFSFGISEHIDIPGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE8</accession>
    <name>A0A087RLE8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rps3</name>
        <name evidence="8" type="ORF">AAA799O18_00650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.563"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="211" mass="23384" checksum="D1E9C6FC74E99CD5" modified="2014-10-29" version="1">MTQLKNLIKDNYNIMLLNDYLRKEIKEAGFSKVEISKTPLGTKVTLFVTKPGIVIGRKGSNIKPLTDKLASDFGLKNPQISVEEISVPELSPSVMCNRMAGHIERGTAFRRATMWTLQQIMSNGAMGVQITVSGKLRGDRSAFEKHSAGVLPRAGHYAKVVVSEDIAHVETPMGLIGIRIRIARKEKIIPEFELKSCLSKILKSKLIKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF6</accession>
    <name>A0A087RLF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="46" mass="5606" checksum="308E666FAA266EE5" modified="2014-10-29" version="1">MIDKNIVKDPNAIPTRPTIIASSKKFLFFFMFFDLFNYVYYENLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG1</accession>
    <name>A0A087RLG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyl-D-glucosamine kinase protein</fullName>
            <ecNumber evidence="1">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.544"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="101" mass="11074" checksum="EEBA491EB96F0007" modified="2014-10-29" version="1">MARTYWKKKSIVQDLSDEKATQWKKEFLENFGTGLANVIDILDPDVIVLGGGVSNIPFLYDEGKKAVYDKVFSDSIETPILKNSLGDSAGVFGACLLNSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG5</accession>
    <name>A0A087RLG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="5 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aroK</name>
        <name evidence="12" type="ORF">AAA799O18_00620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 10"/>
    <dbReference type="EMBL" id="JOTC01000023">
        <property type="protein sequence ID" value="KFM14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.538"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="284" mass="30540" checksum="7D1022FC1B7C71CD" modified="2014-10-29" version="1">MRVVKATVHGAVSIVNAIATGKGAALGISKKTDVEIETTQGTGITIETKNKQISSRLINRVIKKIVPKSKLSKTKFRVYLESEIPTGYGLKSSSAVSSAVAMGCAKLFKSEMTDFEILCSGVDASIETKVSLTGAYDDACACYYGGFVVTDNYKRKIISSENCRNDVSAIIFIPKSRKRGNVKRLKTISGVFEQAWNFAKNSDYWNAMKINGFATSTILNSDPKIIFNLIEAGALGASVSGNGPSIAAIAKKNTLPKLKNILSTLEGNTMIANINNKKAEVHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH6</accession>
    <name>A0A087RLH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComE operon protein 2</fullName>
            <ecNumber evidence="3">3.5.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comEB</name>
        <name evidence="3" type="ORF">AAA799O18_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.534"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="187" mass="21254" checksum="EDD156DC8DE5DC54" modified="2014-10-29" version="1">MFKVKLSSYIREDKITLMSTSFERPTWDEYFMLQAELAKLRSNCITRQVGAVIVREHRQIATGYNGTPPGVKNCFEGGCKRCQDRMEGKIKSGESLDRCLCNHAEANAIMHCAILGIEAGSKDAILYTTFVPCLECSKMAITIGIKKIFSLNEYPETDYKLLEKSGIKIEKLDKKKIQYWAKSLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH9</accession>
    <name>A0A087RLH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar efflux transporter for intercellular exchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="96" mass="10656" checksum="8E6A90BA4877DE2F" modified="2014-10-29" version="1" fragment="single">MLELDQTTMSIIGILAGILILSGWIPQIAKGYRTKKLDDVSSYLMILIFVGAALWLIYGMALDDVYIMGVNLTAMFLTMTVLAMKLKYEKTAQTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI8</accession>
    <name>A0A087RLI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="99" mass="11204" checksum="77FDE511049B27BB" modified="2014-10-29" version="1">MEVGNTQLRKYEEYAFVLDFKSRSKSTTVRGRTGSIVIAIGEERLTLLEILGNENTIFEVGERVYIGKEGRSKVQSVLGKITYEKISVSAQNEIKIILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ0</accession>
    <name>A0A087RLJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.511"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="325" mass="36717" checksum="A685E1FFFC20EC10" modified="2014-10-29" version="1">MILMQFSNIEPSYTSKDGCRLIWKGVEEDDSDTIILNKKELEQLIDLLKGDSSGEVDLEDQVSRIMVNSDITEFNLKDHNLLEVKTADLQKHVLDYAKIPHTPQYVHINPKEYYPSISIRKYDEPKKVDETKSTQISLLEAILASKPKKTSRDLSQSDLSRIFATRRSTRKFVKTKIEGWMVDKILAAADTAPTAGNFQGFKVFYIKNQKTKEALVEAANNQPYVNAPVVLVFCMDPSRVKMNFPPEILEKFSIQDATLAAAFSMLAASGLGLSSIWIGMIDEEKVKSILGTDLKPSSILCIGYPEKRRSPKTRRNLKELIQVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM57</accession>
    <name>A0A087RM57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdenum cofactor guanylyltransferase protein</fullName>
            <ecNumber evidence="2">2.7.7.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mobA</name>
        <name evidence="2" type="ORF">AAA799O18_00584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="195" mass="21751" checksum="BD9D4F1EF9EC2C49" modified="2014-10-29" version="1">MIGLVMAGGKGTRMELSDEKLLLQYKKPVIFHVIDALKNSHCFSKVVVATSPNSPDTKHVLEQRGIETLATHGNGYVNDLNSLLQKMSGFVFVSSGDLPLLDEKIIQDITKKFNSKNVWTSFLVSKGFLDSLGLESSLLVNSVKGIDSTYTGISIINADKIKNHNLVEEKHIILDDKRIAFNLNTKKDYELLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM70</accession>
    <name>A0A087RM70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.495"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="437" mass="50123" checksum="924F80D06CA8AEF8" modified="2014-10-29" version="1">MTKFFSKYNLASIILFFLIIGVSIPSTTILNSWAIHENEYVKTQKSNPIPDWIRNNAEWWADGKITEDDFLYGITFLVDNNIIKITNKSIFEKTDDAIDSTIPTQAKRVPDWIKNNAGWWAKGQISDSAFVSALEWLISKGIMKIDVHRISFIPIEDVIFADALRKHDKSDFVHLYSSLFEVYVRPDGYTLEETEDGEKRVWISPILGLHPEKMDLYNELSLWHDPQRAVVIYPIFTGTAYAEGGFYDYYNGRCDHCTTTTLKPAGLLYTSSGNAVQALSLLGYDLINDIDVDKNPDILKQYDKVVVLHNEYVTRAMFDAITSHPKVIYLYPNALYAEIEVDYQANTMTLIRGHNYPPEDPVSNGFDWEFDNTHPYEFDNECKTMELYSIEDWRSNVGVDVARMGANTHWMTNCYPEIMFYSSGYVATALLKAIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM73</accession>
    <name>A0A087RM73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisG</name>
        <name evidence="9" type="ORF">AAA799O18_00574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.498"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="7">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="8">
        <location>
            <begin position="248"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="331" mass="38268" checksum="CB9916CA2DA8EE07" modified="2014-10-29" version="1">MTDRIYISYQCLDKNCTSLEEATFKLLEESWTKVRRRPRTYRVFLDDPDIQVKMLRPQEIPTLVGDGLYDVGITGQDWVNENKADVEKLLDLEYGKIKLVIAIPDSYKYKSLDDMILSYAKKKKTLRISSEYLTNASKFIKNCKSYKKLYGSKDPQIVTPWLRLGTNKNVQIHLSFGATEAKPPEDVDAIMDVTETGTTLRQNQLKIVETVMESSAHLIANKKSLKDKQKRQKIFDIVTLMRGAVQGRKYLHIYMNVQEKNMNKLLTEITSLKRPTISPLSEDGWYGVNTVIPKSEFHRLVPKLRKIAQGLVVHEPKQILELEEIKRDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM78</accession>
    <name>A0A087RM78_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">AAA799O18_00579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.503"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="201" mass="22265" checksum="9727AEF185A728A7" modified="2014-10-29" version="1">MKVAIFDYGAGNIFSLKNSLEKNGAQVDVITGLNKSKEYSGLLLPGVGNFDPAIRSIRDYSSTDFKDYVGESMPVLGICLGMEMYFEKSEEGKEQGLSVINGEVVLLPNTMKVPHMGWNSLDIERQNKFLEGVNDGSWVYFVHSYMIKTKETGLITANADYGIKVPAVIQQKNFIGTQFHPEKSGEIGSLMLSNFLSECKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMI9</accession>
    <name>A0A087RMI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ytqA</name>
        <name evidence="14" type="ORF">AAA799O18_00547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.477"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="72"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFM14693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="526" mass="60084" checksum="798B2EE1B4F203F7" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ0</accession>
    <name>A0A087RMJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">lysS</name>
        <name evidence="9" type="ORF">AAA799O18_00548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.478"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="43"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="530" mass="60089" checksum="D6CEFFA0198C60EC" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ1</accession>
    <name>A0A087RMJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="64" mass="7180" checksum="5ED7826C58280EC8" modified="2014-10-29" version="1">MAHNEHNKPKRTGLFLIVFGAVLLIVAPTQYSSSQELGMLALIGGFIMGGLGFYLKYVRRKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ4</accession>
    <name>A0A087RMJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aquaporin Z protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aqpZ</name>
        <name evidence="6" type="ORF">AAA799O18_00557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.482"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="234" mass="24617" checksum="A68CE63A9747FB33" modified="2014-10-29" version="1">MVSPRNWFAEAIATYALVFFGPLSVILSVVAFGEGLSVEAIIMISLGHGGAIGLMVYAFGHISGAHINPAVTIPMMITKKISVGDGIGYIIFQLIGAIVAAFSLKAILPEIGAKVNFGTQGGPSDLLNNSVMAGLAVEIIFTFFLVTVIYLTAVHKKAPASIHGISIGGMVFLLHLVGVPLTGASMNPARTFGPALASGFWEFHWLYWVAPIVGGIIAGVIMNYVFVKKAEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK1</accession>
    <name>A0A087RMK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA methyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="217" mass="24976" checksum="C094F793BD2DC573" modified="2014-10-29" version="1" fragment="single">MNYSIAIPDSSLIDESSKLDKTRKISIIARACAIFQVNEIFIYRDGHENKNDLILLTTLLRYLETPQYFRKQLFPKIQQLKYAGVLHPLKTPNHLTTSNPKMLKVGDIRDGLIINYKGKKFVDIGINKLLQYFGKDKPGTRIVLQIKTLNPKLTIKEIQKEQLKNYWGYKVKERSNLLALLSTWNGNTILTSRYGKIFTGSDAKKYGKVNKPILVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK8</accession>
    <name>A0A087RMK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein</fullName>
            <ecNumber evidence="2">2.6.1.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioA</name>
        <name evidence="2" type="ORF">AAA799O18_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.466"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="263" mass="29459" checksum="7E499DCCAA52F0AE" modified="2014-10-29" version="1">MSEWTKFPKIISGNGMWLIDQDGNKFLDGVASMWCNVWGHSKKELISVIIKQTKKLQHSSLFNFTNEPAEILAKKLTKLSPGMAKVFFSDNGSTAMEVSIKIALQYWNNLGLGNKSKIATLENGYHGDTFGAMSIGYIPEFFSKFNSKLFSTIRFQVPNSYRLPINTSIEEYKNGCLEKIEKKICEDESIAAFVMESGAQVAGGVNIYPIAFQKQVNAICKKYDVLFVLDEIATGFGRLGSMIEYKKQMCCPDIVSFGKMLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK9</accession>
    <name>A0A087RMK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein</fullName>
            <ecNumber evidence="2">2.6.1.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.467"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="175" mass="19811" checksum="C0D55F9D13A82777" modified="2014-10-29" version="1">MPRYCIIWENAGYLTFAATLTTKKISDSFLGSFSEMKHLFHGHTYTGNPIAASLANENLRLYEKLKLIQKIQNTSKIFKNRISEFSDLEIVGDVRHKGMLMGIELVSDKDKKSPFKAKKSINKIVFDEGKKHHIFFRTLGNIIMLVPPLAISKKEVNLLIDGTINTIKGISKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML7</accession>
    <name>A0A087RML7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="44" mass="5095" checksum="5397808150BFDCE6" modified="2014-10-29" version="1">MDSGHLDSLIQEIIKTVDDNTAEMNKISNEKTGKKTTRKYKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN2</accession>
    <name>A0A087RMN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase protein</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE</name>
        <name evidence="2" type="ORF">AAA799O18_00524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.456"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="194"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="453" mass="50809" checksum="C2E3DB328ED99425" modified="2014-10-29" version="1">MSMKKVLQHVDKNMNVLVKDLRILIQQPSVSAKNQGIKKCAYLVRSTLKKSGINAEILTMKGYPPIVYGEVKSKKNPNKTLLFYNHYDVQPVEPIELWDEDPFSGKIKGNRIYGRGSSDDKGELITRIRAVASFLKVTGDVPCNVKFVIEGEEETGSAHIEEYLKKYRKKFSCDGVIWEFGHVDSKNRPIIDLGMKGLLYVELTLRESKMDAHSSLAVLIKNPAWSLTEAIKTLRDSSGKILIKDWYKEVQSLSKSDIKILKAFPFDEKEFRKEYGIREFLGNKTGLEIKKSLVADPTCNIAGIVSGYYGEGAKTVLPAEARVKIDFRLVPKMNPKKQIMRLKRHLKTNGFGDIKIKVYHGEAAARTNSKHPFVSDVTEAARGSFGKFLLSISSAGTGPMHAFTHILKAPAIAIGSTYVFSRIHSPNEFTRTDLLKKATKCMCLILNNFARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMP7</accession>
    <name>A0A087RMP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">dtdA</name>
        <name evidence="5" type="ORF">AAA799O18_00486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.419"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="258" mass="29156" checksum="062EE591892DCABF" modified="2014-10-29" version="1">MELLVAYQEDPAGHNMAKFISQDLEKNGDVYKGQNFDLVIIQDPVISADWIEEKFDYDGYVFLSKHAAESNVLALTCHNTGNFSDANFGGNSRQVSIPHSYLQKSYMQSLWSVRNKFPGFQITIEATHHGPTALSKPTLFIEIGTTEKEWNDVNLCNSVAQIIVEVMKKKQKSYPMAICFGGTHYSDKFTTELIKGEYSLGTVVPKYAFQQIDKKLFSHIIERNMGATIALLDWKGMGKNKQKILAMLEETDLEVIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMP8</accession>
    <name>A0A087RMP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-3-methyladenine glycosylase II protein</fullName>
            <ecNumber evidence="8">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.420"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="99" mass="10946" checksum="4124F26B336FCC0B" modified="2014-10-29" version="1">MTTSIEVYSKLLKVPKGKITTYGDLAKAIGLKNGQRAIGLIMKNNPFPVIIPCHRVVKSNGEIGGYTYGEKIKSNILSKEGITIKDGKILDFDKRKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMP9</accession>
    <name>A0A087RMP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L19e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.421"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="5">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="157" mass="18234" checksum="59937A4F923CE2B1" modified="2014-10-29" version="1">MQGCLNVPVNLRTKKLLVSRMYGVGLKRIKFDTDHLDDVADAITRENIRSLITANTIKIKQISGTSRGRARLKKIQKRKRSVKQGSRKGRKGAKIGRKEAYVIKVRSLRYRLKVAKDRKEITNKEFWFLYKKIGGNTIRNIAHLRTMIEEIKAKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ9</accession>
    <name>A0A087RMQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">30S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps5</name>
        <name evidence="8" type="ORF">AAA799O18_00498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.431"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="222" mass="24186" checksum="F18ADBBFD0E931BF" modified="2014-10-29" version="1">MSQNSQTRTSAPTNQRFQRRERKRVEEEVWIPKTNLGKKVVSGEIDSMAEILSKGLRIQESGVVKKLLPDLKTEVIDVGIIQKMTPNGQSTRFKALVAAGNENGWLGIGMGKSKQMRIAIEKANNAAYLNVSPVKLGCGSWECRCDQKHSIPFKVRGRGGSVTIEILPAPRGLGIVAGGKIRNLLRLAGLKDAWTTANGSTSTMNSTSKAVLQCLRHTFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR3</accession>
    <name>A0A087RMR3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">adkA</name>
        <name evidence="10" type="ORF">AAA799O18_00502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="192" mass="21262" checksum="26617B2B4DFB498C" modified="2014-10-29" version="1">MEESKKVVIVGIPGVGKTSLVTRIAELIKQKNKTVSVHSYGTVMFEEAKKAGIKNRDELRTLPIEKQKELQKMAALMISKLQDDVIFIDTHAFISTKAGFYPGLPNYVIQIIQPTNFIAITASPDEIHNRRMKDGTRERDPISIEDIKKELAVQDAMLSSCSVLSGSPMKVIFNHEGKIEEAAVNVINAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS0</accession>
    <name>A0A087RMS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.441"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="152" mass="17924" checksum="8F2EA16D491E68C5" modified="2014-10-29" version="1">MPSDQEQVWIKMWKNNSSDLRDKAALWRKQNAIIRIPKPSRIIRARRLGYKAKQGIVVIRMRVGTGGMRKQRPRGGRRPKHLGVTRIKADVSMKQVAERRVLERYRNMKLLGSYFLYKDGMHYWFEVILADPSHKRIAKDKEIRKRVLSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS1</accession>
    <name>A0A087RMS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="211" mass="24182" checksum="0FA4615F87419344" modified="2014-10-29" version="1">MKITALLLLLLVIMSTLPYMSQTFAVVTVTIETSQDIYHYGEHLSMTINVSEITGDIATVYIIDMEERKSILLSPPISQKTTELPSRHPFDATIWKAGFYTLEVEYSGEKSAVQFSIEDTGEIALPFWIKDLAKMWITEPLVTDKDFTRAIEYLIQNEIIKIPYTEPEGETIASIPDWVKTNAEWWLYEKISDTEFTLSLQYLIKKGIITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS7</accession>
    <name>A0A087RMS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsZ 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ftsZ2</name>
        <name evidence="2" type="ORF">AAA799O18_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="313" mass="34614" checksum="5C8A11D7EFFDE317" modified="2014-10-29" version="1">MTFQLTEPILLIGVGGIGARLTEKTKKSLNSDCLLISHDQKDLTSENSIKISTKSVVNPSTHLIRGSTLEASGEIKKNIDNYSTVILMSNLAGRAGAGIGPIISKICRQEQKNLLSFTIMPFKFEKERIFQSGVALKRIRKDSQCTIVLDNDALLDSNPELTQQQCYEIANKAIECITTSLKSSEISEDTNILSTSKTVDDIEVSLKDSLRMLYEDAPPNSIKRSMLYIYGNNNIPVGVLNTISNITGGTFDEDSLHVYMSSNESKIAMLSSIQGETRFDKYDPLGIISSENTIDWDEPECSINCELDLKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT3</accession>
    <name>A0A087RMT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAC2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.409"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="242" mass="27089" checksum="703B469CF40CECBD" modified="2014-10-29" version="1">MKDRSFLDNQVYEIKKTVLKNPVIFAGFVGAGLVGPLSIGYMIEKLKMEEIGYLRSNHLPPSTVFMQGRLRHPFRLYANKEGTICAIICEITLRMEGLHDIISTILEWAEKNGSNEIIILDGVASTTHDNKAFCAAEEDLCRVMEDNDISMIPQGFITGVAGGLLNECLMRKIQGVTLLVKANDRSPDPLAAATLVDAVNRAYGMNIDTSDLRKEKKRIGVDFKELSDKYTEHRKIDSNMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT5</accession>
    <name>A0A087RMT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cation exchanger YfkE protein</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yfkE</name>
        <name evidence="7" type="ORF">AAA799O18_00478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.412"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="311" mass="32038" checksum="9DDB624207442A47" modified="2014-10-29" version="1">MEIAINALLTVVGLAMLCFGGNWLVSGGVSIAKKLRISQMVIGLTIVAYGTSTPELAASVAAAVGAHTDLILGNVVGSNISNIGMVIGISAIISPLIVSKATTRKEVPIMIGVMLLLVAISVDGEISQYDGALLIAGLIAFTVYTLSRAKKERKQEEEDPSTQKSSMPKAVGLVAIGSGLLYLGGYLTIENVVLIAQGIGISETVIGITIVAIGTSLPELITSITAIKKGHTDIGIGTIVGSNIYNILMIMGVASVITGIAVVPGIFTDYLVMIGFAVVLIAFLRSGIIPRPAGIGLAIAYAVYLGYTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT9</accession>
    <name>A0A087RMT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative periplasmic serine endoprotease DegP protein</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mucD</name>
        <name evidence="3" type="ORF">AAA799O18_00482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.416"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="381" mass="40349" checksum="42486EF2C629F88F" modified="2014-10-29" version="1">MTKSGFVVGGVTGAVAVILIFAFILLPDQESITPDLIVSNGNDITKFGDETTLSIKKNLTLVELFEKSEEGVVRIDVDKISSYREPGSLGSGFVFDDLGHIITNAHVVEGASSITITFLDGSQYNAQLIGSDKFTDIAVIKVEEKPRYLHPLQMGDSSILKVGEQVAAIGNPFGLSGSMTSGIVSQIGRLLPSQDTGFSIPNVIQTDAAINPGNSGGPLLNMVGQVMGINTAIQSGTGQSAGIGFAVPSNTISKVVPVLIEEGKYSHPWIGISGQDIYPELAKIRDLDQTKGFLIVNVVPGSPAEMAGLKGVSEIKAIGDKEYPADGDIIVSVDGNEVRKISDILIHLQEEKSVGDEMILGVLRDGEVMHIILVLVERPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN65</accession>
    <name>A0A087RN65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine--tRNA ligase protein</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metG</name>
        <name evidence="4" type="ORF">AAA799O18_00424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="107" mass="11639" checksum="184011816BED6014" modified="2014-10-29" version="1">MSATYDDFKKLDIRVANILKAEKILGKTKIIKGTIDLGKETRSVIIGGAEFYEPEDLVGKTVVVIANLETKKIAGIESNAMLLAADVDNKPFWLTVSSEVQAGTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN69</accession>
    <name>A0A087RN69_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">16S rRNA aminocarboxypropyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AAA799O18_00433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RLI" evidence="8">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Ribo_biogen_C" evidence="7">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="164" mass="18301" checksum="E0A823A8D3426400" modified="2014-10-29" version="1">MLKQDDPKKCTAAKLVKFGLAKPISQTTSRTLVLDPFSKKMLLKSDKKLVNSITGVDCSWNLTTTVFDKTFSGISRRLPPLLAGNPVNYSKLNKLTTVEALAAAVYIMGDFTLASLLLDKFKWGHTFYTLNENLLKDYCKAESESNIFEICDEYGLARSTMTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN71</accession>
    <name>A0A087RN71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.373"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="429" mass="45955" checksum="BEE56D6575D35A6E" modified="2014-10-29" version="1">MILKRFSIVIFLVSVIAVGSLAPAFASSQLEVTIDPNSDTAVAKMTYQRSIVIDYSEGGKVAEVMNGKSDKLEFTASSSTTGMNSLIAKLNSYVASKGSQARITDLDLDYLVSFTGRTGNASLDYKIVLTPVIQDFVIKAGDGNSPTLIDIDWRGFGALGPVVISTLMHGDVEINLPISAIEGFFPALGLSMKSSEASELLTERLMNGDGIKDQPVGNWHFLFDPTGIGVDAAQHGFSTGSVLSSFTMGESSIREGLIREQVSETTFTSDKVYIIKSIESSANASIDIIGFANRDTLGSSEIFGVTPQAPEGYASTSSGEFPAFILYGMAGMAAIGGVAMMMMSKRKLSKEKGHYQQTGIDPSQLTGVQTSASAGGYQTVRGEAQVKGLEDYNQHRNYYNEEKPQVEEKTEDKPSSKRGALPKGFKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN92</accession>
    <name>A0A087RN92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AN1-like Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="74" mass="8722" checksum="56F8CCAA35D52DBB" modified="2014-10-29" version="1">MLQEKCAYCGDMTDMPFECNYCKDPFCSEHRLPEDHRCVKLTQIRTKKFGERRVVRDGGTGKRKGFRRMLGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA5</accession>
    <name>A0A087RNA5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rps12</name>
        <name evidence="5" type="ORF">AAA799O18_00387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.339"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="145" mass="15942" checksum="84FB59F0DB9C1AD0" modified="2014-10-29" version="1">MAKSPLGLFAGRILKAKKKHQRWAISTYKRRELGLDKKANPLAGSPQARAIVLEKVGVEAKQPNSAVRKCVRIQLIKNGKTVTAFLPRDGAMNFIDEHDEVHVEGMGATQGGAMGDIPGVRYKVFKVNGISLKQLVTGKKEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC5</accession>
    <name>A0A087RNC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase glutamine-hydrolyzing subunit A protein</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">guaAA</name>
        <name evidence="2" type="ORF">AAA799O18_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.317"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="225" mass="25459" checksum="43E25149FA1BEA42" modified="2014-10-29" version="1">MNNVLVIQNARSEGLGLFRQLLESDGYVIETIQAKQEKIPSKRYSLLIILGAPESVNDDLGYLSNEMDLIQNYVRSSIPVLGICLGSQLIAKAFGASVYHGTKKEIGFFDDLRLEDKSISDLFTGFKSPFTAFHWHEETFTLPQNAVRLVHSSDYPNQAFKIGTAVGLQFHLEADESMINSWLVSTHSISQNEKEKILNDIEKNFSVLKQNISIFYKNFKNEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC9</accession>
    <name>A0A087RNC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome subunit alpha protein</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psmA</name>
        <name evidence="4" type="ORF">AAA799O18_00369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.321"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="241" mass="26433" checksum="2EC06552795DCF70" modified="2014-10-29" version="1">MASRGYDMTPTMYSPDGRIYQVEYAIETVKRGTLAIGIQASDGVVIAVEEKSRDLQVEELTQKIFQVDDHIGVAAAGYIPDARVQVDNARFFAQSNKLTYDEPVDVETVAKHLADQSHQFTQYSGVRPFGVALIIGGIDKKGARIFVTDPSGTFVAYSAVAIGANSDEVSDFLEKNYKNDLTIDGAILLAISAINLKSDEKGVKHIKMSTIRSDTKLLERVPLSELEKHVHATETKPAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE6</accession>
    <name>A0A087RNE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="72" mass="7772" checksum="9EEE5CDADC6DC78D" modified="2014-10-29" version="1">MKYIPPKKLKVLMIMFFGAAGFGIFTGLAVASSGMQGLIITLLGVINLCLGGLMGFLLLTQKPKVRDSRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF7</accession>
    <name>A0A087RNF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="127" mass="14585" checksum="34C11ECCFBF5CC46" modified="2014-10-29" version="1">MKVTKLSAVTLLISDMKKSVDFYSKIPNFKIVFGGPDNQFTSFLIDDMAKSYLNLKLNKTHATDFGRIIFYVDDVDEFFTYMQNDETISVLGKLESKPQDATWGERFFHMLDPDGYRLSFATPIGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG5</accession>
    <name>A0A087RNG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L40e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="3">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="56" mass="6491" checksum="8709283078B8C232" modified="2014-10-29" version="1">MPITDPEKKQIAQKARLHMKICFTCGARNPLSATRCRKCHNHYLRLKNRTLGIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH1</accession>
    <name>A0A087RNH1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">purD</name>
        <name evidence="12" type="ORF">AAA799O18_00350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.302"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="104"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM15025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="420" mass="45615" checksum="0528E9A7BF913F26" modified="2014-10-29" version="1">MVNVLVVGSGGREHAIGWKLGQSDYVDRVFHAPGNGGTLNNESISVDNLEALATFASENGCFTIVGSEAPLAAGIVDVFNENGLKIFGPTKMAAQLESSKIWAKEFMKRNNIPTAAFEVFDDASKAKEYVNKIEHNVVIKADGLAAGKGVIVCSSKNEAEDAIDMMLVNKKFGDAGRNIIIEDRIDGVEASYIALSDGKIAIPMATSQDHKRIYDDDKGPNTGGMGAYSPTPVIDEILSGEIQKKIIDKTILALRNEGITFKGFLYAGIMLKDGEPYVLEYNVRMGDPECQPILMRMDSDLFQYLNASVEGTLENISSISWKSKSAVCVVLASKGYPNSYPKDEEIFGLEEVFADAYVFHAGTKVKNEKILTSGGRVLGVTALGNTLDLAIKNAYSVTEKISWKNKYSRMDIGKKGLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH2</accession>
    <name>A0A087RNH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase protein</fullName>
            <ecNumber evidence="1">6.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="186" mass="21110" checksum="975079C36BD2E05A" modified="2014-10-29" version="1">MSVSVQKAALRKHLLEKRDATSAELRNISSKKIYQKLKRVDSYINSQNIACYFPIGSEVDTNNIMLDILERGKNMLLPKIVDNNLEFYSIPNLEKLEKGRFDIMEPKDSCKKAEKIDCILVPTVGISKSGDRLGYGSGYYDKFLSFTDAVKISLTYSKQIVKSIPSESYDIKIDLIITEDEIIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH3</accession>
    <name>A0A087RNH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="4">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="4">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">folD</name>
        <name evidence="7" type="ORF">AAA799O18_00352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="4"/>
    <dbReference type="EC" id="3.5.4.9" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.304"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="287" mass="31377" checksum="EBE32F8B75BF647D" modified="2014-10-29" version="1">MIGQKIDGVEVSNAVKDILKNAVEKLKSEGVEPCLATVLVGDDPASATYVKNKHKACEKIGIKTKDHKLPTETTQKHLNEIIDKLNWDKEVHGILVQLPLPNHLDEFVTVSNISPIKDVDGLTPQNIGLLSMGKSILKACTPSGIMEMFYYYKINLEGKSVVMINRSNLIGKPLYHLLLQNNATVVTCHSKTKNLKDLCQNADIIITAVGDRTKFKLTSDMIKQDAIVIDVAISRHEGKLIGDTDYDDIIQKASWVTPVPGGVGPMTVAMLLKNTVTAASLNKEIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI5</accession>
    <name>A0A087RNI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat polysaccharide biosynthesis protein SpsF</fullName>
            <ecNumber evidence="2">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spsF</name>
        <name evidence="2" type="ORF">AAA799O18_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="264" mass="30685" checksum="5AE051684A4C4343" modified="2014-10-29" version="1">MSDIGCIIQARIASTRLHGKAMLDVENQKPILYFVIKQLQECKLIDKIIVATTTNEEDNQIFNYTKNLGIDCFRGSSENVLDRYYQCAKEYSISTIVRIPSDKPLIDPEVVDSVISKFKNNSYDYVTTFSYKNPTFPSGAEVEIFSMNALKKAWEKAKLPSEKEHVVTYFTNHEEEFKMTCIKNSENLSHLRWAVDRIEDLNLVRKIVSKIKRRPILMKDIVDLLNKEPELLEINKSVNRKEGEMKSLKEDQEFLQSRPRSKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI8</accession>
    <name>A0A087RNI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="475" mass="55365" checksum="2390E99B35571DB4" modified="2014-10-29" version="1">MIGKNTMLNKSTDNLKIFLFDSSCDLKELQQSMENKNSLVITFDYESHKLLNENNINHEISDIYLNRLDLETIQKKSYELVEWFKKEKSNELEYKGINIGSIMRVEFNYFLVPFLKNFVSIIKICQTNDTAEFVASISLYEILKTLTNNVKKLNENSVTKEEFYYDSVTIPLKIKNHSFSLKLSKSKFLKLKNISEKSIHLLFGPTNLHMNEKSILLVEFDPVKYRQFFSSMSKSMSNVILYNRRRPAIWNSNSYTIIKKSNCKIATLNDLADKNLERNVKDGESLVEEKISSVLLNTVFFKSFFSIYNYSFWQIIEKKFKNLLKKRFLEAIKEIEITNKLFEKYIFSSIVVMSEIGTTEQIVVKLAKKHLIPVVLLQFGMNFDDETEGTNNMNKFQGVFPVDSDEVIVWGPIEKKHQLKNGVKEEKIQVLGNPFYDRIQKIRTSENNYILLATSGPVIENSIDLTIEEIEKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ1</accession>
    <name>A0A087RNJ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alaA</name>
        <name evidence="3" type="ORF">AAA799O18_00258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.233"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="390" mass="43334" checksum="69EA2AEF0A01E109" modified="2014-10-29" version="1">MKVSKKVSGVEYAIRDIVSAAKDLENQGRVIDYLNIGDPVQYGFQPPDNVKQALIDAVKNGKNYYSPSEGIPELRDAIAQKENSKGLSIGKENVIVTNGVSEGLDMVISSIVEEGDEVLLPGPYYPPYASYVRLHGGIPVEFAVDLENSTPDIDDIRAKITPKTVAICLISPNNPTGAVFEQSSLKKLIDIANEHDLYIVCDEIYDQIVFDEKFVGIGKVAGNSPVIVLNGFSKVHLMSGWRIGYIAFNNSSQLELIRENLPKLSRVRISTNYPVQFAALESLQGSQEYISEFVSELKKHRDFVVKRLNDMPGISCSNPKGAFYAFPKIENNPFKSDKEFVLELLKQKNVLTVNGSGFGTKYGSNHFRLVFLPNMEILKSAMNKIEDFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ6</accession>
    <name>A0A087RNJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="86" mass="9829" checksum="D190306690D06854" modified="2014-10-29" version="1">MSKIFHLSIIIATLFIIPTVTLSFAAETAGEYIDRKAEIWNLFFRMMTVAFVVGGVIAGTMVWQVWRFRESNPKSKPTPYEEKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK5</accession>
    <name>A0A087RNK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mrp</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrp</name>
        <name evidence="2" type="ORF">AAA799O18_00277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.247"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="107" mass="12153" checksum="A500FFCB3709E004" modified="2014-10-29" version="1">MAQDLKQVRVKIFDELSSIVDPEINVSITELELIDEVDIQDNNVKVDLHLTSPFCPAVFGFKICQDIHDNLLKIDGIDDVKINVSNHFMAEQINNQVNNSPNPHKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL2</accession>
    <name>A0A087RNL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-RNA-binding protein Alba</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">albA</name>
        <name evidence="2" type="ORF">AAA799O18_00284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.254"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alba" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="77" mass="8305" checksum="4AD5C8592AAF0543" modified="2014-10-29" version="1">MAYVTTTIIQLANLPSVSIKARGMSIGRAVDVAQIISRKTENAGYSVGKIQIGSETLESKDGRPRNVSTIEIEVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL6</accession>
    <name>A0A087RNL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="245" mass="28829" checksum="C68B0CCF38FBE533" modified="2014-10-29" version="1">MIIKIDHITICSTDFESDLNYFLNLGFKPSILNRKLKNLKIKNVLMKSFCKYQKFALLESNNNLDVEILGYDNVNSGTPYIEPEFINSEKCLNNFSEFKNHFQKNQIPIKFSNDKKFTGFRFGKIKIYTRSVNDSQIFWEKLGFKTISQKNNKHAKMMFNALTNNQSLELNLEYAEIKNTHYLDDRGFNCIAFITNSSVNEKEFFDKQNYQTTNIESFEVNKKKMDIFFCKSPQGEIIELISLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM1</accession>
    <name>A0A087RNM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-deoxypentalenic acid 11-beta-hydroxylase protein</fullName>
            <ecNumber evidence="1">1.14.11.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">penH</name>
        <name evidence="1" type="ORF">AAA799O18_00293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="243" mass="28245" checksum="1E4A4EB990C790E4" modified="2014-10-29" version="1">MNVEKKYIENGVLVFSTGLENNLRNIRAKFTKIFDNSARMNGLDPIKNDKDVAKFSKTNHELWVSSYDQLRFLPEVLAISNEQIILKNIKKCGIKFPVVDEIVLRGDMPYDDQWRSETHQDSDYFQGSMNSLIVWIPFQDIDSQIGPLDVVKGSHKNGSINDQGKSINDSEFTSITMKLGEALVFSQFMVHRSGKNRSDDIRFSLQLRINDLEDDEWAKRKFFFPKRKFVNSPRIDFPTYFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM2</accession>
    <name>A0A087RNM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="4">GluTR</shortName>
            <ecNumber evidence="4">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">hemA</name>
        <name evidence="7" type="ORF">AAA799O18_00299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="5">
        <location>
            <begin position="183"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="356" mass="38981" checksum="BC9F052E2FCF5DC6" modified="2014-10-29" version="1">MNARVTFRNMPLYKLANFSFKDISAACKSFNENAGSSECIIVQTSSRIEVFTVSGVHTGEIPDARRAEGKKLDVSKILATWSSLAELDQFDLDHWDQTLEIYKNDDAYEHLIRLACGLESLVVGKEEILVELKKAISVAQEVKTSGKILDKLFDTCIRIATSIRDSSGIDTGVETVGDKAVKIAEESMGNVETKHILLIGTGEIAGLVAKSLNKKGYAFDVTSMTIERATGFSKILGGNPIEFEGVLPGLDKFDIIFVATTADAFLITFDKINKVMKKKKKGTLMMDLSEPRTVDEKVATIPGIKLVNPEQIAEMIEDSTKARKSAISAAEELIKEELPIIQATMKQLSSEPLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM6</accession>
    <name>A0A087RNM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.268"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="372" mass="42787" checksum="010194CEE746A23A" modified="2014-10-29" version="1">MSGKDESVTSRNSLMGTKSGKKIMKQALFKSKGYRQFNQYKEEYETNFPEFAKRFTNDMLQQIKDDTSPNTTQQKFGEEVGSTEIILDSSQIDPIKSKLESFDVLNDRVLRILNSNFVKMTFPVFNALFDGSAEYFQDKKDPKLREDVVEGHIIAIDLSEPMDRIVDKDEDLDYLDDYKLMNPYILKLARDKIAKGGEDVLKQFEAGFKDARDGQYLDTKLKQNPTSITEKELDESYKKYRSVMGTAGCNMALLRKPLGEIFQIGMGKASESVGCGNEIEDSIRDKAVKIPSWPLYYSLSENDVRKGFNLTMKKSDAYLTDARKALNNMPENFSHRSFLEFLFLTVEHYNEFWFKKLEKADIWSDLAANLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP3</accession>
    <name>A0A087RNP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trpB1</name>
        <name evidence="12" type="synonym">trpB</name>
        <name evidence="14" type="ORF">AAA799O18_00225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.207"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="54"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFM15097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="396" mass="43404" checksum="D6101C989445994B" modified="2014-10-29" version="1">MKIGMPKDGRFGDFGGKYIPETLVPAIEELEENYQRFKNDKSFQKEFDYYLKNYAGRPTPLYFAENLTKNIGGAKIFLKREDLLHGGAHKINNTLGQALLAKRMKKKRIIAETGAGQHGVATAMACSCLGLPSEVYMGYKDTVRQQQNVFRMDLLGCKVYPVKSGSQTLKDAINEAIRDWITNVDSTYYLLGSAVGPHPYPVMVRDFQSIIGKEIKKQMKGVPDTVIACVGGGSNAIGTFYPMIDDDVEMVGVEAAGKGLKTGMHSATLNAGKKGVLHGMMTYLLQDNDGQIKETHSISAGLDYPGVGPEHAFLKDNGKVKYKSATDNEVINAFLTLTRTEGIIPALESAHAVSHAIKIAKTKSKSDSIVVTLSGRGDKDIDIVKQYLRKNVKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU9</accession>
    <name>A0A087RNU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein HinT</fullName>
            <ecNumber evidence="3">3.6.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hinT</name>
        <name evidence="3" type="ORF">AAA799O18_00172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="136" mass="15346" checksum="313048F6DF5A7E75" modified="2014-10-29" version="1">MDCIFCKIAKREIPAKIISETSNSIAFLDAFPLSRGHTLVIPKRHYEKVQDMTYDDNMDLFGMLHKIVSSVDKITGSTLLAIHNGKKSGQEIPHVHVHLIPRQSGDSAGPVHSMFKNRPKLSDKEFEELYAKIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV5</accession>
    <name>A0A087RNV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="136" mass="15742" checksum="D5437F5FF7EB68D1" modified="2014-10-29" version="1">MGLFGSRKAFCTICNKSITHKNKAKREWGVKSPLCSDCYLDKMKETYDATIIKKCVTCGLKSKVTTLWEPRWQWDMEGLLCKKCFDEKELDFNEKKNFCCICGGKLGFIRYNPKSGWKIKGQLCKDCWDAQKIQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW3</accession>
    <name>A0A087RNW3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">lig</name>
        <name evidence="16" type="ORF">AAA799O18_00186</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.168"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="330"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFM15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="585" mass="65749" checksum="75A6199605BA143A" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW5</accession>
    <name>A0A087RNW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-splicing endonuclease protein</fullName>
            <ecNumber evidence="3">4.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.170"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="PTHR21227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="1">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="178" mass="20425" checksum="4FDC4EA7DB135DEC" modified="2014-10-29" version="1">MKGELIENRIIVWNIQDAKKLFNNGYYGKPIGIPKPNPEEINVPLVLDLIEGCYLQEKSKIKIYKNKKKVSVEDVIKICRKEYHNFDKKYTVYKDFREKDYVVNPGIKFGCDFAVYQNGPGIDHAPYLIQVYNQNDSISSTSVVLAGRLSSSVKKKFILAIPGGKTQVDYLALDWWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY2</accession>
    <name>A0A087RNY2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ORF">AAA799O18_00205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.187"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="198"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="395"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="567" mass="61748" checksum="D7D85679A4D4878D" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP42</accession>
    <name>A0A087RP42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose ABC transporter permease protein TsgB13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.123"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="350" mass="36695" checksum="E0AEDC0608CFC5B6" modified="2014-10-29" version="1">MSLSFAKPTTRTIIRTLIPIGTALLAFVVTGFLLLAGGFDPLEAYGLILQGSFGGVREGGETLVRTTSLLLTGLAVGFAFRCKVWNIGAEGQLYFGAIGAVVIALTVAGQIPVFGVIIAIIFAMIFGAGWAAIAGVLKSRLGVNEIIVTVMLNFIAILFVDFLVHGALKAPGFEPQTALIPLTSQLPILIEGTRLHAGFLVAIAAAVLIYLILFKTKTGFSLRATGVNPKASGYAGINVKRSILLTLLISGAVAGIAGACLVQGVNDRLLVGISPGYGFIAIIIALLGREHPLGITFVAIFFGALMSGANLMYQTMGIPVAIAETLQAMVLIFALVGEFFARWKFKEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP45</accession>
    <name>A0A087RP45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA ligase ADP-forming subunit alpha protein</fullName>
            <ecNumber evidence="3">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sucD</name>
        <name evidence="3" type="ORF">AAA799O18_00145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="388"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="569" mass="62771" checksum="0254942B601EB29A" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP51</accession>
    <name>A0A087RP51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar-specific transcriptional regulator TrmB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.132"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="118"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="256" mass="28542" checksum="25FBF20A15E69CFF" modified="2014-10-29" version="1">MSISNQTRKSLEKVGLTSYEIKAFTSLLRNGELNALDLSQKSTLPYSKIYEVLGTLEEKGWVGSDESRPTRYFAKSPNSALQTTKQNNETEFLKNEKIIMTELSPLYEKSGTSERPDIWVITGYMNIATKILEIVESCRKEVLIAIPKAGEELVKQALPRIRQLHDKGIKITILTSDKFDKDAIKGLKRVSTVKIKKGLFGGGIISDKQYVVILLGPEVSHSSSSEIIAICTDHAALSGFASEYFEYLLKDTSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP54</accession>
    <name>A0A087RP54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.135"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="131" mass="14839" checksum="43987BF1E1B0A7FE" modified="2014-10-29" version="1">MVKIDATTSLENFRRFTLVSTCSSFAPQSYTEDAEVFPEREESLGSIYVEAADKVTLKKIRDITFVNARDVLGIIYNSKTGNTNLKWRQIRHNSGKVIGEASSNSLVNLVQSGVITREWVEKYVQKMTQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP64</accession>
    <name>A0A087RP64_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">pyrI</name>
        <name evidence="10" type="ORF">AAA799O18_00164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.147"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM15268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="151" mass="16780" checksum="9C5474C097B937C6" modified="2014-10-29" version="1">MEEETGLIVTRIKNGTVIDHIDGGKGLHVLEALEINGKEGDVITIALNVPSGKLKKKDIIKLENKFLEEDDTNKLAVIAPSSTINIIKNSQLAEKRLVSLPDQITRIFRCSNPACITNSKEHLESVIDVVDKDNLVLKCRYCSRFLDISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP91</accession>
    <name>A0A087RP91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="1">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">top6B</name>
        <name evidence="4" type="ORF">AAA799O18_00018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.16"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Topo-VIb_trans" evidence="3">
        <location>
            <begin position="415"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="612" mass="69297" checksum="D962FAE1DE35972B" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP95</accession>
    <name>A0A087RP95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="97" mass="10907" checksum="85D7F40EFCD0293F" modified="2014-10-29" version="1">MFSARLINHSNTQLLNICDSNLLGRTLIRDKFSIKISESYYGERIVEKDEAENLLRKCDNINMVGKEIISLSVSIGVGSQDGVKEIDGIPFLIVFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA1</accession>
    <name>A0A087RPA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pyrophosphohydrolase protein</fullName>
            <ecNumber evidence="3">3.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rppH</name>
        <name evidence="3" type="ORF">AAA799O18_00028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="16588" checksum="32F84A98DDC8ACD8" modified="2014-10-29" version="1">MINEISAGIVFVQNILGENKFLLLNYPQGHWDFVKGKIEKNEELYETARREAKEETGITDFQFIDGFEEYVEYDFWFKNEKIHKKVIFFLAKTDTKKITLSNEHFDYIWLVYNDALQKITYENAKNVLSKANKFLLNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA4</accession>
    <name>A0A087RPA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">purA</name>
        <name evidence="9" type="ORF">AAA799O18_00031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.29"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="333" mass="35919" checksum="1FEEBDD2AFC25D01" modified="2014-10-29" version="1">MPSTVAVGGFFGDEGKGKIISYLSKNDNPTIVVRGGAGPNAGHTIKDGKTTYKVRMLPSGFLNKHARVMIGPGVVVDPQVFFKEIQEFGVSDRAFLDRHCGIIEQNHLDQDSKGRLKEKIGSTGSGTGPANAERAMRTLKMAKDVESLSSYVTDVPDQINTALKNQENILVEGTQGTHLSLWHGTYPFVTSKDVTASGICADIGLGPKNVNEVLVVFKAYLTRVGTGPMPNELDADETKQKGWAEFGTVTGRPRRAAEFDFDLALRSIMLNSATQIAITKLDVLFPECAGVKTISDLGNEAKSFIKNIEDKLKVSVTLIGTGPLVDDIIDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC9</accession>
    <name>A0A087RPC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="79" mass="9358" checksum="C33F7455D2274CC6" modified="2014-10-29" version="1">MKENVMTSTALQFRGELKKGKLIFRVRIWIDAIASTPDKWLDDFPDGFTHYWDFDNLREAIKFHRDFNAKWGLPDPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD0</accession>
    <name>A0A087RPD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="71" mass="8452" checksum="CE2B1517EA1DEBFC" modified="2014-10-29" version="1">MNEQQKDLKKAEQELFETIISMILYLNKNGIHLDAVREMIQMKVEDAFAQYPKLAEDCQWKNRTGQYDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD3</accession>
    <name>A0A087RPD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-acyl-carrier-protein reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">AAA799O18_00070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.62"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="215" mass="23637" checksum="7748405E163A33F2" modified="2014-10-29" version="1">MKTAIVLGGSRGIGKAIADSLKSINCNVIATSKNDLDTSNLENVSSFAEKHKETDILVLNTGGPEPKEFFSVTEDDWKRYHNQLFLGFCTLLQKIKINDNGYVFLISSGVIKEPDSKLIISSAYRSAFSSVFKILSKQFAGKQISCINIAPGPIQTDRTKELIDDVEAFAKTLPMKRLGKPEEIGDFVKSIVENDIKYLSGAVIDFDGANSNFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE1</accession>
    <name>A0A087RPE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate formate-lyase 1-activating enzyme protein</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pflA</name>
        <name evidence="8" type="ORF">AAA799O18_00078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.70"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="352" mass="40050" checksum="E69B19D473274AAA" modified="2014-10-29" version="1">MSREAILYEKRPNDKVLCTACARYCEIGKGQIGLCGIRGNENGQLDLYVYGKVIAGHVDPIEKKPVIHYNPGSSIFSIATTGCNWLCRYCQNSDISQRRKVEGVDMTPEQVANTAIEHGAQGIAYTYNEPSIFIEFARDCGVAARKKGLFNIFVSNGYDTPESVKMMDEFLDCITVDFKGSAEPEFTRKFIGVPDPQPIFDTILEIRDKTKIHMEITDLIVPQAGDNLDHARKLTKFVYDELGPETVIHFLRFHPDYKMMEYPSTPIKTLEKHYEIAKSEGLKYVYLGNVPGHPWEHTYCAGCNEIVVKRFGFDIQQWHLDKNNKCKFCGNQIPITGSLAKDYKQERFQFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE7</accession>
    <name>A0A087RPE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="55" mass="6534" checksum="060145BB75F74F65" modified="2014-10-29" version="1">MCECPKIHFYEVEFKLDGMIVVPTHKNCGDRLNEKQADNFQKELVKSWGFQEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE8</accession>
    <name>A0A087RPE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="291" mass="33729" checksum="9C04AE0AD01EDE83" modified="2014-10-29" version="1">MDVKKLLERLSIKDYPVGIGGCRNNDLWYDCCEFDLTIFDGKNQSESILEYDGTFYQIYHGTLTETSPEILLQYHNMTILLDDQWELRILLSKIKEKQEQLFNSYVKNCLIEAGVCITKAKNGLDIDAYASSWLKCAAYFLADAISAKNFLRPSPTHMLKFLREFDKNKINEFISVLTESIGIERATPSLLSRMSKSTMGFSDMIENNSHSRIISQKYHYLKNRSLFTDCYFYLGYINRNNFIKIKNLHRKPELIHILKTAFDLESDPARIESQANKLKQATNSLLSLIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF1</accession>
    <name>A0A087RPF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.80"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="4">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="164" mass="18434" checksum="867B7C8867589A28" modified="2014-10-29" version="1">MHGECYRRANGQPYTRKEYIKGKPQIKIAKFESGQKGNYDFIVQLLINEKIQITHMALESTRLTANKTLEKTTGETGYFSKLRLFPHILLRENKMIAAAGADRLQEGMRRAFGKAVSLAARVEHGQCIMEMHVKKEHVEVAKKALKGACVKLPGTPSIKVVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF6</accession>
    <name>A0A087RPF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose synthase catalytic subunit UDP-forming protein</fullName>
            <ecNumber evidence="2">2.4.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bcsA</name>
        <name evidence="2" type="ORF">AAA799O18_00103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.85"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="676" mass="76484" checksum="82DBD01F2125E7BA" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG4</accession>
    <name>A0A087RPG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ORF">AAA799O18_00111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.93"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11365">
        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="272" mass="29412" checksum="F7D4137242DA6886" modified="2014-10-29" version="1">MVELSIVDKLKRSKILDLLQEGKRIDGRGLDEVRPLSIDTGVVPNANGSARARLGDTEIVCGVKIQPDKPFPDMGDKGIFICTAEILPLAHPSAETGPPTPDVIELARVVDRGIRESGMIDLSQMVLEEDKFVIGLFADNVVTDHDGNLFDACSYASVAAVMTSKIPKWEMKNDKPAIVDGETLDAPITTIPISITMGRIGEFIMIDPNLDEWGCMDARITITTNSDGNIVALQKGGSAGFTFEQLVKCSELSISTGSKIREIIKQATEVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG8</accession>
    <name>A0A087RPG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome complex RNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="62" mass="6907" checksum="D393CDD49B024641" modified="2014-10-29" version="1">MIQTIEASTNTTITIGQNGLIILKSDNDVDLKKAIALIKMMDKTLDDTNLEECIQNILDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL24</accession>
    <name>A0A087RL24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000046">
        <property type="protein sequence ID" value="KFM14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="187" mass="21467" checksum="0BEEBAE76123CCC0" modified="2014-10-29" version="1" fragment="single">MSQEAERVYTVNLGKVLLSPDNQRAKRAINMIKEFARHHMKTEEVKLEEEVSHLIWSRGIRRPPRKIRVRMTKTDEGYILISKYEGEEEAEKKEEKLESKPEPTAKPESKPESKPEPEPTAKPESKPESKPEPTAKPESKPEPTAKPESKPEPEPESKPEPTAKPESKPEPEPESKPEDEPDFFKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL26</accession>
    <name>A0A087RL26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000046">
        <property type="protein sequence ID" value="KFM14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="92" mass="10159" checksum="7048DDCCD688F342" modified="2014-10-29" version="1" fragment="single">SCLKKSGSSSGFDSGSGSGFDSGLAVGSGFDSEVDSILHIPFDPFLKTMAEDRHPEHRSIKEMYTFTFGKYQIWGASARMLRQIFMLLSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL38</accession>
    <name>A0A087RL38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl11</name>
        <name evidence="5" type="ORF">AAA799O18_00760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.648"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L11" evidence="4">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="92" mass="9677" checksum="85B5DC207233A56A" modified="2014-10-29" version="1">MGNRTASALLLKEAGIQKGSGTSGSEWVAEVSVDSIAKVAKVKLESSYANSVKSVAKQIVGTCVSLGIKIEGKTPKEFTAEINEGKWDSKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL40</accession>
    <name>A0A087RL40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription elongation factor Spt5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="3" type="ORF">AAA799O18_00762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.650"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="161" mass="18147" checksum="AE368BF0B2F445BD" modified="2014-10-29" version="1" fragment="single">EKIVMRMLEARIKLDQKDEEEIAKSKEGGKEIEIDPAFPRVKNVQSVLLLDDLKGYIVVEAEDASSMFNAVQGLRHVRGQLRGELTYNEIDKYLIKKSTVSELAVENTVEIIGGPFKGMKATVTRIDHEKEEATVVLLDASYQLPVTVDANYLKLIRQSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL43</accession>
    <name>A0A087RL43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism protein</fullName>
            <ecNumber evidence="6">4.2.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">queD</name>
        <name evidence="6" type="ORF">AAA799O18_00754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000041">
        <property type="protein sequence ID" value="KFM14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="117" mass="13357" checksum="43541F8442A64BE8" modified="2014-10-29" version="1">MQTKIGVEFEIDFAHTLKGHPKCGKPHGHTSRIVVEASGELRKGATYEDNMVIEFDEMKKTCWGVIQQLDHADLDDMFDFPTSENIAMWIFDNLKDKIPISGVKFFEGSNKYCEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL54</accession>
    <name>A0A087RL54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="5" type="ORF">AAA799O18_00744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.638"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="99" mass="11647" checksum="24C6008195B21A8E" modified="2014-10-29" version="1">MKSYDHIVIWLDYFNKTLSRKKGRRLPKDKCVFDPSLKELIESSNDAGLKPTETNDQVRFPKRAYVRSGYIILEKKFSKTKILNKISEKLVIKRAKQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL62</accession>
    <name>A0A087RL62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">nadE</name>
        <name evidence="8" type="ORF">AAA799O18_00739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.633"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="256" mass="28836" checksum="3DF00F06C831F4A8" modified="2014-10-29" version="1">MNQEIQQEILRQDYAKIQQNIESFLKNQVSQKKANGVVFGLSGGIDSTTIACLCSKVFKKNALALVMPDSAVSPSSDTGDALKIIGEIGIDYKLIDINTIHKRYSNYLEPDELALGNLRARIRSNIIYYYANLKNFLVLGTSDKSEYLIGYFTKFGDGSADILPIVSLYKTQLREFAKNIGVPDNIITKKSSPNLWKGHDAEEEIGISYEEIDSVLYCLIEKKLSVDETIQKTEISGKSVEKIYQMYQKSQHKRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL72</accession>
    <name>A0A087RL72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-isopropylmalate synthase protein</fullName>
            <ecNumber evidence="2">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000034">
        <property type="protein sequence ID" value="KFM14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.622"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="398" mass="44262" checksum="AEE641EE98EE38AF" modified="2014-10-29" version="1">MNDPNYYAEEYNSIEKEPRRIRILDSTLREGEQHPGVSFTVKQRIQIAWELDYFGVDQIEISPIISPDHAEATKTIIKQGLKADIVAHGRALKEDIDASRKCDASWVAAYLGISDIHLKDKLRISRDEALNRAVKTVEYAKSHGLKIRFTVEDGSRADPQFLIKVCKAIEDAGVDRISLPDTVGILRPIGMYNFVKSVRSEINTPLDAHVHNDIGFALANAFAACDAGVDQIHTTIDGIGERTGIPSLAETAVALTYLYKSPNDFRLDMLGDLSRLIEQYTKIKPYDSKPIVGSSAYKHKAGTHLAAVLKNPAAYEPIHPRSVGNRRKIVFGELAGKTGAEYLMSLLGMKEDVDNAKNIAAGLKNIRMGDLLEIPLEEQTKETERKIINDEKGRKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL73</accession>
    <name>A0A087RL73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator LysM protein</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysM</name>
        <name evidence="5" type="ORF">AAA799O18_00721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000034">
        <property type="protein sequence ID" value="KFM14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.623"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="137" mass="15365" checksum="09851E1A0622BB44" modified="2014-10-29" version="1" fragment="single">RDKTDERILEFLQKDSRESFVEIGKKLKMSESAVRRRVKNMVDNRTIEKFTVQVGEADSTSAIVLVSVDSSIDTSKVSAKLTKLNAVKTVYEITGQYDICVIVRAPNITEINKCIDDLRKISGVIDTNTVIILKTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL77</accession>
    <name>A0A087RL77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine synthase protein</fullName>
            <ecNumber evidence="1">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000033">
        <property type="protein sequence ID" value="KFM14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="94" mass="11062" checksum="9BDEFA4AFD1F83DA" modified="2014-10-29" version="1" fragment="single">MFDMNKTFLRCRECKKEYDSTFKYICDDCFGPLDVHYNFPTITKDTFTSREQTYWRYFDLLPIIDKSNIVSINAGMTPLVKAEKLGKKIGLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL83</accession>
    <name>A0A087RL83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroquinate synthase protein</fullName>
            <ecNumber evidence="3">1.4.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroB'</name>
        <name evidence="3" type="ORF">AAA799O18_00708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.614"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102042">
        <property type="term" value="F:dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="350" mass="38922" checksum="F444EF3DCA9AA448" modified="2014-10-29" version="1">MVTSKQLIIHPNVAKNQLVRFVKNLEEEGVKLVYADPKNLAKTKIQTIFPSQNANYIILDKTTKKPKGKKIGKRFKVLSNKDIERIFDSAKKGLDFVIIEVKDWKIIPLENIIAKLHKLHTKIFAIARNPKEVRKMFSILDVGVDGVIFNTGSINEVRNVMVYLGSKRFDLSAAKIIDIQEVGDGERVCVDTASMLTAGEGLLIGSRANFLFLVHNESVGSSFTSPRPFRVNAGAVHCYTLSPDGTTKYLSELETGSEVLVLDSKGKARRVAIGRCKIEKRPMLMIKAKVNEETGGIIAQDAETIRFIKSNGHLVSVTHLKKGDSVLVYSKPATGRHFGMEVSNEYILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL87</accession>
    <name>A0A087RL87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23-bisphosphoglycerate-independent phosphoglycerate mutase protein</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apgM</name>
        <name evidence="6" type="ORF">AAA799O18_00695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.602"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="393" mass="43246" checksum="E6300ABDA4892381" modified="2014-10-29" version="1" fragment="single">TPNLDLLTRNGTMGEVISVGKGIAPESDIAVFNMLGYKFKHDDYVGRGVVEAIGIGIDFKDGDLALRGNFATLNNDGVIIDRRAGRKIEKHDAESIGKEIEEKLEFSDQNTSVIVAPTIDHRLVIRIRSNVHLSSNITNSDPAYVRVAGMGIAKAVADFMKIEKCLPLDEEPNSKVTADLVNEFTESSLNIMKRSKVNERRRKDGKKLLNSILLRDAGNRFPKVTPINDLHSLKFSCIVDMPVEIGISEILKMKAYSAGGLTDYEKKAQVAAKALDEQNAIYVHLKGPDEFGHDGDAHGKMKNIEEIDKRFFGTLLDNIDTSKDTVIISADHSTPCIKRGHSDDPVPLLISGDMVPNDNSQRFTEKEAKRGKIGLVEGVQVVKTGIDIIKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL88</accession>
    <name>A0A087RL88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.603"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="182" mass="21134" checksum="E079D99A839DD92E" modified="2014-10-29" version="1">MIHLKNSDYSPKDAETIRSNARDLSYGMNLTIRDCRVSSKFIELDISIPKNNLELLLEKLLPIGKVDHSRHIIEEQIEKNQSIKDGIFYFNNERFWESHEALEGAWKQCIGDEKELIQGIILVAAALVHYQKYENEICLSVLNRALKKLHDKTGEYHDVNIDSIKQKIIEILDKKEIVTFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL93</accession>
    <name>A0A087RL93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pus10</name>
        <name evidence="4" type="ORF">AAA799O18_00701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="391" mass="44675" checksum="176542EF3267A95C" modified="2014-10-29" version="1">MQKHSMIEGYDKILLRSKSILKEYTLCDNCLGRFFIKLTGFSSTSRLGNRIKRSLNFKTITKCYICKNIFSLTDFYVKIMQDASTGYVFSSFLVGAVLKRSLVEKDDKIRSKFRLRGADGIKTEITREFGKRLSKKTKSNLVHLLPDITFTMNFRTEKCEVKTKSVFLYGRYLKNKRGISQKQESCQDCKGTGCIFCDNHGITHFDSVEGKISQFLYEKFGTDQVKFTWIGGEDKTSLVKGKGRPFFAKLLSPKRQNVKLSKKSVFDGITINGLRTIDHIPQGSIPFRSKITISIITKKSVPSDKLKKLKQLENISITLIDKRGKQIKKTIYKLRYKKNSLHSHTINIDADGGLPIKRFVEGNNVVPNISEILSVECFCKKFDINQITLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA7</accession>
    <name>A0A087RLA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="349" mass="39466" checksum="24889A326583B97F" modified="2014-10-29" version="1">MNKIPIFFLLFLVTSMVFVTTPITVHADSQLDILIKISLNTKEHIKTDIEKAADISKEAYLQFDEGVKETDLLIEAAEAGDVVSARQHFISAMVAFKKVSIATETVADKSQQSLTPDRSQTIEKYENNIIKLKEISDKLNAGVDFEQIDQLLDLAKNNYAQGSFVQNEKVLSQIASEGREIHKLLYEISEQSKIYRAQHFAKKQAERITDLILEAKQIGLHQTAIDLEESKVQLLQANSTQVIKQQFKIIIIHKQKVDNAKDLQQAILDSLENKAKKLASDVEVNSGAEYFLKKAFSLIEDVRMDIKDLEYAPTMMRDDSKYVDLTIGSKIKTIKDILVKVERLAYTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB2</accession>
    <name>A0A087RLB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase protein</fullName>
            <ecNumber evidence="2">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bhbA</name>
        <name evidence="2" type="ORF">AAA799O18_00679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.587"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="359" mass="40933" checksum="39216D7327ABD3B1" modified="2014-10-29" version="1">MKEYVARNTYIYPPQPSMRIIGDMIGYCAKNVPQWYPISISGYHMREAGATAVQEIAFTIANGIEYIQTCIDRGLKIDDFAPRLSFFFCCTIEFFEEVAKFRTARKIYAKILKERFHAKNPKSLQLRFHTQTSGESLTAQQPDNNIVRVAVQAMAAVLGGTQSLHTNSKDEALALPSQEAAKIALRTQQIIGYESGVTKTVDPMAGSYYMESLCDEIEEQVWDYLKKIDKMGGALKAIEKGFFQSEIRQNAYRLKKEVDDNERILVGVNKFSEESEKKHDLLRIDDSLGRKQEKAIKQIRKSRDNKKTEYALSKMQKAAETDENLMPFILDAVLAYATTGEISNTFREVFGEYRPKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB8</accession>
    <name>A0A087RLB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-octaprenyl-4-hydroxybenzoate carboxy-lyase protein</fullName>
            <ecNumber evidence="2">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiD</name>
        <name evidence="2" type="ORF">AAA799O18_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000027">
        <property type="protein sequence ID" value="KFM14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.583"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="480" mass="53551" checksum="FDC012D9BF5B9FD1" modified="2014-10-29" version="1">MPIDDIQQFIEKLEKDGQLKRIKTEVDASLEIAEILRRVSYTKGPAVLFENVKDYEMPVLGNAFGSIKRLEIGLETTDFSEIGQRIADMTKMEIPSGIFNKIRKLPELSKMSESFPKLEKDGPVTEIINQSPTFDNIPILKSWSKDAGKFITFGLVATKHPETGVRNLGVYRIQIIDSTHALMHWQKHKRGAAHHDLSKEKNNKIETAIVIGGEPATVFSAIAPVPEGLDKYLFAGITRKKGIKTVKCKTVDLEVPANAEIVLEGYVDAADVRDEGPFGDHTGYYTPKEPFPTFTLTGIMQRKKPIYLTTVVGKPILEDAYIGKAIERSFLPLIRMLHPEVTDFSMPPAGWFQGLAIASIKKRYPGQAKKVMMGLWGMGQLALTKIIIIVDHDVNVHDMNEVIWAITTRADAARDTIIIDNTPTDTLDPASSRVNLGSKLGIDATQKTKDEGFEREIQEQVMVDDNTKEKVDSKWSSYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC5</accession>
    <name>A0A087RLC5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="115" mass="12758" checksum="F1F82925DAA00D24" modified="2014-10-29" version="1">MLINNFKSLATTKAKKDALQILEAGLAASEPKKFLRNFVKKNEINVGKIHLILSNYEKILVVSYGKAADLMAEFVSEKVNVSQGIIVIPKYTKSHFTNXXXXXXXXAILYLIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD4</accession>
    <name>A0A087RLD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="76" mass="8207" checksum="BC235DE223D0C5AA" modified="2014-10-29" version="1">MATSKAKRSAAAKKAARTRKRNAAKRKAAAKKAAAKRKRRAAAKKGGRRKAAKRGGKKKGGKKKGGKKRKAAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD8</accession>
    <name>A0A087RLD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.552"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="96" mass="11054" checksum="E6CAA0C9FDF8AA19" modified="2014-10-29" version="1">MVLDAEFIKQTNKLISETLELYRTAGASPRIGKVWKCKNTGDFLCGFFVGEMVGSALSAFQVFHKREPTPDEHMQIVEIVEKYNEEIIEFFSQFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE6</accession>
    <name>A0A087RLE6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="6" type="ORF">AAA799O18_00648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="67" mass="8106" checksum="D1D4C93ACD930CEA" modified="2014-10-29" version="1">MVNLKNKTIREFNQKDLQDKLEQMRTELSKLRVESKKGTLRKESGKLRKYRKNIARIMTRLNELTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF9</accession>
    <name>A0A087RLF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.542"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="544" mass="58167" checksum="6F93824EB8C23F82" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG4</accession>
    <name>A0A087RLG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase protein</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroE</name>
        <name evidence="2" type="ORF">AAA799O18_00619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000023">
        <property type="protein sequence ID" value="KFM14318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_C" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="91" mass="10196" checksum="AA929142D6A5883F" modified="2014-10-29" version="1" fragment="single">SEYKFIINSTSLGMKNEPSPISTESIGKNSIVYDIIYKPVNTDLIKKSKENGATIIYGYEMLLSQAACAFEIWHKMPAPYDAMKRILLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG9</accession>
    <name>A0A087RLG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="104" mass="11782" checksum="3D0B10CCD9CF3B14" modified="2014-10-29" version="1" fragment="single">MTFQFYKNVSYYNELSSDQLTKVYDQDKRLHGMVKITTKRGTSTANVENVKNWAGETFKQFQKDQLKAAGPNVDLVQKRGTSTIKVKDIPVVAQPLVKGQKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH5</accession>
    <name>A0A087RLH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase RhlB protein</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.533"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="339"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="498" mass="56688" checksum="4561AA40D8C4557F" modified="2014-10-29" version="1">MLMTKNVEHEFIVPNSIEERDYQINLALHAKTENSLIVLPTGLGKTTVALHVIADFLSKRKGGILFLAPTRVLVNQHYEFLVNTVKLDDIALITGEDLLAKRKKLWINSIICATPEIARNDIIRKIVDVDQFSLVIFDEAHRAVGDYAYVTIAERLNICNTRILGMTATLPSEKEKAKEVCDNLHIKGIAERNDSSPDVKPYLQDTSTEWIQVDLSPEMRIIQRYIKLALDQRYKELRRNGLRLSDNKSLSQLLNARQFVLKQNRRSAKPLFTAIRITYALNIFEAHGITTFLKFCERTKNKKGAGIKELFESDPNFTTAINLAKDAQAKNIEHPKINKLEEILRNTDSKILIFSSYRDSVNVIHKKLVDMNISAEILIGKAGDAGLKQKKQIEIVQKFRDGITKVLVATRVGEEGLDISDVNMVIFYDNVPSSIRFVQRRGRTGRKDSGHLIVLIAKDTIDEAYYWIGKRKIKSASNMADKLTKHLEKTDRVIDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ2</accession>
    <name>A0A087RLJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="85" mass="10091" checksum="DB9CAFE306F9C51A" modified="2014-10-29" version="1">MKIFYQCVPKIDMEPKGYELLKIETKINMLEKELTSHFDDLKKCEIDESSISENSTYKKLQKMNNCCLKLLETYREYASKLKNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ3</accession>
    <name>A0A087RLJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein AsnC</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asnC</name>
        <name evidence="2" type="ORF">AAA799O18_00593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.514"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="79" mass="8840" checksum="751E33E45AF02829" modified="2014-10-29" version="1">MAEAYVLINCEIGSEEKVITELKNIDGVKEVHGTFGAYDVLAKVESEQVEALRETITWKIRKIDKIRSTLTLMGIEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ7</accession>
    <name>A0A087RLJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein BirA</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="2" type="ORF">AAA799O18_00597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="149" mass="16799" checksum="B0849D5690766D97" modified="2014-10-29" version="1" fragment="single">NDLTLKGKKIAGILLDTSLESNKIEYLVLGVGINFKIKPYKLEKQLKKTPNFYGVASLVKKNEKPLMLVKQFLYELEKFFQMINSGYNKKIIVEWTKRSSTIGKKITIPTDTSRITGKATKIDTDGALIISRGNNTTKVLVGDVLYKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM54</accession>
    <name>A0A087RM54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine deaminase protein</fullName>
            <ecNumber evidence="3">3.5.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ade</name>
        <name evidence="3" type="ORF">AAA799O18_00581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="159" mass="17533" checksum="0B78D200D403693A" modified="2014-10-29" version="1" fragment="single">MFLGLPSAIRNLNAVAIGDKDADLVLENCSLVNVYTREILPDIQIAIYQDRIAYVGQDASHTRGGKTAVIDLEKKYVTPGFADPHIHIDQFVSPTEFAKKSLLCGVTSLFSDPIDIVSTCGYTGFKEFIKMTSELPVRFFHMVPGGLPVDRKFSHGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM76</accession>
    <name>A0A087RM76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-hyrolase-like domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="308" mass="34329" checksum="69D2C3E0644C7223" modified="2014-10-29" version="1">MKSDEFDSIIFDCDGVLIDVTESYDTTINKTISYVLKEVANITVDTPLTNELLLSFKSTGGFNDEIDITYAGILCFIAAEKLNKNPTELIFDVINNADDSGIAYVENFLKKIDVDVSDVEARLNYPSIGKNDLIHSTFDQLFFGPELYGKVFQKKSKFSEKGFIENDNVIVTSELIEALKKKFNDKIAIVTGRGFNAISSSLKGILNKFNVENSVFLEDESRDLAKPNPQSLIRSMKGLNSKNCLYVGDSMEDMILAQKATELGFQVSFCGIYGSGKLPEMKKNMFIKKNASFILESINFLPKALNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM88</accession>
    <name>A0A087RM88_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csl4</name>
        <name evidence="5" type="ORF">AAA799O18_00562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.488"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="182" mass="20089" checksum="CF168E4B968E2DB9" modified="2014-10-29" version="1">MSNSVLPGDKIAIIEEYETGKNSYNDGEVIRSTVVGEGDIDKKERIVNVKNLKSTSVPKSNDIVIGTVAAVMGSMFIVLVKFINSKPVKSQVECICSTTNIRKRNIALVNDLVKIKILGELNGAIHGTINSPDLGVLFTKCRKCGRDVKPLRDIIKCIECGWTDDRKLSSDFLKSDFIVMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM92</accession>
    <name>A0A087RM92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase protein</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">AAA799O18_00566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.492"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="286" mass="31477" checksum="CAC2C6ADAA3AE79C" modified="2014-10-29" version="1">MISYMNKLGSVPVGNSNPVRIMGILNTSPESFYKKSISISKQRIIDAVHRMEQEGADFVDVGGMSTAPYLTTMVSEKTEANRVIKAVKIIQQASNLPISVDTCRASIAREVLELGVDIINDVTGLKYDPMMSKIIEKYCPSLVLCAFSKQITNGNQVLKTKNLLKASLKIAKSANIPRSKIVLDPAIGFFRRKGRGAIFTRINSDWVKRDLLILKNLKLIKLNNPILVSVSNKSFIGKILKKANPLDRLAGSLAAEVVCILNGADIIRTHNVDKTKEVITIVQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMI8</accession>
    <name>A0A087RMI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="75" mass="8953" checksum="3E582771BE07F419" modified="2014-10-29" version="1" fragment="single">TKEAADKVTLVQLKNLKFRRSLARKRNRSSEKVKKKLKTSVLYSKIKRLVRKKKSSSKKAKKKRKTSVKKKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML3</accession>
    <name>A0A087RML3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyceraldehyde-3-phosphate dehydrogenase protein</fullName>
            <ecNumber evidence="3">1.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gap</name>
        <name evidence="3" type="ORF">AAA799O18_00540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.471"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="350" mass="39938" checksum="49E00A24CEC81297" modified="2014-10-29" version="1">MKKVFVNGYGSIGSRIAKFIKDDSDIDIIGIGKYTPDEKVQQAIDSGFSVYVPKDKITDFNNHNVSGSIESILSDCNLVIDASPGGHGFLNKKNIYEPNNIMAIFQGGETTFGNNAVSDILFNSRVNYVDAFEKKYVMQGSCNVTGMGRILNPLREKYADRLTRFDVTLIRRWADLEQTDKQIVDTIEMTENPHHGADVKAYLGKDAPLFVRAIKVPTRQMHLHIMDIRFKNNTPTSDEIHDLFRNEYGVAILYTANGTKDIRDFAESTKFNFKDTNMAHIHANMTKTTKDTVQLMYSDDQTGIVIPENHMLLQAMLFQREYDEAVKHTDELFHMDEKKKLLEEYFAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMM6</accession>
    <name>A0A087RMM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="40" mass="4855" checksum="A06AEC3703560351" modified="2014-10-29" version="1" fragment="single">MYTENEEDANNFKEVLLRWQTKSQQQKPSDLIRINKTKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMM8</accession>
    <name>A0A087RMM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB protein</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="3" type="ORF">AAA799O18_00520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.452"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="150" mass="17353" checksum="DAE1C55FE20085AD" modified="2014-10-29" version="1">MNWKDLNQRNVRKKKEEELADKIIKTDKEWKNELTPEQYNVCRKKDTEIPFTGIYWDCKDKGIYRCSCCYAELFDSKTKFDSGTGWPSFFEPIISDNIECVNDTSGGMLRIEVNCGKCGAHLGHVFDDGPQPTNLRYCINSISLHLDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN0</accession>
    <name>A0A087RMN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tRNA pseudouridine synthase B protein</fullName>
            <ecNumber evidence="2">1.8.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.454"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="158" mass="17849" checksum="AB9D074E2A5B5333" modified="2014-10-29" version="1">MKSNLISKSETAQILLQINSQWKIQLPKLKNVKFHYVDGKGIIITGTGFTAVKIGEDILPFLDDTQTLEKFPNVVVDMGAIKFVCKGANVMRPGILKFSDFESGEIVCVTEESHHKFLSVGKAKISSEEIKKTEKGEVLKNLHYISDDFWEVKKEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN3</accession>
    <name>A0A087RMN3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">nnrD</name>
        <name evidence="2" type="ORF">AAA799O18_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.457"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="286" mass="30329" checksum="0E5467B56E145A59" modified="2014-10-29" version="1">MSSTITSKLVKKFVPVRKSSSRKGDNGKVLVLGGSYIYHGAPALSSLAALKTGADLVYTCVPKINVQSTRAVSPNLIVIPLVDSKLTRGAVNKLLGQIPDDLDSATIGMGLSIQDPEALKLLVKSLLDRDVRLSLDATALVNYILPLLSGKNVVVTPHAGEFKKMFGESPPDSKNARITMVEKFAKEHSITILLKGQTDIISDGAKTYLNPTNTPGMTVGGTGDILSGIIAGMLARNRNTLESAVISAYFNGLAGKSTQKKLGPHMTATDLLDALPSVMKSFDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ2</accession>
    <name>A0A087RMQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C5a peptidase protein</fullName>
            <ecNumber evidence="6">2.4.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">scpA</name>
        <name evidence="6" type="ORF">AAA799O18_00491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.43" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.424"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="336" mass="37339" checksum="C182DA68F34EC350" modified="2014-10-29" version="1">MLLSDVKGTLDIFYHPDFVSYFSSRGPVSPFYIKPDVVAPGAFINTTDINKNYNISSGTSFAAPHVAGTAALILQKNPQLTPEELKSILMTTSDKVSDQYNKKFPIEVAGTGRINASKAINAEIIITPPNLIFNLSADNQIQTKYLKIKGINYDTMSVRFEDKQVADFDYNLDNQNLVINAKLIQQSLGEFENRMVITHNKIDYDIPIIVRVSKATIMVNDDNGKLSFDVSSPTSWSYAKISITNKETGKKFTESIAPNKNSELTVYEPGEYWIEAKIKDDDKTLSAYATIQVEKIEHGGKNLANTLNLPEKPFLIIASIMIVTVIVGLLARRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ7</accession>
    <name>A0A087RMQ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ORF">AAA799O18_00496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.429"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="152"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="303" mass="33797" checksum="F4BDAFF02910BA27" modified="2014-10-29" version="1">MKLVTKDLLTGDEISSKEFLKLIDFSIKLKKQNKTGKEKSLLKNKTLAMIFEKPSTRTRVSFEVGMSQLGGHAVNLSSNQMQHSRGESAEDTAKTLSCYVDAIVARVYEHDFIEELAKYSTIPVINGLSNSYHPCQTLADLMTIKEHKKKFKDLKIAWIGDGNNVCNSLIFGCSKTQIQISIATPKGFEPNSDVVKKASKYTTVNLTTDPELAVRDADVIMTDTYVSIHDSDAKSKKFLPTFQVNDSLMNKAKDNVIFMHCLPAKRGYEVTNSVIDGPQSVVWDEAENRLHTEKALLISLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR2</accession>
    <name>A0A087RMR2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">secY</name>
        <name evidence="15" type="ORF">AAA799O18_00501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.434"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="14">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFM14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="484" mass="52363" checksum="5F57F859AC46C29C" modified="2014-10-29" version="1">MAEGTITNYVRKVVAKAEPYLPQIPKPKKKVPLQTKLLWCGACVVVYMVMGQTPLFGATTPEFDFLAFARVIFASQQGSLVELGIGPIVTAGLLMQLLRGSDILKFDFKNPEERGIFQTATKMLTYIVICIEAPIYGLAVYGANIADPTVMGILIGQLIAASIFVMFMDELIQKGWGLGSGISLFIACGVAQQILWSLFSPLPAGDGGPIGILPYIFELGFLDASTGMFGHNLADAIFRSNQLPSIFGLCLTAGILLILVYTQGMKVEIPIVSTKYRGFSATYPIKLMYVSNIPVILASALTANAVFIGQMLWAQLNPRNASPFFNILAQFDPTSPSSPIGGIVYYITPPRGLELVALDPMRGVLYVLFMIGIVVVFGKLWVELGGLSSKKAAQNLLDADVQVPGFRRSNKPVEALLNRYIPSVTILGSVILGLIAGVSDILGVFGSGIGILLTVDILINYYNQLVREKVELVMPRLGAWLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS6</accession>
    <name>A0A087RMS6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="6">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AAA799O18_00515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.448"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="131"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="422" mass="47149" checksum="571C222CF1C10C24" modified="2014-10-29" version="1">MAKIWVEAYGCSASFADSEMISGLIVNGGHTLARSQSESDLNLIVTCSVKDATATKMVHRIKQSESKPLIVAGCLPKAERHTVEKFAKNASMMGPNSIGKTLEVVETTLSGSKVVALDDTDLSKVGIPKIRLNPIVGIIEIANGCMSECTFCQTKLAKGDLNSYRVGDIVRQVRKELDDGCKEIWLSSTDNGCYGFDIDEDISSLIHKVSQIPKDFRIRVGMMNPMFMPRIRDNLLKSFENHKVFRFLHVPVQSGSNDVLNHMKRGHTVETFKDVVKKFRTKFGPFTISTDIIIGYPTETQENFEETITLLKETRPDVVNISRYSQRPGTVAAEMHQVDVMEVKRRSKQLTELINDISFENNRKWVGWKGNVLFNENLGGQVKGRNFAYKPIFVNEITEIGQICIVRIVDATTHSLIGEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT4</accession>
    <name>A0A087RMT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.410"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="115" mass="13395" checksum="B8F1E23DA8CF5B35" modified="2014-10-29" version="1">MRARLTYVPVDVADQFADFIIERDEQVLDAVKARTRDYSTLSLIKLLYQLRGNPMTFSDLYAKSKIRMKKSFLNYLHLCLNYKFVTKKPVGANVIYTITEKGTNMLGMFIQNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT7</accession>
    <name>A0A087RMT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.147</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cofH</name>
        <name evidence="11" type="ORF">AAA799O18_00480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.414"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="67"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="417" mass="47147" checksum="48C74709ACA16FD5" modified="2014-10-29" version="1">MTLEDTNLDSKLKHADPIIAGILNDALSEKEIDIKDAVMLFSTKGIELELVCSVADELRKRRVGDVVTYVVNRNINFTNVCIKQCGFCAFSRDFREEEGYLLPVEEIVRRAKEAHELGATEVCIQAGLPPDMDGELYEKICREIKKEIPKMHIHGFSPEEILYGATTNGITIRDYLLRLKNAGVGTIPGTSAEILDQKMRDKISPGRISVKDWIKIIKTAHKIGIRSTSTMMYGHMESYVDRANHIGIIRKIQKETGGFTEFVPLNFVHTEAPMYKHGLHKGIQPGADSDDIMLTHAVSRIMLNNCIDNIQMSWVKTGEKMSQRLLKCGANDFGGTLINESISTAAGSQHGQLLKPKQIRRLVRDVGRIPAERNTTYKILRTFENEPKEEDLDNVDDSKFGSYFDLIKIKKFRYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN27</accession>
    <name>A0A087RN27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative uroporphyrinogen-III synthase protein</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemD</name>
        <name evidence="2" type="ORF">AAA799O18_00444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.381"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="206" mass="22741" checksum="BADB46B53E09BA31" modified="2014-10-29" version="1">MSSKAVSLLFDTAKSVDKFEKLRLAVANTTVIAVGPKTRSVLEKENVKVAHMPQRYSSVGIGEVITKLNAVGKKVIVPRSGASTPFLKDLLEKIGLSVIELYLYDICTFSDTSQWNEFRNLFSQNKVDGIIFTSASSVNAFFEIMTKDRDEKKLVEMLQKTTIVSIGPFTSDELKKFQVKNIIADVHTVPGSVEAMDKAFSLAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN37</accession>
    <name>A0A087RN37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OB-fold nucleic acid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="97" mass="10937" checksum="802BF4A2F2F746D4" modified="2014-10-29" version="1">MTTCEEAKQMRTGINITAKITDKGEPRTVNTKYGETQVCDAYLEDDSGRIKFTIWGDDIQKVKNGDQVAIENGYTTTFRNEVQLNKSRNGKMEVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN41</accession>
    <name>A0A087RN41_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">AAA799O18_00463</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.395"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="169"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="317"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFM14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="418" mass="46756" checksum="CFD3779A5D88B9E7" modified="2014-10-29" version="1">MKQNIINARVTFRKSPIHVLEKFAFKDMPDACLAFKKNSSVSECVIIQTCNRIELFATSDNHNVDEIKNTWALLTGLEDNAFKDTLEVCENKDAYEHLLKLTSGLESLVVGEEQILGQIKESISLARDAKASGKRLNKLFERSIRIGTRIRNSTGIGRGGISLGSMAVKLAEENIDNIKSKHVLLIGTGEAATMVAKSLKKRGYAFNVTSRTLERSIGFSQTLGGKPIKFEDVLSGFSNYQIIFVATTAPYFLVSFDRMKDAMKNKETGTMILDLSNPRTVDEKVATIPGIKLMNIDQIAEMIDKNMEKRRNKVSTVENIISEEVPIIEATMKRLDAEPLVKDVFTNADSIRMKELRKALQMLGETDEKRIKIIDELTKSVVESIVSAPMNNLRKASEQGNPELLDIASKLFNYKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN42</accession>
    <name>A0A087RN42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysG2</name>
        <name evidence="7" type="ORF">AAA799O18_00464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="181" mass="20808" checksum="92CB97B2992261C3" modified="2014-10-29" version="1">MISNKSNSQIEKHAKQGKIKFKKIKLNDARFLSKYKPYLVMATTTDRALNRKIVEKARKMKSYAYASDDPEISDFAHPSVINIADTVQVAVSTGGSSPAMARKIKLKVESFLKKNISSEDIYQIKLQKFARLEAKQVLSTQIDRKKFLYGVMNDKRVKGLLKEEKYKMAQGRVKKMLREWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN47</accession>
    <name>A0A087RN47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-glyceraldehyde 3-phosphate reductase protein</fullName>
            <ecNumber evidence="2">1.1.1.267</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.402"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="333" mass="37804" checksum="E0D308CDC745BD25" modified="2014-10-29" version="1">MKYKKLGKSGIKVSEIGFGAWTIALNWWGKEIEEDEAKRMLKKAYDVGINFFETADMYGKGKSEKLIGEVFSGMRNEVVISTKYSYDFENVDQIGHKELPQRFDAEFTNNALKNSLTRLQTDYIDVYGLHNPKLRHIHDDTIFQTLDGLIGDRKIKTYQVALGPAIGWTEEGIEAMERKNVSAVQTVYNILEQTPGNELIERGAEKDVGILVRVPDASGILTGKVDADTKIDEKDHRSVRKGEWIKASLKKVEQLRPIAERNDLSIIELAIKFIISKNPISSVLPTVISEEEIEKFAAMSDGNYINSSDMKEIDDLYNSWWKESPYELKATVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN80</accession>
    <name>A0A087RN80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell volume regulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cvrA</name>
        <name evidence="2" type="ORF">AAA799O18_00399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.346"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="100" mass="10565" checksum="2F5AB90EC73985FC" modified="2014-10-29" version="1" fragment="single">GVIAAIAIYIGRIIITKSVLVRGFSKLDRKVTSVMIPRGLAAAVLATYPLSMGLPNAEAYPQIIFFVVITSVIITTLGLGGAKKIPAPESHDGGFIKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN84</accession>
    <name>A0A087RN84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase protein</fullName>
            <ecNumber evidence="5">2.7.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prs</name>
        <name evidence="5" type="ORF">AAA799O18_00403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.351"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="291" mass="32024" checksum="90B5286A72E11B9C" modified="2014-10-29" version="1">MVKFAVVGGNASKDLARRIARRLKARYIETQTKIFPDGESKITFGGIPKRSVVLVVQSTYPPVDTNLLQALSIISQAKKASSKIYAIIPYMGYARQDRQFLSGEVVTMSIVAKMLQAAGTKKVIFVDIHSKAALNHFKIPIENVSAIPKLAIYFRKMKLKNPLVVSPDMGGSLRAKEFAGLLNTDFITLKKSRNRNTGKVLIQSSRVDVHGRDLILVDDIISTGSSIIKATQFLKRKKCKRVFVACTHGLFIADAERKIKKAGASQIISTNTIPRSTSKVDVSGVITESFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC0</accession>
    <name>A0A087RNC0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">ribK</name>
        <name evidence="19" type="ORF">AAA799O18_00360</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.312"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="101"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="104"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFM14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="227" mass="25434" checksum="2A43D24584D3FC75" modified="2014-10-29" version="1">MPDLKIQHILILTQLLSKGARYNFVQVTTSSLGKIIKKSQQAASTYILDLENNGLIERLMKGRKISVKITHKGYSELLKLHSVLGYSLDSSPSNIELRGSVVSGLGEGSYYMSLKGYTRQFKSKIGYIPFPGTLNIKLNQQYDLQAVQQLVNLEGISIDPFSDGKRTYGWVKCYHAKLNNSINCELIRLERTHHGNSVIELISKNNLRKIAGIKTGSKVKIKILTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC7</accession>
    <name>A0A087RNC7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gdhA</name>
        <name evidence="10" type="ORF">AAA799O18_00367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.319"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="191"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="424" mass="46447" checksum="56C554CC1A5F6BE2" modified="2014-10-29" version="1">MTQPDPFENASKQVNDACDVLGITDQGIRDYLIMPNRFLRLKVPVKMDNGSIRVFTGFRCQHNNDRGPYKGGIRYFDPEGGVKYMEREVMALSSWMTWKCAVVDVPLGGGKGGIFVNPKKEKLSDGELERLTRQFASRIAEVIGPQKDIPAPDVYTTGKEMTQIMDTFTKMSGNNYSPGTITGKPIPVGGSLARNVATGLGNAYCIREAAKILNVELKGAKVVLQGFGNASTFSGEYLEKMGAKCIAASDSKGSILVPDGFKVQELIDWKQKEGSVVGYPGSKEISTEELLTTECEVLVPGALENQITAEIAEKLKCKIIGEAANGPTLPEADPVLHKKGIFVIPDILANSGGVCISYLEWVQNNMGYYWTFDEVASKMEAKIVKGLSDMHELSKKHNIDNRRAAMVLAVERVLEAFNHKGIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND5</accession>
    <name>A0A087RND5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="46" mass="5157" checksum="A31B0B18BF8E3F11" modified="2014-10-29" version="1">MRVYNMKWPIFMIVSGVGGLAVLILLAYLAIPEPLIEYCQVGQNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE7</accession>
    <name>A0A087RNE7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">pdaD</name>
        <name evidence="7" type="ORF">AAA799O18_00321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PdaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.278"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5023494470" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023494469" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="183" mass="20168" checksum="3DF6D9FFCA85695B" modified="2014-10-29" version="1">MLDLVAKKIFLTKGIGIADDKLTSFEFALRNAGIAGTNIVLISSIFPPNAKLISRKDGLKMIKPGQILFTIYSRNQTNEPQRLISASVGVAQPSDRTKYGYLSEYETFGKSEKQAGDYAEDIAAQMLASSLGISFDIDKSWNEKRQSWTISGQIYKTKNITQTAKGNKYGKWTTVFAAAVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF5</accession>
    <name>A0A087RNF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.286"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="97" mass="11023" checksum="BDE29BAB60D93E90" modified="2014-10-29" version="1">MNVIDTAINYRAQKSERTVGKAVSELIDEGKINRSEIFVSTKNGYVTNDADIQEDFMAYIMREFGKTGIVKEGDISSQYNCMTIPFLEDQLARSTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI1</accession>
    <name>A0A087RNI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.223"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4910" evidence="3">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="1">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="2">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="455" mass="52415" checksum="656879777E2D56D4" modified="2014-10-29" version="1">METNFQKLIDQIPEIGENIHELIVELFPISRSITGNGLRKTLRILKNHIPLEIFEVPSKTKAFDWEVPREWNINDAYIKNSKGEKIVDFKKSNLHILNYSIPINKKISLDELKPHLHSLPEYPDVIPYLTSYYNENWGFCITHNQLLQLEEDEYEVFIDTTLEDGSLTYGEYFISGKSEDEVLFSCYPCHPSMCNDNLSGVALLTFLAKHLKNLSLHYSYRFLFIPETIGSIVWLSRNENNLAKIKHGLVATCVGDSGISTYKKSRQGNAEVDQTVIEILKKSGDDYKIVDFEPQGSDERQFCSPGFNLPVGSLRRANPPNFVEYHTSADNTEFVKAKYLADSFSKYFRVILKLEENFGKFDSKNNEERPKIDSKNDQVFLTLNPKCEPKLDKFGLFREIGGQKYNDALTILWVLNYSDSKHSLRDISLKSGIDFKQIKQAAELLQEKKLLKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI7</accession>
    <name>A0A087RNI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WxcM-like domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="151" mass="17173" checksum="0A200F72FFB27613" modified="2014-10-29" version="1">MNADGITGISLETFPTKNIDGGHINGKLTVIWRDWDNILKFHPKMVYVSHVNPHEVKGPHLHTKRDSYFICIRGKVVFVAKDNSGNYHEIESSEENPVLVQIPKNIASAHINLSDDTSTVLALADPAWRPDDDEMKNVAFDDYDWKKYNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ2</accession>
    <name>A0A087RNJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="133" mass="15448" checksum="B32B650F94090A6F" modified="2014-10-29" version="1">MSKRDEFLKKQKILRLATLDKNDNPHVVPVWYLFSSKKLYIGTNSKTEKAKNIKNNSKVSFCVDIGINSPDIFGVMGRGDTKLIMEKNKVSRIEKIILLRYFKTLNNKSAKDLLDETDCIIEITPKEYSVWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK3</accession>
    <name>A0A087RNK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaerobic magnesium-protoporphyrin IX monomethyl ester oxidative cyclase protein</fullName>
            <ecNumber evidence="4">4.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bchE</name>
        <name evidence="4" type="ORF">AAA799O18_00275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.245"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="194"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="680" mass="78003" checksum="16CE6F289CF94311" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL1</accession>
    <name>A0A087RNL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylisocitrate lyase protein</fullName>
            <ecNumber evidence="1">4.1.3.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prpB</name>
        <name evidence="1" type="ORF">AAA799O18_00283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.253"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="285" mass="31479" checksum="D21BE51EE11768DB" modified="2014-10-29" version="1">MKSIRKLLNHKSKPLVIPGVYDAVGAKIVEKVGFEAMFQTGYGTSATLLGMPDYGFIGSTETMDNARRICHAVSVPVIVDADTGYGNALSVNKLVCELEAAGASGIFLEDQKWPKRCGHMKGKEVISKDEYAEKLQAALDARTSRDFIIVARTDARATEGLDKAIERGLFYKKIGADVIFVEAPKTIQEMQKIGASINAPLVANMIEGGATPIISQSKLHSMGFKIILYPLSVLFSNTFATLRTLRELKRSGATRESENRMVSFDQFNEIVELSKYTKLEKRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL5</accession>
    <name>A0A087RNL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylmenaquinone methyltransferase protein</fullName>
            <ecNumber evidence="2">2.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE</name>
        <name evidence="2" type="ORF">AAA799O18_00287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.95" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050342">
        <property type="term" value="F:tocopherol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="229" mass="27092" checksum="0BD5F1EAB498AC45" modified="2014-10-29" version="1">MKKYNAQKEWNKALLKQKSLAYPAEYVIRIFKGNYPKLQLSKKSFSRKKICDISCGDGRNIVLLDECGFDVYGTDITKEIVKHTKENLKQLGIKSIIKVGNNSHLPFDSDYFDYLLSWNSCYYMGNNLDFNLHVNEYARVLKKNGYLVMSIPKETFPYFKECKKLKNGYYIIKNDPWKLRNGEVLRSFKNKEEIMKVFSTKFKNFIFGSIDDDCFGYNYHWFLVVCQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL7</accession>
    <name>A0A087RNL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoglycoside N-acetyltransferase III protein</fullName>
            <ecNumber evidence="4">2.3.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aacC2</name>
        <name evidence="4" type="ORF">AAA799O18_00289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="259" mass="29755" checksum="98725A6E900BE3C7" modified="2014-10-29" version="1">MNKYDYTIQNILDSLKQVGLKKGDSIFTYSNLGFFGKLKNTETSEDYCAAFRDAIFKIIGNAGTLVVPAFSYSFCNGTRFNVSSTPSVCGMFSEYIRNDAQSKRSNDPNFSISAIGESAEYFTQDCQSHSFGKDSFWERYLKKNGKFCNFNFDSGSTFFHYVEKILDVSYRYDKEFRGFLKLDNKYVEKVFVHYVYDKEKPENGPDFEKFHKKAIELKKVKISNLGKGQIVCVSAKNTFDLIKNEIVTNPNFLIKKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM8</accession>
    <name>A0A087RNM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.270"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="519" mass="58345" checksum="F8D1BA7CFC4550D7" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN5</accession>
    <name>A0A087RNN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="81" mass="9172" checksum="72FD1C2509903CC5" modified="2014-10-29" version="1">MNISFILVQCTIGHEMEVLRELLRLDSVKEAKGTFGYYDILVKITASTNKDIENVITKKIRKIKNVTNTTTLSVIPEQDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN7</accession>
    <name>A0A087RNN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">purL</name>
        <name evidence="9" type="ORF">AAA799O18_00219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.201"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="433"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="548"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="722" mass="79727" checksum="7CB892BB5B61179A" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP1</accession>
    <name>A0A087RNP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">AAA799O18_00223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.205"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="306"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="533" mass="59368" checksum="0D8BF5DED322D45C" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP6</accession>
    <name>A0A087RNP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component II protein</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpGD</name>
        <name evidence="2" type="ORF">AAA799O18_00228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="196" mass="22000" checksum="47280DF99179C919" modified="2014-10-29" version="1">MKFLIIDNYDSFVYNLAQRLGELGVSSDVIRNDKITISEIKDRNYDAIVISPGPGTPEDERYFGICKNVILELGPKTPILGVCLGHQGIIDCFGGKVTNAVNIRHGKTSQIKHYDDSLFKEVENPFRATRYHSLVGEKTIIPDSLKITAVAEDDGEIMGVSHKKFFIEGVQFHPESIMTDEGKKILKNFIERVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ1</accession>
    <name>A0A087RNQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="84" mass="10194" checksum="E6157109DEA2F686" modified="2014-10-29" version="1">MRFRIEALIGDRYDSTDSLTEAEIYNWLLNIQKNDILKVETEDDYWEDIPEQLFELIKTSIKKKNYKYEMAKGHLWFELDITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU4</accession>
    <name>A0A087RNU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 21-aminomutase 2 protein</fullName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.150"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="155" mass="16957" checksum="1E2CEEEDC2781ED2" modified="2014-10-29" version="1">MDYANTSEFSKSNRAYIGGGTFSANPLTMAAGNSTLRTIKSKGNSFYRKLNNLGSETRKMLDKKFDGQVITTGSGSLFLTHFLSASISEIKNATDAAKCNIIKLHDYHFHMIANDGIFFLPGKLGAFSAVHTKTDIKNIAKSTDKFLTKFKNKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV8</accession>
    <name>A0A087RNV8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rps10</name>
        <name evidence="6" type="ORF">AAA799O18_00181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.164"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="102" mass="11524" checksum="CAE24307DF081740" modified="2014-10-29" version="1">MTQSARVKLTSISLPKLGNVCDEIMTIGEKTGVKIKGPIPLPVKQLNVVTRKSPCGSGTETYEKWEMKMHRRIIDINADDKVIRQLMRLKIPDDVYIELSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW1</accession>
    <name>A0A087RNW1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AAA799O18_00184</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.166"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFM15165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="181" mass="20193" checksum="0831DE42E82A63AA" modified="2014-10-29" version="1">MLLIQXXXXXXPILDASTDRLHNIAGTYVGKDDPICLLRTQKKFPATEEAGSVFNNPHYVSGNTRGSHNMPLMPVKINSAATINFCIPIVQSLVFSMHDGKLTGPFDGFSTADWDHIREIATKKALAMRSQGFIHPATLVPSELEYAEGYKTRMGILNDKMKPIKDKLQDDHPKRSYEDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW4</accession>
    <name>A0A087RNW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.169"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="222" mass="24971" checksum="0715B3709CC7B432" modified="2014-10-29" version="1">MINSSMYSGELEVQAKRKAIAVLQDEINRILNAGRELSTLPKLLVKKDTSGVKNALEQISSIEEEVENLRRKITREVADVGGLIMNRENLLNTAYTMDEIAGYITGISFKLSNVKIKTLKSGNLEKELSELIELVVDEIYKLNEIIRSLNANSGKAIELAQETQKIEREIDIKYRKMSIKALDKITNTKELLLVKDIIEGIEEMADKCQEVSDSFILLALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW6</accession>
    <name>A0A087RNW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="125" mass="14295" checksum="A0481BDA945C86A1" modified="2014-10-29" version="1">MQDPNPLPWGAQDRFQAHFIVKRDSGEKLLRFTARTNLKTTGYFGSKKITGVSWEGGELAEQLNADSSLNKKLIKQSVDDATIFVDPTNNGIRIYGKWKNSHDFRITKELFEIYDKIAGYIKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX3</accession>
    <name>A0A087RNX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="226" mass="24693" checksum="E9841C165906AB69" modified="2014-10-29" version="1">MTFTTDIDNLIRMRVGDVNRLRNIKDTIRHDNFITTVDKEYVESLISKHIKKQTLDELEINVKPKTYTKSEVNVEPTSTETVSSSSSLFSGSNNKKLGILAGVAAVIALVVVVGFSGVLVGQTGDYDIKSTLSQKLTLDIDESSYKNADIISVSGNAKVSDGKSLTLLIENTTGELIWKEYISTKGNGNFSTLVLAGGYGWDSAGTYTLKAQYNDLENKIEFGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP35</accession>
    <name>A0A087RP35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-1-monophosphatase protein</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">suhB</name>
        <name evidence="3" type="ORF">AAA799O18_00135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="255" mass="28977" checksum="EA1D242E6930AFDB" modified="2014-10-29" version="1">MNYTKELDVAKSVAKEMGKIQLKNFRKNLKVIRKSPKDFVSNVDLECQNISYELLRKDFQYEILSEEKKTQDEIGTELFWIIDPVDGTHNYISGLPNFGVSIALATKKEFLLGVIYLPYFDEMYYAIKNQGAFMNSEKIQVSKNNDLEKSMITFDNQFYLNKKAFDVYKKIVDSCFTTRILGSAVYDFCLIASGKVDARIWNNTKVFDFAAGLTILNEAGGKVTDFGGNQVNLDTHDILGSNSFVHQELLSTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP41</accession>
    <name>A0A087RP41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glucose ABC transporter permease protein TsgC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.122"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="309" mass="32819" checksum="E88B9EFC486118F7" modified="2014-10-29" version="1">MIEIAVIVTLLASGLGLSTPLLFAALGEKIAERAGVLNLGVEGMMIMGAFAGFMGAFITENIAVGFLFGILTGAVMAGLMAFLNVTLRTNQLVAGLAVWLLGLGLSAFLYRLAFGIGTAPRVEPLAAINIPGFSDIPFVGPVLFNHDPLVYIGWAMVPILYVIVFKTKIGLTLRTVGENPRQADTQGISVVRVRYYAVMIGGAMAGIAGAYLSLVLVGIFVEDMTGARGWIAIALVIFGRWHPIGIMGACVLFGMVDSLQFSLQAAGVQAPHQIMLMLPYIMAIAVMAFTYKRTTQPAGIGQAYTREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP49</accession>
    <name>A0A087RP49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIG2-like domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="126" mass="14117" checksum="B09F7223BD444B99" modified="2014-10-29" version="1">MTIELFVNGTLMRGLTLHKNLDGANFLGEFHTLPIYRLYSIDDIHPGMFEVEEGGVSVAGEMYSMNDEIFQRVKNGEPSGLYFGDVKLNNGSTVKGVLFPREAAESNYKDISNFGDWRAYIASLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP58</accession>
    <name>A0A087RP58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain containing protein</fullName>
            <ecNumber evidence="3">2.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.140"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="302" mass="34182" checksum="828098F1D351B33B" modified="2014-10-29" version="1">MKCDKCENTSVYSRKYSGENLCSECFSNSILHKIARTISKYKMIKNNELVCVAVSGGKDSLVLLDVLNKMSKTHNFRLSAVTIDEGITGYRDEALEIVKNFCSQLKIGYKTFSYKELFDLTLEESLHLRSEQKLSSCSICGTFRRRALDHAAQTINADVIATGHNLDDVLQTFLINALSGDVSKIGWMNPDRSSNKLKKIKPLCEVYESEIVFYAFINNLPFQTEPCPHMDEGIRTEIREFLNSLESNHHGIKNNMYNSVLKLSEITKKANQKEKRICLVCGNECTGKICSVCNMITRLTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP61</accession>
    <name>A0A087RP61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aniA</name>
        <name evidence="10" type="ORF">AAA799O18_00161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.144"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="238"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="359" mass="40450" checksum="09A1AD1BF72A8DE4" modified="2014-10-29" version="1">MPNSEAYVFSTGQKMAVVIAVVSLGFIGYLAFPGLDITAQEQPEIFVTHTGAVVQTTGDVLDPVYTIQEVEFDPEKYLREFDYGKVSQLEDGTILREFTIIAEDDKIMEIAPGIFYNVWTFNGQVPGPTIRATEGDLVRIHFTNNGSKEHTIHFHGNHPAEMDGIFEIVGSNGGQFTYEFIAGPVGVHPYHCHVMPVEEHIGHGLYGIFIVDPKDGRQQADEMVMMLNGFDTDFDGENNLYAANTIPFYYQHHPIQVSTNELIRVYVVNMVGLDPINNFHLHGTLYKYYPTGTDIVPSEFTDMTTFSQSERGILEFEYEYTGRYMFHAHLTEFSEKGWSGIFYAKDSSQPSMEGYAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP77</accession>
    <name>A0A087RP77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease</fullName>
            <ecNumber evidence="8">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnhB</name>
        <name evidence="10" type="ORF">AAA799O18_00004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.3"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="9">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="220" mass="24953" checksum="078D4894E4E41D8F" modified="2014-10-29" version="1">MKNFVLICGVDDAGRGSVLGPLVIAGIAIKRTKINKLKKQGIRDSKKLTPLARERLYKKIINIVDDYYVARIPPKIIDKSVFNHSLNHLEAQYMAKVILKLSPSIAYVDSCDVNPRRFGKEISKLTVHSKIKSYHHADSKFVVVSAASILAKVSRDRAITRLNKKYDIGSGYPSDLKTKMFLKKSIKLYKSLTFLRKSWKPVQILIKKKTYPKNVPITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP87</accession>
    <name>A0A087RP87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.13"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="122" mass="14034" checksum="EA90D2EBC265FDB2" modified="2014-10-29" version="1">MNYEKIKKDLISEIGLSQNQAEVFLLVTLKGKMSVSQIAELSGMTVDEAKETSLKLVELGGFIDMSEIEYEAMHPRFTAVNMYRRMCERENIVFKKNSILDNIGIVLEEPYDDVRTKYNKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP89</accession>
    <name>A0A087RP89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.14"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="120" mass="13661" checksum="C1EBB6D2B6F3786C" modified="2014-10-29" version="1">MSQRADSSFANFILIGVAAITTIYWVHILKKMAKDQKPKYKVNEPEAKNWVYDLIKGDNQFVFVAEVPGPDDRIMVRLIDGVLYVRGSGSFSKEVVIENSNEMQITDFKYRNGVLTLQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP93</accession>
    <name>A0A087RP93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rio1</name>
        <name evidence="12" type="ORF">AAA799O18_00020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.18"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="11">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM15297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="263" mass="30229" checksum="88386F758021BFE6" modified="2014-10-29" version="1">MTSFSENFENEELFLNANDFSKIKKHFLSDGFKKNKTVNEVLDKSTVMILHDMIRTKIISYVNGIVSAGKESVVFWGMSPDKHDIALKVYLTSTSSFKKRSIYIEGDPRFSRIKKNTRSLVYLWAKKEYKNLIHSIENGISVVKPITVKKNVLAMEFIGKKGVPTKTLVQSQINEKDYKSAMSLIKQLYKQANLVHCDFSEYNIFKTNKGLILFDMGSAIDLEHPNAKELLKRDINNISKFFVKRGLTVENPIDVFNRITNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP98</accession>
    <name>A0A087RP98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="165" mass="18428" checksum="CF1D658F7A83BFD9" modified="2014-10-29" version="1">MGSKKGIGITIAILVGVVAASFLVYLIPENTEMKFVVSDFEKNLDDVDERTSMLSTGIEKSFDDLINHKLSPEEYFITAGVTQSQVNSLIIELTLSNPPQEWAASYKTYADALKILNEQIRESVVVANLMKDDNNSDSINEIISKIYELRAELLNLIEKSDNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP99</accession>
    <name>A0A087RP99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.24"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="375" mass="40877" checksum="D4A5173605550EF6" modified="2014-10-29" version="1">MPQSKLKRDIEASVATNLLVICVDRDDDVGKKAGISTPVVGRNACIEAAQRLALEDPEDADSNAIFSAIKTYEDLISDGYKAEVITVAGVESRSVQGDEKIASEIKSVLKKFSADGAVIVSDGEDDEMVIPIIQNVIPVVSVQRVVMKVSRTIEHSYALFGKFLKMVVYDPRYSKFFLGVPGILLLIGGVGAVTGYTAEIFAVLVSILGGAFLIRAFDIDKAWSNWAKPTPEGFIRLFTLITGLILIAGSIPAGITSVDVENLSADLGIVNIITDNIVMGQFVSGMIPFLWIGIGTIFVGILFNNWLNRKLRHISDILRIIVLVSLYPTVYQFTNILRFDESSFSLILPLIAGFGVTAASATLLIRRYRKKKDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB0</accession>
    <name>A0A087RPB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyladenosine biosynthesis protein RimN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimN</name>
        <name evidence="2" type="ORF">AAA799O18_00037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="199" mass="21994" checksum="B53E5CC07DE441C3" modified="2014-10-29" version="1">MRVSCTDSDIKIAIKKIKAGQIIVFPTDTVYGIGCDPYNKKAVLHLYEIKKREKTNAFPVLGLSKTELEKIADFNMLEEKIAEKFWPGQVTLVLKVKDEKIRKSLGLDKKIAVRVPDNQCVLSLLKECKLLVGTSANISGTVPFIDPNECVNGLTGYDLLIDGGIISSQGESTIVEIEGDNINILRNGSVTEEEIRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB1</accession>
    <name>A0A087RPB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THUMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="55"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="172" mass="20062" checksum="C36FA2CAA52D0AE6" modified="2014-10-29" version="1">MNLFITCAKNLESETEGEIKKILNEYGDQRPEIYRSEMRGILFVNTSKDTSKIIDWVKIRISEEPWFIRYCLRIIPIQTEADTDIEKIKQSVQKLKNIIQKTDSYRITIEKRNSDISSKEIIVEVANIFLNKVSLNEPDWIVLIEIFGNKTGVSILKNNGMFSLEKSKRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB2</accession>
    <name>A0A087RPB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase binding CGI protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="258" mass="29100" checksum="905ED7650F1D469B" modified="2014-10-29" version="1">MITVKLMGGAKKSFSTDSITLEESSLTINELIDYLIQIKPKNSLEFDTKNLLIAVNGIDSSALQGYDTKLNDNDVVSIIPIIHGGTHSRIQFSIMHSNAEIFHMLNDKKFHIEFLKELRNKHPQLIIQALSSQFILGVNHAKKILAISLYAKKNKTLLSKKIEIDILMRFACTTQISHAIKTAGRKPNRDFFIIAIGKKPTLNKLYSEVKTSLNSKQFSKANQQYLKKQFKISKKQISTVSSKNPLDDIIVEKAALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC0</accession>
    <name>A0A087RPC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="72" mass="8258" checksum="939EB3BE50AD4AED" modified="2014-10-29" version="1">MDKYLLVVLGFLLIGIPIAFVSPTTGELREAPFIPLFYASIGGIIAVIIYGSYKAKKERQRANRERRRKFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC3</accession>
    <name>A0A087RPC3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">thiL</name>
        <name evidence="3" type="ORF">AAA799O18_00060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.51"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="316" mass="35583" checksum="14A7B3A2270D3107" modified="2014-10-29" version="1">MSRLSEKKIIKIFQNKLNNGSFVPEDVELFKTGKKHFVVKVDTLVESTDIPPKAKLQDSVRKSLVSCISDFAAKGVKPVFGIVSLTIPKRYSKLNIVNLAVGVKKTAKEFQIKILGGDTNEGKELVISFSLFGFSKKIVKRNGAKINDLIICSGPFGYSKAGLSILLKNKKCLKKFETKAKRAVFRPSCRLDFGLKNKNYFSSSMDSSDGLSTTLNEMSNQSKRKFVITQLPSEKDVFVFANSNRLNVNDLVFNGGEEYEIVATVNPTHIAKIKKYAKRNKIRLYEIGYVTKGRGVFHQKNGKLIRIRDEGWRHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC7</accession>
    <name>A0A087RPC7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="3">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rtcB</name>
        <name evidence="11" type="ORF">AAA799O18_00064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.55"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="218" mass="24232" checksum="E09467C016A37FB2" modified="2014-10-29" version="1">MADRELACVPNKSEEGESYRAAMFAALNFAWSNRQMITHWTRKSFERVFKQSESDLDMRLVYDVAHNIAKVEKYKIDGKLKSVVVHRKGATRAFPANRDEVPAKYRDLGQPVLVPGSMGTGSWILLGKENSMSLSFGSTAHGAGRMMSRTKARRNFKESEVKKSLNDKGIFIKSLTRDGVVEETPQAYKDVDAVVNVSHELGIATKVAKLVPIGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE0</accession>
    <name>A0A087RPE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="127" mass="13893" checksum="C980151F5C96B6CB" modified="2014-10-29" version="1">MSKYSSIVDNKPTLLTLVVICVVAALSIPVLIPHFGHGTHIFHLLLHTGGIILAVFLTILGINAYSKIKTKKLAITSVAFFVFAIAEIISLLDATTVHYYDIPGYEIAHMLMICMIGIFAYGIFRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE3</accession>
    <name>A0A087RPE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.72"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="214" mass="24170" checksum="5F604AE4FEC64F24" modified="2014-10-29" version="1">MAMPSDDSFVPDDENSERAPNVDSYRITCIDFIKDISHDYLAWVDRYKLPEEEDKTRRTEIASIIERTNEWIAKVPQTFKAVDVVMNDGIQKMAEATAGKPFQIGVFVNKKSGYTMASPGIIDVNVKAMCREGRKAKLGFHGKEERFRFETTGTAFFDETSITEDESDLLDINLKLNAEKCTQRDVISFTVVVSEIQDGSESDRRGVSTVIHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF0</accession>
    <name>A0A087RPF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-splicing endonuclease protein</fullName>
            <ecNumber evidence="3">4.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">endA</name>
        <name evidence="3" type="ORF">AAA799O18_00092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.79"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="1">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="189" mass="22261" checksum="11D9E9AC685C3E14" modified="2014-10-29" version="1">MSIETDLMQGVLLKNRTVILDPDIQRELEHRGYGEMEKNELLLKPFEALYLLYTNKLIIYKAKKNIDFDSLLQIFKKQDENILTKFLVYRDLRTRGYTVKDGFGFGSDFRVYGKGDFGEKGAKFLVFSLNEGKQEKVGKLQKKIEEITKMGKEPIIAVIERRGEIIYYKISRINFNQNVPKMEMKYFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF8</accession>
    <name>A0A087RPF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">AAA799O18_00105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.87"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="271" mass="29910" checksum="0FC98529D1FE73BC" modified="2014-10-29" version="1">MKINKIAIVSKFGSKESEKAAAKIAKKLLKSKSQIFTIAPVSVEGAKKVRSLDDLKRIKLDLAITLGGDGTTLRTFRNLENETPLLAINVGGNRGILSEITLSEIDKAIQHIRKNEIWIDKRTRVTASCNNQTFQPALNEIYVNRKNLTKTAEFEIKFQNDTVKQKMDGVIISTPSGSTGHSLSIGGPVLHESLDVLIITPVAPVHRLPSIVVPDEKIEITCSHDCNIVMDAQVIKSAGFGELVTIKKFKKQAVFVRLKKKGLRQMNKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF9</accession>
    <name>A0A087RPF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoribonuclease Nob1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nob1</name>
        <name evidence="5" type="ORF">AAA799O18_00106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_6" evidence="4">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="159" mass="17788" checksum="EF2B573F94E232CB" modified="2014-10-29" version="1">MVFRVLDSSAFYAGIPFSSNKSSYITPLVYEEIEHIKKDHDAVQILIETKRLTVCDPESLFTIAVNDAAKKSGDFPNLSLEDISTIALSLQLNAELITDDFAVSNVAKNLNIKVIPVMTNGIKNIVTWVYYCPGCKRNFSKTTECPNCGNMLKRKPHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH0</accession>
    <name>A0A087RPH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome maturation protein SDO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.99"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="105"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="236" mass="26508" checksum="862AC12C7FA8B5E5" modified="2014-10-29" version="1">MSQIVINMTVKLTVVKYTFEGNKFEILVKPDSALDYKLGKIKEIASVLVSDEIYSDSSKGTRASSEKLQKAFKTEDALTIAEKILQKGDLNLTTEQRRKMTIEKRKQLITFITKTFVDPRSHLPHPPLRVEQALKEASVSIDPFKRVEEQVKDIIENLRSIIPLKSENLLLEISIPAQYVAQSYSVLKSTGVLKKEDWQPNGSLKAILEIPAAARPNVIDRLGAITKGTAFVEMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI0</accession>
    <name>A0A087RPI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="178" mass="20901" checksum="B30AA1BEC752531F" modified="2014-10-29" version="1">MVDNISIMQLRFYGISPWEMEVIHGLFSNKFRISQEETEEVNSDFVSGLTIIIPIQFSEEFFKWFGFKTWEKVKSILKEMKRRRGRGKAIITEIVFTGNPNVRFVADLNQSHLFNNSIEKIDFMLELLPYHLNEDGIPKNLSEVIYKFDTDASKWRLNVAMVGDKKFITTKKGWQIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL16</accession>
    <name>A0A087RL16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000050">
        <property type="protein sequence ID" value="KFM14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="155" mass="17442" checksum="908DB1A2D9B56824" modified="2014-10-29" version="1">MALQYGAYIAMAGIGLYAIFVGEMISIFNYMLEPSGEALLDDFIKPPVDASGKILQFISIGVAPGLVMSATAYMIARKFGSKQIGWLIIIGSTTLFIEQKFIHDSGLVGHIEDVVVRKAYDRWNRKRSSRFYCYYNPAIIHGCFYTNDDCRRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL28</accession>
    <name>A0A087RL28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000044">
        <property type="protein sequence ID" value="KFM14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="76" mass="8718" checksum="B49537A07B347813" modified="2014-10-29" version="1">MSDLCVTCGKSKFAHSFEEANDCKKKINQEITTLRVRKITRDSLAKICTKEMSFDDVITQLLKSYDDHLNALYGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL41</accession>
    <name>A0A087RL41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000041">
        <property type="protein sequence ID" value="KFM14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="33" mass="4040" checksum="C18F6CCC69FFB526" modified="2014-10-29" version="1" fragment="single">MYTENEEDANNFKEVLLRWQTKSQQQKPSDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL60</accession>
    <name>A0A087RL60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine--tRNA ligase protein</fullName>
            <ecNumber evidence="9">6.1.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysS</name>
        <name evidence="9" type="ORF">AAA799O18_00737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="9"/>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.632"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="8">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="254" mass="29532" checksum="10352F243C653D7E" modified="2014-10-29" version="1">MKYLGKNFEIHGGGRDLIFPHHENEIAQSESSTSKQFAKIWMHVGMITINGEKMAKSIGNVKSVKHVLENWGPNIIRLFCISGHYTKPIDYSEKFLKENITKLRQIESCYYELRLAEGTGEDNIAKKLVSECKKEFDSALNDDLNTPLALTAFYRLIKEINYMAADEKITQTTSSIILPEFENMMDVLGIQILKVSNVEKNEINQLIMKRNEYREQKNFEHADKIRDQIMEKNIIFVDHKNSTRWIKQEKIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL61</accession>
    <name>A0A087RL61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine--tRNA ligase protein</fullName>
            <ecNumber evidence="5">6.1.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="4">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="205" mass="24002" checksum="4AC8E0371552E6AB" modified="2014-10-29" version="1">MLIFDTLGNKKRELEFSDKAKIYLCGVTVYDEAHIGHARTIIVFDVLRRFLESQKIPVEFVQNFTDIDDKIIERAHEKNIPALELARQYIKHYYTDFDNLNVKRATRYPKATEHIDDMHNLISNLIDKKYAYLTKNGVYFSVSKFSEYGKLSKKKTNDLVAGSRVIVDKEKNDPLDFALWKFSETEPFWDSPWGKGRPGWXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL71</accession>
    <name>A0A087RL71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000034">
        <property type="protein sequence ID" value="KFM14225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="45" mass="4723" checksum="C8655134520053BF" modified="2014-10-29" version="1" fragment="single">MTNCPECDASITIPEDAVEGEIVTCAECGASFELTKASDGFELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL74</accession>
    <name>A0A087RL74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylaminomethylideneamino imidazole-4-car protein</fullName>
            <ecNumber evidence="3">5.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000033">
        <property type="protein sequence ID" value="KFM14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.619"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="179" mass="19604" checksum="526972723B9CDB3C" modified="2014-10-29" version="1" fragment="single">LGRGRNFDLLKNIAESVKIPVQVAGGLRNYQIIAYALEFATRIVIGTLAFKDKTVLASYLAQYGNEKLVISVDHNDGLIAVNGWQQTTKIPLVDAVNDFKKMGFSEYLSTSIVRDGTLEGPDLEPLKRINEIDGINLIVSGGISNIDDVIKVKQLNPFGVILGKALYENQVTIEEAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL76</accession>
    <name>A0A087RL76_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ORF">AAA799O18_00717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000033">
        <property type="protein sequence ID" value="KFM14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.621"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="109" mass="12238" checksum="B0EB89FB1E1F7AE7" modified="2014-10-29" version="1">MEQNITNIDFSKGDGIVPVIVQDANTNEVLTLAYSNKESLERTLSTGNSWFWSRSRKKLWMKGEESGNTQKVRKVLADCDSDALIYLVEPEGPACHTGERTCFHNSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL96</accession>
    <name>A0A087RL96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.611"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="224" mass="25164" checksum="1D6D0C874D15803B" modified="2014-10-29" version="1">MRSASFFSGGKDSTYAIYKAKRSGHSVECLVTLFPKSPESQLLHFPAIELTKLQAKTMKIPQIASELNSMSILNTLLEKAKEDFQIEGVVHGGISSEFQKKCFESICKENDLKTVTPLWKIDPKEYMNDLINSGFKFILTSVSSDGLDETWLGKIITISDVLRLSELSDKYGFNLTFEGGEAETFVVDCPLYSYPIKISKSEKIWDGYRGRFEIEVASLNSNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA1</accession>
    <name>A0A087RLA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="161" mass="17863" checksum="9BC971EB967AF00E" modified="2014-10-29" version="1">MSKKPIIGGIILAAIIGVVSVDAQINPDNPENETSLNSEVWSARIAGPEFDNIFNHRYSPIILERKVAYEFGFVPMGDSPERLKISVGGKGSGVEVFSELFVLEGTLIDTGISEYYTWDYTGNKNFEISYQQCPNQKTCNYDIIVKRYGNLKGSVTISLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB9</accession>
    <name>A0A087RLB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FO synthase subunit 2 protein</fullName>
            <ecNumber evidence="8">1.21.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000027">
        <property type="protein sequence ID" value="KFM14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.584"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="327" mass="36497" checksum="D36309C7C5C06E1A" modified="2014-10-29" version="1" fragment="single">VAGALTRKKFGKKATFVKNIILNYTNVCITDCKFCAFYRPPTHNESYTLSLNEIESRVKAAWDLFKIRQVLIQGGHNPELGIEYYEDSFSMIRKKFPQVGVHGLSTSEVDMISKVENSSTKEVLARLKDAGLQSLPGAGAEILTNRVKEIISPKKITSDDWLRIMEEAHALGIPASATMMYGHVESNQDIAEHFRKIVQLQEKTNGLMAFIPWSFEPNNTQMQKEGTVMYGAGGVQLLKMIAISRLVFDGLIPHIQSSWLTNGIGMAQLALQYGADDFGGTLIGEEVVSCTGARSTELTDKKIIDCIHQIGFEVEERDNFYQTVCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD6</accession>
    <name>A0A087RLD6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="74" mass="8504" checksum="A1DC95BEF3A25C10" modified="2014-10-29" version="1">MYPERKRSNWWYLLPIFLGIIGGIIAYFALRRDDREKAKKCMYLGLILLAVGIILDISLAGFAPIPDTWYGVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF4</accession>
    <name>A0A087RLF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="6" type="ORF">AAA799O18_00656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.569"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="328" mass="36682" checksum="A32EE023C08FC7EB" modified="2014-10-29" version="1">MGHRRHSTPHRGSLAYLPKGRAKSMEARIRTWPKVDSDQPKLLAHAGFKAGCVQIVSIDDREKTPNHGKQLVSLGTIIVTPPVLVIGIRGYSKNLRGRHAEFDLYANNLPKNISRLFNPNETTTNNSEKSLDGIKEIFAIIAITPKSIGLQQKKPYVFEVPVTGGDIKEQFTFLNEQLGKNIKIDQVFEAGTAVDVAAITKGKGWEGPITRYGVKRKQHKSRKSVREVASLGPISPQYVMYTVPRAGQRGFHQRIEYNKRIMVMDNTENTKFKINPDGGFKHFGNVNGDFVIVRGSVPGTYNRLVKLRAQIRNAPLKKNKPNVLEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG2</accession>
    <name>A0A087RLG2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="10">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">guaA</name>
        <name evidence="13" type="ORF">AAA799O18_00628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="10"/>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.545"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 10 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="218"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFM14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="507" mass="56544" checksum="25A94DB57DE7EEBE" modified="2014-10-29" version="1">MDKIVVLDFGSQYSHLICRRIRDFSVYAELVPYNISLEKLKKLNPKGIIFSGGPSSVYDTKAPTPTKKIFQMQIPILGICYGHQIIVNNFGGKVKRVNKEYGSAVLSVDDNSDIFNGVGDSIRAWMSHGDEAKVIPDNFEIIGHTENARAAAISNKQKAVYGIQFHPEVVHTENGNQILKNFVLKVCNANQDWTLEKFVENSIENISSLKGNILCGVSGGIDSTVTALLIHKAVKKRLECIFVDNGLLRLNEAKEIEKMFTKNFKVNFTKIDAQKQFLSKLKGIVDPEEKRKIIGEEFVKVFTKFAKSKGKFTWLAQGTLYPDVIESGVSKGPASIIKTHHNVGGLPDWLDLKVLEPLRDLYKDEVRKVAKILGVPQSLLVRHPFPGPGLAVRIIGEVTKKKLDIARVASKIVEEELQNAKVYDKVWQAYAAVGDDKAVGVVGDERKYGNIVMIRIVDSVDAMTADWTRLPNELIEKISNRITNEIDEVTWVSYVVSSKPPATIEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG7</accession>
    <name>A0A087RLG7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroC</name>
        <name evidence="10" type="ORF">AAA799O18_00622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JOTC01000023">
        <property type="protein sequence ID" value="KFM14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.540"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="364" mass="39139" checksum="D0BA4518840CBA42" modified="2014-10-29" version="1">MAGSSIGRNLVLTSFGESHGKCVGAVLDGCPAGLELNEKDIQKMLDLRRPGQSLVSTQRKEGDIVEILSGVFRGYTTGAPITTIIWNKDHDSRSYAKLRTAMRPGHSDYPAYIKYKKFNDHRGGGRFSGRLTATYVMGGAIARKLLKATLGVETNAYTCKIGKIGMKNQATRQSLKSIYTNEVRCPEKAIAGRMKKSILDARKKGDSLGGVIESITSNIPIGLGEPIFSSLESELSKAIYSIPAVKGVEFGSGFLGSEKHGSQNNDLYTFRNGKVITKTNNAGGILGGISNGMPIIMRVAFKPASSIGKIQETVDLKTKKNTKLRVEGRHDPCVVPRAPPVVDSIVSLVIADQALQGGFIKPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH3</accession>
    <name>A0A087RLH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.531"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="132" mass="15241" checksum="A9CEF903F84F827E" modified="2014-10-29" version="1">MNSYFSVNDANKILPVVIKKFSYAKKLKAEVMKMEHQLSSNVSTSTIDEHVIIKRKFNSMVTKFYQSIEDLESTGVVLKGLDDGLLDFPAKRFDEEIWLCWKEGETEIKFWHEKNTGFMGRKPISVSNESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH4</accession>
    <name>A0A087RLH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 14-dihydroxy-2-naphthoate octaprenyltransferase protein</fullName>
            <ecNumber evidence="3">2.5.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menA</name>
        <name evidence="3" type="ORF">AAA799O18_00613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="78" mass="8867" checksum="5BD6567E5B5DEA96" modified="2014-10-29" version="1">MISAWLRVIRVRFLLASIIAVTVGLVITWWYTNNISIFDAILTMAGVLALHASVDLLNDYWDFKRGIDTVSHKTKMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ1</accession>
    <name>A0A087RLJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="60" mass="6730" checksum="5470F2016231D6D2" modified="2014-10-29" version="1">MLLWIVAAAAGILISGILIYKYIKTPKHDVLGFSMYCKICGKKIVGLKCPSCTQKKNDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM55</accession>
    <name>A0A087RM55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="3" type="ORF">AAA799O18_00582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.504"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="93" mass="10673" checksum="17D85519BC6E22A6" modified="2014-10-29" version="1">MNIPKEINRFCPKCKKHSIQKISIYKAGKRRGTAAGERRHALRKKGYGGQKFPKLAKPAKTTKKVTQIFTCPECKKKTMKKGIRIKKFELIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM58</accession>
    <name>A0A087RM58_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">AAA799O18_00585</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.507"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFM14562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="241" mass="25085" checksum="73206FBE31FA00BB" modified="2014-10-29" version="1">MLKEISSVFSFLTIIPSNNTNLETVARYMHIFPIIGIAIGLLIGSVGFGLSFFLDPLIVSLLVVGSIAIITGIHHTDGLADFADGLMTKGTKNKKLKAMKDLSTGSAGIASVVLYVVGAIIALSLTSGYELLQAILLSEILAKFSMVLMAGIGNSAAVGSNSPFMQIMKDKRRLAVAGIITIIPLVVIGGTIGLILFGATIGVTLFLVALSTRSFGGITGDVLGATNELTRLSSLLIFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM69</accession>
    <name>A0A087RM69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="55" mass="6574" checksum="A467A1CCEA793F0A" modified="2014-10-29" version="1">MAQEFKIVVDGIDTPIIKKNRIIEAKLYLEKNLVINLKFLHYIKYYLSLNHILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM86</accession>
    <name>A0A087RM86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase protein</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.486"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="228" mass="24228" checksum="011D3E97F9342766" modified="2014-10-29" version="1" fragment="single">PIIDKSNIVSINAGMTPLVKAEKLGKKIGLDNLYIKNDSVNPTFSFKDRPAGVAISKAKEFGLSSVGCASTGNLASATAAHAAKADFPCYIFAPSDIEHAKIVQALSYGANYIAVDGTYDDANRIAAQIGDSKGVGVVNINMRSYYVEGSKTLAYEVAEQLDWRVPDQLIVPTGSGAMLNAICKGFEELEAVSLLNRVSEMHMNCAQPHGCAPIVDAFKNNSDDVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ2</accession>
    <name>A0A087RMJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="270" mass="31459" checksum="21CC65CA1FCD65C2" modified="2014-10-29" version="1">MKWFGQSKKKETEDYEKEYLDRLKKQPEDISKKKTSKHSTEKIETGSTNDKLKVQDNESTVKNMESVSEKLQLVKEEYNQVIGNLMHAKKEQKSVIDKVQKSNNEYDDLISKIKLVQADLLKLNNEFREKNENLSKITEEYKKHSLVIQEINNSKKEVVELKAEIKKYNDELESVKVKAGSFPEINKMREEKKKLENEIVQKRKEIESGIKELKFIQNQIANVGKNKESTNVVDAASAVVASMKQKLQNTQKELDLVREALEQERKTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ1</accession>
    <name>A0A087RMQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">AAA799O18_00490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.423"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="441"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="530" mass="58436" checksum="2644B4B0522348B8" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ3</accession>
    <name>A0A087RMQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subtilisin J protein</fullName>
            <ecNumber evidence="6">3.4.24.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aprJ</name>
        <name evidence="6" type="ORF">AAA799O18_00492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.83" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.425"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="303" mass="32873" checksum="A13A0A4243D62FE6" modified="2014-10-29" version="1">MNLQKIFFLLIIVSIGTIFIATQFQNQENFVVLVNNSGPYIGTSVPYSYGYDGSGIIISVIDTGVDFNHPDLFGFGTDGKIIGGYDFVDNDQTPEDTDGHGTQVAGIIASNGSLRGIAPNSKILAYKVSEDGESVPSHLIIKAIEKSIEDGANIINISLGINQTNTKIDQAVTKAIQNNIFVVTAAGNFGPELNTIGSPGMNPNAITVGATFNNIQSSLVSIFEIEDKTFNVFPMVGTQSLEEPITSQIIFGKYGKIQDLLDLDIKDSILLVERGSGVENEIFYFSDKEKKRIYFRCKSNCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR9</accession>
    <name>A0A087RMR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="155" mass="16921" checksum="B79FB66279282DA1" modified="2014-10-29" version="1">MKSVIFLIFILSIVIILPAYAVDISELENVGLKFKYIINSGENAFEIEGVANFPVLPPTFSETDKSLTFNVETGNEEGNECEFYIPKGFFVGAVTVLLDGQEVFPIINENDNSIYIGMTINGKGEHVIEIVEMKSLDMESQEVSNGGGCLIATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS2</accession>
    <name>A0A087RMS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="215" mass="22942" checksum="8FE92BF93EF7FC25" modified="2014-10-29" version="1">MLFFLVLSPAFVYAEPQTITVETDYLSYEKGSVILVSGSITNFDTSDPVKVYEVALRIIDPNNNIITISQILPSDVGSFLYNVNTAGSLWKFAGDYNISVNYGDTSATTTFSFIIPEVEAAEAAEAAEAAEAAEAAEAAEAAEAAEEKCGEGTHLEDGACVLDEIVSVESTPAPSTSSAETVSSWIYSITFAVLIAFVIAIFLYLISRASRKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS4</accession>
    <name>A0A087RMS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.445"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="461" mass="49288" checksum="DC4F277F05A2DE50" modified="2014-10-29" version="1">MFTIAAIAVMGGALFGSSFTSQMTGAAFSSDVNALQKIHDMGGLELVMPAAFAEAGSCDSEAYKNRTVVEFPLTGVSIDLPRLGGGTWSAMTFSEQIPGPTLRVTQGDVVKMTLTVPDGEPTPHGNDMHASQVTAVPTFGAVQPGTEKTYCYIAEVPGVYKYHCSGVNVAAMDQHVLQGMYGIAIVDPIDGYSKLMVEKTAVNANGDVSRDRQFYSGDALEWQLQYQQMYLTDGGTYDATKMFAHDTVYTAVNGQPFGYVPNEIHNLLNGHPGTNIFVAQPWNSMDLKQYQSQLLFTPTGLHNRIFIENQGNEPVYFHIVGEILDRVTQGNRVQSGGTETWLLGGSQNMIVDLVFDEPGIYAGVNHDYAAIYTGAATIWVAGLPLPTINETATALGVVQGAVDAGAYSGVLGNPYDAIPPYGEQSIHHPAKNVHCMCSDSVAAAQAADGAVELWVVVPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS8</accession>
    <name>A0A087RMS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="44" mass="5169" checksum="3F15EC235900E6EB" modified="2014-10-29" version="1" fragment="single">ESKPEPTAKPESKPEPEPESKPEDEPDFFKQEDTKRKLKRKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN26</accession>
    <name>A0A087RN26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Siroheme synthase protein</fullName>
            <ecNumber evidence="6">2.1.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysG</name>
        <name evidence="6" type="ORF">AAA799O18_00443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.380"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="208" mass="22988" checksum="24B0F90C48773898" modified="2014-10-29" version="1" fragment="single">KIISMIPKKAKSVYVGRAVGDNYNHQDDTNELMVEYAKMKRHVVRLKGGDPIIFGRGGEEAEYLKRNKIKFEIVPGITSGIGSATYAGIPLTHRKFASSVVFVTGHEDFEKKKEDVRWKKLAKSTDTIVIMMGLGRISLICEQLSAGGMEKNMPVAVIQDGTTTKQKMVIGTISNIVQKVKQSKIKAPSIIIIGKVVSLSKTIGWRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN33</accession>
    <name>A0A087RN33_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">pgk</name>
        <name evidence="10" type="ORF">AAA799O18_00450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.387"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="403" mass="44437" checksum="D438383DD2453C02" modified="2014-10-29" version="1">MRFLTIDDFDFKGKTVFLRVDMNCPIDPETLDISGTKRIEETVETIDSLKNSKIVMASHQGRVGNTDYIGMEKHAKVLEGLVDRKIKYIDDIMGTAAQNEIKKLNDGEILLLDNLRLCAEENYEFTNSDAEKTIMVKRLAKLFDACVLDSFPSAHRAHPSIVGFSNILPVCAGRIVEREIKKLDEIMSVSKAPHVIILGGKKVDDRLEAIRLLIKNGRAENVLLTGLIASVFLRAQGRIKSSLGINREDEIVADAHSLIGEYPDVFSTPVDVAIEQNGKRVELDIRELNKDDQIFDLGPKTIEHYSKIISGAGTVFISGPAGFFEKDGFDYGTKTLLEAVSNSMATTIVSGGHLTSALKKFGLAEKITHISTAGGALVRYLTGTKLPMIQSLEESAKKFRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN35</accession>
    <name>A0A087RN35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="105" mass="12049" checksum="A8E59FE5D742C1F8" modified="2014-10-29" version="1">MEKTDIETIPIIKTFDLKDEKDAYDAAEEMVGIGFYKEKKGFKVLMPKEPKKTAKRIGYIITTSVSAGLRKAGQERDIKYWTYYHDKEHYAIVLASSKVVQELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN39</accession>
    <name>A0A087RN39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.393"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="103" mass="12492" checksum="CA7E576842C3D095" modified="2014-10-29" version="1">MRDDQRFEIQSAFDLLPHVIGCSWATIWFRLNKIKNPTREEFREKVSEYFKMLDPLLSVYPKEKNFEEIINYLKKRNAVELQKINAGKNPEVEKRYDRYVDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN43</accession>
    <name>A0A087RN43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nirD</name>
        <name evidence="7" type="ORF">AAA799O18_00465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.397"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="337" mass="39346" checksum="55307BF559B377F3" modified="2014-10-29" version="1">MDKLDTEILNEIQWTFPLVAKPFDVIAKKFEISPDEVKDKLIQLKRKGVLRQLSAIFDTRKLGYTSSLVAMEIEPDKLEHVAHQINKHPGVSHNYEREHEFNLWFTLAVPPGSDLEKELEKFSKLDGIKKTRMLPTLQLFKIGVKLDMVDDKKHEVKPSEEKKKITDVKFVATEEDKEFIRELQKDMEIVDRPFQKAAENLGMTEDQIFEKLHHYEEIGVMRRYAAILRHREAGFTANGMIVWKVPKERISEVGNKLGAFPQVSHCYERPVYPDWPYNVFSMIHCKSFDEAGEVAGQIQKQINVDEYKILFSAREFKKTRVEYFVESDFSLEEKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN44</accession>
    <name>A0A087RN44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="128" mass="15345" checksum="19064AD430F012D2" modified="2014-10-29" version="1">MTKPWIPEPYGHPRNKTTWKPFASKTEDKRWEKEQGKCQGYKKKCKKQLSKAKRNFDFDHRMGNDDISFRNCQLLCLECHRAKTKAEARKPERRSKISKTKKRNEARKPPSLKKQSRSEFKVPKIPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN63</accession>
    <name>A0A087RN63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="342" mass="38510" checksum="9FF648D966155542" modified="2014-10-29" version="1" fragment="single">MNLALDIFNYILVAILIGVSATLIFLIKSMFRTFRETPFLDKFKKNKHETPKVSIILPARNEEKFIGDCLDSLLNQDYTNYEIIAINDSSEDSTGKLIKKYAKKFPKLISVDARPKPEGWIGKNWACMEGYKKATGDLLLFTDSDTKHATPALSLAVSHLLSLELDALTVIPKMLCLDPITKITLPVISIFLHTRFSALRVNDVTKNTGYFFGSFYIIKKSTYDSVGTHESVKEELIEDGALGKKVKELGFKMRMVDGQHLIDAVWARDYFTLWNALKRLMIPLYLQNAKIAIGSSFAVLFLLFMPFPLFVYSSIFFNISISLSILFVVATIASILVYVGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN64</accession>
    <name>A0A087RN64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.365"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="15512" checksum="187E32AC4E0BCC30" modified="2014-10-29" version="1">MVIIASSISINSSVDTVWSIISDLDNEPKFWKGTKETRIISKDGNVITREIIIAFRDSKCMQRVTLQPKEAIHAEFTKGIIKGSKTLRLKPMENCLSLEANWDIKMSGLAGMFTGMIKKHVQSGTEQALESIKLKAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN67</accession>
    <name>A0A087RN67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Germination protease protein</fullName>
            <ecNumber evidence="2">3.4.24.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpr</name>
        <name evidence="2" type="ORF">AAA799O18_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.368"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="373" mass="41964" checksum="3C234FB6B1633CB0" modified="2014-10-29" version="1">MDFSNLDILDEFFGTGDSSPIMMLVWIIPIILFVFYGQRIQLIITSGDIKKKLAELEQFRNDSRNELIQYVKKNLAAKDNVTQKFDRFFDYFTVMPVDIDPNGIIPKIHRLIRSREDTTRKQIQSLFSEIDTMEITKIQNLLEVVTYLQLLHRIVRHLFLTAKKQNNYPMILPLQMMLPFIMEQAEALKDAVPAFKQGQPIGDGIGPLVVGEMMLGTKKQKAEFETVYSESKFKDRKLILLKAEGPYATVGRPSEAAQVLVEQYKPDIIVMIDAALKLEGEDSGTVSQGFGAAIGGIGTDRFKIEELATKFDIPIFSIVVKQSVKDAVTLMKKEIANQAENVKNQVHEMITDNTNSGQTVLVIGVGNTLGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN68</accession>
    <name>A0A087RN68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">map</name>
        <name evidence="8" type="ORF">AAA799O18_00427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.370"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="7">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="297" mass="33178" checksum="99A22D05E3BB654C" modified="2014-10-29" version="1">MQIEDYLKAGKIAGEVRENIRKKNWIGSTLEEICVYAESEIVKRGAKCAFPVNTSLNEIAAHYTAEPNDPKTVSDTDLVKIDLGAQINGYIADTAVTVNYDPQYDILVKTAEDALQSAMSMIKVGVKSKDVGRKIQNTIMDMGFKPIANLSGHSLEQYTIHAGKTVPNMWTIGSFSFSENEAFACEPFVTTKNGLGFVRNGKIKNIYALVSRKKTKDEKADMLAEYIWTNFNMLPFALRWLLKEWEEKEARKLLEILMKKKVVHAYAILVEANGKTVAQAEHTFIPTKTGVTITTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN72</accession>
    <name>A0A087RN72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-phospho-L-lactate transferase protein</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cofD</name>
        <name evidence="3" type="ORF">AAA799O18_00436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.374"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="306" mass="34084" checksum="AE318AA10013D3A6" modified="2014-10-29" version="1">MITILAGGTGSVKLVRGLASQRSDINVISNIGDDYWLYGLYICPDIDTIVYGLCDLLDQDKGWGIKKDTFGFLRQMEIFGEETWFRIGDRDTATHLTRTNMLKNGKSISYITEWMCKKFAIESKIIPASDNTVSTRITTNKGKLHLQEYWVKYRGMDTIEGIEYEGIEKARPNPDAISAIHNAERVIIAPGNPLTSIGPMIMMKGIRKELIKNKRKVIAVSPIIGTSAVSGPAGKYLEAAGVEVSAYGVAKFYAEVCSKLVIDTKDRILTKKIESLNMGVYDTKIKMINKKSENALASFLLKQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN74</accession>
    <name>A0A087RN74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX protease self-immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.376"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="328" mass="36744" checksum="7F953E516FCC0044" modified="2014-10-29" version="1">MQILGVPHGALISVIFCMMILSFPIGAYLVFNSEIGNDITYEYPMDNLSLFLAGIGFEIPIEFELGDGFVIIWCTFLILFAVSMFGPKKNLVRTLQSIVSEGKYQIQDNYIVVTVKWFSVLIIVSASIIAVQEFFGVFIEPPNEPNQLIQFFGVSLAPIIEEFGFRVALIGIPLFTFYSRKFSLKLLAKSLWRPFQNIHNVNVKSALLLIVIIGIFFGVAHIISGEPWSTGKFAQVASSGIIIGWVYFRYGLAPAILIHWATNYFIFSYAYIIADINNISVESAFTNSLLNTMEIILIVTGVISVTVLVLNYVFSKKKFKPDNPQVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN76</accession>
    <name>A0A087RN76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sjogren's syndrome/scleroderma autoantigen 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="108" mass="12019" checksum="68B961A53F6F3D6E" modified="2014-10-29" version="1">MSKDLIQKAAKMVIDGATILSEPCPYCKGVRVMKDGTALCVNCGKKPDQKPIKKRAKIKKSNIALSTLERKLEKLSHQLEKENNPTKQQELIKTIDSLIGVMAKLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN81</accession>
    <name>A0A087RN81_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
            <shortName evidence="5">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">tfb</name>
        <name evidence="8" type="ORF">AAA799O18_00400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.347"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="219"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="304" mass="33803" checksum="FF803DAF1C4A6B59" modified="2014-10-29" version="1">MVDKAQNLKEKCPRCAKGTLVTDNESGEMFCSKCGFVLTEKLQESGPEWRSFTQDEHGDRARAGAPTSLTMHDMGLATIINPANKDASGRPLTSQMKSTIERLRTWDSRSQVHEPVDRNFRQAFSELNRLKDKLAISDTVIEKAAYIYRKALDKGLVRGRSISALMASALYAACRDAATPRNLKDVEQAANIKRKDIARCYRLLVKELDLKMPVTDSVQCVARIASKIGIQEKTKRYAVKVLKIAQKNEVSAGKDPMGLAAAALYLACVKNDEDKTQRDIAEAANVTEVTIRNRYKGLKDSFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN87</accession>
    <name>A0A087RN87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.354"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="173" mass="18810" checksum="98A620002D72575D" modified="2014-10-29" version="1">MPGSGKSTIVSALKARGFEALNLGDGVRSEAKRRNIEPTGDNLGKLMLELREKNGPGAIADLLTEPIKNSQSKVIIIDGVRSTAEIEVLKNVGSVKLLSIEAAADTRYKFLSSRGRSDDPATREKFEERDNRELGVGIGESIAIADETIVNNDITLDELAELAYKVIEKWIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB6</accession>
    <name>A0A087RNB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-aminoadipate--LysW ligase LysX protein</fullName>
            <ecNumber evidence="6">6.3.2.n4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX</name>
        <name evidence="6" type="ORF">AAA799O18_00356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.n4" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.308"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="238" mass="26277" checksum="3DD05E0C153D0A76" modified="2014-10-29" version="1" fragment="single">NTHGFQTVLQRCVSYYRNTHSTATLEGLGARVINCLNTGLLAGNKLFTHMLLQKAGVPTPDATIAFSKESAIESLEKNGYPKIIKPTVGSWGRMVSKLNDRDSAEGVIESRESMHPIHQMYFLEEFVQRPPRDIRAIVIGDKVAAAIYRNTDGTNWKTNTHLGGSAETCEVSNELEDICIKAKNTVQGEIVGVDLMESSEKGLVVHEINNTTEFRNVVRVTGVDIPAQMLDYVKSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND0</accession>
    <name>A0A087RND0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase protein</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.322"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="229" mass="25683" checksum="184405DDA9183BB0" modified="2014-10-29" version="1">MGLGSYWGEVLDVLQEIIPVYDKVNSYISFGKDSEHRKRAINGRIKKGDKILDAGSGFGNMSKTALDLVNGDAHIVLYDPLLQMIKNNDRLFQEKPEAICGVFEHVPFKSKQFDVVLSGYSLRDAISLLKAISEIHRVLKKGGKWIIVDLGKPDESIVRFGVSFYLKLILPVVAYMAGGRLGLKFAALHRTFKLWPKNKKLESMLLEKFTSVEFEKDLMGGAIMVAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND2</accession>
    <name>A0A087RND2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type II methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.324"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="256" mass="29846" checksum="F4E77911439025E5" modified="2014-10-29" version="1">MKKFSVNKIYNQDCIDGMKGIPNGKIDLVITDPPFAINFKAKKANYNRTASRVLSGYSEVNAEDYYEFTNIWMKQVKRVLKKSGSMYVFSGWNNLKDILTALDANGFTTVNHIIWKYQFGVVTAKKFVTSHYHCLFVCKDNKLRKFFPYSRFKKNAKTSDGKSLHYQDKEDVWIIKREYWTGDVKTPTKLPAEIIKKILQYSSEKNDLVLDPFLGSGQVAVISKMLGRRYLGFEIVKLYYNFAVKRLQKNVYRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND7</accession>
    <name>A0A087RND7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Topoisomerase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.329"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="SSF56741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOPEUc" evidence="6">
        <location>
            <begin position="114"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="414"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="524" mass="61414" checksum="903ABF13F46911BC" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE0</accession>
    <name>A0A087RNE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="275" mass="32206" checksum="4122003F58E9C065" modified="2014-10-29" version="1">MSAEKFDPYVSEWISFSKNPKHNLIEKSLKLAQILEYPDLNISKYIEKINEIGNSLKLKINNIKNPTYLMSMLNEHFFEKYGFTGDDEDYYDPRNNFLNTVIDKKSGIPITLSILYSEVARYVGLELRIVGFPGHVVVKYEEEMILDPFYRGRLLTIKDLEEILYTNFGEEVQFIPEYVNVATTDQILTRLLRNLKNAYTQSYAYDKAMRCTDMILGMQPESPEEIRDKGILEERLLHYDKALPLLNKYLELEPEAEDADFILELIKSVREKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE4</accession>
    <name>A0A087RNE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM14998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="85" mass="9632" checksum="ECC6D3DE78B255DE" modified="2014-10-29" version="1">MKGSQFNMHKGFVLMNCDLGAEEYIIEELTKISEVSQAYVTFGAYDIIAEINTNSQNDFEETVSMKIRRLTRVVSTMTLTVVNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF2</accession>
    <name>A0A087RNF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="408" mass="46719" checksum="EDE6B17ACA97FEBE" modified="2014-10-29" version="1">MSNTENSPIISYAVFFCTLAVIILTLITVIFPALFSSYFGLYAENLEPFELGHQATFLITGNVIIFGLGILYYKKKIPSTLSSVIEKIRIFELSKKVSVVVLLIILGIYVGFSAPELFIDESTQWGDYKVLEEALELWPFGETDNVWIQEQNDRYVRMFLLDVSYDLFQNIKLLPFIASILVVFFTYLLATQFCKKRFAGIISVLVLLQSHIFLKFDTIAVYENFWVLFYLVSLYVIQKKWFLSPVFYLLAFFTKAYVAPYFLMTLFSAYRSEISRGRKIAILGSYVAIVVLAASLIFLGETIYPDVIEINYNKFILGFQAVSTQLRFDFLFTMTILPVIVGLVLLSKNKIKEADTILILIFGTIIISPVLVMFTAHYEIHAYRLIPLLVFFSIGVGMFFSKKLTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF4</accession>
    <name>A0A087RNF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="37" mass="4419" checksum="E926D3F3AA2740F5" modified="2014-10-29" version="1">MIEGFATPEGTANFLENLQRERRILEKHMILHYLMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG3</accession>
    <name>A0A087RNG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone-menaquinone biosynthesis methyltransferase ubiE protein</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="225" mass="25377" checksum="0067B9DC88650CE6" modified="2014-10-29" version="1">MLAESAKNLVPKFFDETGETYDGVVSYGTLGQDRYWKRKILEEISNGDSFLDLACGTGILTREIAEKFPDTMIVGVDITKSYLDVAKQNSSSFDNISFILDDAEKFKLDSKFDCITASYLPKYCDPEVLVKNCINHLKPGGKIIFHDFTYPKNPVVRGLWNIFLTFLRLVGCFIPSWKEALIGLPKLIRSTTWLNSYSNVMEKSGLKVDYQYLTYGASAILTGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG6</accession>
    <name>A0A087RNG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinyl-CoA ligase ADP-forming subunit alpha 2 protein</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sucD2</name>
        <name evidence="4" type="ORF">AAA799O18_00345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.297"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="265" mass="27966" checksum="6A1C7627546484B7" modified="2014-10-29" version="1">MLDYGTNIAAGVTPGKGGKKFLDVPIYETVKEAVSTSKAKISIVFVPAKFFLEAATEAFQAGIKLLVAIPEHVPIRDTMQAIKIAKENNAIMIGPNTPGVIIPGLIKIGIMPASPFKKGNIAVLSKSGTLLYEISNNLTTSGFGQNFTMGIGGDPINGTRMVDAFDIVKDESELEGMVIVGEIGGQAEEALAEHIIEIGFKKPVVGYIAGRKAPKEKRMGHAGAIVMGNYGSAESKIAMFAKANIPVAKRPSEVSILLAGKIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG9</accession>
    <name>A0A087RNG9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ileS</name>
        <name evidence="11" type="ORF">AAA799O18_00348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.300"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="690"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="1066" mass="123960" checksum="A19E5D145EA3DF10" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH6</accession>
    <name>A0A087RNH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="122" mass="14665" checksum="A0510527663F35EF" modified="2014-10-29" version="1">MKIIKDILSTFLGYSEDNFEINEENDSTNRQNDEYIGDEIACEQAIIKCRMKHGRLRKTTTRFCEKRFGKTTTKRTKWRLDMREKRGRNNTKELISDITETLKPFWDSYLEQKKKDDFKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI4</accession>
    <name>A0A087RNI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase protein</fullName>
            <ecNumber evidence="2">2.6.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnB</name>
        <name evidence="2" type="ORF">AAA799O18_00246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.87" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.226"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099620">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose aminotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="360" mass="40921" checksum="1038C6BC7F00C972" modified="2014-10-29" version="1">MKKIKLFDPIIGISEEKEILRTLRSRFWASGAGNRKVQQFEDKFCKYLGSDNCIAVNSGTAALNLALSLINIKNKEVILPSLSFVSTGHAILVNGGRPVFVDIDPQTMCIDHDEIEKSITPRTASIIPVHFGGLPCNLKEIQNIAEKHNLAVIEDAAHAAGATYNKKKVGCHGTAVCFSFHPVKNLAMPTGGLISINDKQYKKFRSLLLARRWCGITDRKETNYDVKELGWNYYMNEFSAAIGLEQLKKLDKLNNIRKKIAKRYSQELKIVTKMPYRTNCSYHFYWILVKNRNALRKKLSKYGIETGTHYKPIHTFSFYSSKNKLKFTENVGKQIVVLPCHPNLKKHEIDKIIKLTNKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK1</accession>
    <name>A0A087RNK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="172" mass="19857" checksum="4BEBFF60FCA81441" modified="2014-10-29" version="1">MQILKLVFLFFIIIPMISLIPEAEAHPLFNSGEEWIGDHRVQIATLPEIPAVDEEIQVLFQVVDADFQELDQFTMGIRVFYDGEQIDAVMPKMYQNGHMEMDYTFEMSGNHVFRVDLYDVADDGRPLTYTFNISSQNTFGFVFISAVTMGGIMTGIIFIYVYWSKRRSKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK4</accession>
    <name>A0A087RNK4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">argH</name>
        <name evidence="4" type="ORF">AAA799O18_00276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.246"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="3">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="486" mass="54271" checksum="C42C0CC1B3530691" modified="2014-10-29" version="1">MYRSRLGKNLGKITLDYVSSLNDDVEIALYDILGSQAHAIMLYENKIITKNEIKKILKGLENLKKEKFEKKSSSEDIHELIESLIIKRIGIDAGGKMHTARSRNDQVAVDIRMKIRDDINIVCQCLLDTIKSLVVLAKKHQDTIIPLYTHLQQAQVGLFSHYLLSYADALFRDLDRLYVTYGRVNENPLGAGPIGGTSIPIDRLSTGKMLGLKGIVENSIDATTTRDSAVEYIAAIAILMTNLSRVSKDFSIWSTSEFSFLELSDEFTSPSSVMPQKKNPDILELTRGKTSHVIGNLTSMLSTIQGLPSGYSRDLQQINPAIWSASKIVISALLIMESMLKTVVINKKNMRKAAEDGHLIALDLAEKLVHHDISFRKSHQIIGRIVKLAHKSGKPISKLSESEVKKVIKGKEVSLKLLMELIQSTTLTSSLHARKSQGSSGISEQKRMTLHRMKKIEKYQTGIKTRSLAVQNSLNKLNKKVKQLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK6</accession>
    <name>A0A087RNK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase iron-sulfur subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">frdB</name>
        <name evidence="4" type="ORF">AAA799O18_00278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.248"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="265" mass="29851" checksum="2FA2C271A1CFAE76" modified="2014-10-29" version="1">MIKGGALPKGFERPSDSSSQEKYEEVKSSSKTLTLRISKFNPEKDNISTFLEFTVPYQRWTTVLDAILEVKSHYDHSIGVRYSCRQATCGSCGMIINGKPKLACFTKISELDSDVVTVEPMNNFPIIRDLAVGFERMFTTHKRIKPYIINEESETVGTKEFLQSPEDVEKYIQFSSCIKCGLCNSVCPTMATDSTFIGPQALAQAYRYIADNRDKGKDERLRIIDEPHGIWRCHFAGSCSQVCPKGVDPAMGIQLLRGYLLGYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK7</accession>
    <name>A0A087RNK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase/Fumarate reductase transmembrane subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="119" mass="13140" checksum="ADFFBD331E28F7FE" modified="2014-10-29" version="1">MSSIMRESHIMKIHYLTALIAVGFVIIHIMIRFTHGSFANSLEFESVIANYKSIPYAIVLEAMLILISVHGFNGLRIILLELKQGNAYENAVTYGCLAAMIALIAYGSRTIIMASMGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL3</accession>
    <name>A0A087RNL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="70" mass="8285" checksum="DB48F01531B38B9D" modified="2014-10-29" version="1">MTTDITETTETSNTAHPIQHKLKHPIQHKLKHPIQHKLKHPIQHKLKHLIQHKLKHPIQQETQSTLVKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL4</accession>
    <name>A0A087RNL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.256"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="183" mass="20218" checksum="0870C443EFBBCB39" modified="2014-10-29" version="1">MNKLVKIFQILDSGSREDKIKVLESLNQSNKPEVIRKIISMLNDSEIRVRGEAFSSLFLNKNDISEFLIQGLNSKSSNEKGFSALVLANRGDSNAIPALELLTKESSDLVRSCALGALGHLCSNQSSAIIRNCFTDEMLEVRKSALDAFFKIGGKIFSSEAKQLTKDADDELVSLVKKISKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM4</accession>
    <name>A0A087RNM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="106" mass="12045" checksum="2001EB88E9794F6A" modified="2014-10-29" version="1">MSWIKITMKFDGTCLVCNQKVRAKDTGLWSKGIGVKHEKCAEVKEELRCVICDGSAGCIRCEFIKECDLQAVSQLCICKKCEQEQNSFDSYKNSVMKKFPLLNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM9</accession>
    <name>A0A087RNM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">ilvE</name>
        <name evidence="17" type="ORF">AAA799O18_00311</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.273"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFM15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="304" mass="33820" checksum="EE02563AB4D16C44" modified="2014-10-29" version="1">MKEVGKIWMNGKLVPFNNAKVHILTHALHYSTAVFEGIRCYNTSNGSAIFRLPEHVDRFFNSAKLYGMKMRYTKKQITDAIIKTVKASGLKECYIRPIAYYGYGTMGLTPTLNKVDVSISCWEWKMGESKAGKFSGAKCKISKWIRIDSRSQPMQAKSAANYSNAALARVEALKSGYDEAIMLNNNGKVAEGSAENIFIVKNGIIKTPPLNADILNGITRDSVIRLIKADGIKLIQKNISLKELLKADEVFMTGTAAEVKSVTKINKTSIGNGKVGIITKTLQKSFIDVVMNNDDRFTSWLRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN3</accession>
    <name>A0A087RNN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="68" mass="7736" checksum="3DA2AF11C696F66D" modified="2014-10-29" version="1" fragment="single">MGQNSDSDKENNNTKKESDLKKFLKKRSFIYLMCAVAFVVIVVPDMIAPSDLEKKLVENLENDEQNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN9</accession>
    <name>A0A087RNN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5'-monophosphate dehydrogenase protein</fullName>
            <ecNumber evidence="3">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaB</name>
        <name evidence="3" type="ORF">AAA799O18_00221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="137" mass="15846" checksum="2BB00C8D410CC10E" modified="2014-10-29" version="1">MGQIRDIMEKNVITIEKEQTIFQAAQLMKVNDISFVVIVENGNPVGVLSERDFVQKFCVDNKKPDEIMISEIMSYKFRWVEPTTEIEDAIQKMLNNNIRRLLVLDNKKLVGVITQTDLTSYLRDKLLVDGTIKNIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP2</accession>
    <name>A0A087RNP2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="8">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpA</name>
        <name evidence="10" type="ORF">AAA799O18_00224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.206"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="267" mass="29276" checksum="3A81897F083540AB" modified="2014-10-29" version="1">MSKIQDKFKELKSKNEKALISYIMTGFPNENTTLSIVRGLVKGGTDIIELGFPFSDPIADGPVIQNASTVSLNKGAKIEKFFSLVKKIRKEIDIPIVLMTYTNILYTHGYAAFMSKAKNVGIDGLILPDMSIEESKEYLKSAKNNNLDTIFLVSPNTKNDRLKKIARASTGFLYMVAVFGTTGVQTKIHNYTIDAIKITKNAVGGKLPMGIGFGISTPADVKKYVSLGVDAVIVGSANLEIIENTPLSKLQNKITEYTKKLKKSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP4</accession>
    <name>A0A087RNP4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trpC</name>
        <name evidence="6" type="ORF">AAA799O18_00226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.208"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="5">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="254" mass="28184" checksum="4A7F4F44285E52FB" modified="2014-10-29" version="1">MLQKLVENSQNAINDGIYAVTDTLPKSDIDLQESIRNNNHASLITEIKFSSPAEGDIRQISDPLQIAKSMISGGAQALSILTQPYLFNGSPEYFVKIRKNVKIPLLMKDVMIDKIQIDAAKKMGADYFLLIQALFDNDYVTDLDRLIDYGHKKGLKILLEAHTKTEFVNALKTNADIIGINNRNLDTLEINLETTKQLLEDFQKSKIILSESGIKSVEDVKFLHGCGADAFLIGTSIMKSPDIQTSVSKLVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ8</accession>
    <name>A0A087RNQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribofuranosyl 5'-monophosphate syn protein</fullName>
            <ecNumber evidence="2">6.3.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purP</name>
        <name evidence="2" type="ORF">AAA799O18_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1246" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="146" mass="16460" checksum="1B514EE0BC0D6F06" modified="2014-10-29" version="1" fragment="single">MVSIATLGSHCALQVLKGAKDEGFKTVLLCEKKREHLYRRFGFIDKIFLMDSFLDLLEKKCESMLQENNSILIPHGTLVAQMSSEQIESIKTPVFGNKYILRWESDRALKEQLMKEAKLNVPKSIPDSKQINSLVIAKRHGAAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU3</accession>
    <name>A0A087RNU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-1-semialdehyde 21-aminomutase 2 protein</fullName>
            <ecNumber evidence="2">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemL2</name>
        <name evidence="2" type="ORF">AAA799O18_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.149"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="233" mass="26320" checksum="F0EA6BC32D42A099" modified="2014-10-29" version="1">MLKNDLKVYKKNTRKSEEFFKKSRILHVNGVHHNIRFFEPYPFVAKSSKGKFLIDLDSNKYVDYWMGHWSLILGHSPKNVRTDTKKQLDKGWMHGTLSKNSINLSEKISKAVPVAEKIRYASTGTEATMYAVRLARTATKRKIIAKIDGGWHGYTTDLLKSVNWPFKKSESCGIVEEKYIVSLPYNDLINSLSILKSKCSDLAAVIVEPVLGGGGCIPATKEYLAGIEEFXMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV0</accession>
    <name>A0A087RNV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="92" mass="10257" checksum="7063732E03390044" modified="2014-10-29" version="1">MEMHDSKKYGITFLVAFVAAGLVIATVVFPFWNLIRADVYEEVVIMLNERGKCYVDTSDNIPKTIDNCSHNIGDVVTIKYGQGLAYAEIVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW9</accession>
    <name>A0A087RNW9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.174"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="251" mass="26732" checksum="33F935C6C531A8E6" modified="2014-10-29" version="1">MLEELWLIPLGFVAGILGSIIGLGGGIIIVPVLTFMGFSPTLAVSNSLFAVFSNSVASTAMYARQKRIELSLGWRFGLMVVPGTILGAFVSSEISPDIFKILFALVLISSASYIFLKRKIEEKPIDVSRLLLVFSAGASFFAGIISSLFGIGGGLIFVPLMVVALGISMKRAAPTSQFILMFASFSGLIMHSMLGHPDYYQALLLLIGAFAGGILGARLSLEIKENKLKILVIIVLIAAAIKLIIDSTGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX0</accession>
    <name>A0A087RNX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ACR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.175"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="164" mass="18391" checksum="767F2422F0D49986" modified="2014-10-29" version="1">MATRTQVLIPIAAAAVIVGIIGMLSIPTDVKLESVEFPQGMIKLDDKILVVQIADNDSLRMRGLMFQEELTFDQGMLFVFNEPGTHPMWMLNMQFSLDIIWFDENLHVTAIEKNVPPCQTTIEVVTCRENGVSGDNAKYVLEVTVGFVDEFNITENSRLELISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX5</accession>
    <name>A0A087RNX5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.180"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="185" mass="21043" checksum="C2CEE4C5896A0D83" modified="2014-10-29" version="1">MRILSRKFYNRDTVQVAKDLLGKTLVRKIGKQKLTGTIIETEAYKGKNDPASHASKKKTERNKVMFGQVGWSYVYFTYGMHYCFNVVAKKDEEQSGAVLIRSIKPLLGITDMLKNRKIDVISNLTNGPAKLTQAMKITTKHYNVDLTKNLDLFIMDGIKPTKIIARPRVGITIGVDKLWNFSFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX7</accession>
    <name>A0A087RNX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppD</name>
        <name evidence="6" type="ORF">AAA799O18_00200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.182"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="311" mass="34716" checksum="35CFD7493292075A" modified="2014-10-29" version="1">MPNIDISDLSVNYKTSHGDIHALENVEFQLKDGESIGIAGESACGKSTLGLSIIRMAQGGDVVSGKIMFNGKSLLDMPDSKFDEDIRWKEISMVFQGAMNSLDPVFTIEYQFTEVLKQHKFKGNSDKLIHDVIRSVNLDQSILKKYPHELSGGMKQRVVIAMALLLKPRFVIADEPTTALDVLIQAQVINLLKKLKKKGMSIMLISHDLAILSEVAEKIGIMYGGKMVEFGTASEIYHNPKHPYTQGLLDSIPMLHKEKKLSFIPGKPPDLVSPKSGCRFFDRCPDAMEKCKTRPPKIKTNSGYVLCWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX9</accession>
    <name>A0A087RNX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-isopropylmalate dehydrogenase protein</fullName>
            <ecNumber evidence="5">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">leuB</name>
        <name evidence="5" type="ORF">AAA799O18_00202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.184"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011828">
        <property type="entry name" value="LEU3_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02088">
        <property type="entry name" value="LEU3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="339" mass="37315" checksum="329900505FE0DA02" modified="2014-10-29" version="1">MSGKYNISLVTGDGIGPEISESAFSILETINDNLDIHFEIKKLEAGDTVLKNTGQALPVETFEVIKNSDACLKAPVGESAKDVIVYLRRMLDLYANIRPAKSYPNMPSLRDDVDLVIVRENTEDLYTGEEFDIGDVSVAMRIISEKASKRIANYAFKIASQRKMKKVTCVHKSNVMKKTDGLFASTCSKVASNFSDIEFEEMYVDACAMNLIRQPQSFDVIVTTNLFGDILSDESAQVVGGLGMAPAANIGDDFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLEWLGNKHNDQKCIDAGQKLESVVYDVVKNNIKTKDTGGNKTTMEFTKEITSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY3</accession>
    <name>A0A087RNY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="133" mass="15531" checksum="A554A5668AD454CC" modified="2014-10-29" version="1">MTEKEVIKVIESFFDVGKTKNFSVLREIQMNDSMFSSFSDVPPYNLKNYSDTITLEELRFSSISDYEYKIIDPIISIYGNIAIIKFRLMQKGMLVDNKAFTGTHITINGRATFVLIKEDSWKIIHYHLDKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY9</accession>
    <name>A0A087RNY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome-activating nucleotidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pan</name>
        <name evidence="4" type="ORF">AAA799O18_00212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.194"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="397" mass="44985" checksum="A409DFAA50DF0E3B" modified="2014-10-29" version="1">MNMAPQELEKSASQYASDAIKYDSQGARGMAVAHYQKAIDSLLKLMHLYPDSKLNKIYTERMGSYQNRIKVLQATGTDIEPVVDPTASPQEQQANLSKPKQDNFDDMVMKEKPDVKWDDVVGVDDAKNALRESIVYPTKRGDLFPLGWPRGILLYGPPGCGKTVLAAATANELDGYFINVDGSSMMSKWLGEAEKNVSRLFKMAHGYAQREGKPVILFIDELDSLLGERTNEIGGEVRSRNQFLTEIDGINDKGKDTKLYVIGATNKPWSLDHPFLRRFQKRIYVSLPSLEAREKLFALYTNQLKIDSRVRLHTLASIFDGYSASDIKDICQSVQLKVVNEMFHTPEYVEPVNGESLSQPRDLMMKDFRETMARRKPSVSMDAIRAYYKWSEQFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP36</accession>
    <name>A0A087RP36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase protein</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA</name>
        <name evidence="3" type="ORF">AAA799O18_00136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.117"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="360" mass="38849" checksum="13BD6C53B28488E2" modified="2014-10-29" version="1">MNKPIIGITMGDPAGVGPEIIGKAFADKMIYEICNPVLIGDKNAIDDGIRIAGNTIKTRSIENVSDANFEFGVIDVLDLKNVDMKEMKYGKVSAMCGKASGEYIEKAVDLALKKEINAITTCPIHKDSFQSGGYLYPGHTEMLAQLTNTEKFTMMLTHGDFRTIHVSTHVSLKEACERVKKDRILHVIKLANEGCKALGIKEPRIAVAGLNPHAGEYDYRDPEGSPGGIFGDEEHKEIIPAVKAAQEQGINAIGPIPGDTVYPQSLKGGKFDIVVSMFHDQGHIPMKLKGFVYDADTKDFGSINGVNTTIGMPIIRTSVDHGTAFGKAGKGTANCDSLKQALQSAVRLAKSGYYDNGFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP38</accession>
    <name>A0A087RP38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="259" mass="30334" checksum="D720FEB7E313A2E4" modified="2014-10-29" version="1">MTQYVFLGHDVDWRKQGASLEHIMARKERFEPSVLEECDKKNPYYNIPDYMEIEEKFGVKSTFFFRTKYEDGDFADYENDIRSLIDGGWEVGLHLDPSSIDDSKKILEEKTKLESISKTEIKSNRVHYLGFNDDLPNKLQELGFVYDSSVRRSKDRIDENEMGYLKYGNLIEFPITIMDAYLFTHMKIKEEQIIPTFESTLNLGRKVNDSFNVITVIWHDNVLKMKGGRMYKKILEYLTSQDDVSILRGIDLASMINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP40</accession>
    <name>A0A087RP40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.121"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="416" mass="44444" checksum="EF7488CED5BF5C1A" modified="2014-10-29" version="1">MANGIKEKIEDANKEAIDKVLASNPVLVDVKPAIETVPGMKKNMIMHAGPPTDWQNMCGPMKGAVMGTLLFEGLAETKDEAVKIIENGEIEFSPNHEHHAVGPMAGTTSASMPVFVVKDETHGNTAFARLVEDKVQFGDYRDEAVNGLQFWRDKLSVAIGTAVQKAGGINLKNIIGKALYRGDELHNRPDAGSSMFANMIITNLIETGMDHNELLPVAKHLISDDIFFLGLSMGACKATMDAAHGIEYSTLVTAMARNGVEFGIKVSGLGDEWFTGPASLIDGLYFPGFTADDANPDMGDSAITETAGLGGFTLAAAPAIINLVGGTPDEALKYSKQMQEITMTKNNGYTIPALNFEGTATGIDIRKVVKTGILPIIDTAMACKDPGKRMIGAGLVKPPMEAFKKALHGFAKKYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP43</accession>
    <name>A0A087RP43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="517" mass="56873" checksum="DFB0E38680FBCEA4" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP59</accession>
    <name>A0A087RP59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.142"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="163" mass="17259" checksum="9FD5370035651441" modified="2014-10-29" version="1">MMLKLTMKDILKQKTFAFIAIASGAILGLVYYFLTLSSAVNHNLVSLVVSPEYLAASIGLTFMVAILGGINIALVVYNIKTQRMNLQKGGTSAIFGGALAAFTPGCPACTTSLTAVLGIVGGLAIFPLQGLELKFVSIAALSFSIWWAMRNINKASCCTMENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP65</accession>
    <name>A0A087RP65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type ATP synthase subunit I protein</fullName>
            <ecNumber evidence="2">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atpI</name>
        <name evidence="2" type="ORF">AAA799O18_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="175" mass="19511" checksum="A8A70C170179CEB6" modified="2014-10-29" version="1" fragment="single">LALISGAAINPTWDRLVEVNPIAYMYYGLIFGGIALMVACDKSKGPMKVMALMEVATIISHILSYTRLIGILLASVILAHTIDYVFLKSINIGIPLVILGTMILFIGHLFNIIIGVFEPGIQGARLVYVEYFSKFYRGNGKAFKPFGSLRRFTEGLYHSEQQEVKKQDKPKLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP83</accession>
    <name>A0A087RP83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">AAA799O18_00010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.9"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFM15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="170" mass="19022" checksum="65B98EF14D085FBD" modified="2014-10-29" version="1">MNLKERIAEYSDFPKKGILFRDFSPILRDSAALSFVVEEFSKQYNPEDVDVFVGIESRGFILACALAQRYNKGMVMLRKEGKLPGKTEKTSYTIEYGKAVMEIQKTVLHEGEKVVICDDLLATGGTAKAAAVLVEKVKAKVTGFAFIIELTELNGIKEINNYKIVSLVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP92</accession>
    <name>A0A087RP92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.17"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="189" mass="21016" checksum="7C3952B8AB344D7D" modified="2014-10-29" version="1">MSFEKLIRIPEDRIGVLIGKSGNIKSEIEKKCSVSLEIDSDSGEIHIHSAGSITDIQPFKAMEIITAIGRGFSPNKAMTLLKEDHVLHVINLQEFVGKSTDQIERIKGRIIGEKGKARINMENLTNTSISIYGKTVSIIGSPNRLKNVIDAISSLSSGSMHGSVYNKLEAVRRREKLEKLQLWENQDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP94</accession>
    <name>A0A087RP94_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eIF1A</name>
        <name evidence="1" type="synonym">eif1a</name>
        <name evidence="4" type="ORF">AAA799O18_00021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.19"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="103" mass="12151" checksum="2533D411687765C0" modified="2014-10-29" version="1">MGKRKVLNESALKEIRLPEEGELLGRVIKLLGSDQVLVKCTDDITRRGRIRGKLKRRIWIRDNDIVIIAPWDFKATERGDIIWRFTLSQVDWLKDNKHIPKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA0</accession>
    <name>A0A087RPA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">uppS</name>
        <name evidence="3" type="ORF">AAA799O18_00027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.25"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="265" mass="31001" checksum="3DC0D0A5645472A1" modified="2014-10-29" version="1">MNINGILDIALNISGLYRFYAKRLEKEVVNGDRPNHIAIVLDGNRRWAKRNLVMREHGHFKGADTVEDLLDWCEEFDIKIITLYVLSAENLDRKNEELDYIYDLIKTRLEKLYNDPRIHKNEMRVKAIGRIELLPDSIKDVLSRLDNATKDYSNHFLNIAIAYGGQNELVDAVKKIGTKIKEGKLDTNDINKDIIEENLYTSHLPQPSADMILRTSGEKRMSGFLMWQSAYSELVFLDIFWPEFRKIDLMRAIRTFQKRKRRVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA9</accession>
    <name>A0A087RPA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="110" mass="12354" checksum="EFD7598131D8A12C" modified="2014-10-29" version="1">MVLDHILKITTVSRIMASYRTHIKIVGEILDTTLESVDEYDGTSITHLIRKANISHGRLSVILNNLVSQGLLEQVNSEGCCRYKISSSGQEFLSAYKTFRDFSEDFGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB4</accession>
    <name>A0A087RPB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD related DNase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.42"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="251" mass="28965" checksum="5AD667438177879E" modified="2014-10-29" version="1">MTWLYDAHIHLSDLEYEQDIPLILNSMKKLHIKACCVSMDYDSSKKTLELGNESDSILPFIGMHPEKAQDDTESMFRLIEENNEKISGIGEIGLDHTYSNSEEELLKQKEVFRTHLSFAEKFRKPVSIHSRKTLDEILEILPSYNIPSILLHWFDGSKKQLQQAMGLDYYVSFGPVMVYSKDKQVLLSKSNKDKILVETDGPVRFSRCFSNRIAQISFIPSVIFCASKVLGINYENMCRILEENSQRFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD1</accession>
    <name>A0A087RPD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="128" mass="14638" checksum="F5651C1B2262DFE1" modified="2014-10-29" version="1">MLSFEALAAAIKYSDYRNPTSIWWFARVSLNFNSKEVEHDALTCLNSLLDPNFKPAKWLGESERSLSKWKKLAAVTLQVVEQNKKKGKKQGDIVDLDRKIYHALKRKYGKSWSPIGGVLKKKMGNPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD7</accession>
    <name>A0A087RPD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein AAA799O18_00074</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.66"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="278" mass="30333" checksum="2CCF5C6AADEC0A34" modified="2014-10-29" version="1">MEVRTPAVSGTFYPDDEKELKSLIHDCFTHPIGPGKMPPTGLDQKIYGVICPHAGFVYSGPVACHSFYSISSSTSKLAIITGPNHYEVGQNIASMIDVSWKTPLGLVEVDSESALELRDGLDILELDSFSHSKEHSIEVQIPMLQETFSHEMKILPVSLINQEQQTATNVGTAIAKIAQKKDAILIGSSDFTHYEENEFAHRQDLALIDPILKLDVDEFYKILYERKVTACGFGAIASIMTACKELGATKGKLLKYATSGDVSGDKSSVVGYASIIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD9</accession>
    <name>A0A087RPD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="165" mass="19486" checksum="6251247433731B8F" modified="2014-10-29" version="1">MARPELILRTIEKNPGIRFREIMDELGLKNGTLSHHIQKLEQQSVLRVERTPRVARFYPLSVKDEEISIIKRLRQETPRRILRLLLDMDEVNFSEMFLRIKRSPGTTSRYVTELVDDGIIKDRFENGKRFFSLPDKNTVDKLISKYHPDLMDRTIENYADIISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG2</accession>
    <name>A0A087RPG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="81" mass="9328" checksum="653F6FA490D8A937" modified="2014-10-29" version="1">MTLIFNTKIEIDAEEKTKAVFNSINIDNKFYPENPTKTDMFCNEKITILIESNQLAHMRANINSCLRLIQASYDSIESLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG7</accession>
    <name>A0A087RPG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome complex RNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="173" mass="19493" checksum="93D116F5F56727E5" modified="2014-10-29" version="1">MKNLDKKKRYVLPGDVITTAPLRLRENVTLEGKRILATAIGLSDVSYDSVRVISLTGIYLPKIDDLVIGKIKYIHGNSWFADINSCYEGMLLAKDVFGRGSNTNLIDMKTRLDKSDLILARIANCDRTREPLLSIAGQNLGKIDSGELIKISYKNSTSDRKTWFYDTDNRSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH8</accession>
    <name>A0A087RPH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP protein</fullName>
            <ecNumber evidence="2">6.3.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cofE</name>
        <name evidence="2" type="ORF">AAA799O18_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.107"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="255" mass="28274" checksum="4EA5FEEBE025FD28" modified="2014-10-29" version="1">MEVLPIKAVRKQGKFDLYVELKKLVRKNGILLKEGDVIVISSKYISNSQGRIVNHDSIKPSKKANELTKKFSINKELSEVIIRESDFVFGGVTGFVITSSDNIMAPNAGIDKSNSQDELILYPYEPYLVAEQIKRKFFLDYSIHVGVIITDSRLMPARVGTTGVAIACSGIEPVLDRRGTKDLDGNALKVTFQAIADNLASIANHKMGEGDETLPVAIIRDSGAKITDRKIDPKEMTVSHDQCVYVRGLKNWNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI1</accession>
    <name>A0A087RPI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.110"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="145" mass="17166" checksum="0448BB42A48540B2" modified="2014-10-29" version="1">MNIIQVNKIFRKSIIKGFFEEELVNLDFKKTNIKHPTISGEGLMQSHLLHVFFDIETGSDYPDGDEWFIADFLFPYDMKIPDAIKGPDYFTTISIGNKKNFWHHREMVRYKYGKTKKLSEALEFLETKYKELHSLVEPLEKDIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI3</accession>
    <name>A0A087RPI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate synthase subunit KorA protein</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">korA</name>
        <name evidence="3" type="ORF">AAA799O18_00130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.112"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="127"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="395"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="510" mass="56226" checksum="C354C26FDEBD9294" modified="2014-10-29" version="1">MEPKVSSIIELAKESGVNAYPISFSDTLSNIAEELKRPELSRMTRMFNVLGVSFSLGILKAPIAPLLESIEEIFSTKPTIADLNKKAANFAYNYASAKFSGFNASLNETDKKPNIMLVQGHQGSALGKMVCGCRFQSYYPITPASDESEFLETHEILQVKENRPGSTTIVQTEDEISAIGMAVGASLTGTRSATSTSGPGFSLMAETLGWAGINEVPVVISLFQRSGPSTGLPTRHGQDDLLFAINAGHGEFPRIVYASGDVEDSFYDTGKCFNFADIFQLPVIHILDKFIASSVVTCNRFEPDLVSIDRGKLLEKTDGDYKRFAHSPDGISPRSKLGLENGVFWNTGDESDEHGHISEDPVNRVQMMDKRQKKVEQILTLVPKNDQAVAYGKSDICIVSWGSPKGPILDAIEMHRKEGHEIGFIDIKLLEPFPTEHVKSLLKDSSVIVDIEANMTAQLGSLIRQNLLKDPDYYVLKYTGRPMTCIEIFDSLKKILEKKAEKRQVLLYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI4</accession>
    <name>A0A087RPI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate ferredoxin oxidoreductase subunit alpha protein</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="112" mass="12395" checksum="1702648D4E252B28" modified="2014-10-29" version="1">MVFDYSWLIGGPQGSGVDTAANIFSRVGIKLGYHVFGKREYHSNIKGLHSYFVVRLSDNKIRSNVNGANIMVAFDAETMIRHGLSISKNGAIIYDSSVVNTSIDEIKFQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL21</accession>
    <name>A0A087RL21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA double-strand break repair Rad50 ATPase protein</fullName>
            <ecNumber evidence="2">3.6.3.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rad50</name>
        <name evidence="2" type="ORF">AAA799O18_00777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.31" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000048">
        <property type="protein sequence ID" value="KFM14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.663"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="1">
        <location>
            <begin position="47"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="254" mass="28436" checksum="2528C649E46A52A9" modified="2014-10-29" version="1">MQKIPLTIIPGQLVGIANLDSHAKTIYESIVSLEKSTDGFDQQELQKNIESRADSMTRLTQINQEYGEISGNIKKAKIELENLGSTLTELKHVEKYVTELENIQENVYNRDGPVGKSLRSWSLEIISQKASEYLEKLNTKIQRISLSEKTRDVNISCYSRNTTLDIESLSGGEQVSVALALRLGMSHLLGASNLNFMILDEPTAHLDGERRKSLVNVLSQLTNLKEDSSMQFIIITHDAEIFDDSSVXTIVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL22</accession>
    <name>A0A087RL22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000047">
        <property type="protein sequence ID" value="KFM14176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="291" mass="32218" checksum="EC34F28583E72942" modified="2014-10-29" version="1" fragment="single">APTVELEITPTIIMDKLEFENLYIQTNKEKVQVNQSYSKNTENGLEVITYKLEDGYLATQDYYIGLKFFDADAQEYDATKVTKAVVGHFDFADKDSSGTDIKSQLILDEEDIWKEDEGYLGNFYGDGMDFTIFTANRAYKITVKIEATEAEPDSSFAGDFKIAGFNNITDLYIMPADVDTLSKDYQAIFINDTSVDITKLVPKFLASSGATVTANGTAQTSGTTVVDFSKGAVKYIVTDNSNTQEYFVNVVKKSADAKLFVNGPNVRELQLTKNEGHDIFIANVGAKSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL46</accession>
    <name>A0A087RL46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000040">
        <property type="protein sequence ID" value="KFM14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="22" mass="2539" checksum="9AECD58CEDBEBE98" modified="2014-10-29" version="1" fragment="single">MLVTRVMFFVTTDGFLVNTIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL50</accession>
    <name>A0A087RL50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000040">
        <property type="protein sequence ID" value="KFM14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.643"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="441" mass="50113" checksum="3846F2515BE98BD4" modified="2014-10-29" version="1" fragment="single">IAKIMNENFVNIKVDREERPDLDDIYQKVCQMSTGQGGWPLSVFLTPDQRPFYVGTYFPAIDSYGRPGFGSLCRQLAQSWKEKPKDIEKAADNFMQNLDKIQQFTAPSEIDKSILDEAAINLLQIADTTYGGFGQAPKFPATSDLSYMFRYSKLSGISKFEKFALLTLKKMAKGGIFDQIGGGFHRYSTDARWLVPHFEKMLYDNALLPMVYAEAYQITKDIFFENIVKKTLDYVIREMTSSDGTFFSAQDADTNGEEGQTFVWKKQEVEKILGEDSKIFCVYYDITDGGNFKGNTILANNINSSALAFKFGKSESEIQNVISKCSDKLLEVRNKREQPGKDDKVITSWNGLMISAFLSGYRITDNTKYLDIAKKSIDFFQSNFEKNHILHRTFKNGQPKLNGYLDDYAYMANASIDMFENTSDSKYLLFATDLSNNTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL52</accession>
    <name>A0A087RL52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="4" type="ORF">AAA799O18_00742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="117" mass="13409" checksum="DA7BC6CD0EA0763C" modified="2014-10-29" version="1">MPDGNYVFQLKPEYSSSVRKYASKPILARATQKTLSYIAFEQPVSSKQLVEIRGSGVYGHLKELRQLDFIKNQNIGRLKIYSTTEKFQKYFGIPGDADILKQKLFKRVRKASEITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL57</accession>
    <name>A0A087RL57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.629"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="69" mass="8050" checksum="D829D1836B9E6E3A" modified="2014-10-29" version="1" fragment="single">SIDFPIDIVDVFRPSDQVLEVVQEAIKIKPKVIWLQEGIHNLEAEELARKHGIKVVFNRCMLAEHQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL66</accession>
    <name>A0A087RL66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000036">
        <property type="protein sequence ID" value="KFM14220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="95" mass="10773" checksum="8B2EBC16BD0E8235" modified="2014-10-29" version="1">MENIEYTGTVYVLDHKYPEPLIQHSVKKLQQLGIKKEDIELTDAPDNPQIGNIIVEVFPYHLDIARVRTIRNSSFISGTIMTVELKSDAEGNYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL68</accession>
    <name>A0A087RL68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000036">
        <property type="protein sequence ID" value="KFM14222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021834">
        <property type="entry name" value="DUF3426"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11906">
        <property type="entry name" value="DUF3426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="257" mass="28704" checksum="D99387F743C235D5" modified="2014-10-29" version="1">MQIFSVFLILLIFVIPDVWAQPYIENDYHYIGYDGTLHIVGEVINDSDKPLNQVNIFATIYSDDKIIHQTNTETLTNVIMPGMKGVFDITMTENIEGVDSYILDIDYKITHPKSQVIEITSSQLSYTQFDNLVIQGTVANNGDATANMVKVIATLYDRDGNVIAVSQIRTEPDYLRANDETFFLIAIPGGDNTDNIVDYSLIAESEEYTAVPEFPFGSGVLLIASLSAYIVLTKNPSVVTKNITRVTNIGWILNRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL78</accession>
    <name>A0A087RL78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase protein</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA</name>
        <name evidence="3" type="ORF">AAA799O18_00712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000032">
        <property type="protein sequence ID" value="KFM14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="518" mass="58891" checksum="D6B7E07726DA287A" modified="2014-10-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL81</accession>
    <name>A0A087RL81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FO synthase subunit 2 protein</fullName>
            <ecNumber evidence="2">2.5.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.77" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="77" mass="8585" checksum="EAA778B8B3822253" modified="2014-10-29" version="1" fragment="single">MSQITKQIHDSEIGDILANSLQGKRLGFDDYIRLLDSDNVHLMGLVAGALTRKKFGKKATFVKNIILNYTNVCITDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL84</accession>
    <name>A0A087RL84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-dehydroquinate dehydratase protein</fullName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name evidence="1" type="ORF">AAA799O18_00709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.615"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="78" mass="8727" checksum="9329F0AD260AFE23" modified="2014-10-29" version="1">MIYKTCVSIAEKTPKKLKQTLSKALKKSDYAEVRLDFLNQNSVPEALQLIKKDLKKCVATLRPISEGGNFSGSEKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL85</accession>
    <name>A0A087RL85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-dehydroquinate dehydratase protein</fullName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.616"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="132" mass="14980" checksum="9FF9EEADD2C29C30" modified="2014-10-29" version="1">MLDVEFNTLRKNKNTSHYIKNTGTDMLVSWHDFNKTPKVSVLRNKIIQMKKFSNNIKIVTMAKSINDASHVLSLYSDTKVKLIAFSMGEYGKISRLLCLLLGSPYTYVSLGKPIAPGQFSVDEVKSIFTMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL91</accession>
    <name>A0A087RL91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">AAA799O18_00699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="S27a-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="56" mass="6178" checksum="67DF92F0613B4364" modified="2014-10-29" version="1">MAGKKGTSPSVYKYYKIDGEKATKTHKICSRCGKGVFMSEHKGRRTCGKCGLTEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL99</accession>
    <name>A0A087RL99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.593"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="180" mass="21453" checksum="843093262F53A260" modified="2014-10-29" version="1">MSATNTLRDDHKQIKRLDKIITKCYSDINAGKTIPFSDLEKITLIISEFLDSIHYSREEDSYFPCVASYDHLKKEIRALLIEHEFSRRIASKIILHLKRWKNGEDSSEPVVRFLRTYSIYLNDHISKEEDFFERAEKEVLSKEEEKDMFEDFQSAMAITKKMDSILKDIDYLENQQWFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB4</accession>
    <name>A0A087RLB4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triosephosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="3" type="ORF">AAA799O18_00681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.590"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="218" mass="24101" checksum="D9D9992EF2BB840C" modified="2014-10-29" version="1">MFIINCKNYNEISGEKISKLAVIAERISKKHKIQIALAPPHHQLALIKKSKLLVFAQHLDDAKVGSTTGYMIPEIVKKSKINGSLINHSEHRIPSKEVTNLVKRLKKLKMKTVVCVKNVREAEKYAKLNPTYVAIEPPELIGTGRAISNERPELITKSLLAVKKARNSTKLLCGAGIVTTEDVKRAIELGSHGILVASGIVKSRNWNKDIEGFAEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD1</accession>
    <name>A0A087RLD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="32" mass="3956" checksum="9F008C8C8538CF2D" modified="2014-10-29" version="1">MLNFQNVVWLENLKMLFSQVGYGHKKHWSEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE4</accession>
    <name>A0A087RLE4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ORF">AAA799O18_00646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.559"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="145" mass="15686" checksum="501025200A59AE33" modified="2014-10-29" version="1">MSQGRSRGKASKGVIEFRPYVTRVIPVGAQIVCADNTGAKILEVVNVHKYHTRVSRLPAAAVGDFCNVVVKKGKAELRKQVHGAVIIRQKYAIRRLNGVRVSFEDNAAVLITPEGEVKGTDVKGPVAAEASEKWPRIANLASMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF0</accession>
    <name>A0A087RLF0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps19</name>
        <name evidence="5" type="synonym">rps19p</name>
        <name evidence="7" type="ORF">AAA799O18_00652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.565"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="130" mass="14711" checksum="B5589F1BDE8F9DFF" modified="2014-10-29" version="1">MVKEFTYRGLEKKELENLSLEDMLKLFPARARRSLTRGINDGKRKLIEEIKMAKTGKDITIKTHLRDLLILPYMVGVTINVFSGKEFTPVTITTEMISHYLGEYVITNKRVSHGAPGVGASRSSLYVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF8</accession>
    <name>A0A087RLF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.541"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="6">
        <location>
            <begin position="287"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="461" mass="51140" checksum="EE518C132A312253" modified="2014-10-29" version="1" fragment="single">FIKMTSELPVRFFHMVPGGLPVDRKFSHGKTLSLAEVKSALKIPDVLGLGEVFSWIKVTKRDSKTMRTLSTMLENNCVINGHTAGASGKKLNAYVSSGILSCHEPINFDQIVERLRLGMWIMIREGSIRRDLKNIVPIILLNKTYIDRLMFCSDGVDPTDMERFGHIDHCIRESVKLGLNQIDAISMASKNCFDYYNLGKDLGGIAPGKLADILVFDDIIKMKPKKIFVGGRLVASNGTIVCKMKKHTLPKWMTKTVKPRKFSEDDFTVKSRANSVNVNAIFMKGEIVTAQENVNLPVKDENVVASIDMDVWKVAAFDRTFGSRKHTVGFLKNFDAKIGAFASTWNFHENNMIVIGSNEKDMAKAANSLVSTQGGMVVVNEDKILSSMPLQMAGIVSTDSFETVSENFANLNSVLADAGCKFKKPHLVPLFLPFIALPDIRILSTGLVDVKNRSFLKIITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG6</accession>
    <name>A0A087RLG6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">AAA799O18_00621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000023">
        <property type="protein sequence ID" value="KFM14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.539"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="423" mass="45535" checksum="58445CD2E670B82C" modified="2014-10-29" version="1">MNCRVEKSEVSGTITCPSNKSYTHRAIFLASLADGKSIVKNILKSGDTDATINACKNFGVEVKETGNNITINSSGKLKIDNVMIDAANSGTTIRFATAISALSNGKTVLSGDASLKKRPMKPLLDALESLGAKCSSNNGNPPISVSGKIKGGEIQIPGNISSQFISALMITAPKLENGIILNVRDNLVSKPYLDATIIAMKKFGVNVETVIPYQKYNIPEQSYKPTTFTVPSDFSSISLLLSAAVLVGENLTIQMSMGDMPQADEAIIDILEVMGVVITLNKNTIKIKSPAKLTGGKFDLSNSPDLLPAIAILALKTSKPIKIFNVKHARYKETDRIKILARELSKLGIKVVEKNDGLILKNSGSLTGANLDSENDHRLFMAFCIAGMYVGNCIVSNPESVKISYPDFIQEMKRIGCNIFLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH0</accession>
    <name>A0A087RLH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.528"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="274" mass="32184" checksum="D61C1BCCDD412607" modified="2014-10-29" version="1">MLKKYNDMTKIYEKVAENFLELASLQRLNILFKLLERNRKRIEPLAKELDATKQEIHRNLVRLEQSGLITKDREGKYRLTTFGRTICAEIPSILFLSQYRDYFSDHDFGDIPVKFVMRAGQLATGLHVKGITKTLEKWKSVYKNANKYIYEILSEIPADLFDPVVKKIKNGIKYQYIVSESAIVPEGRITMLKKSGFYGLIEKGLIERKMIKSVQVVTVLNEKEACIFFPNRNGEADLTEMFYSDNDMFHEWCLDYFRYCWYGSDIFQESKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH8</accession>
    <name>A0A087RLH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase I protein</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.536"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="1">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="185" mass="21039" checksum="0A6EDB812EC9BADE" modified="2014-10-29" version="1">MLSGRKKNYLGVTKTGKVDVKGLTGKKSHTPPFIKTLFFELLDILSMVNTIDDFDRAKNKVADKISECVRKIQAKEIPLTELAFNVMLNKAPNDYTKTIPQHIRAAKQLESIREIKKGEIISYVKILNKPGVRPVELARQSEIDSSKYLEFMESTLDQITSSMDLDFDTILGKPKQTGLDQFFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI3</accession>
    <name>A0A087RLI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.522"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="60" mass="6837" checksum="B76CC0E5F8742DCC" modified="2014-10-29" version="1">MATHGSLTKAGKVRGQTPKVEGRKRVGTSSSLRNKSNFKKRFILSRFPGQNKPGQRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI5</accession>
    <name>A0A087RLI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="88" mass="10269" checksum="B10E281ADB079606" modified="2014-10-29" version="1">MRKIPRPFKMPWGKGMVIDEISISSQYHEPTIQLLEFDNGDKLLRFCSYSHGRFSRSPLMIDENDLSRLGKAVVKGKEIRKFITKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ5</accession>
    <name>A0A087RLJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.516"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="299" mass="32648" checksum="53637636A4B0EAAA" modified="2014-10-29" version="1">MDNNLAKQRCPSCTKTKMVLDDTTGELFCSFCGFVVTERITEGGPEWRSFSNDGEDRSRVGSGTSITMHDMGLSTIIGPQNKDATGKPLDSSMKKSIDRLRTWDSRSQAHTSSERNLRQALSEMDKLKDKLTLTDTVIEKAAYIYRKAIERKLVKGRSIHGLVAACIYAACRITETPRTLDDIADGINIKRKDVARSYRIIFRELDLKIPVADPVKGVSRIASVAGLGEATKRKALILLNKAKKIGIVAGKDPMGIAAAALYLACISAGGNKTQKEISIASGVTEVTIRNRCVGLKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM56</accession>
    <name>A0A087RM56_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="4" type="ORF">AAA799O18_00583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="PTHR11594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="65" mass="7194" checksum="ECB71CC53F084530" modified="2014-10-29" version="1">MKKERILIPEPNSKFLKVNCKECEEENIVYSHASTVITCKSCGNVIGKPTGSKVEIIGKISETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM59</accession>
    <name>A0A087RM59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">cobD</name>
        <name evidence="13" type="ORF">AAA799O18_00586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.508"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFM14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="323" mass="35279" checksum="E6B666EF0B349FA8" modified="2014-10-29" version="1">MILESAVIVGFALLLDFLVGDPKTKYHPTAWIGKLIALLVPFTKSNSVRKELIGGILLVSVIVVTVCTTLVVLDIGISLLTIDIVSLIVSIAVGSILLKTTIAIRGMQKHALAVVDAVEKVDLDSARNHLSMIVKRDTKNLDKNHILSGVLESVSENTVDGITGPLFYYALFGLPGAFVYRVINTVDSMIGYKTTLFRNVGWFGAKCDTVLNYAPSRLTGLVMILSALILGYNWKESLYIMRRDSRKLESPNAGFPMAALAGALGTRLEKMNYYTIGNGNIEFTKSHIISAITLMKVSSILFCGIITIPIIMTLSFLGWWIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM74</accession>
    <name>A0A087RM74_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisD</name>
        <name evidence="11" type="ORF">AAA799O18_00575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.499"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="435" mass="47198" checksum="40D92854A3123073" modified="2014-10-29" version="1">MIKILQVRNIDSFVESRRQKILEKDRKTVQAILNKVRKNGDSAVKKYERKFNGRKTSQLRVSEKEIKEAKSKISRKEYRAIGELKFWLGGINEVDVRNMVEEAVKKSGREPMGLLEEFGVGIERSLVPIPSVGCYIPGGQARYPSSVVMSVTPAKIAGVKRIVVVSPPGRDGKIDPLTIAAAKRCGATEIYKVGGAQAIGALAYGTKSIPKVDKIVGPGGKFVSIAKSLVSDQTAIDMVAGPTELGIIANASSNPELVALDLISQAEHSKDTMCFVITQSKAMAKQIQKSIGKLIPGTERSSIIKESISKNGFIAICKNENEVIELANKIAPEHLELMVGNAKTLSKKITGAGLLLIGKNTPSAASDYILGTNHILPTNGFGRTRGGLSVLDFLKLQTVVESNKKRFLELRDSLKALTDAEGLPNHYKAVKRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM89</accession>
    <name>A0A087RM89_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="9" type="ORF">AAA799O18_00563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.489"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="282" mass="31573" checksum="4FAF99FC59A51080" modified="2014-10-29" version="1">MKRISFQGERGAYSEAAATTFFRESDDKIETISCGTFAEVLKNTENDGSDYSVLPIENSLEGSVGESNDLLLSTKLNVIGEIYHRIHHCLIGTGSIADIDTVYSHPQALGQCRQFIQKNSLKTIPSYDTAGSVKIIKDLNKNNAASIASKNAAEIFDVPVIQDGIEDNTNNYTRFLILSKKSVREVTELEEDAWSNAKTSIIFSVKHEAGALYQIIKEFTECGINLTKIESRPNKDTPWEYNFYVDYEGYQHDVQEKEMLQRIKGNCTFLKILGSYPAAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM94</accession>
    <name>A0A087RM94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="83" mass="9404" checksum="31E89DEB24C761D2" modified="2014-10-29" version="1" fragment="single">MGFSDEQIHDILELKEQLTEKIETHIEEIKKLEKNIVTLNTILKQSSFTKASDLTISASETMKEERRITVPITKNSDGSTIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK5</accession>
    <name>A0A087RMK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="34" mass="3639" checksum="947B3E08A66F49EF" modified="2014-10-29" version="1">MNSRFIVVGIALGIMISIAFFVGSPMFGGFDMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK6</accession>
    <name>A0A087RMK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-amino-7-oxononanoate synthase 1 protein</fullName>
            <ecNumber evidence="2">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kbl</name>
        <name evidence="2" type="ORF">AAA799O18_00533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.464"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="376" mass="42640" checksum="33554265A02D12CB" modified="2014-10-29" version="1">MTHNLDYVNTHLKNIKKKNLYRKMYDTALSGPYIKINSKKLLNFCSNDYLGINPPKIISMQNQSSSRLVAGNDEMFKIFENKLSKHKSKENSLIFPTGYMTNLGVITSLVSNHDHILSDELNHSSLIEACKMTRAKLSVFKHNNMDDLSLKIKQKAGKKFIITEGIFSMDGDFSDLKRICEISQKNNAIIILDDAHGDFTVGNDGKGTANHFNVSKKIDVYISSLSKGLGSFGGYVSSKRNVIDMCINTSKSFIYTSALPAVIVNDGINRFDSDREKKRKKLWKNVKYFTSELKKIGFNIKSSSHVIPILIGKEKTALEFSNYLFRNGIYAQAIRYPTVSHNQARIRISMTARLTKKHIADALTIFEKAKKRFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML1</accession>
    <name>A0A087RML1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-coenzyme A synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.469"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="180"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="464" mass="52266" checksum="8D1E16E6D6238CBF" modified="2014-10-29" version="1">MVAGIDDIAIYIPQLYFDASDFAKARGLDPGKLSRGLGIEQMAIVDTNQDPACLAANACLKVMQKNKLTPDQIGRLYVATESSFDESKAMNSYVIGMLEQIYGQETFGHCGGIECKFACVSGSYALYDNTNWIRADEADGKYALVVVSDIAKYDMGSSGEVTQGAGAIAMLLNDKPRLLAFDPKVTSTSIKNEYDFYRPFGKETPIVHGQYSNLLYLIQVKNALVEYKRKVKDTKLINVKEDETILDYVDFLNMHLPYSNMGKKALAYLVRHEWRTLPRWKNIIKQTGVEEPIPKDPRGTIESVLADAEFMAKDHQFTKLFTNTDEYVELYESKLASSLIASKMIGNLYTASLYLGFRSSLEFEYQKGVKLDGKRIGFCSYGSGASAMIFSGTIQPEYEQIVKEMNLETEIGPRTKLSLEEYEDLHENKRGPEKNIRSANKEFILTDVKTSPESKGERYYRFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML4</accession>
    <name>A0A087RML4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AAA799O18_00541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.472"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="415" mass="46363" checksum="17DA62BD453C6C70" modified="2014-10-29" version="1">MDIILEITALITLIGLSGYFSGLEVALVSVRLSKIEQLVKNKVKGASSLHKLKSNPSRMMSSVNLGNNLASIAATALATDISLKLFGDEGLAIVVGIMTFLILVFGEITPKTYCNANATKVAVRNSRILLAFSYAFFPIVWIFEIITKGMIKLTGSSDMPPGLTEDEIKEIVDQGLKDKAIEKQESELVHGALNFDDIIIRSVMTPRPKMFTLRSKMLLFEALPEINKNGFSRIPVYSENKDKIVGIIHVRDVLKHFESENKMITLEQVMREPFFVSQEKKVSDLLKEMQGRKAHMAIVIDEFSGVEGCVTLEDLVEEIVGEIHDETDITKSNFQREGSDTIITNGDIEIDEINKIFRTNITYGDDYASLNGLLHEKLADIPKEGDRIVIDSLHIIVEKVLRNKPEKIRIEKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMM9</accession>
    <name>A0A087RMM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hom</name>
        <name evidence="10" type="ORF">AAA799O18_00521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.453"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="9">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="8">
        <location>
            <begin position="156"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="336" mass="36290" checksum="20D2AA602DCECA1D" modified="2014-10-29" version="1">MRIILCGFGVVGQSFAKLLESRSEDLYAKYGLKPKIIGVFDSTGSAVETSGINASRLIKMKRKYDSVKKYSSTKNNISGLDMINNLKAEVLIETTTSNYKDAEPGMTHIINAMKQGMHVISVNKGPLALAFPSLLELAEYNNILFRFSGTVGGGTPILDYAKNSLSGEQIISFNAILNGTTNYILTNMANGMSFDDALSDAKKRGYVEADESLDLDGLDAAAKLVILANWIMGMKVTMPDINRTGIRKVDSKTIKKAADKNCAIKLIASCNKELVVEPKEIPMDDPLCVSGTLNAISFTSEHSGTQTVIGRGAGGIETASSILRDLIDIRNEITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ5</accession>
    <name>A0A087RMQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">pfdA</name>
        <name evidence="6" type="ORF">AAA799O18_00494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="15510" checksum="273A0B3FD9F29A52" modified="2014-10-29" version="1">MSEEKTQQLLYQMQMLEGYFSELTQKEGAIISIIKEASSAINSLKSIDNKTDDEMLVPMGLGTFVKTKLIPNQKLILNVGAGVAIEKDQNYAINFLESRLKEMQVALQEIDGQKQQVSASLEQGKQQMNQLLAASRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR5</accession>
    <name>A0A087RMR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase protein</fullName>
            <ecNumber evidence="1">2.7.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmk</name>
        <name evidence="1" type="ORF">AAA799O18_00504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="191" mass="21453" checksum="09058EFF99EBAC67" modified="2014-10-29" version="1">MIKSVIISGPPAIGKTTIAKGIGKEFGLRHLSGGDILKELAQDEGFDTGGNDWWDTSEGMNFLSHRQGNSEFDKKVDAKLKKLFLEGNVVITSYTLPWIVEGGVKIWLAGSMENSARRMTVRDNLSKNDTIKIVQKRYDENKIIYKTLYGFEFGEDLSVFDRVIETDNLDAGHVLEIAKSTVREFFEIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR6</accession>
    <name>A0A087RMR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tRNA pseudouridine synthase B protein</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truB</name>
        <name evidence="2" type="ORF">AAA799O18_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.438"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DKCLD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="247" mass="28193" checksum="154778382F44C22C" modified="2014-10-29" version="1">MKLKQLENLITFDQDITDDNYGTYYNKRSVEQLLKYGLILLDKPPGPTSHQVVAWTKRILEISKAGHSGTLDPQVTGVLPLGLGEGTKALGVLLLGPKEYLALGRLHSLPSNEQLTDILRQFSGDIYQKPPQRSAVSRQTRIRRIFELELLEQKERLILIRVLCEAGTYIRKLIYDFGEVLGYGGTMIELRRTRVSQFHEDYPLVTLHQIANAFTDWKEKKDDSALLKSLLSTIFYFTSHTTIIMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR8</accession>
    <name>A0A087RMR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="118" mass="13334" checksum="819C85B846BADE28" modified="2014-10-29" version="1">MAPQVQFLREIRDNTVLQTESGTNFMTGFNHFYYSFSPTIADYERENPIFKEAVKLALTPLLISLTLLQYADINSESEMLGYGIGVIILNIGMYFIAPAVLIMKIRKKSKYGKTGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMU0</accession>
    <name>A0A087RMU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="92" mass="9963" checksum="5B2C9D4C3C432C64" modified="2014-10-29" version="1" fragment="single">VYSSIFFNISISLSILFVVATIASILVYVGGILDSTKGVGLGIKYSLFVPVGSFIVVCGFFAGLLQANSKNAVSWRGRTYYMKDQIQKSINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN30</accession>
    <name>A0A087RN30_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cysteine desulfurase</fullName>
            <ecNumber evidence="3 5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">csd</name>
        <name evidence="7" type="ORF">AAA799O18_00447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.384"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="30"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="415" mass="46325" checksum="81EB97DA9919133C" modified="2014-10-29" version="1">MQSITNSLDMQCRPDFPILERRVREDKALVYLDNAATTQKPIQVIDAITNYYKKQNSNIHRAVHALAEESTEAFEVTRSKIAEFLNVANSEEIIFVRGTTEAINLVSYAWGRDNVQKGDIVVTTEYEHHSNIVPWQILAKENGAELKYIDIDDNGELMLEQLDEHLATGKVKLVAISHVSNVLGTITDVKEVITKCKNAGAKILIDGAQAVPHMKVDIGNLGCDFYAFSAHKMLGPTGVGVLWARKELLENMRPFQGGGDMIREVHKQETIYNDLPYKFEAGTPNVADVICFSAAIDYLTKIGMNNVRNHEITLTKYALEKMSKVKGLVIYGPKNSDKQGGVISFNFKDVHPHDVATIIDKNGVAIRSGHHCAQVLMEKLDVAATNRVSFYIYTTMKEVDTLIDSLEEVAKVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN31</accession>
    <name>A0A087RN31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU-like protein</fullName>
            <ecNumber evidence="2">2.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nifU</name>
        <name evidence="2" type="ORF">AAA799O18_00448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.385"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="149" mass="16555" checksum="639A4D70349C5324" modified="2014-10-29" version="1">MSGDPIYTEMIIEYSRNPSNFGKIENPHIHRHDSNPLCGDSIDLYANIDGSKISEVKFDGKGCAICMACTSVLTEMIQGKNLDEIKNFKKDDLLAELGLEHLIKTSPVRIKCALLSLKALKHGIYSYFVEKMNDVEAAGNLKEEAASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN34</accession>
    <name>A0A087RN34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipid phosphate phosphatase YodM protein</fullName>
            <ecNumber evidence="3">3.1.3.68</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yodM</name>
        <name evidence="3" type="ORF">AAA799O18_00451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.68" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003850">
        <property type="term" value="F:2-deoxyglucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="219" mass="24439" checksum="F3F26838AC47EA47" modified="2014-10-29" version="1">MKNLIFETRSRGFVLLVVAFLIITSLVYTQTTQQFDDSSIAYFQSISGNPQLDITMWIFTEIGGIIPIMIFCFVMFVWRKTRRMGLILLLAVLVGTVASGYLKDYAVERPRPDLEYLGSELPLEIESDTTVLGGKGSFPSGHVTRAAVIAFVLGLALSERFPRGWVLLWIFPACMALSRIYLLQHYPMDVIGGVLFGVIIADILASKLKLSSFTDNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN38</accession>
    <name>A0A087RN38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.392"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="206" mass="23410" checksum="81F69D8CCDA5815F" modified="2014-10-29" version="1">MTDIFETIIEYSYLGIFFLLIAVNAAPILMPPTWIILSSFFALDASLDPILLAIVGATGATIGRFFLKHISGFFRRFVGKEQESNLDAIGNFLNRKKFGYTLTSFLFAATPLPSNMLFVAYGMMRAKSIGLYIGFWCGRLVSYYIMITISKAVLTPFLQLFEDRIIGIIAADIVGIGSVIFFTCINWRVLLFERKLRFVRPRLWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN75</accession>
    <name>A0A087RN75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.377"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="102" mass="11299" checksum="6DA1D04901A6EB53" modified="2014-10-29" version="1">MAVICSTCGLPDDLCACGELDKDNTHIIIRLETRRFKKKGTMIEGLDPKINNLENVAKELKSKYACGGTAKDGYVFLQGDHRDTIKDTLVKLGFAEESIDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN82</accession>
    <name>A0A087RN82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine 23-aminomutase protein</fullName>
            <ecNumber evidence="6">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.348"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="451" mass="51685" checksum="EACE7AAC04FA0542" modified="2014-10-29" version="1">MIKEVMTEQQALWSVNDTTSIKSYTLINFRTIPQIQQLPEETQFQMEVVGNVLPFKTNNYVVEQLIDWDNIPNDPMYVLTFPQKGMLIPEHYDKMANTLRNGADKKEIARVANDIRLQLNPHPAGQMELNVPQLKDGTKLFGMQHKYDETCLFFPSQSQTCHAYCTFCFRWPQFVGMDEMKFAMREGQQLVQYLKEHPEISDVLFTGGDPMIMKASMFSVYTDALLDAKLPNLKTIRIGTKAISYWPYKFLTDSDADETLKNFEKIVKSGTHLAIMAHFNHLVELSTDPIKEAIKRIRKTGAQIRTQSPLLAHINDDANMWAEMWQKQVSLGCIPYYMFVVRDTGAQHFFGVPLVKAEEIFRSAFKHVSGLARTVRGPSMSATPGKVHVLGVSEVNGQKVIVLQLLQGRNPDWVGVPFFAKYDENVIWLDDLKPAFEEKFFFEGKYATKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN86</accession>
    <name>A0A087RN86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.353"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="134" mass="15168" checksum="9682672EA18BDBF2" modified="2014-10-29" version="1">MRSLDVDCKVSAYCTINASEDISKVRASLSNVLTDMDEKLTGDSLVASSNNYESLTKIYEAMRIRKTKSAYRRHLMRNMTEDSTWFYLNKQAAFANVIVLCDEADESPLGPIKVVLHSKNIEDVIDWLVSDPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN88</accession>
    <name>A0A087RN88_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="Kinase-A_anchor_nucl_local_sig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AKAP7_NLS" evidence="2">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="179" mass="20259" checksum="95FEF4A960EC2523" modified="2014-10-29" version="1">MRTFVAIEVNNKDVLNSIHKIQIELNIKAKPVELPNMHFTVQFLGEVSEEMIGKISDALNSIEFSAFSISFASIGVFPKPNFPRVIWIGTNDGVNELEKLAEMIRSKLLQLGFSPDKKFKPHVTIFRVKNKIEDLSDKLEKFSSCYFGKQTVSEIKLKKSELTPNGPIYTDLLVVKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN93</accession>
    <name>A0A087RN93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="91" mass="10180" checksum="2867A891ECE82A7F" modified="2014-10-29" version="1">MSHLDVDIIDFLILTIIPVAMLFVIEMICRAIKIVSWIKLVIQGITMVGFAIAYMTVITPHVLTALCLLALAGALFYQARRSKIDPKKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA0</accession>
    <name>A0A087RNA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpoB2</name>
        <name evidence="8" type="ORF">AAA799O18_00382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.334"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="7">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="151" mass="16675" checksum="B1831A86C0672340" modified="2014-10-29" version="1" fragment="single">DMKYQLERSGQKRGINAVAAAIRPGIISDKLNNAIATGNWGRGRVGVTQLLDRTNYLSTVSHLRRVQSPLSRTQPNFEARDLHSTHFGRICPSETPEGSNCGLVKNLALSAIISVSEKAEDIIEKLYEIGVSHFTDVKPDVKVLEFLLMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA1</accession>
    <name>A0A087RNA1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpoB</name>
        <name evidence="8" type="ORF">AAA799O18_00383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.335"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="6">
        <location>
            <begin position="42"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="7">
        <location>
            <begin position="417"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="512" mass="57168" checksum="3509ED5745F5D150" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA7</accession>
    <name>A0A087RNA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.341"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="106" mass="12505" checksum="EE6794D5EBD85DE6" modified="2014-10-29" version="1">MLREKGKYASATQNRRIVWQKIIWPLILELDDVAFSLKQYQRKRDQVCHKTTLKISEMSRGLVSLIQKGVIIKENNTYSIHYRIIPYMRVKAVCDYGTAINETKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA9</accession>
    <name>A0A087RNA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Digeranylgeranylglycerophospholipid reductase 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.343"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="336" mass="38943" checksum="F05FC6BE3EDF74F7" modified="2014-10-29" version="1">MKIAVMGMGVAGSYLVSRLKNDHEVVGFERMDEIKHDSICAWGSIKSTMVDLCKKSGIDFEKYVVHDGKTMHVDMNNQERFQIGLHGLCTYEKLSLIKDFIKDSEVHFGINKKLEELESEFDIIVDCTGFHRIYLPKLEQDFCLPTYEYKIEYENGVPFDDFYIKPFPHMSGYFWYFPMGKNLAHIGAGDYNKQHVEETNKFFKKYGGRVTKTVGRPIRLATPNLCKPFYKGKVVGVGESIGTVYPLLGEGIIPSMMCADIFVKNLGDNESYEKEVDEYFKIYGKVFNFIRNKLHNKFSVLKMMPDLLSIFRYMKKNEERFGMEIHMRDLMKVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC6</accession>
    <name>A0A087RNC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toprim domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="127" mass="14860" checksum="DC8DB1062A0F17D8" modified="2014-10-29" version="1">MEFSEKEIDDIKKFIKHLNSKKESVVIVEGKRDSNALKKLGFSGKILEFHSFKGIVKFSDSVAKYKNIILLLDGDRKGRYLTKRIIDLLEHRTKIDLSFKKKLISITKGKIRFIEQLICYKPIQFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND9</accession>
    <name>A0A087RND9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.331"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="396" mass="45683" checksum="5F83C5AADDAD7165" modified="2014-10-29" version="1">MSELYEFAEALMAQLSVEIDEEKVISELAKKIKEDRNFTVEFDNVEKISQNIFPILKQKVTSYTGLEVSNDLSIEYLGLDEFKKLKGKKVFTDTGRTFVDKLFDAVTKNDLKKISEIIKEDTAKFLVYSTYVKSYISKLSTTYGDYLDSKIYLNMFILGDYPKIILYKQGSPYEVKEESVKSGYLGALKMTILEEIVHSVQTNLQRLNTQAVIQVNEINEELAKTILALDDKIVTQLTEYLQLQLVPDEFKIANKANLFFMLNPDNFITNVMGPDVMTYTKVEIDPKISDLVPSLQEIYQRWLKPIQTQHAIFTTMEGMAEFVVQQILKDDTNFQNYLTTFVGTDISAYSVKKSTGKEFTQYLFNRFGKTTFEKLVMDPPNTKELKNPQLYLNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE9</accession>
    <name>A0A087RNE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="417" mass="46332" checksum="0CCED3C090545888" modified="2014-10-29" version="1">MLKSVILILLVVCSLFTVPAVYSSHNPCKPGYIEIVDSETGFTKCVFDKTNIEEMPVKLELEFSDYQEHIQILVNQKEKTTEIRTVLWSSNSQDIMLPPALENAILNSEKVHALIFTTKWMCAPGVATEACIMIQVNREGLGQFTETVQENTRKISDQIMLNSQFIGMDAEFHSIILESAKTSEDIPALATAVYVLTKTFSTEKLISLIGNQLLDEEIRLGGGFYDILNVMSSNVYSEFTISLTPNNDGIIRSIGMSISSAGLPEEFAGETVDPINLFSASFPDFAEDEFYRSTYFSDGFHPLNTVINIRVISEPDYQVKTVNSYLIQKIGSADDLKDSGWFFTSNSNGLIEGRYLFGSDSFVSKQDLIFTLTNNKAEYLGIQPQVAAEVTEAKSPEPEGGGCLIATAVKWRHKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH5</accession>
    <name>A0A087RNH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="294" mass="34890" checksum="B42B4CC8CDE438C0" modified="2014-10-29" version="1">MGILDSIRDWNDRRKENEYERERRKEELRKERTKINKLLNKFTVKHLKDFCLEYIGSSPADELITDEEDEEFDDEDEQGKVGKAITYGKKFTHKFQDKGEKHDRTLYVEFIWRKLMSGVIEQDQINDFSLKKRIVPRNYFGVKSDAKEDKKEFSTILSIIQSDFEPERITGKDKEDKFQSQLTVFLKAKFPDKKIDREVVLQNGDRVDIVIDDKFALELKVPIDRIYLRNLTAQLEEYLEEYDFLGVVIADITEEQEENEEEPMTQNINEYVDRFKSKFGVQSVVLPIKFKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH9</accession>
    <name>A0A087RNH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="344" mass="39666" checksum="FE9DECB9F2CCAF6A" modified="2014-10-29" version="1" fragment="single">ITNLLFFINSIELVEGCNSITLGRFIIFFISSTQMPDNDDQPVEMRALPVVTARGCAFKCSFCHYVFWDDPYRNRSPKSILAEIKHLIEKYNVNYIEFWDDLSFASATQVEKLCDAIFESGMKFKWNTAIRVDLFSRARLSDEEALRVAKKMKKAGCYSCGFALESGNPEIMKMMNKKIEVDAFYKTVYTLREAGIITQTSVVFGYPIETKETIKQTFDQCLKAGLYPSIGFLLPLPYTVMYDYAKANGFITDEDRYLESITERQDICLNLTKMADEEIMAEIKNGARMLNEQLHVGLTEETYIKTKGYKSQRIKKKLKRPESMKRTENDVTLNYAAAEFKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI3</accession>
    <name>A0A087RNI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudaminic acid synthase protein</fullName>
            <ecNumber evidence="2">2.5.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pseI</name>
        <name evidence="2" type="ORF">AAA799O18_00245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.97" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="248" mass="28478" checksum="D7C1177528BD24DA" modified="2014-10-29" version="1">MTLKSFIVAEIASNWEGNLSKAKKLIQESKNAGANAVKFQMWRANDLYNNKHPNWNFIKKSEITFEKAKKLKQIADKTGIEFFCSAFYPEAIKFLEKLKVRRYKIASRTCLLKDPYSIDTLLAKARTKKPVIISMGMGGNKNKIKDIFKKNKKTFCYCVSKYPTSLNEINWNEAKKFDGFSDHTLGIIAPIIFTVIKKQQKAEKIIIEKHVKLKNSKGPDASTSITTKELEELISQIKIIEKTKFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ4</accession>
    <name>A0A087RNJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dinucleotide-binding enzyme ral function prediction only protein</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fno</name>
        <name evidence="2" type="ORF">AAA799O18_00261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.236"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="223" mass="24446" checksum="74F801FAC64F193D" modified="2014-10-29" version="1">MKIGIIGGTGGMGKGFALRLCKKHKILIGSRDAERATTVANEYTNFAKEIYGEISGTISGKDNLSVAKESEVLILSIHYENIDTTCSQLLPNVNDKCVVISPIVPMTKTDAGFEFIPIKSGKPFSHQLVEKYMKDKTKLVSAFHVISEKKLVNPKKILDYDIFVSGDDKNSVEIVNGLIQEIDGLRPIYIGPGSLAYMVEICTPLLINAMIKNKMNNPGIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ9</accession>
    <name>A0A087RNJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multicopper oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.241"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="187" mass="19562" checksum="C660A871EDAD81DF" modified="2014-10-29" version="1">MSEHDETVWRTSPGRVGKLMAVLCGTVIVGGIIFFALGDYWISELAPAGNTFAGISDQAAAPVVEQTGADIPVTLDFIESADFRTLAFNALPGDPGNNPTINAKVGDRIIFNILNAGKSFHAFGVTLDEEGFGGILGDSAVASPNNPLKPGDGGTSEFIPGEPGTYYYICTVPGHREMGMVGTIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM3</accession>
    <name>A0A087RNM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="238" mass="26547" checksum="9B0EB6631215AFB3" modified="2014-10-29" version="1">MSEDEKTEPVTLSEAEAEAAVAKAEFEAAKAEAEDAKPEDGALRQTTISDAVVASEAVTRAETAYQLTKEKLKSARAASEAAWKADYEAAKAQVGEIDQAGQLFTNKRKQERIFRREMGEPEFFLMHKGPVKPILTGDEIETISRQVLIPKNQTPKYNPEHILSPEFSGGTNYESGIQDLIDETRQKLDQLLNDPEANPQEIELTKLALKKLNYLFENYNLGMNVFRTAKGGREKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM5</accession>
    <name>A0A087RNM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor C large subunit protein</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfcL</name>
        <name evidence="2" type="ORF">AAA799O18_00302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.267"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="386" mass="44184" checksum="6D1A157121F4BCDF" modified="2014-10-29" version="1">MMWSEKYRPKNILDLIGNEEARKILVEWFTKWKRGTKPILLIGPPGIGKTTLANLVAQQFGYDLISVNASDVRNKQNIHEILSPVLGNQTIFGKPMIFIDEVDGIHGRADYGGGEVVIKILKEATVPIVLAANSDLSNKMKSIKKAVQTIQFRPLPPRLLRFYLDKILQLEDAKISSDSLIKLVTESKGDIRSMINFAQALVTGFNPPTEKSFEILDVEEGVNAFYKSNSVDEARSVIYSLRIDPREKINAFYSSIITSNISTDDMQKFLQIISTADMLYGKIMKTQQWRLLRYLDAILLGLYRKNLPIRYSKYNLSWPILNRIRWDGAKIKSLLDSLVKNMHVSKSTFSSIYFRFLLLCIKNEKIDLELDKTLEEIIQKEIDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM7</accession>
    <name>A0A087RNM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol-1-monophosphatase protein</fullName>
            <ecNumber evidence="1">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.269"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="266" mass="29194" checksum="DBF0CDC2A622C61F" modified="2014-10-29" version="1">METIEILRTVSKLVYENVKDLAGTKESIAGDFGRGAGGDISRNIDIIAEKTVIDYLKEVNFDCVVLGEECGRVALSTNPKGFVIMDAIDGTTNAVRGLPIFCCSLAFATDERIDSITDAAITNLSNGDIYWASKGKGSFLNEKPISVHKEKPVYKVVGINISASPPELIHRFIPIFEKHHHVRHLGANALEMAFFAQGSIDVFIDFRKKIRIQDMAAGYLLIKEAGGLLFDENLEPLDSDISYEARLSFVAAASKEILNEILSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN4</accession>
    <name>A0A087RNN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="54" mass="6535" checksum="272512979A10FD5D" modified="2014-10-29" version="1">MIRAVCKDYGYDCDFFIEGDMDKVVQEFGRHIKDKHGIEYEEETLIKFMLNHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP5</accession>
    <name>A0A087RNP5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">AAA799O18_00227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.209"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="74"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="348" mass="37801" checksum="692FBE4C62943B6F" modified="2014-10-29" version="1">MIKDLTQHLSRGDSLTIEQMTSVMNEILGGTQNDQDVADFLKNLTQKGESDDELLAMLNKMEEYSLHISPNCKGKIIDVCGTGGDKLKTFNISTTASFVIAGAGGNVAKHGNRSISGVSGSADIFEYFGIDLNSEPNKVNETIEKFGIGFMFAQRFHPAMKNVAKARKVVGGRTAFNLLGPLTNPAMVKNQLIGVFSENYQERIVKILKRKNAETVMAVRSDDGMDELSTTSKNQICMLKNNMITKMTLDPQKIGLQNGNISDIQISSKEDAIKSFVTVLNDSANKTKIEITALNAAGGLIVSDMADSFTDAVELALGTIHSGKAFDKLENFVKNCGDMEKLEGVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP8</accession>
    <name>A0A087RNP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">AAA799O18_00230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.212"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFM15102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="557" mass="59116" checksum="F39416302A50256B" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU8</accession>
    <name>A0A087RNU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaJ1</name>
        <name evidence="9" type="ORF">AAA799O18_00171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.154"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="231" mass="27220" checksum="87800F7EFB7DBBAA" modified="2014-10-29" version="1">MNAKRANQILMLDTDASFDDIRYAYRKLVLDLHPDKNKNEAKGEKFKIVSEAYHYLKKQHKQKNSKYQNTRKQQKNNYNEHNSEGDWSKFTKDFETNQEFWNQYEKAFWDDYKLNADKKSDTNHFKNPFWDEVKQNINSKSEKTDFKKQHNTHAHNLFVEIDKSLCIGCCSCETIAPNVFSVDKLKHINPKSNVHNLHGANEEKIMDAAETCPTKAILVDEKNSGKRIFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV6</accession>
    <name>A0A087RNV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="80" mass="9878" checksum="037C41EA0C97ADBE" modified="2014-10-29" version="1">MQRLLGCTKNSKWVIMKFFKKFECELCKEKFSKQEQLMHHQEITHFKDMPYDCKICNENFSSMLDMRNHLRKKHSYKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV9</accession>
    <name>A0A087RNV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 1-alpha</fullName>
            <shortName evidence="5">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor Tu</fullName>
            <shortName evidence="5">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tuf</name>
        <name evidence="7" type="ORF">AAA799O18_00182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.165"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="443" mass="48212" checksum="2BD03BC26406C302" modified="2014-10-29" version="1">MVIKPNLLDIDMADKDHLNMIITGHIDNGKSTTMGHFLMDLGVVDERTIAQHAKESEETGKGDTFKYAWVMDNIKDERARGITIDLAFKKFETPKYFFTLIDAPGHRDFVKNMITGASEADCAVLVLSAKEGETDTAVAPGGQAREHAFLLKTLGVSQIILAINKMDDSKFSEDAYKAAKDKGEKLVKSVGYKVENVPCIPVSGWTGDNLVKKSENMPWYSGKTLLEAFDDFKVPEKPTGKPLRLPIQDVYSITGVGTVPVGRVETGTMKPNDKIVVMPSGAAGEIKSIETHHQEMPSASAGDNIGFNLRGIEKKDIKRGDVLGTPDSPPNVAKEFKAQIIVINHPTAIAPGYTPVMHCHTAQVAATITAFESKINPATGAAEEENPKFLKVGDSAIVRIKPVRPTCIETFQEFPEMGRFALRDMGSTIAAGVVKEITEKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX6</accession>
    <name>A0A087RNX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated golgi family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="213" mass="23690" checksum="54E0ABA7C28F0609" modified="2014-10-29" version="1">MDLWEIFPFTPEVGYLGLTIVSFFGSLIPFVPVPSFVLLVTMAVGTQFDIHILALIAAFSATAAKQIIFYISYGGRRIISEKTKKRMKPFQKLVKRYGATAAFVAAATPIPDDIVYIPLGLAKYSPKKFFIATLLGKLVLCYILVLISHYMGLSILEPILADIDDPLPVYIGIILLGAAMTIIVILLLRLNWERILGRIAPWTIEDDDDNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY1</accession>
    <name>A0A087RNY1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase small subunit</fullName>
            <shortName evidence="6">AHAS</shortName>
            <shortName evidence="6">ALS</shortName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvH</name>
        <name evidence="8" type="ORF">AAA799O18_00204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.186"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="155" mass="17406" checksum="1E53698C8526AF34" modified="2014-10-29" version="1">MWAILSIRVENKPGILFKVTHLFRARNFNIDSISVGVMENPEFSKMIITTVGTEKQIAQIVKQLDKMIDTIEVKRLDEQKSVYKELVLFKIKLSKSSDSAEISKLANTFGAKIHSDQEDSMIVELTSTPKEIKSFEESVKPFGVLDSARTGVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY7</accession>
    <name>A0A087RNY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="95" mass="11243" checksum="C7CEA870CE6752D2" modified="2014-10-29" version="1">MDSQLKKTDSLLSEKRIKLHIFVPSKRKIWTVVGMDKEYWFDPDLDFCSCPGYYFNNQCYHLDNFPLAKTRNQIESTTFSDDEYKSFIASLLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNZ1</accession>
    <name>A0A087RNZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="66" mass="7529" checksum="8A6683BF919D1CD9" modified="2014-10-29" version="1" fragment="single">QLFGGDCILVDYPEMMDVLESLRNDDTLKKLFICDLGLSKKNSDNFVEILSELTKKTSFSYICRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP47</accession>
    <name>A0A087RP47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cpkA</name>
        <name evidence="5" type="ORF">AAA799O18_00147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.128"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="328" mass="35335" checksum="33E77DDBA3ED0CC7" modified="2014-10-29" version="1">MGKKNQNDSKKIVIALGGNAILQKEQIGTHEEQQENIKKTAKSIASVVLGKHQYKVSAITHGNGPQVGNLLLQQEFAKNMPNLPMHTVIAMTQGQIGYMLQQALQNEFLKLKKNKRVVSLVTQTLVSKNDPKFGKSSASKPIGPFLTETEAKKLRDKTGYIVKKVKPTGEKTWRRVVASPKPLEIVELDILKEFIDDDSCLPIAGGGGGIPVIKSGSSFKGIDCVVDKDHVGALIAKSIGASVLLILTDVDKVKLNYGKPNESDLDALTVKTAKKLLKEGQFLEGSMKPKILAMIDFLESGGDMGIITSLDNALAALNGKAGTIISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP62</accession>
    <name>A0A087RP62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.145"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="497" mass="56515" checksum="8515A7049633523F" modified="2014-10-29" version="1">MEMNSTKICLFLTCLMVIPISQAYGHGFGIDTTAPLNYEDRKIVISVEMFPMYFDDTRDTKIRVHAYDKMTEEGISNATILLSIYKNNEKIFQDSMISTNGELIIDVEKYDYLTPYFKSGGLYHYKMDIISLDGSDDAADYLSGYTADVSVADTTYHKFKNTKNIDTEFRHKSYYDVISNFVYEPSQKTITFEMPFDWEGKNISHIQVVHEEVFFSKDLTELISSNYDAKINGIDVFKSNIQIDDYSDEDGRIVHFILLQDHVKFFKNTIKKELSKQAMEPLPDKMYFELIPNNEITFPISVLTINGDYQVDLSWDPKEILPDSETRFIYTIRDGVSLDLLYNSNFDFIVSKDNKQIHKSSESARIGGGFVDFVFPADGTYTITFDKIRGTKIFTSYTVIVDSSQVSKLSIPDWIKNNAGWWADGQIDDGSFVSGLQWLISNGIMSIPPTEQGAGSDDAIPSWIKNNAGWWADGQIDDGSFVSGLQWLISNGIMKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP74</accession>
    <name>A0A087RP74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroorotate dehydrogenase B catalytic subunit protein</fullName>
            <ecNumber evidence="3">1.3.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrD</name>
        <name evidence="3" type="ORF">AAA799O18_00001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="108" mass="11305" checksum="FE1B60F214DF6683" modified="2014-10-29" version="1" fragment="single">MKPTLSTSIGKLTLERPTILASGILGISLDVFERLYHAGAGAVVTKSLSKEPWDGYVNPTIFSVKGGGWLNAVGLANPGATNFAKMISSNNVVPIIVSLVGSVEDDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP82</accession>
    <name>A0A087RP82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MG2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.8"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="718" mass="78966" checksum="F5436FDE268E60C4" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP88</accession>
    <name>A0A087RP88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="31" mass="3732" checksum="A948967255464159" modified="2014-10-29" version="1">MAPIKRRTIIGTTKFSEFWFEDIEVLLNFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP97</accession>
    <name>A0A087RP97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA topoisomerase I protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">topA</name>
        <name evidence="2" type="ORF">AAA799O18_00024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.22"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="47" mass="5280" checksum="E4714B9E79DD9B87" modified="2014-10-29" version="1">MTTAYCVKCREKREIKNPQETKLKNGRPAVKGVCPECGTNVFRIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA3</accession>
    <name>A0A087RPA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.28"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="221" mass="25469" checksum="382983C18DA24474" modified="2014-10-29" version="1">MNKFPNYIEVNSPLEFGRLVCALERSTRVSFLHEHNGKKVLSVQMDMLKESPVIYYTPIEKFGHFLSYGFKSGREESLMVDCTIDNSKLYSPIVKIKSLPQSLQALPNNKTEKYQPIEFEDLGSLAKLSYGFEEAPFPLFSFPFKGKWLIGVFLNFNEDGDSYYCYVSLNEEPNKPFLKYTTTNASQPVFVANTTEHGYSYIKIVKLHETHPLVNYDQIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA6</accession>
    <name>A0A087RPA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Fe-trafficking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="92" mass="10808" checksum="66A9355B09082000" modified="2014-10-29" version="1">MTRICTKCKNEIPDNEELEPIPSSYPCCTKCWGEWKENRVMVINEMRLDMSLKDHRKLLKKHEKVFVGVLTPEGDVVDYTNEENRNPEEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB6</accession>
    <name>A0A087RPB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AIPR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="583" mass="67832" checksum="4EC9FCA44E1A99FB" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB9</accession>
    <name>A0A087RPB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="93" mass="10345" checksum="31DC29F85F4B7711" modified="2014-10-29" version="1">MVAYRTSMQIVADLLVATEECGQDGIKTTSLLSKANLSHSRFEKFVSNLTGAGLVNKIEYDGRNVFVITPKGTQYLEQYKKFSDIAESFGLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC5</accession>
    <name>A0A087RPC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11970" checksum="E96D1F83830C4794" modified="2014-10-29" version="1">MPYFEISTTKYDEDVKTIQVAITKMAALCDIDSGFKLGEPISKFGWTFFQILVNQELYFGIEDKFSDMIRKCKGSNQDEKFTDFLTSYFESRGCNVKVKMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD4</accession>
    <name>A0A087RPD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="100" mass="11755" checksum="02A5B0D994A4A3FB" modified="2014-10-29" version="1">MAFKAYLETKGRKTGKIHKVELLVVQYNNRFYFSRRNPNCDWLKNAIVNPNVTVSFNRQTFSGKAKLVTNILLNKKICQLKYEDEKRANEERVVLEVDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD5</accession>
    <name>A0A087RPD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="69" mass="7533" checksum="DFC6CFA8821F8EF8" modified="2014-10-29" version="1">MPQAILAIAGLIAITVALIGQGIEMRKIRIRTYGESGVGHPNIFLDKKNVKWYILIAIGFGLAYSAQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD6</accession>
    <name>A0A087RPD6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AAA799O18_00073</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.65"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="206" mass="23153" checksum="0CA33E4080691AC7" modified="2014-10-29" version="1">MPDDTRLTDSDGVLLVKTARQAVTEFLSTGNRIKLEAEHEKKFSFDSGVFVTLNKHDGLRGCIGFPMPEKKLSRAIIEGAIAAATEDPRFPVVTTKELDDITFEVTVLTQPMEIDVSNPMEYLTKIKVGRDGLIIRHSFYSGLLLPQVPGEYGWNVEEFLQHTCHKAGLEKDFWKSGKAKIEKFEGIVFKEETPKGEIMREKPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD8</accession>
    <name>A0A087RPD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plastocyanin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">petE</name>
        <name evidence="4" type="ORF">AAA799O18_00075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027560">
        <property type="entry name" value="PEFG-CTERM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04296">
        <property type="entry name" value="PEFG-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="3">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="298" mass="31781" checksum="C27163E6BE23457C" modified="2014-10-29" version="1">MQKKLYTLFGLLAIFSIIAVTPSAFADHMSVTVTNAPGSSVPGCEETAEGCFIPSMVTLDVGGEVTWENNDTAAHTVTSGSATDGPDGVFDSSLIMAGSTFSHVFDDAGTFDYFCMVHPWMAGTVMVGAEEEHGDDHGDEMKHGDEMKHGDEMKHGDEMGHGDDHAASGIEDISDQFTASVTSGVIHHIGANSDDDTLLVHLFGADDDGELKIVLNPDIITAFDDGSYFVLVDNEQVEFEQMGKTLHIPYYSGAERIEIVGSHVVPEFGTIAMIVLAVAIVSIIVITAKTKIALIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE2</accession>
    <name>A0A087RPE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="142" mass="16775" checksum="CEFFA16010279717" modified="2014-10-29" version="1">MNRKSEEFFINYLKSLPNSHIKQFYNDVEWTPYPVLVIKEFQRRFKPKDTEFLDKLLESVDDAKKKGQKIGKLAKIRGIKLSKRVKTRTKKTVLKKITKAKRMIRPSDDNVELIKKLGELKKVGIITNKEFQAKKKQLLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE4</accession>
    <name>A0A087RPE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.73"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="168" mass="19751" checksum="E9A4B1F5BBC96474" modified="2014-10-29" version="1">MIFTTITKDLQKELKSNLPQIMILLKKQPAIAYKKIGDIGKEVGKKYNIELLVNFPHRGKIEKFDMYGKQDLSFIVDMEKTRFPIERELIKEKAREIFGEVETEDAYMYEGKEGVKVFLGPANESGRKEDRIDILPHSLHVWYEFTDKVTEFCDWLLKNVYLMKVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE6</accession>
    <name>A0A087RPE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.75"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="517" mass="56977" checksum="BE2F2E8A07876DBE" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF7</accession>
    <name>A0A087RPF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-containing ferredoxin-2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zfx2</name>
        <name evidence="2" type="ORF">AAA799O18_00104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.86"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="318" mass="35915" checksum="E2EFE1132E34D33F" modified="2014-10-29" version="1">MSLLLKDRVYTMESPTAKRGVYPMHGYKLGLYRIPIKLEDPAEIKSILEGMKKTFEMDSYADRIYVTYRWTEENIPDPDADGYEQVELSVTVEIVTGEVIDVIYQIYPVEKFGAPQWVQDYRKKADHFAKMIIDTLLRNTILSDKMIESLMKIEKISEDRSLVRLEELTPLAQIVPDAKPIAKVEKPKPAVEGKKQVIVRDGEEAVPGPIDIEYKDKMNSSAPFKTKTGNMIQTWGRDGTDNKVMGVWGEFCSVDFDICIGDGACIDACPVAVYEFFDFPGNVASTKKPLQINEPDCIFCLACEGVCPPQAIKIYPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG0</accession>
    <name>A0A087RPG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crossover junction endonuclease MUS81 protein</fullName>
            <ecNumber evidence="3">3.1.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.89"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="228" mass="25364" checksum="6DE2B83BA8DAA42F" modified="2014-10-29" version="1">MNLSKLRIVVDEREKKSGIPDLLNGIGINLEIKMLPVGDYIVAPETIVERKSISDLVSSIFDGRLFDQCNRLKEHFQFPIIVIEGNVGEIEELTENPFVFYGAVSSVAIDFKIPIISTPNASHTAKLLVSMCSRKDVTKGPFIKKIRKSDDLQKQQLSVLCSLPGVGEKTATRMLEKFGTPLKVFSASTIELSKIIGLGEARAKKIKKMLQVRSKHLKKTSQKTLHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG5</accession>
    <name>A0A087RPG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="8" type="ORF">AAA799O18_00112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.94"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="6">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="7">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="245" mass="26509" checksum="1F6562DAA358BCF7" modified="2014-10-29" version="1">MGGRKTDVVLLDDNGIRCDGRKVNETRKVSIKTGVLKNADGSAYIEFGGNKILAGVFGPRDVHPKHMSNPDTGILRVRYHMEPFSVTERKNPAPSRREIEISKVVKEALEPAVILEKFPRTAVDVYLEILQADGGTRCAALDAASVALADAGIPMRDLVCACAAGKAADTLILDVNNEEDQAGQADMPIGYMPNLGQITLLQLDGILTADEFKKCIEIGIDGCKQVYEIQKSSLREKYFSSGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH1</accession>
    <name>A0A087RPH1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpoD</name>
        <name evidence="4" type="synonym">rpo3</name>
        <name evidence="6" type="ORF">AAA799O18_00118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.100"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="5">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="199" mass="22053" checksum="C85F387031583A99" modified="2014-10-29" version="1">MYSIKVLNDDDKKISIRLKGVSLQYANALRRICLNGVPVFAIDTVDMIENSSVIADEDISHRLGMIPLKTELSSFNESDSRVMLVLDSGDIQSPRTITTAELSSQDEVVKPISDKIPIAYLAPGQRVRLEAYARLGRGTEHAKWNSANISVLTNTDKEDEHVLTVETTGALKPSEIILTGIDELSKRLEEFKENLGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH2</accession>
    <name>A0A087RPH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.101"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="115" mass="12388" checksum="0B8743197ED31C45" modified="2014-10-29" version="1">MINRAVLSLVKELKQASKKNKAPLWAKLANLALKPSSSMRVVNLTRIDKVTKNDDVLIVPGKVLGTGNISHKITLCSFSISTTAAKKIIKSGGKIIRSSDMIQKYPTGKGVMLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI2</accession>
    <name>A0A087RPI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ketoisovalerate oxidoreductase subunit VorA protein</fullName>
            <ecNumber evidence="6">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vorA</name>
        <name evidence="6" type="ORF">AAA799O18_00129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.111"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="5">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="321" mass="35221" checksum="06338CFBB19BE7AE" modified="2014-10-29" version="1">MATKLGDYKTGVHNDWCPGCGDFGIVNAIQMSLTEMQIPKHKAAIFSGIGCSGKTSHFINTYGVHTLHGRVLTFAQGAKIANPEMTIIAAGGDGDGLGIGAGHFVAAGRRNVNMTYIIFDNAVYGLTKGQASPTLKLGEQTKSLANPNPNYNVNPIALAISSGFTFVARSYSYDVRQLKDLITAAVKHKGLAFIDVLQPCPTYNDLYTRDWFSGLDQINEETKKPTPRIYNLADIDYDPVVHYSTIDELNQKLGQALEKSLEWDTKIPTGIFYKNELITPYTKRITDKIPNYLENPAAKQNISKNGKPTTDISKLLDSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL34</accession>
    <name>A0A087RL34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000043">
        <property type="protein sequence ID" value="KFM14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="121" mass="13319" checksum="B8EC592417AA36D4" modified="2014-10-29" version="1" fragment="single">KKTIEITKDDELTVNGDCIIGTNSSLACIDLPEKFKKKLQNLDTTIAFTIVADGHSFSIRGKGSEKLTLKHASDIVLRKSAFTCSRTIAIKCDKASDDIPRIMVKKLQNPKTSGKLIIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL42</accession>
    <name>A0A087RL42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flap endonuclease 1 protein</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fen</name>
        <name evidence="1" type="ORF">AAA799O18_00753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000041">
        <property type="protein sequence ID" value="KFM14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.644"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="150" mass="17490" checksum="4269BC71210C7D5F" modified="2014-10-29" version="1">MKLFASSSFSVYIDVEPEIINYQKNLNLLEITEKQIIDIGILVGTDFNPDGFERIGPKTALKLVKEYGKLEEIPQIQEPLKQIDYNQIRNIFLQADVTEVDKIGFKDTDYSGVLDYLSNERDFSRERVQSSLNRLKRGLEKRSHTLEKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL49</accession>
    <name>A0A087RL49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000040">
        <property type="protein sequence ID" value="KFM14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="178" mass="20612" checksum="6AC76AD44BCFBB08" modified="2014-10-29" version="1">MQLIYLITHFWDDPSNGFFFTADNHEKLIIRPKNNYDLSMPSGNSVAAYMLLKLYHITQNKQFLEIPKKILESKAIAAAENPFAFGYLLNVLYLYYQKPTEITIINNKDSELVSSLRKKFLPESIMVMVKNEKDLTALSKYPFFSGKEFQQTETKVFVCKNFSCSLPLSNLSEIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL63</accession>
    <name>A0A087RL63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="85" mass="9586" checksum="B829B0B14A159068" modified="2014-10-29" version="1">MIFYEFLKFITMIGKLIVTAIILGGGAFLLLSDSFEEYISPYASATATDIENLKNDPAVQDKINHVIEVIYEKFISLKLSLSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL69</accession>
    <name>A0A087RL69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000035">
        <property type="protein sequence ID" value="KFM14223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="208" mass="24093" checksum="4663E02ECDA713AD" modified="2014-10-29" version="1">MILLVSILKLDSKCNGYICVPYTHDKFTVNVKEMLSSSRNIKTIHFVTATFSDEIKAYFPTSTNHYMLAKFDDNQKIIRDATKFTNINPSFVFSIDEKLFERDTGSEERFISMYYLEYNDHDIATDLANTIVTKEKIRQAGFAHMNLFTRSEPKFAFPYAEKFVILEATDNKSHQSICKYCEKLSQDISRKGVTMHNFASLSLLEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL95</accession>
    <name>A0A087RL95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal recognition particle 54 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.610"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="98"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="99"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="238" mass="26403" checksum="123518B4B06B3759" modified="2014-10-29" version="1">MLDNLKSSLRAAIKKIVNSSGIDEDLIKELSKDVQRSLLQSDVNVKLVFEITKNIESRSLNETPPPGLSRKDHIVKILYDELAKMLGNDTEFHFKSGKINKVLLLGIQGSGKTTVTSKLAKFLSKQGYQIGVIGVDTFRPGALVQLRTMCEKSGVEVYGEEKNKDSPKIVENGLKHFKNANLDIILIDTAGRHKQEKDLLDEMKQINKVASPDLALLVIDGTIGQQCFAQAEAFHKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL97</accession>
    <name>A0A087RL97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 5A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eIF5A</name>
        <name evidence="2" type="ORF">AAA799O18_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="48" mass="5723" checksum="B9A488173A34CA8D" modified="2014-10-29" version="1" fragment="single">SNIQVMDSETFETIDVDMIDEEVEGKLEQGKDIEYWKVMDRTKIMRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL98</accession>
    <name>A0A087RL98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell volume regulation protein A</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="93"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="418" mass="45073" checksum="F268C68641EC22DD" modified="2014-10-29" version="1" fragment="single">MNLTFLAILDNFVSFFRDEVFSNVDTSELAGRNVRDILKSYFEENPISQPDPGGSGYNFIPEGIANLQNTLANLSFGDSLVASAPILLLAASVVIIMGVLGEAFFKKTGIPDILFLMVLGIIIGPVLGIIQPEAVLQIVPYFAAVALIIIMFDGGLNLHIGKVLKTAHFAVVLVIVGFTVSVGIVAVFAHYGLGWDWIASILLGSIVGGSSSIIVFGLVKKIHISEDVKSMLSFESALTDIFAVIIAFVLFEAALTGNFSLDLLGVTIGKAVMVGLVLGLGVGIPWMFVISKLKNAQHSYMLTIGMVFMLFFLATSFGESGALTALVFGIMLGKKNYFTRVLKVKFPEDVIDDSLHSQVTFLVRAFFFVFVGLLASFAQIEYVIFGVIAAIAIYIGRIIITKSVLVRGFSKLDRKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA3</accession>
    <name>A0A087RLA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.596"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="131" mass="14349" checksum="DADC906D77E69448" modified="2014-10-29" version="1">MTATQQHDTHTANTLSKELAEVRKVRRVLGNARMAIEQIELRLTTFHDLGDTVVTVMPTIGLMKNMKSSLAKFMPGADQELNNMAEMLGGLMTETFHSSDASFGVDAVLDAESEKIMQEASAVAVHRFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB7</accession>
    <name>A0A087RLB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000027">
        <property type="protein sequence ID" value="KFM14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.582"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="126" mass="14638" checksum="EF3402B2B71335EA" modified="2014-10-29" version="1">MTMDDFEKEYPDFDWKNTPAYKHPGGKNCPCPKHEYIREQINFTKQVNESGKDARVTLKFCPEHYKVYMDEVIPAMPLKYKVLTKIALKIGAIKIIVLKHMESDLCFYCRFGSGGHNKKNELPPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC3</accession>
    <name>A0A087RLC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coenzyme F420-dependent N5</fullName>
            <ecNumber evidence="2">1.5.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.98.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.574"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018537">
        <property type="term" value="F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="361" mass="41049" checksum="94D5A517982AC879" modified="2014-10-29" version="1">MLKFGIQNGLNVARAGYSEDQILTACMLADRTGYDSIFYMDHTNVPQWKNAIVLDPWVMLSAIAAVTNNVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQNLKEFCIPFEKAVSKWEEQIQVIKKLYGSTPDNTVDFEGKYYKLESACLQAPPIRKPHPPTYMASGGKRTLRLTGKYGDGWLPIGYTPELFEDHKKQIEVSMDENNRSQEEKDNFQMALDIDVYFSEDAEESWARMKEAVKVSLFKPEILRVHELKDIEGFDFVKYFTEYSMSNQDWIVKMREAATKIPDHIARSSTAVGTPDDVIPVFERFMKAGVNHFVIRFWGKNYFGSIDKFASHVIPYFKEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC6</accession>
    <name>A0A087RLC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.577"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="155"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="262" mass="28934" checksum="DFB47CFFCC1149E7" modified="2014-10-29" version="1">MNCGATINEFNCVRKHLSQIKGGKLVQKMNCDGCALIMSDVVNNDISVISSGCTFYDNTTSSDALKIIRKYSLEAKFPKNVISCLKRKLHSKITIQKNLRVKNEIIATNQDCLDAMVSKSRILGFKTIVSPVIQHDVSVSAKILVKMIPKSKRSCIIFGGEPTVNVKGKGKGGRNQELVLQILKLIHDSNHNLIISSVATDGLDGNTKYSGAFIESNSYGSEEIAHYLKNNNSNLFFKKYAGLIKTGHTRTNLMDFGLILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD0</accession>
    <name>A0A087RLD0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltA</name>
        <name evidence="7" type="ORF">AAA799O18_00670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.581"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="391" mass="44345" checksum="748B10DB93061045" modified="2014-10-29" version="1">MDTKNIGLRNIEVADTRISFIDGEKGKLIYRGFDILDLTKNSNFEETCYLLLHDELPTKNEFNSFKDNLSKARIIPKQMQINMGNWRKDADPMDALQAFVAAFGGYYDEEFSNKEASYERAINLIAKVPTIISSWQRIRNNKKIIHPDSNLSHAANFLHMLTGDKPEPEIEKIFDICLILHAEHTFNASTFAAREVASTRAHMYSAASAAVGALSGELHGGANYEVMKMLLEIETKDNVESYIKEKFAKNERIMGMGHAVYKTIDPRSYVLKELSKRLSEKTGQPWYDITNQVEQTTAELMKETKGVEIFPNVDLYSASVYYMLGIPMDLNTPLFAMARTAGWAAHIIEEKFAEAAPKPMLYRPKAVYVGKYAGPQGIDYIPIEKRNEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE5</accession>
    <name>A0A087RLE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S17P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="109" mass="12352" checksum="F60DFBD1129AC44D" modified="2014-10-29" version="1">MIRNIGIDIKQPKKEPSENEKNNPFNGSLSVRGKIFEGIVIKTKGKKTVVVQKESPIYFTKFRRYGRSKNTIHAHNPSNLDVQEGDRVIAAECRPISKTVSFVIVEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE7</accession>
    <name>A0A087RLE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="47" mass="5545" checksum="6DD6FD7B492CB6AA" modified="2014-10-29" version="1">MPKQDTEIKIDKDCELKEATTESEHITLEEEKIKKIETLEEEEAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF2</accession>
    <name>A0A087RLF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="47" mass="5146" checksum="CE3DC321F3B1541C" modified="2014-10-29" version="1">MKLVKDLSVLDLAPGAAPIRLTVYSKNAINEISKIKSPHLELMVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF5</accession>
    <name>A0A087RLF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="36" mass="3959" checksum="C62CA9D606B6698C" modified="2014-10-29" version="1">MKKKRNFLLLAIIVGLVGIALGSFTIFLSINNILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF7</accession>
    <name>A0A087RLF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA methyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="90" mass="9916" checksum="AFB4E6BADB217F6B" modified="2014-10-29" version="1" fragment="single">GNTILTSRYGKIFTGSDAKKYGKVNKPILVVFGSPEKGIYEILSENIKKTQNANIYNFFPNQATETVRLEEAILGTLSALNILSSHNTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI2</accession>
    <name>A0A087RLI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative threonylcarbamoyladenosine tRNA methylthiotransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.521"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="268"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="575" mass="65208" checksum="6CBC672B039203C3" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI4</accession>
    <name>A0A087RLI4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">radA</name>
        <name evidence="10" type="ORF">AAA799O18_00602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.523"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="383" mass="42131" checksum="89AF5774BA2E93A1" modified="2014-10-29" version="1">MEDLRLDSLPGVGPVTTKKLSDAGVHNIMDLIVRGPVELAEITGMDKDTASTIVEKARQSLVEGGMLQKDYVNAWEIYKRRQDIGKITTGTECLDILFDGGIETQALTEVYGEFGSGKTQLCHTMCVTVQKPKEEGGLNGTVLFIDTENTFRPERIVSIAKAYGMDPERVLNNIIVARAYNSAHQTLILEEASQMIQENNIKLLVVDSAVGLFRSEYLGRGTLSERQQRLNKFVHLLVRIAETYNCAALATNQVMASPDVFFGDPTRPIGGNVVAHTSTYRVYLKKSGKKRIARMVDSPHHPEQEVIFALGEAGVIDPDSDAKKKTTKTIKSSKLESDTKSDTKSDTKSDTKSDTKSDTKDIQKSNSSVGVDNKTDDKPESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ6</accession>
    <name>A0A087RLJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetratricopeptide repeat domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.517"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="ZnMc" evidence="7">
        <location>
            <begin position="245"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="394" mass="45537" checksum="B0D9C657CDAAAA96" modified="2014-10-29" version="1">MLEFYRILEIDPNNVVSLNGLGLGFGNFGEYDEAIKYFERAIKLDPDNHVSKNYLNYVEKIKKKYPINPTEKPAYLLKLEKNDIPYWVKNNAGWWATDKISDNDFISGIQYLVENKIIMLNSENTKKNSSNVIPIWIKNNAGWWANDEIPDEAFVSGIKYLIENGIMKITVHENTELVKKELERKAWNFKQYIKKIQLDIKNEKRYIELPNPSPAVLKKYWVNYHKWNLDQYLSLSSYSFPDRKVNLVDDVYRIEYAFYVNEQPNGLPLDHVNTLKNAITFWENTELIASDGKKAFVKFYEVNSRSDANIWVTWVIRNLGEGVLGHANIGKGVVEVALAGYSCDGSSQLFTVETVETIMIHELGHSLGFMHSTDPDNIMYPSIKEVNFAYCLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM68</accession>
    <name>A0A087RM68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA 2-agmatinylcytidine synthetase TiaS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="1" type="ORF">AAA799O18_00569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="116" mass="13571" checksum="2FFC69A1934A9DB5" modified="2014-10-29" version="1" fragment="single">EITQLEKHISLVNPTCKKCNKKMKSKGNRQGFECNKCGKKLFSKLNLQIPRKIQAKLYLPVISAHRHLTRPSQRIKKRNKSTLFEPSFPWFNVFKADGKFLNNNTLDNHSIILEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM71</accession>
    <name>A0A087RM71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose / Sorbosone dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="194" mass="21272" checksum="9E3C32587916F7FC" modified="2014-10-29" version="1">MDKRIRIAGIVGAIVFAVIIWTSPSNPPPIPEPIISSDNEFVQVLATNLEKPRAIDFAGDKIFVTEKIGRVRVVESGVLLEESLATFRSVNTFDGGLLGIAVHPNFIENHFLYVYFTYENNGTLWNKIIRITESENKLVEAVTIFDNIPGSAFSNGGALKFGPAGKIYAXXXXXXXTRISGSSIIGRKNSPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM90</accession>
    <name>A0A087RM90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="156" mass="17002" checksum="2D4DA0BAAFDCBF27" modified="2014-10-29" version="1">MLSKYTVIGLIVGGIITILGLASMVDSLTNPNEIRQIDDTFGVGGSDKIRFNAPMNSFQTLTITGDTFDVKILTPDEKNNVKNSYKDKAVFSWTNTMSGENIIQIQNTGKSEFNVAGTVELSRDPLFFTYHILVIIAGIVVIGFSAAFSAKKPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ6</accession>
    <name>A0A087RMJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="257" mass="28162" checksum="9E6AD2E8256A1914" modified="2014-10-29" version="1" fragment="single">KRKTAKRKTAKRKTAKRKTAKRKKPSSSKALEAKIAQLEAKLSNLSKPQTQTQAPPPPPKPAPKPETQAPPPPPPPKPAPKPAEKAPPVLVYEQWKSVGTKNWNDQKPIVTGYTASSDRYWASLHVQNAPDVPAANWNDQKAIVTGYTQPGNKYFATRQRLAYHPRDKTFQPEIAASVTGGASTQTAPPPPPPPPPQPESQGEPQVSSSKKSKQQELEDYEKEYLVRYEQQQQEAAEAEEDAQAGTASKKGALPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK2</accession>
    <name>A0A087RMK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome subunit alpha protein</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.460"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="244" mass="27043" checksum="F276B639207C45DD" modified="2014-10-29" version="1">MPSQQGYDRAITVFSPDGRLYQVEYAIETVKRGTLALGIKTKDGIIIAAEERSRKLQISDKPQKLFQIDHHIGVAAAGYIPDARGQVNDTRFFSQSSKLVYDEPVDVETVAKHIADQFQRFTQYAGARPMGVALIIGGVDNNGNSLFLTDPSGTYVAYDAVAIGANSDIVTEFLKKEYKNDLTIDEASTLAIAAIYLASEIKKGIEHVKIFQIKNDTKQFKILTDEQITKFAESAVEKYPTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK3</accession>
    <name>A0A087RMK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.462"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="111" mass="13164" checksum="57193897DAB30C66" modified="2014-10-29" version="1">MKEFEVTLKVSENPTIHIKKLKNYFSEIPLDEILFGLKFAKNRWVAKDAGVLKVGRKSILRKEIHSVTTEQAQWRLKNWKMMIANYRRRGYSYPTISRIKKLLIQIANKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK4</accession>
    <name>A0A087RMK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="217" mass="24174" checksum="4142F7C58BF73121" modified="2014-10-29" version="1">MGYITKNWNGFKNSLSLSEKVLDKVKPGTALKNRLENSQKQLQMQIIRLEETQKKLQQNHDRIFKKIVDAKMSRNESSAKSFAVELQEIRKVKNTIGSAKLAMEQVQLRLNTISELGDIVVTLSPCMSLIKGLAPSISNIMPNLSTTMQDLSSMLGNMMSDSSFTTEPVFTPNQSSGDIDAILNEAHDILEGKTKSSMPEPPSTPTQSQQKENEFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML0</accession>
    <name>A0A087RML0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">AAA799O18_00537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.468"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="227" mass="25032" checksum="8EF2DD70FF35B9A5" modified="2014-10-29" version="1">MKSLFVTGTDTDIGKTYISAGIVLALKKSGINVGVMKPFMCGTSQKIASLDDVTTLTNAANVNDPRELVNPFFFPIPASPYTAAKNLDVKINIEHVVNSFEKLCEMHDLMLIEGIGGIMTPILKDFAILDLIKKLQTNTIIVTSSKIGTVNHTVMTCEMCKNLEVPIKGLIINNFDSEGYSIPQLERDLHDLTNLPILCSLPHMNNLNLNDLAQTIENRIDLLSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML6</accession>
    <name>A0A087RML6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="124" mass="14817" checksum="6B62F579429DAC36" modified="2014-10-29" version="1">MTDFEVYLKGIIQQILVSYQTLTELKDAQNDLENMKKEISKINGLFLVIKNKLEKEKNQSDRFVVLHKLISYYIETYDFSREIDVLKQIYYKDSDRLKNLRTLIIDSLNDKKIIENLQLLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML8</accession>
    <name>A0A087RML8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="34" mass="3811" checksum="AD265561D677AB7E" modified="2014-10-29" version="1" fragment="single">MYGNTILTSRYGKIFTGSDAKKYGKVNKPILVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN1</accession>
    <name>A0A087RMN1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">psmB1</name>
        <name evidence="9" type="synonym">psmB</name>
        <name evidence="10" type="ORF">AAA799O18_00523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.455"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005005712" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023458431" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="199" mass="21484" checksum="277BECF2F315F5F8" modified="2014-10-29" version="1">MTAMYMPGATAVGITYNEGVVFASERRIAYGNFVVSKSTKKTFVITPNVGAACAGLVADMQLLSLQISALAKIRKLEIKRDVPPNTIAKMMSNMMYERRFFPLLTQVIVGGLVDKPTIFTLDPLGSVLPDDYAAVGTGAEMALGILDQQYKKQLNEVEAIDLAVKSVRAASMRDSASGDNIDVLVINKDGTKESTEKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ8</accession>
    <name>A0A087RMQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">AAA799O18_00497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.430"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="162" mass="18154" checksum="8C6B3385CEAA12EC" modified="2014-10-29" version="1">MAYSKILRRIRNEKTNYNKRKRMLMGHSGFITVQISNENTQVQIHQPKLTGDIVISSAHSRFLTQKGWKGSRKNIPAAYLTGYYAGKKALGKGTNSAIMYSGTRKYTQRMAAALKGVIDAGLDVPANEETFPAEARINGEHLKVKNDIKNMKSSLDNEVEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR1</accession>
    <name>A0A087RMR1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="7" type="ORF">AAA799O18_00500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.433"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="6">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="166" mass="18651" checksum="105B0C9F7197040B" modified="2014-10-29" version="1">MPTRFRKTRKFRGSRNHGWGQVGQHRASGHKGGLGQSGMLKHHFSSMLKDDPDHFGHGSNNPPQRNIIKKWATVRDLDDLYLRYGKQENDKKILDLKALGFDKLLGGGQVKNAYSIRIDQFTSKAEDKVKNAGGELVEKKKKIDQLTSKAEDKAKNAGEKLVEKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT0</accession>
    <name>A0A087RMT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="15866" checksum="E519FBFD41FD6123" modified="2014-10-29" version="1" fragment="single">MPESKEGENTADMLVGHLLDAKRKHDEDKNVETEEVQHLQKGTDYLTTFLLQQGIQQKKETSTNKPPGLDELKKEFVKNLVNNGFVSIADNGRTVLTENGKEFLNKQTKEAADKVTLVQLKNLKFRRSLARKRNRSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT1</accession>
    <name>A0A087RMT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Citrate transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AAA799O18_00474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="54"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="478" mass="51670" checksum="7C602F1B3658ED10" modified="2014-10-29" version="1">MDVEVVSHFSMKGMVIGIIAVVVLNLMLFTLPEYIGLELTITMMATLGVLLGMYVILITEVIHRTALALFGSLVMLIVLFYTGALDPHDSVDFVIGAIDFNTIGLLLGMMVIVGILGETGIFQYIGIKAAKISKGNVWKLLVLLSIITAVGSAFLDNVTMVLLMVPVTISVCKLLNINPISLILAQIFASNIGGATTLIGDPPNIMIGSAAGIDFMSFAYHMTPEIIITMAVTIVLFKFMFRKDLKQKPENLEKLQALDEKKEIKDPMLLKKASIVLGAVIIMFMLHGMLDLDVSIIALGGAAVLLVITGIQPFKALHHVEWPTLLFFCGLFIIVGGVEVSGALELLAHNILELTGGDLGATMFSITIVSAFASAFVDNIPFTATMIPIIESISVDPTFSQNLTVFDYNPLWYALAFGADLGGNGTLIGASANLVAIAVAERFGYRIFFREFLIKGLPLMVITTLVAFGAFYIRVLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT8</accession>
    <name>A0A087RMT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="4">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cofG</name>
        <name evidence="11" type="ORF">AAA799O18_00481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.415"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="55"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="389" mass="44692" checksum="49C2C4C03D6D3A20" modified="2014-10-29" version="1">MSRLEFDFEALNQVLDGREITKNDAYEVFSHSKYNSEKIFKVASNLRDIHKGKTVSFSKKAFFNIINLCRDTCSYCTYKAEIGESKLSMMNIDDVKKLAKSATKLRCTEALLVTGESPEQKYDEAAKWLRKNGFSSTGEYLAHCSELVLDEGLFPHTNAGNLNKSEMNELKKTNVSMGLMLENSSRRLLEKGMPHHDAPSKDPKARIQILKNSGELKIPMTTGILVGIGENEHEIIDSLFTIKTLHEQFGNIQEVILQNFEPKQDTKMKDHPSTSQQYFKRIVAMARIILHEMNIQIPPNLSPTNYDDFLDVGINDWGGISPITVDYVNPEFAWPQINTLEKKCTEQGFELKARFPMYPKFIKMINPNLKEKIEKLSDDENYVRREFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN28</accession>
    <name>A0A087RN28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS cluster assembly protein SufB</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">AAA799O18_00445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.382"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="466" mass="52888" checksum="694004A2C89C5392" modified="2014-10-29" version="1">MTTEDLKMDYSKYDFKDSTEMYVHLSKKGLTKDTVREISQLKDEPQWMLDFRLRAYDVFMKKPMPQWGGDLNKIDFQNIYYYAKASDKTEKNWDDVPEDVKNTFDKLGIPEAEKKFLAGVGAQYESEVVYHNLRNDLAKQGVLFLDTDTALKEQPEIFKKYFGKIIPPEDNKFSALNSAVWSGGSFIYIPPGVKVDMPLQAYFRINAENIGQFERTLIIADEGSEVHYIEGCTAPVYSSESLHSAVVELIAHKDAKLRYTTIQNWSNDVYNLVTKRAYAYEGATVEWIDGNIGSKLTMKYPGIYLMGRKAYGETLSIAFAGKNQHQDTGAKMVHLAPDTTSKITSKSVSRANGRSTYRGLLRVRKGATNVKSTVRCDALLLDDTSKTDTYPYMEINQEDATVTHEATVGKIGDEQIFYLMSRGFSEEEALSLIVNGFMEPFTKELPMEYAVELNRLIKLEMDNSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN45</accession>
    <name>A0A087RN45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="72" mass="8376" checksum="2CA284814D37E119" modified="2014-10-29" version="1">MILLDHLKIRTDIMNDEEKIKKAATFIDSFLVRTNTNLKKYAASKDSPDKESIIEILESQKRVLEKIKEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN46</accession>
    <name>A0A087RN46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="43" mass="4837" checksum="2C03DC21ECFB239D" modified="2014-10-29" version="1">MTDEDDEDEEKIVNLRGIAIIAAFIISGIILYLQTSEWQANTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN50</accession>
    <name>A0A087RN50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter protein</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.405"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="260" mass="28962" checksum="4DA307653EE18676" modified="2014-10-29" version="1">MATLEIKDLCVTREGKEILKGVXXXXXXXXXGEVHAIMGPNGSGKSTLAYTLLGHPKYQVTKGDILLDGESVLKLKTDQRAKKGLFLGFQYPTEVSGVGFSHFLRTSYNALSKALKDDEREVFITVREFQKYLKENVNDVGLKDEFLSRYLNEGFSGGEKKRSEVLQMTVLKPKVSILDEPDSGLDIDSVQAVAKAISKTFDKNTTTILITHYARILNYLDKLDFVHVFAEGKILKSGDSSLAGKLEEKGYDWVLEKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN73</accession>
    <name>A0A087RN73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase protein</fullName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cofC</name>
        <name evidence="1" type="ORF">AAA799O18_00437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="209" mass="23772" checksum="8F1AE8599C5F9A91" modified="2014-10-29" version="1">MKTCAIIPVKTFSEAKTRLDISKTQKEEICKAMLEEVLITVSKSRSIDKIILVSKDESAFKLGRKFNTVEIFDDESGVNHAVYLADQYTFDNKYDCSVIFPQDIPTMKSSDIDNLLGFCKSENSIIIVPSRQLNGTNALVRRPTNIMETQYDRGSYTFQLDAANIVSQKVSVALIRRIMLDIDDEHDLTFMLNQNEKPDFCKVISKFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN77</accession>
    <name>A0A087RN77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit SecG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secG</name>
        <name evidence="10" type="ORF">AAA799O18_00441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="54" mass="5983" checksum="D2859E10D369D541" modified="2014-10-29" version="1">MADKKNAPLPASSAGLLRFFEDETKGFKIDPRIAISMPISIIAISWALEFFMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN85</accession>
    <name>A0A087RN85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rnz</name>
        <name evidence="11" type="ORF">AAA799O18_00404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.352"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="300" mass="33305" checksum="2A12CBB336C8ADEC" modified="2014-10-29" version="1">MMELIFLGTSGAMPTLERSTTCICLVRDGEILMFDAGEGAQISYLKSNLGWNKKMKIFVTHLHGDHCIGILGFLQTMTLQNRTEPIEIYGPKGIEELIAANTKIMNFGLSFPVLITPVNEGIIVSEEKYQVHACEAEHSVPTFSFLFEEKEKPGTFYPEKANSLGVPKGELWHKLQQGEEVIIENKSIKPSEVMGPNVPGKKVGISGDTRPTKKLEGFFKNCDYLVFDSTFSDELKEKAVESCHSTAKEAATFAKNASVSNLILTHFSARYKDEKVLLEEAKTVHNSVIAANDQLKVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN91</accession>
    <name>A0A087RN91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.358"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="249" mass="26799" checksum="1B5359193D9BB1D3" modified="2014-10-29" version="1">MTMSIEGKVAIITGASSGIGYATALVLSKAGAKVAIGARRVDKLSQLENEIKKNGGEALAQKLDVTKKTECDTFVKQTVKKWGTVDILVNNAGLMPLSFVKNLKVDEWEQMVDVNIKGVLFCTAAVVPHLKEKKSGHIVNISSVAGRLVFPSGSVYCATKHAVTAFSEGLRQELSTRSGIRVTCVEPGVVETELLNTITDESLQSFIETAKKSQGLKADDIASAILFAVQSPEHMNVNEILVRPTTQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN95</accession>
    <name>A0A087RN95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
            <ecNumber evidence="2">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ORF">AAA799O18_00419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.362"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="118"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="486" mass="54960" checksum="A8DC5FCE2BF024A6" modified="2014-10-29" version="1">MPYKVIGGKPTQIQYSGDEVFSMIKRSEIKFIDLQFTSLPGRFHHTTISSITFTKDQMIDGLPKLDGSSIVGFTSIDDSDLILKPDPSTFGIIPWMTDKKSARMLCDIYRGAGRGRLETDPRGICQKAEEYLKTQGFDDSFWGPEVEFFVFDKIHWDVLTPYKGQSYSIESNEAPWSQEGTGYPMGLQEGYYPSTPSDTLTEYRNECVEVLNENFGILCDNHHHEVATAGQCEIDISYDKMTNAADSAQSYKYVVRNIAKKHGKIATMMPKPISMDSGSGMHTNVSLWKSAKNTFYDKDDPDELSQTGRYFCGGIMEHAQGLTAITNPTTNSYHRLVPGYEAPVYIAWSTANRSATIRIPGHFKGEKYSHLKRLEYRVPDPSSNPYLVFSAVLSAGLDGIKKKTDPGEPIHEDIYKMSRTERKKKGIGILPANLGEALDALESDRSFLNPIFTDHVVDRIIELERRDQREISIRPHPHEFYLYFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA8</accession>
    <name>A0A087RNA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.342"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="234" mass="26820" checksum="9CD484AC4D55B264" modified="2014-10-29" version="1">MSQEEIKKSLELLEKDWDIDPIIKDFHLARRDDVSENSIKVNDVVFHIPFLNKIRKFILWKCYWPDCSNCCTRQGRLPLTSQDLITIGSGMKYQKTSNFIKNETVIATWEEPSPGGGFTTMTSINLKRKDDETEADDGSHIKCRFLDKEGSCSIHPTRPGVCYLYPFSTWLQNEKGRARVHATFQFTGDCPGFYLDDSIDSMKEILQEYSEIIYDYNLKSSGTMREGLGSISLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB7</accession>
    <name>A0A087RNB7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.130</ecNumber>
            <ecNumber evidence="2">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lysK</name>
        <name evidence="4" type="ORF">AAA799O18_00357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="2"/>
    <dbReference type="EC" id="3.5.1.132" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.309"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="374" mass="40999" checksum="119490085DD9B0A2" modified="2014-10-29" version="1">MESHFTVTTRFAVKTLEKALKIYTPSLREKGLAEFIADKCDDLGFNDIHTDEVGNIIATKGSGSPRILLCGHMDTVPGRIRVRKEGDFLFGRGSSDAKGPLIAMLFAAASVQEKNGTVMFVGAVDEEGNATGIKSLVKDKPKVDYAIFGEPSGVRNITIGYKGRIAINLKINVGDSAHASAPWLAKNAIEESSLFTNEIKKSLESEQSDRKKGMQLTATITEIKGGLSHNVTPRECDSTIDIRVPVDMNCKMVEEKISQAVNDIAKKRSVEAFYSIIDETEPFEAEHNSSLVRALTLGVLDIEKARPMLIRKTGTGDMNVIGNQLKIPVVTFGPGDPHAAHTIDEKISIDEYLRGIDVLKRTIQHLKRLHDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC3</accession>
    <name>A0A087RNC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybutyryl-CoA dehydratase protein</fullName>
            <ecNumber evidence="2">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crt</name>
        <name evidence="2" type="ORF">AAA799O18_00363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.315"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="253" mass="27300" checksum="162A569BA05DD4A4" modified="2014-10-29" version="1">MSNLTISNNEGICTVKINRPQKLNAMNIDVAKEIITTFQQLEKDDNVKVIILTGEGDKAFSAGADIEYMSKISPEESERYAKLGQELTATVENVTKPTIAAINGYALGGGCELAMSCDIRIASDNAKIGQPEVTIGIPPGWGGTQRLMRIVGIAKAKELVFTGKPINAIAAKEIGLVNHVFEQSSLMDEATKMAETIAANAALAVHMSKTAINKGRNADLDTGLGVELLAWRNCFSDPEREKRMSDFVNKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC8</accession>
    <name>A0A087RNC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.320"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="124" mass="14183" checksum="755073980DD0D577" modified="2014-10-29" version="1">MGSKISQLFAQKYINLETYKKDGTPVRTPVWFVIDNDVIYVITRENTGKVKRLKNNQNIQIATCSFKGKPKSEWMKGIAKKVTDEEAEKATKLRKKKYGFSVMLTSLFSSQKGNPIVYSIELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND6</accession>
    <name>A0A087RND6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="41" mass="4910" checksum="0AD471B3B20A30A4" modified="2014-10-29" version="1">MFSISYHLHVQIVDFDKNLLKQYINLTTEMFSKTGQDEKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE8</accession>
    <name>A0A087RNE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="114" mass="13064" checksum="89ACE99FCDE0063A" modified="2014-10-29" version="1">MAPQVQFLREIRDNTVLQTESGTNFMTGFNHLYYSFSPTIADYERENPIFKEAVKLTLTPLLTSLTLLQFTDIDSESEMLGYGIGIILLNMGMYLVVPAMVTLKLVKKYREINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF0</accession>
    <name>A0A087RNF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ORF">AAA799O18_00324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.281"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="197"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="593" mass="67659" checksum="A97C38BA14196834" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG2</accession>
    <name>A0A087RNG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.293"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="227" mass="25198" checksum="B22ACFD4C572F9E8" modified="2014-10-29" version="1">MLQDRTSEWFVPKFGSRNFRVTIGLLFLPYTSIVTCFAAWGSLSGSFETERLIAICLIYFLALGVSAHLLDAVGGKTKPWGDLPKRKLWTVSMIVLAVAFSIGMYYAFLDSPLLFAIGIAEGFFLFAYNLELFGGKFHNNASTILSWAILPVFAGSAIQTNSISLEAIMFCGVSSIITYVLITTSRKYKHLRRNNGNHSEIKRCEVILKLLTVGVLVGTVTFLVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG4</accession>
    <name>A0A087RNG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase MdmC protein</fullName>
            <ecNumber evidence="4">2.1.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mdmC</name>
        <name evidence="4" type="ORF">AAA799O18_00343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="209" mass="23965" checksum="8F9A91BADC6D0D50" modified="2014-10-29" version="1">MINEKIQNVLSRLEKDIDYENSHRAEVPSEERLNCISKNIGMFYNIMLKSINAKKILEIGMSVGYSGLWFADAVISNMQSDGQVITIDREKFKIDKATQNFEEAGVSSLIKIRRGEARKILHEIKEEFSENYFDFIFIDADKESYIEYFDLCLPLVRKGGIIGADNILLPERFNKMMADYLSHVRSNPNVQSVTIPIDNGEEVTIKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG8</accession>
    <name>A0A087RNG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.299"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="113" mass="13244" checksum="2DBAE6070E51DBFA" modified="2014-10-29" version="1">MYSVDMVKQISLDTWSVQHLMDLLKKGSRIVKKTNTPIILYRQTLEEEDNSYEEVVCTLTNQYIIEQLIVSGGMIVPAFKQQFVFTIEEFPERLLKKSKDLFIETVNLLEKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH0</accession>
    <name>A0A087RNH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cobB</name>
        <name evidence="5" type="ORF">AAA799O18_00349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.301"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="242" mass="27100" checksum="F223C3F5F9BD69C6" modified="2014-10-29" version="1">MKMFDIVSQQLNDSRKIVFVTGAGISQESGIPTFRGKDGHWRKHDPMRLASIDTFYDDPKLVWEWYEDRRKNILAAKPNEGHFAISKMEKFRDVVVLTQNIDGLHQRSGSTNVLELHGSIIRIKCTVCNFSDNITKNFESLPPKCECGNMLRPDVVWFGEALSQDIWKNAIKEASTCDIMIIAGTSLVVSPANTLPIYAKENGATLIEVNPEKTVMSNEMDLSIQATSANALPKILSILTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI2</accession>
    <name>A0A087RNI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="150" mass="18100" checksum="EF0F2BCDE16E4BAA" modified="2014-10-29" version="1">MVKEAYYLQRVKVDSDSDAKFLFDLLKERDARANISHKKMPSYNSHIRFIKSKPYKVWYIIYMKLDHKLRYDWKEKVGSIYLSKNDEIGIFISKKFQGKNIGKYALNDLMAKDTRTKRYLANVNPKNKKSIQFFKNNKFKLIQYTFEFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI6</accession>
    <name>A0A087RNI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 46-dehydratase protein</fullName>
            <ecNumber evidence="3">4.2.1.115</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pseB</name>
        <name evidence="3" type="ORF">AAA799O18_00248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.115" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.228"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="335" mass="37784" checksum="4BE0743FBBB91686" modified="2014-10-29" version="1">MLDGKKILITGGTGSLGIALTKKLIESKAHSIRIYSRNESKQVEMQDQVSDPRLRFLIGDVRDLERLTKAMEDIDIVFHAAALKHVPIVEYNPFEAIKTNVLGSQNVIDACLKENVETAVCIGTDKAVSPLNTYGATKHLMEKLFVTASNYINPLRYKTKFLAVRYGNVLGSSNSVIPKFIEQIQSGKNLTITDPNMTRFTITMNQAVDLILTAIEKGHGGEVFVPKLKAYRLDILKDAILDILKTSVKIEKIPVRQGEKYHEALINSEELRNTFEIDSLYIILNKQMHRATFSKWNDLKITTLNHEYSSDKVEILAKEKLIDIIIKEGLLTRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI9</accession>
    <name>A0A087RNI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="123" mass="13801" checksum="C0095DC0F4159541" modified="2014-10-29" version="1">MVREINPKIRVRKTGEISKLIEECDVFVMIDVSTVILDAQLLGKPVISVRVKDSGYGIPSVLASNSCLIADKDNFQEILTRVLTDSKYRQEAIDRGYNYAKSYVVNIGTASEKILEHLHKTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ3</accession>
    <name>A0A087RNJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="78" mass="8987" checksum="A240171C4C36B428" modified="2014-10-29" version="1">MSEEYPRRGRNWLTAMGVLFLVVAAVTLVRDIIIWSPDFVVQFFFDSDINAQKVSLGAIAFGLFMIIWGYKKQNVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK0</accession>
    <name>A0A087RNK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme A synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctaA</name>
        <name evidence="6" type="ORF">AAA799O18_00267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.242"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="130" mass="13837" checksum="90B5CAD3C5DAF543" modified="2014-10-29" version="1">MVIGGYISAAGLGLTCPDWPLCPNGLLPDDEYFIEWSHRLIAATTGALVIATAVGSWITAGSHWKIRTTGTLAAIFVVTQITLGALVIDTMLHAVLVSVHFGIGILLFAMVLLTTLFAFRLKPKSIQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK2</accession>
    <name>A0A087RNK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.244"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="215" mass="24333" checksum="7086E7FC2E85C5B4" modified="2014-10-29" version="1">MPKALNLHRKDLPALTIVSKSIEIKAPVDTVFTYFARPEHVSDQLKDQERVGMTVIPMDIKEGMGVGTTFRIIGDFDGKRLTWDCETTQFDRNQKISAKMIKGKFKRWDITNEFKSLGENLTRVTMTVDYEMPLGPLGGIIDKLKFAKSAEKGMENALYNVRGLLEGNGSIPVYITLDAYQKLLAEKKKMNNVPVSKVLTSILEKYNQVETEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL8</accession>
    <name>A0A087RNL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanine--poly ligase subunit 2 protein</fullName>
            <ecNumber evidence="2">6.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dltC</name>
        <name evidence="2" type="ORF">AAA799O18_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="80" mass="9615" checksum="FD7C0125A8150EC3" modified="2014-10-29" version="1">MDVENWLFDWFEKNTPAKKYEISKKLGENYFDNGWLDSLKFIELINDVEQEFDILFSNDEFQNRKFATVNGLREIITGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNM0</accession>
    <name>A0A087RNM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinylbenzoate--CoA ligase protein</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.262"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="491" mass="56674" checksum="E876D897E2888C09" modified="2014-10-29" version="1">MELQIKTGNLIKDIFRNNWEETFIFDSINSKDYTYQEFFELVLEIKQNLEKRNIKKDEAICLILPNSVELIALYFAALLLEITVVSIDPNRGVEEIKQMCSVRECKLYFGKNLDINKKFEPISNLIRNKIFNSVDKNALDIFVGLNYNSLFTITFTSGSTGIPKGVMHSFNNFVKSSLLFKNRFEFSKNDIFYHNLPLSYIGGLLNLLILPFVSESKIVLGQQFSISNIPNFWDIPIKYSVTTFWFIPTIIGLLLKLDRGNEGIEFTTKNKIIGLVGTAALRGDIKRDFEKKYHIKLFESYCLSETFFVTTNYEGNDRKNRVGKLIDEAKISFDKDNEILIETPSMFLGYVGLDNNQFFDNKGRYFSGDLGILDTDGFLQITGRKKDLIIRGGFNISPKKIEDFIMDLGFLEQIVVLGFDDLYMGEKIVCFFTTKKINYNDDLKAINKQIITRLGQDYKIDEFKKLDSIPRTTSGKVDKPIIRDYYKNKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN0</accession>
    <name>A0A087RNN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional aspartokinase-homoserine dehydrogenase protein</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thrA</name>
        <name evidence="2" type="ORF">AAA799O18_00312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.274"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="331" mass="37056" checksum="7683460A003B80FC" modified="2014-10-29" version="1">MEYILQSHGMKSKVVGLDNWPIITDSNIESTNFLVSESNKKVEFLEKLFDENQVVTIGGFIGRTKDGVITTYERGGSDRTAADLGILLHKKFNVKIDLEKDSSVVSADPKIISDGLTDVENLSYNEARLAGMFGMNILDPIAIKEILENGVSMPIVITDIRNPEKITTIERKSTNKNGHPIKIITGKKNCAILRMEDESAHKLLDSLENKKRYSEFVILSPFTKDGIKFTRILFLDGDYIKRNEKYVLGFDALATITYNRGVITLIGDEMWRVQQIVSKTSAKIGESGINILNIDAQEETSRIIVVVEDSGNNIENAISTIHEERANIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP0</accession>
    <name>A0A087RNP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">AAA799O18_00222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.204"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="90" mass="10168" checksum="DBABCA8B5C695369" modified="2014-10-29" version="1">MKINMPVYLVHVTIENKPGISDPEGETILNDLVLKGNYGSISKIRSGKVLKFQINDKTKKSAVEKIHKLCDELRIFNPLVSKVTIEVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ3</accession>
    <name>A0A087RNQ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">prf1</name>
        <name evidence="11" type="ORF">AAA799O18_00235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.217"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="426" mass="48043" checksum="4AF48B647C65DE9B" modified="2014-10-29" version="1">MKKIDVEKKDSVKLYKIRKTLQELSKITGRGTELITVYIPKGKQLHEVITNLREEQGTADNIKSDLTRTHVVDSLSRVIQRLKLYKKTPESGLAIFCGALPREEGGPPGSEVVKSFEIDPPKDLKTFLYRCDDHFHVDILKDMLKDDNLIGFLAIDAKDAGWGLLHGDKIEVLKETSSGVAGKHRQGGQSAKRFQKLREMEISYYFTRVANTTREYFIDIYPIKGLIVSGPGPTKEEFVNQNYLEYRLQDMIIGTIDASYSGSEGIREAFTKSTDILSNFRMVEEKQFVDKLFKQINSHSGLGVYGLDDVINYLKNNVVDMIIVTDNIELFRIEVKCNRCFHIDDKIVEQSIVIKTKTEFQNLPCSSCKSKDIIVSDQDIIDYLALLATKVGTSIEVILGTTESGSMLTSLGKIGAILRYNPNYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU7</accession>
    <name>A0A087RNU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="151" mass="17244" checksum="244E097E8F2925B3" modified="2014-10-29" version="1">MKKSNILSSPVKKVKVNYFTGPVKLHEISGITKPIEHDMYHVIFRNSARTKLHYHTGGQLLIVTKGNGSLVFYNKKSSGVSKFRISRTKMINLNYGDTVYIPAKMLHTHGSVKKNQIFSHIALNFHPTKYTKPRTIWFESDLRSIVTGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV1</accession>
    <name>A0A087RNV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 type domain signature protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="62" mass="6989" checksum="61A1F3F0ABBA3101" modified="2014-10-29" version="1">MIMQYMGLFSKKNKNETKCDVCNLELPTPERLERHKKKAHANVPEKKMDDTAGGSPGEGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV2</accession>
    <name>A0A087RNV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydrogenase protein</fullName>
            <ecNumber evidence="3">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hbd</name>
        <name evidence="3" type="ORF">AAA799O18_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.158"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="382" mass="43223" checksum="5D21957C249CD92C" modified="2014-10-29" version="1">MSVEEIKSITVLGSGIMGHGISQVSAMAGYNVVLRDIEQKFLDKAMEKIKWSLDKLVSKGKISDNERNKIISRIRPIVDLNDAVKDSDLVIEAVPEIMDLKKKVYAELDNVADDDVIFASNTSTLPITEIANTISRPERFIGIHFFNPPQLMKLVEVIPGQNTQDSIVDLTIDFVKSVKKIPVTCRRDVPGFIINRLFIPLVHEACYVMERQKIQQTKIDSAVKYKLGFPMGIFELADFTGMDVIHKATIEMHLRDKKVILPHPRIEQLFNENKLGKKNGEGFYKYSSEKYERIELSEELAEKCDQTQIIANILNNAAWLVTNKASDINEIEKAVNLGLGLKKPLFETANEIGIQKIVDELKKLAQQYGKFYEPDPLLLSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW0</accession>
    <name>A0A087RNW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AAA799O18_00183</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFM15164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="214" mass="23422" checksum="593132F2031484C6" modified="2014-10-29" version="1">MKITVSVIKADVGGIGGHTRPSDGLLNAVRETVKSNEKSLIDHYIGYCGDDAHIIMTHTQGVRNSGIHKIAWDAFMAGTEIAKQEGLYGAGQDLLRDSFSGNIKGMGPGVAEMEFDERQNEAFTVFAADKTEPGAFNYPMYRLFVDALSNTGLIVNKSLAEGVNINIMDVEEGKIAKLSLWEDKPTIEAALMYPSRYVIDSXXXXXXTNIRCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW7</accession>
    <name>A0A087RNW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="93" mass="10533" checksum="DAE7E686607FA85D" modified="2014-10-29" version="1">MVTRNVKLCAQIRYDMEDSESDTIVIKNWPEKYTDILNQIGVSAVPNEIGEDDVEKGDYYSRCFSQTTRMVTNKGSLKISGRNIDAVQIIQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW8</accession>
    <name>A0A087RNW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase 3 protein</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.173"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="550" mass="60071" checksum="BC288DCE9BAC664C" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX1</accession>
    <name>A0A087RNX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.176"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="116" mass="12973" checksum="A5E67F51009C02F7" modified="2014-10-29" version="1">MTDPLKKHLDKLKIMTESAKRRSGLYSDLANLDDKHLRRSLTALHKAPAPGKKIQKIGFIMLWIPEPTGITCAVGGPMILAGRYLDKVYNGSKISDIGNHTKDTFSTLHDFKQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX8</accession>
    <name>A0A087RNX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">aspS</name>
        <name evidence="8" type="ORF">AAA799O18_00201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.183"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="137"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="431" mass="49485" checksum="A4FD6C6313F80867" modified="2014-10-29" version="1">MISMKSNRTHYIENVKPDMKDQEIILGGWVEDLRKMGKMTFLTLRDATGITQIILTDDVMKSIDDITRQSVVRVTGKIQDTKARDFECEVKASEINVLARATHPLPIDPIGRLESHIDNRLNSRALDMRNQKTASIFKIRHHVLASLRKTFLEKKFIEITTPKIIGSASEGGANLFSLDYFGKQAYLAQSPQLYKEQMTIGLERVFEIASFYRAEKSHTGRHLSEFTSVDIEAAFMDYIDVMNVLEDLVLNTFKHVSENCKTEQEIIGNKITIPNKPFEKITYSEALEELNQKDTKLEFGDDLLDSHLRIIGENHPGFYFLTDWPIKLKPFYIMENQDNPEISESFDLQFGYLELSSGGTRLHNPEKIKMRLSEQNLDPAKFSEHLHAFDWGMPPHAGWGLGLERLLTVIIGIDNVREVILYPRDPERLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY4</accession>
    <name>A0A087RNY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DeoC/LacD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.189"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="269" mass="29497" checksum="BD08955A094B320E" modified="2014-10-29" version="1">MDWGLQNRINHIIRPNDNRALMLAVDHGYFLGPTERLEVPRKTITPLLKYCDSLMLTRGVLRTSVDSKFSTPIVLRVSGGSSIIGDDLSNEQITVSFNDAIRLNASALAMSVFVGSKYEQQTIVNLGKLVSESEEFGIPVLAVTAVGKEIGQKDARYLSLACRIAAEQGAHIVKTYYCENFEKVVDSCPVPIIVAGGKKIPERDALELTYNSIKGGAVGVDMGRNIWQSDNPVPMIRAVRSIVHGNSNVDDAYNLYKKLCQPEPKSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNZ0</accession>
    <name>A0A087RNZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">recJ</name>
        <name evidence="2" type="ORF">AAA799O18_00213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.195"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="184" mass="20154" checksum="B5B57C92F6AEA610" modified="2014-10-29" version="1">MEERPIATKLLQMYDRQFVLVNATVLTYNIVGHQKDAEYLLYLVEELSDSTYPHDIPNAFEFAQIQVGKLAEIISKVKKSMKISKNLAHMEVLDSGASGAVNFVLGLSGKNVGVAYKERIDNGIYAVSVRGSRSCKVHLGRLVSSLADELGGSGGGHDKACGAIIPKNKIKKFLQKMNSQLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP37</accession>
    <name>A0A087RP37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-3-O-acylglucosamine N-acyltransferase protein</fullName>
            <ecNumber evidence="2">2.3.1.158</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lpxD</name>
        <name evidence="2" type="ORF">AAA799O18_00137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.158" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.118"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="220" mass="24320" checksum="948ACD274D90B3BF" modified="2014-10-29" version="1">MKNVIIFGTGQFAKIIHQYLANDSDIEVVAFTANESYIKDDNFCGLPVVPFEKVESSYPSSEYQMFVAVGYSDLNKKRAGIFEQAKSKGYKLVSYVHPSVVVVGDFEFGENCFVFENSVIQPFVKIGDDVIVWSGSLISHNTTIKDHCFIASHVAIAGSSTIEPYCFLGTNCTLRNGIKVAKECVIGAGCVILEDTKEKEVFVTRSTAIPNFNRDLLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP46</accession>
    <name>A0A087RP46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="52" mass="6155" checksum="7C10548D7D68B13C" modified="2014-10-29" version="1">MIPNNLRVINIGLRFFYQSLTEQKVETAHVNWEPKPKLEKDIEDILDKIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP50</accession>
    <name>A0A087RP50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclic pyranopterin monophosphate synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">moaA</name>
        <name evidence="6" type="ORF">AAA799O18_00150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.131"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="524" mass="60197" checksum="B1884B1C1F43B840" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP55</accession>
    <name>A0A087RP55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pelA</name>
        <name evidence="11" type="ORF">AAA799O18_00155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.136"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="350" mass="39045" checksum="0A16BED25BA92062" modified="2014-10-29" version="1">MLTKIIDNNSISCIPEDSDDLIILRRIIKKGDIIVGETTRVIKQEKDFARPDKGERIKIRLSLDVEKISLDDVLDRIRVGGMIKESNNESIPHGSHHSFIIKIDQAFNIIKKKWTSVEKKLLKTNNQNLAFILIAIDTSDCGIGKLKGTHLHILQNIYSGSSGKRYKTNFKIENFFDEISKALLSVVRTNEQIIIFGPGETKNRFANFLGKTQMGQNHQVKVVEGIDSGGEDGIHLFTKSKSMKEIISNSKLAKVSDIIDEVMFLANKKSRKFTMGLEETRKANQYGAIDSLIFSEKVIQSNNEQEVIDFLNDVESKGSSIYGVDATTDAGLRVTGLGGIISILRFAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP76</accession>
    <name>A0A087RP76_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">flpA</name>
        <name evidence="5" type="ORF">AAA799O18_00003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.2"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="231" mass="26661" checksum="3DE9B0373B9B192F" modified="2014-10-29" version="1">MTKENERILEDKQNIFWFQVEGEKKLATKNLVPGNQVYNEKLLVVNNVEYRIWNPFRSKLAAAIMNDLSNFPFNQKSNVLYLGVSTGTTISHISDIIGESGVIFGIEHASRVARDFLDRVASHRKNIVPIIQDARKPEEFFSVYKKVDIVYVDIAQPDQTNIAIENCKLYLKPSGYIFQIIKTRSIDVTKDPKKIIKNEIKKLEQFFQIKQTIDLHPYDKDHMLVIGTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP79</accession>
    <name>A0A087RP79_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="2">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rlmE</name>
        <name evidence="5" type="ORF">AAA799O18_00006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.5"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="4">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="196" mass="22213" checksum="C86D06C6B7D7B746" modified="2014-10-29" version="1">MKLIDAKKDLYRKLAHEEGYRSRSAYKLKELNKSYRIFGPGNFVLDLGCAPGGWTQFAAKIVGNQGKVMGIDMSFVEDIPRVKMLKASIDDDVTKEIFTFFGKKIKAVISDLSPQVTGNWSVDHSTQISLNYSAVKIMEQVLEKKGNALFKVFDGEYSNEFYEYLKKKFSKIKLTKPKSSRKPSSELYCICLGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP81</accession>
    <name>A0A087RP81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.7"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="685" mass="79500" checksum="2F496A8685566551" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP86</accession>
    <name>A0A087RP86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.12"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="133" mass="15458" checksum="DA4B0C4D5261B8E0" modified="2014-10-29" version="1">MGEIYKCCKEPQITYLAPVNININERTIGSVDVWRCAVCKKKFCEEKQLGIESLTEVVGMPRIENDEKWAVIVSKLQKGKDKWKLVRLRNNGIIKYETADEKILDLKIEDYKIVDDFHTSFLVEDHLNKAVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA5</accession>
    <name>A0A087RPA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="153" mass="17543" checksum="DE5E4DAFE16E1316" modified="2014-10-29" version="1">MSEPNYAGNIIINLASLPDFLRKPILKKRMTEFFSMSDSDKSEIINNALEAGPTIPFPNFSKLFKTWLEVLCTVSEENRYAMFLNYIKLIINSPQKIIAFNLDGILEIFLSLEHSNQKILSVSVQNVFKNMDQDSKRKIILLVPENARKLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB5</accession>
    <name>A0A087RPB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative archaeal histone 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.43"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="73" mass="8111" checksum="BEB3F94FF99F73A6" modified="2014-10-29" version="1">MKSSELGLSAMYRILKKSGAERVSDESANELRRVIEEIAEVVAKNAVDMANHAGRKTVKAEDVKLASKQFNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB7</accession>
    <name>A0A087RPB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="55" mass="6439" checksum="4C1A69637FF00BF8" modified="2014-10-29" version="1">MTPNDKCALCNENMDHTYVPMKEWYIDGHVCGKCYSKKIAEFYPGKHERVNLSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC1</accession>
    <name>A0A087RPC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="64" mass="7329" checksum="D3ECDBE41E21CB16" modified="2014-10-29" version="1">MKHYHVRLGKILEIVGLSLIAGTIYSFVGMTESELRWPVFWGCAGGALAIIVYRNYMRKKQKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPD2</accession>
    <name>A0A087RPD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="165" mass="19397" checksum="A4632D4D7000AD06" modified="2014-10-29" version="1">MPGRWIEIDANLGKCRKITMILKQKNPKLVMDLNSNTIVVYRKDSKLCCPYHRLSKDSIAHQHWDFCPSNPSGICIRQEFLFFPFVSSTYNDYVDKKPHSVWLEGTWAIIDLICHEIAHFAGSSAHSIHGKKWLDIYQKFLRQMVLEVISGNYYTWYTNHYKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG3</accession>
    <name>A0A087RPG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L37Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.92"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="70" mass="7756" checksum="41978F21171F1289" modified="2014-10-29" version="1">MAKKKVSLKGLGARYGIKPRKQFTQIHKTLKASRRCPDCGSLQFSRHAVGIWGCKKCGYKIAGSAYDVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG6</accession>
    <name>A0A087RPG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome complex RNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="63" mass="6627" checksum="817BDEDDF12F29EC" modified="2014-10-29" version="1">MIQTIEASTNTTITIGQNGLIVVSSSETNGLLKALAAIRMVEEQAHIADLTDKVKKMLGSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG9</accession>
    <name>A0A087RPG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome complex RNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="168" mass="18622" checksum="0671504593F8B199" modified="2014-10-29" version="1">MIQNEFVIPGDIIVTGSYTPEQNVILEGDKIMSTAIGFCEIEDNRVNVIPLTGFYIPEIDNFVIGKVISHSSLSWEVDINSYYSSMLPASDIFGRDYSPANDDLSLKLGVGDIIAARIVNAGDTRDPLITIAGQNLGKIDSGELIKIYKNSTSDRKTWFYDTDNRSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH6</accession>
    <name>A0A087RPH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydratase small subunit 1 protein</fullName>
            <ecNumber evidence="3">4.2.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuD1</name>
        <name evidence="3" type="ORF">AAA799O18_00123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.105"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="2">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="160" mass="17956" checksum="B53FC6E38CC8E6FD" modified="2014-10-29" version="1">MKGRVIKYEQDNIDTDVILPGQYLKLHDYAELGEHAMEGMDPNFHSKAKEANIIVTGKNFGCGSSREHAPIAISACGIQAVLALSFARIFYRNSVDGAYLLPIEIDEKTYASISEKDELEIDTAKNEIKNLTKNQKYTMKPFPDLIRKIIEAGGLFKYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH9</accession>
    <name>A0A087RPH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.108"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="189" mass="22299" checksum="AFDAEAEAAF5B1C9E" modified="2014-10-29" version="1">MVEYLTKYPKTVSFLDVVCGSLKGMVNIDGSSCVEQLHVVVKKNADELFRIFSQEGFTKIKFEHKQPFQIGHGLSLKLKKPWEMHVRFVKLKKELVAIHAEVEVSRDYLQHLFGQRTPVVYEIENLLKKYQIEYKVWNSRIKKYVQTVFSNYKIKLVTPNIPVFAWKPMLFVISTVGLMYLWKYLDTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL17</accession>
    <name>A0A087RL17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000050">
        <property type="protein sequence ID" value="KFM14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.667"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="143" mass="16499" checksum="00AEDD56FCCA4268" modified="2014-10-29" version="1">MSEIIIREIEEDDLEKEFLDTLDFLRKASDIDKNDPTEILKKIKQNPNHIIHVAVDEIIGSTTLFIEQKFIHDSGLVGHIEDVVVRKAYEGQGIGMKLVSSLLDVAKQRKCYKTILNCEDSLKSFYEKIGFKKATNEMRYDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL20</accession>
    <name>A0A087RL20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000048">
        <property type="protein sequence ID" value="KFM14174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.662"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="174" mass="19715" checksum="4F816C781478B06B" modified="2014-10-29" version="1" fragment="single">NKIIYEESKRYRMSIVPQSRLDLLTEMEEEYGKKDTQYFVKLLDHEDYVIRCRATCILVDIGGEDKVQYIARVLKDDVNELVRHEAAFSLGQMCYSSGIVPLEDATKNDSSMFVRHEAAIALGVMGSKKSRETLENALNDPDEPVRDSAVVALSNLEFMEKLSKNEKFAKLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL35</accession>
    <name>A0A087RL35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="ORF">AAA799O18_00757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="146" mass="16476" checksum="E8262AF9FCA0D5C3" modified="2014-10-29" version="1" fragment="single">MHENRTKFPKKKAQMYQLLQDLPKKYNVTALVRMEKVRASQLLPLRKKLQGEVEIVSIKDKIAQKAFEKLDIPGIKKLKEKLTGQCLFMFTNMSPFKLNVLLGKNKIMLTARGGDIAGVDVVVPPKNTGIAPGPMLTEFKENKIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL37</accession>
    <name>A0A087RL37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein AsnC</fullName>
            <ecNumber evidence="5">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000042">
        <property type="protein sequence ID" value="KFM14191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.647"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="157" mass="18093" checksum="1E12B32191D1B566" modified="2014-10-29" version="1">MERFDELDMKLLLELTKDGNISVPLLSKKLEINASVLYSRIKRLVRKKVIKKFTIEIDESLLGIGVKTSVGINRDPKLKQQIHKQLLEIPEVSSIAEVTGRFDIILRVYTKDLENLHSVVMEKIGKVEGIQNTETFVELQKTDKDPVYLIKNFEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL44</accession>
    <name>A0A087RL44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock-like protein CspLA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cspLA</name>
        <name evidence="2" type="ORF">AAA799O18_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000041">
        <property type="protein sequence ID" value="KFM14198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="94" mass="10933" checksum="FFD6555F094E4CBB" modified="2014-10-29" version="1">MKEATSIARFQSKLGFRKTIKLYTWHPHENKMETGTVKWFNRRKGYGFIQRESNDDLFVHKADVQGFINEGDKVEFEIGQGEKGPNATNVKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL45</accession>
    <name>A0A087RL45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-coenzyme A synthetase protein</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000041">
        <property type="protein sequence ID" value="KFM14199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="42" mass="4631" checksum="16D4F9683A49C2FF" modified="2014-10-29" version="1" fragment="single">LLKSIARNDKIGDISTLEDGTAVEEVQTAFDELQKAVKKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL51</accession>
    <name>A0A087RL51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ScpA/B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="112" mass="12893" checksum="48AF723B1CAE538D" modified="2014-10-29" version="1" fragment="single">FPYLDELLDLLENLIGSIANPRSQRGGRLGFEPVEPPDFKEYFVSFENLVSKYQDMIIRKIRGKGKGMLKDIVVDLETLDSIRCFFAVLFLARDGKIEIEQHDNDIEITLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL55</accession>
    <name>A0A087RL55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000039">
        <property type="protein sequence ID" value="KFM14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="72" mass="8201" checksum="F874FA51A902AA07" modified="2014-10-29" version="1">MHLARSGRVIVRLSNTVSQDQILYNDKNVRVAKVTELIGPVANPYASAISMTNNIKKIFWFLMKSSCRNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL58</accession>
    <name>A0A087RL58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="133" mass="15588" checksum="26E2858A340B43A9" modified="2014-10-29" version="1">MYVSRTSTSFLIMSDQTFSDFYKSLLELVKKFERKNVMLKMEEDIPLNMIRIFGEKTDSVSRAKNSLEDVVELANTTAEHHPYWALLYNSSLISKIILEKWDEDITKEDLSEILWLISELKNSCEKLEDKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL59</accession>
    <name>A0A087RL59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF protein</fullName>
            <ecNumber evidence="4">1.17.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="4" type="ORF">AAA799O18_00736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.1" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000038">
        <property type="protein sequence ID" value="KFM14213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.631"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="393" mass="43878" checksum="F88329E8D5FE491B" modified="2014-10-29" version="1">MPIKIGLIGKTNTGKTTFFNSSTLSTDEISTYPFTTKKSSTSVGHAIQDNPNNSKCSDGWRYIPIELIDLPGLIKDAWKGKGLGNQFLSIASQSDALLHVVDASASIDSSGQITETGTGDPVSDFADIEEELNKWYLKIFEGNREKLQKMIKSENDQIAALAELYQGLGIKKSHVMETLRITGLEGKNTENYNLQDSKKFSSQLRKISKPTLIVANKIDVQGADKNFVRLRERYNDMIVVPASADCELTLRRAEQKNLIKYSPGSEQFDILKTSELNKKQNDALDFIKKDIMGEYMRTGVQFAINVTVFKLLKMNSIYPVANPENLSDKKGRVLPDLVLLKDGATVIDLAKEVHSDLTKGLLYAKDLRYNLRVPTNYQLRDRDVISLVSASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL65</accession>
    <name>A0A087RL65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit beta protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thsB</name>
        <name evidence="5" type="ORF">AAA799O18_00733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000037">
        <property type="protein sequence ID" value="KFM14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="263" mass="28069" checksum="66F47C94A62A5DEB" modified="2014-10-29" version="1" fragment="single">MSAQATSANMPVVLLKEGSSQTKGREAQKNNISAAKIIAEILHTSLGPRGMDKMLVDSLGDITITNDGATILKEIDVQHPAAKMLVEISKSTDNEVGDGTTSVVVLAGALLEQAESLILQDVHPTIIVDGYKKAGNNALQYIKEIAEKVTPDDKSALLNIAKTSMQTKLVRRDSDKLADIVVQSVLAASVRDGENYTVDVDDIKVEKKAGGSISDSSILQGIVLDKEIVHSGMPKKITNSKITLINTALEIEKTEIDAKINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL67</accession>
    <name>A0A087RL67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000036">
        <property type="protein sequence ID" value="KFM14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="16118" checksum="3789D1569E6A745F" modified="2014-10-29" version="1">MYSNEQAKTRGQTFGNELKVIQDDLKNVTHSLDSKISMFKEGNIDRESFLEFTKKHEEEMGEIISRYNFLLTPKGFEKAVELFKLSSKTQLQSDIQIIEWVRTANNAAHIRSDTLLQESFEYEMAALAEYKRAQGMMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL70</accession>
    <name>A0A087RL70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent alcohol dehydrogenase protein</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adh</name>
        <name evidence="2" type="ORF">AAA799O18_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000035">
        <property type="protein sequence ID" value="KFM14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.625"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="328" mass="34683" checksum="81DA9B83F1A95D28" modified="2014-10-29" version="1" fragment="single">LPTGKQVLVKVRAVGVCHSDLHLWEGGYDTGDGFMKVTDRGVKFPVIPGHEIVGAVSQIGDSVVGIKEGDDVLVYPWIGCGSCPTCEKGDTNLCEAPKSLGVFQDGGYAEYSLVPDFKFLIKISGIDLEGTASLSCSGLTAYTAVKKAILNSPENILIVGAGGLGLMGVQIAKALSNANIICADLDDEKLKKAQEMGADYVVNTKNSEASKNIMTVCNEKGADSIIDFVNAPPTVKLDLSVIRKRGNIVLVGLFGGAVDLPLVSIPLKAITIQGAYTGNYNDLVELVDLAKKGIVKPIVSKHYVLDEANNALEDLKNRKVIGRAIITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL80</accession>
    <name>A0A087RL80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000032">
        <property type="protein sequence ID" value="KFM14234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="88" mass="10126" checksum="B360DEEC3FF8C91E" modified="2014-10-29" version="1" fragment="single">MIDKAELNQILAFVAKRWTDLSRDPDNKAVKTLPGSFWMNSVGGPAGKGRWITTLMYTENEEDANNFKEVLLRWQTKSQQQKPSDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL82</accession>
    <name>A0A087RL82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroA'</name>
        <name evidence="3" type="ORF">AAA799O18_00707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.613"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="261" mass="28274" checksum="527C4298E29DEAAF" modified="2014-10-29" version="1">MTSGTEIRLNRIMRKGRMLCIPMDHGISNGPIEGLEKPHKMIYECESHGITCVIINKGIIKTLPRPPKVGILVHFSASTSLSTTPNRKMLTGSVKEALRLGADGISLHINIGGKEEPEMLADLGLISEQCHQWNVPLLAMMYPRGENIKNPHDPEIVAHTARIGAECGADIVKTLYTGDMDSFSKVVESIPTPVVIAGGPKAKTDMDVLQMTEDAMKAGAKGVTYGRNIFAHKSPKKIVEALDAIIFKDQTAKEVASIIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL86</accession>
    <name>A0A087RL86_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000031">
        <property type="protein sequence ID" value="KFM14240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="3">
        <location>
            <begin position="113"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="197" mass="21232" checksum="51F02B7ED03B9FC6" modified="2014-10-29" version="1" fragment="single">MADTYAVIGDPIDHSLSPNIHNAAFRSLNLDCTYIAYKIPKDELASGIEALKAIKIKGFNVTIPHKIEMMKLLDEMDTTCNVIGAVNTVSNEDGKLKGYNTDMVGFLDPIKKKNLPIKDSHVLVLGAGGAARAIITGMIKEKAGKITIANRTLKNANGLVEFAKKIGGNVNAISLQEANNLVSEYKFIINSTSLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL92</accession>
    <name>A0A087RL92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.607"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="235" mass="26712" checksum="7908C1C29FF1688F" modified="2014-10-29" version="1">MNPLVKVKEAFQNGILPEKEYALIVKRFPIVVSGINRLEKASGVSFPAAYVEPSIVLSSSNVGSFEYGILFARTIPIATENAFQVVIQISAPLVAYGLKGTIHAILAHEFLHYLELMRKISKMELLSDEISSNLFENVYADNERLFEPRAVFNDKTLLLHITKKFPSGFRDYKLEDKVIKFWIERNLPTTKIALDTNVTKLSTDLISKIQLKSNLMSKIESFELKGSKLRKKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA0</accession>
    <name>A0A087RLA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="58" mass="6508" checksum="04F7FA20501EA4D3" modified="2014-10-29" version="1">MIILMLLIWFVVTLPLPWLITGDIGQDQVFTILPIIGFISIPFVVLGIAWTLKPDLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA4</accession>
    <name>A0A087RLA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.597"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="138" mass="15652" checksum="0C7ECCE7F38672EB" modified="2014-10-29" version="1">MGLFDVFKDKDDEDDKGGAEEINFESFQNQDNSSEAEPEPQQETTSYSPPAEETPSYSSSQTSSQIGIEALMDKRVKLEEAIDYVGLMIKNLKDKRTKLVKNIEDESVDIKNLKEKLTKINQFIQEENDGLQQQTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA5</accession>
    <name>A0A087RLA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.598"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="115" mass="13050" checksum="F7D346710C0F90E4" modified="2014-10-29" version="1">MRSAMAFQNVPDKAHDSILSMSKQQYRSEMGIMGDILDVTMDGGQRGVIVSAISRKANLSHYAVLDKCEKLINAGLMESARTDRNRLFKITEKGLGFIQEFQRFQSLIESMNLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA8</accession>
    <name>A0A087RLA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.601"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="64" mass="6871" checksum="EC3B3911C3AC08BC" modified="2014-10-29" version="1">MASKKIVVGVGIPMIVTGFLIAIFWAPLVGEIRETVEFVGSLIGIIGVIFFIAGLFYTKEPVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB1</accession>
    <name>A0A087RLB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase large subunit protein</fullName>
            <ecNumber evidence="2">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mutB</name>
        <name evidence="2" type="ORF">AAA799O18_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.586"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="146" mass="15962" checksum="D7926DB992D64AC6" modified="2014-10-29" version="1">MAKEKAKHKQFVTDSNIPVKPVYSKSKNSTGSPGKYPFTRGIHSGMYRDRLWTMRQYSGFGDAVQSNKRYKFMLDSGQTGLSMAFDLPTQIGYDPDSAHAEGEVGKVGVSIASLKDMQTAFNGIDLGKVSTSMTINATASMHITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC0</accession>
    <name>A0A087RLC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="127" mass="14977" checksum="528EEE4765F85FCF" modified="2014-10-29" version="1">MSFTIFRIVLILKGFKKFIFLLKIKFDTIEYLNKLKKNNSYFYTFINRKSLAVGVIFLKPGENDTQEPHDSDEIYYILDGNGFLQINDKSHRIKKEEIYFVAKDTPHYFYGNTKNLSVLYFFGGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC7</accession>
    <name>A0A087RLC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="68" mass="8033" checksum="A880B81199941AA3" modified="2014-10-29" version="1">MKDINEVLPKVPNMRWGALMNKAPTNKKVNDLNKIFPHNGKWHTVFEEKDHTYIDGKIVWKKDKASWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC8</accession>
    <name>A0A087RLC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="132" mass="15340" checksum="A0DD8493E13A48DC" modified="2014-10-29" version="1">MEHTLFYDGTTKKFSWIIQTGDQIKKETREHPPPYISGYKLNIKNDIESKFVALHVGIYWSIGVFIIKDGDTVNVMCDSKKMYEILRTKCKTSDEIINDKIKFINDLLERRKLVVNYHLIDSNENPASNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC9</accession>
    <name>A0A087RLC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.580"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="68" mass="8171" checksum="2782498DCECA10C7" modified="2014-10-29" version="1">MLESHMFFRNMIDELVETSDNDPELLDGLRWLDMQAQKKGLTFYDMVFEVLYKHDVDSKAKDWLNSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD3</accession>
    <name>A0A087RLD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="127" mass="14821" checksum="D3D098E949B771F6" modified="2014-10-29" version="1">MEKLFEKKNLIFIATINPDGSPQLTPVWGNYIDNHILINTAEGRVKHKNVQKDPRVAVSVVDHDNALNMITIRGKVVEIIPDYDYSHINELTKQYMGITEYPFKKENEKRIIFKIEPKKIFVMPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD7</accession>
    <name>A0A087RLD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.551"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="82" mass="9718" checksum="784D331139965616" modified="2014-10-29" version="1">MTRTRRTNRYCVDCGARLVYYPRLSNPKAPNEHRILVYACPDCSNDFDKPKMFSIKRNQVEEPLETVEIEINQVQKNTKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD9</accession>
    <name>A0A087RLD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl6</name>
        <name evidence="4" type="ORF">AAA799O18_00641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.553"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="3">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="3">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="185" mass="20786" checksum="D2BB30F00F32945A" modified="2014-10-29" version="1">MSISQTKNFETEIDIPQNVKVNLKNSMLQVEGPLGKTYKNFKKIPVNISINNNKIHLSAVGTRKKDYAILNTAKSLIQTLCEGIIDGYTVKMKIVSSHFPITIKIDGKKVLIENFQGEKAPRVTKIWGETKVVPKGDDLIITGPILTDVTQTAAEIQLRSKVKNKDHRVFLDGIYKYFKSKGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE9</accession>
    <name>A0A087RLE9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ORF">AAA799O18_00651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.564"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="152" mass="17598" checksum="9C47FC4592B195EA" modified="2014-10-29" version="1">MTEFNYAFQNFDATRHVRAALREKTISHKHAREIAVAIKGLSVEKARDYLMYVTQLKRSIPFRRYKNQVGHRTDPGVMSGRYPQKAATEVLKLIDNLESNAEYKGMDLDRLKIINVTVHKGRLMKRFIPRAQGRATPKNNTYTHVELVAQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF1</accession>
    <name>A0A087RLF1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl23</name>
        <name evidence="5" type="ORF">AAA799O18_00653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.566"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="88" mass="10074" checksum="582F559392A5D8F3" modified="2014-10-29" version="1">MKVSQANKIILNPYITEKTFELVETQKRICFIVEKMASKSSIKEAIKTLYEEKPVNVNTARTIYGKKAFIEFESVDKARDLATKIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLF3</accession>
    <name>A0A087RLF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl4</name>
        <name evidence="5" type="ORF">AAA799O18_00655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.568"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="223" mass="24471" checksum="EE2A3645D9B8EFFA" modified="2014-10-29" version="1">MNVPLLTTSGTKEGEVELPIIFKTDFRKELIHKAFIHLNSHKFQPQGRHPTAGMDVVARSNDPPTGQGTSRIAKMRGGGGGRQGEAGGVASVRGGRQAHPPKAKKIIFKKINKKENKLALCSAISATKSKEIIESRGHKVAKINTFPIIVNNEIESITKTRDMMKILNSLNLLQDVQRLNARKPRTGKSALRGRGTKIGKSILFVVSKSEKLSRACNEFLELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG0</accession>
    <name>A0A087RLG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyl-D-glucosamine kinase protein</fullName>
            <ecNumber evidence="1">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagK</name>
        <name evidence="1" type="ORF">AAA799O18_00626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.543"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="199" mass="21494" checksum="4B0CA98521B43063" modified="2014-10-29" version="1">MQKIGIDLGGTKIEGILVDEKYSVIQRKRIETHQENGYDSILKSIISLINELKAKTNEGTSVGICTPGVTNTNSGLIKNSNTKCLIGMPLKNDIESALGYQIVMENDANCFALAESVLGSSKEYDVVFGVIMGTGVGGGIVINGTLHKGRTNIAGEWGHHTLRPYGNKCYCGKQGCVETYISGPAIEKRWLELTGKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG3</accession>
    <name>A0A087RLG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000024">
        <property type="protein sequence ID" value="KFM14317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.546"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="132" mass="15044" checksum="C8B6BD521EBDC2B1" modified="2014-10-29" version="1" fragment="single">SDLTISASETMKEERRITVPITKNSDGSTIANVFVSDDKLSIVLDENITLDSETPPLKTFFIDRIIGEMKNKDKQEVEKGKIRKDDVIDCIINKNGSAIREIIIKNYRQKERVDELINTATWSLTRMIENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLG8</accession>
    <name>A0A087RLG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase type II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000023">
        <property type="protein sequence ID" value="KFM14322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="82" mass="9404" checksum="54F7CB3C8210E723" modified="2014-10-29" version="1" fragment="single">MSDIEEHRKKIEEITLEMIKLLKTRTDIAKQIGDTKASLGMTVTDEEREDALRNQVTKLCKEIDLDQSTALKFLNLLLNESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH1</accession>
    <name>A0A087RLH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.529"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="290" mass="32790" checksum="72A622A02EB8AF6C" modified="2014-10-29" version="1">MKQNKIKKAVSNKAKKVKRMLKTSKHSTQMLSGSTNSKSYVEMIFQEGEKTVDSNTLMKKAQERVLNSVKNGLEYPPFVDKSEQFLRNHVNSRVHIFVMYIDLVGSTNMSLSLPEEKVVTIISSFAQEMAYTVTQFGGYMLKFVGDAVLAYFNAENDLIYPADNIVNCAKSMLRVLTESINPVLTDNGYPPLAAKIGIDHGQNIIVRYGSDKRKSHVDILGPSMNMAAKIQNMAKPNQLLIGGDVYDKLHPETQKSFKKKTFSEGKWKYKHRKTGEPYQIFAYTLDEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLH2</accession>
    <name>A0A087RLH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000022">
        <property type="protein sequence ID" value="KFM14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="444" mass="51380" checksum="237529DD4041DEB1" modified="2014-10-29" version="1">MEKTSPKIFNVTQLKNEVINLAEKNGFIESCYRAMLDYTIKNLQSSGLGEKYYGYHNIDHLLEIPLGTLLVGDSKQIPNLSDEDLKYLFVSAIFHDFEPDKIIDKPSEDNVLKNLTSDHKIKNLIAQSGTDFEIIKALILRTAYPWSGKLKENGEKSIQKCFDCSNITKNNPKKQEHFLWLGWLLSVIDRMTSYALGNFSKAMHVAKMNSHALGWHPDVLVQRSVSYFDDLTKNEPEMCNLVLKCLSKEMKENFMNNIQMFRELREQELKIQSDFTNKKLKFMIRMEQMKTKPSDGFVNTLQSIFLELPKPLRFNEENFNESLSDSEIILTTLRLNSLDGSIIGFAKGGPLENYNLRAEINDENYGKRNTIFLEPIALSMGYWGLGAGHKLRQSFLMQAHTMNYEYLTSFAFRDVISGRVNSMEKAEFVTKFDPERWDYFRVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI6</accession>
    <name>A0A087RLI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl21e</name>
        <name evidence="5" type="ORF">AAA799O18_00604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.525"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="99" mass="11312" checksum="B5CBB892A9E6455D" modified="2014-10-29" version="1">MTTKKPTGRSHGFKHKSRSIMTKDAPRGVSFLLREYHEGDKALVIIDPRQHKGLPHRRYHGKVGTVNKVSRRSVTLDIKLGNKTKTLITRFDHIKPFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM61</accession>
    <name>A0A087RM61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase protein</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.510"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="29"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="359" mass="40481" checksum="C8BC9EA514000776" modified="2014-10-29" version="1">MKIHPNKSARSHIPASHGGKYGIKNPDVNVIDFSSNVNPLGCHPGVRRYLKKHLESISEYPDPNSTNLRANLAWFTGVPKKQIVVGNGAIEIIYNFCKTFLNKKTYVLIPIPTFSEYEVSAKLCDCKISFFKTMDLSKNLQKFIMKIPRNGCIFICNPNNPTGILIHENEMLKIIVAAKKKSTIVFVDETFIELVPENDESVIKHIKNFENLFILRSLTKSFGLAGIRIGYGVGSSQIIEPLQKIKIPWNVSNLAQRAAGAAICYHPFLDKTRKLIKKEKSFISSNLAKSKKFACCTSATNFLLVKTKIKSKLLQKKLLKQKILIRDCSTFRGLNQNYIRIAVKTRKENIKLLKALGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM62</accession>
    <name>A0A087RM62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase protein</fullName>
            <ecNumber evidence="2">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asd</name>
        <name evidence="2" type="ORF">AAA799O18_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="73" mass="7990" checksum="5623D4A1CEFDED07" modified="2014-10-29" version="1" fragment="single">MKKKVAIIGVTGAVGQEFVLSLKDHPWFEVTQIAASERSAGKNYVDAIRDPESGIIKWEVGGEIPEYIKGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM72</accession>
    <name>A0A087RM72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hmgA</name>
        <name evidence="4" type="ORF">AAA799O18_00573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.497"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="385" mass="41009" checksum="49B7C4DC607AB39E" modified="2014-10-29" version="1">MTDSSISKFFEKSLKERLDVVADFSGLSQDELKIIEDATGGISYDKADNMIENAIGTFSLPLGIATNFRINDKDYLIPMVIEEPSVIAAASKAAKIARIHGGFKAKAEQSYSIGQIQVVNIDVQSAIPKVIGASNEILNLANSKSNTLSKMGKGAKEVSCKDIQTDSGHMLIVELVIDVGDAMGANVTNTMCEAVAPLIEKLTGGKVLLRILSNYSTKRMVRASAVFDKDQVGGEKTVDDIVLAFQFAENDPYRAVTHNKGVMNGVIAVANATGQDSRAIEAAAHAYTSKNGAYSSLTKWSKAPSGNLSGYFEMPLSVGIVGGVIQHHPIAKICMKILGVSTAQELSCIMAVAGLAQNFAAMRALVTEGIQKGHMKLHARKEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM79</accession>
    <name>A0A087RM79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylaminomethylideneamino imidazole-4-car protein</fullName>
            <ecNumber evidence="3">5.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisA</name>
        <name evidence="3" type="ORF">AAA799O18_00580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="87" mass="9649" checksum="0CD439D06A317381" modified="2014-10-29" version="1" fragment="single">MKIIPAIDIMEGKVVRLYKGDPNKKTIYSENPLEVAKKWESAGADMIHLVDLDAALGRGRNFDLLKNIAESVKIPVQVAGGLRNYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM91</accession>
    <name>A0A087RM91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="6">IMP dehydrogenase</shortName>
            <shortName evidence="6">IMPD</shortName>
            <shortName evidence="6">IMPDH</shortName>
            <ecNumber evidence="6 11">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">guaB</name>
        <name evidence="13" type="ORF">AAA799O18_00565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 11">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="6 11"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.491"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFM14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="478" mass="50847" checksum="6B69FF4478F220DE" modified="2014-10-29" version="1">MDIREGLTFDDVLLVPKFSDISSRSQTDLSTQLSRNISLNIPLVSANMDTVTEASMAVTIAREGGIGIIHRFLTIEQEVNEVLKVKRSGSVIIENPYTVNPEQTIQDAFKIMNEKEISGLLVTDSNSKLVGILTERDVLFESINCSKLVKDLMTKDVVTTKLGIDLQQAKEILKNNRIEKLPITDNENHIKGLITSQDISNLEKYPNASKDQKGRPLVGSAVGVKGDFMERTEALLNAGTDVIVVDIAHGHSENAINTVKNIKKAFPDCELIAGNVATAKGAEDLIKAGVDAVKVGVGSGSICITRVITGSGVPQLTAVLDCAKVGIDNGIPIISDGGTRNSGDATKALAAGASSIMAGSILGGTDESPGLTITKNGKRFKIYRGMASLAASMGRKTKETGTLELTDDINDYVAEGVEALVPYKGSVTDIITQITGGIRSGLSYCGAHNIGQMQKNAEFIKISRAGFAESQSHDVDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML2</accession>
    <name>A0A087RML2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative disulfide bond formation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bdbD</name>
        <name evidence="5" type="ORF">AAA799O18_00539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="97"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="290" mass="32071" checksum="77D7F9CABBB152AF" modified="2014-10-29" version="1">MNTNSEPTSDEKTPSFFLDDDKTGKGSLDFQNKSDETVTNETLSNIHGTKVPKTISGIHWPSLVIGAGIAVACIFCGVLMVNMINSETTSILDETPQKQTELAKKQQLSLLVDNASPVLGNPNAPITMIEFGDYQCTFCSKFFHETENSIVTNYIKTGKVKILFKDFVILGQDSRNAANAAHCANDQELFWEYHSILYNNWAGEDTGWADLTHLHEFANTLGLDMDVFSACMSNFKYNELVTLSSIDGEKLGVSGTPTFFVIDQNNDVIKITGAQSYDVFKQVFDSVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMM7</accession>
    <name>A0A087RMM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thymidylate synthase complementing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.451"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="561" mass="66193" checksum="C6A3F0DFB5D028B7" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN5</accession>
    <name>A0A087RMN5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argS</name>
        <name evidence="5" type="ORF">AAA799O18_00527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.459"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="4">
        <location>
            <begin position="238"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="354" mass="40001" checksum="11FB135B4EE92083" modified="2014-10-29" version="1" fragment="single">LWEKVFERMKSENLTRFQDEGDNAGCWILPIENEDDKILVRSNGVATYVAKDIPYAAWKLGVLNDPFNYSKYTAQSNGKVLYETTLDEAQIPKQSFAANKVITVIDNRQANLQKIVTDIMSKFSPESSYVHLGYEAVTLSSETAKLLGNKTDGREVQMSGRKGLYVNADEIIEKLEKRIYLESKERNISLDDASLNEIAHNVANGTIRYELVKPDLDKIITFDINTSLKLEGDTCSYIQYSCVRAARILEKSNKKPDFNASFDQLNTEHDLNLIKQIGMFEIFVNDAAKNYSPKVIAKYCYGLAVTFSSFYEHVKVLKAETPELVNARLCLVLSFGLTLEKALDLLGITVPQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR0</accession>
    <name>A0A087RMR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl30</name>
        <name evidence="4" type="ORF">AAA799O18_00499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.432"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="155" mass="17686" checksum="A668F51A6B919F3E" modified="2014-10-29" version="1">MAKAYLVVRIKGQADVPHWVNTTLNLLKLEKKYRAVILPVKENTAGMLKKIQHYVSWQEIDTKTTKELLDKKGRRTGYKKITTEDISKAGFKTIDDLASSLSEGKISMTKIKPLKPWFALSPPKQGFKRSTKRLYGQNGVLGHNKELTNLVKRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR7</accession>
    <name>A0A087RMR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="148" mass="16576" checksum="CD3465F41A5CBDA8" modified="2014-10-29" version="1">MSKLFLTSAIITLLVLIPVSASGEVYIPDHEYVGFYDHDGIYTVIGGVKNTEMYPVIPSITVSVNDDNRMFSEEYKFSPVMPAQMLPLKIKLPQVTSEKPILEPPKISFESTEYRFEGGYVLYDDSLILHDDGSMTGKIKNGGEQTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS5</accession>
    <name>A0A087RMS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase protein</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ansB</name>
        <name evidence="3" type="ORF">AAA799O18_00514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.447"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="453" mass="49556" checksum="152D6CD8BC16EE87" modified="2014-10-29" version="1">MRYRSDKDSLGSVKIPTDAYYGPFTGRAVKQYHVTGQKPHIYLIKSFVMIKRSAAIANMKTKTLDRKRGNAIVKACDKILAGKYQDEFVVDMINSGAGTAFNMNTNEVIANVALRILGKKLGQYKFLHPNDHVNMSQSSNDTYPTAMNMSTLFALNTLLPIISKLTKSLAKKAKQFSKYKKIGRTHLMDALPVTLGSEFDAYVTSITKSSHAIIHSKKQLEQVALGGTAVGTGANSPKRYRKIAIQELAKISKLGLVEQKNMQHSLQSKFAIANTSSAIRNFAVELGKISNDIRLMASGPIAGLGELEIPAVHAGSSIMPGKVNPSLAECMNMICFSIIGNDTTVAFAAQAGQLELNVMLPVMIKAILDSTDMLTNFLPIFSANLIDGLVSNKKRLQSNIEKSPVIVTLLAPKLGYQKSAELFKESVKTKKTIRDLVISKKLMTKKQVDSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN29</accession>
    <name>A0A087RN29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS cluster assembly protein SufD</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufD</name>
        <name evidence="2" type="ORF">AAA799O18_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.383"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SufBD_N" evidence="1">
        <location>
            <begin position="93"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="466" mass="52495" checksum="2812EECB86423EF7" modified="2014-10-29" version="1">MSQLTLSSIDSSLVEQISAKNNEPNWLKEYRKNSLSVYHDLPQEVSPLYNKYTDARRMNPEQVSLSVDSDSSIPDFLTKRLDEIKNDTSIVQIGSNIYSTNVQDELKSKGLIISSVDDALQNYSELIKKTLEDTNSKEDKYTALNNAAFNSGIFVYIPQNTTIDNTIHLISCLSLDGTSTISRNIVVAEKNSQASIVQELYAPKTSKQQAYLELLNTHAAENTKLTFTTLQIMDQSTVNFSTRSSSLSQDAKINWYLGLFGSMLSRYRIDYHLNGTGASVNDAEVVFGNNDQSFDLNTVVNHNAQSTEGKVVEKSILKDTSKSLFKGMIRINEQAAHSNSFLSGRSILLSKGAKSDSIPGLEILTNDVKATHSASVAQLDDEQIFYLGTRCLSYSEAERIIVEGFLEPLSRTMSYQVRAWITNIIESKWMNKELTINMDEYLKSIVEVEETRYNENEEVEQHYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN32</accession>
    <name>A0A087RN32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="112" mass="13197" checksum="E5BB54BC28C15AA4" modified="2014-10-29" version="1">MVDSSPITTSIRKVIFENFNDVDLKFNNDQIFEILKQNEMIDQSLAIDDIEVHFKELCDKEILRNIAQNFTTQWFKLFELIEKIQCKSCKNESYLILSENKICQKQNCGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN49</accession>
    <name>A0A087RN49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.404"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="225" mass="26228" checksum="EDA8E18D3E00D351" modified="2014-10-29" version="1">MEATDNEQYFFNFSFFKIDPKWRWMADLAKEESAKEVENVIINSGIKFRSYSTLGLRDDAEFLFWFAAETVEEIQDVMSKLYLTVFGKYIIPSRVYLSCTRSSTYARKGTLPSFVLGNEPQKYVIVYPFTKTREWYLLPQEQRQKMMDQHINVSEKYPQVTLNTTYSFGIGDQDFMLAFECDDLRDFQNLIMDLRQTPVSAHVAVDTPMITCVKKDIVPIITSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN66</accession>
    <name>A0A087RN66_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Box A-binding protein</fullName>
            <shortName evidence="5">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA sequence-binding protein</fullName>
            <shortName evidence="5">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tbp</name>
        <name evidence="7" type="ORF">AAA799O18_00425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.367"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="186" mass="20820" checksum="E86C513D6B697234" modified="2014-10-29" version="1">MPQTKPIVSIENVVASATVNQKMDLNDITRKFPYVEYHPEQFPGLVFRLKTPKTATLIFTSGNMVCTGAKSEELSRKAVKNVVQKLRNGGIKVKKNAVVTIQNIVASVKLGERIHLEQAARTLPRSMYEPEQFPGLIHRMPDPKTVILLFSSGKLVCTGAKNEKYVYRSVNTLHALLIEKKLMVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN70</accession>
    <name>A0A087RN70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fructoselysine transporter FrlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">frlA</name>
        <name evidence="6" type="ORF">AAA799O18_00434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.372"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="787" mass="86960" checksum="CB8CE2B0C1D51055" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN83</accession>
    <name>A0A087RN83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.350"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="570" mass="64824" checksum="145E80F7CBC6DAE4" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN90</accession>
    <name>A0A087RN90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RIO1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.357"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="252" mass="28582" checksum="9D9F3BE4E3975B1F" modified="2014-10-29" version="1">MKQSFVKISKITEPPYSDIWVYPKGTRAQIQLRIKELKALGVESISFQGELQIGTISILGKGYVGIVVLGKLGRKKVAVKIRRNDSPRKNLKKEAQLLQITNRCGVGPKLIDFSKNFLVMEYLEGEKIGKWISDLKTKLRSSQIKIVIKKVLEDCYKLDMIGLDHGELSRMPKHVIVGKKITIIDFESSSMERRVSNVTSATQAFFIGSGISKTVKGVYKIPEKKKIINVLRRYKQDQSRKSFESLLNVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN97</accession>
    <name>A0A087RN97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ths</name>
        <name evidence="5" type="ORF">AAA799O18_00421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.364"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="341" mass="36202" checksum="3659F3BC632C3C79" modified="2014-10-29" version="1" fragment="single">GMPKKITNSKITLINTALEIEKTEIDAKINISNPEQMKSFLDEENKMIKSMVDKVIGSGATVVFCQKGIDDMAQHYLAKAGVLAVRRIKESDLTKLAKACGARIITNLDDLSEKDLGVADVVEEKKVEEDRWVFVEGCKHPKSVTLLLRAGSQRVVDEVERAVHDAIMVVKDVMELPLIVAGGGAPETFAATKIVGWAKSLEGREQLAAEKFAEALESIPLSLSENAGMDPIDTLTALRSKQLKGDKWTGIDVMKGEVADMKSSNIVEPLSVKNQIISAATEAACMILRIDDVIATAKSAGPPPGAEGGMPPGMGGMPPGMGGMPPGMGGMGGMPDMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA3</accession>
    <name>A0A087RNA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L30e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="2">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11307" checksum="F41731B4D2F2153E" modified="2014-10-29" version="1">MTKLLEKAIKDTIKKRKPTIGLKQIMHSITSSKLIVISQSVPNEKVKEVETNAKNNNVPTINFEGSSVALGKLCGLQFRVSAISLDSLSNTNTQAIIKENEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA4</accession>
    <name>A0A087RNA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nusA</name>
        <name evidence="7" type="ORF">AAA799O18_00386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.338"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH type-2" evidence="6">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="154" mass="17399" checksum="C948D0E6A80E8A43" modified="2014-10-29" version="1">MTQSIKLTKDQMRMISLFQNVTKVTPRDCLDDAKQDRLIFVVNEGKMGLAIGRKGSNIKSLQNLLKRNIELVEYYDDPIKFLKNMLNPKLINEIKMDTRADGSLQMTVSVNPSNKGLVVGSAGRNAEKARLLAKRYFDISSVQINSHQVAQLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB8</accession>
    <name>A0A087RNB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphthine synthase protein</fullName>
            <ecNumber evidence="8">2.1.1.98</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dphB</name>
        <name evidence="8" type="ORF">AAA799O18_00358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.310"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF357" evidence="7">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="345" mass="39088" checksum="917BB800EC5FF6FA" modified="2014-10-29" version="1">MLWFVGLGVSGRDAITKEVEKIIQEADLVYLESFTSPIYKEHVEEIKNLVKGNFKIAKRWLVEDGQEILKVAKNSTVILLSYGDPYIATTHIELRTRAKLENIETKTVHSTSVITAMIGETGLQFYKVGRIVTIMSEKKYITTPYRIIFRNLIEGLHSVILLEYNQDESFFLDPKNAILSLLDAEKEQKRNVVNENTFAVVVSRIGFKTQKITSGKFTNLLKIDFGEPPHSIIITGKLHFTESDAVNALTECLDKPLDNSNEIKSTSTQMIEKYVPMVRKALEEIKPLYNDSNEFQEVFQNAELYINDAENFLKQGNDENAVLSIGYADGLVDALRIAKGIEPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB9</accession>
    <name>A0A087RNB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD synthase protein</fullName>
            <ecNumber evidence="3">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ribL</name>
        <name evidence="3" type="ORF">AAA799O18_00359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.39" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.311"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="145" mass="16061" checksum="19CC2DBC08BF4701" modified="2014-10-29" version="1">MSSSKKIVLAGGVFDIIHPGHIHTLKAAKALGDILVVAIATDKTAQKMKKRPPLHNQELRCELVDSLSMVDTAVIGHEDDIFETVKQVKPDVIVLGYDQTHQEKFISDGCKRINLDVKIVRLESPVPKLSSSNIEKKYGENIHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND3</accession>
    <name>A0A087RND3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="64" mass="7703" checksum="C3F87976B195582E" modified="2014-10-29" version="1">MASYSAQVATIHRQFQSALKHARSRQAVINCYWRHKAQHERLLKKHLKEEMAQVNRIKSKIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND8</accession>
    <name>A0A087RND8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="51" mass="5816" checksum="5240F467A1F79784" modified="2014-10-29" version="1">MATSNMITMKARFNGKCIECNEPIKIGKEITKNSKGNWVHKFCSDIEEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE1</accession>
    <name>A0A087RNE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.333"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="58" mass="6727" checksum="F9B9686343A672AA" modified="2014-10-29" version="1">MPKSDESETIYERVAKLEDEVAALRDEIDFLKHALRNELARHEIKMVRKGTDISSIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNE5</accession>
    <name>A0A087RNE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD-box ATP-dependent RNA helicase CshA protein</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cshA</name>
        <name evidence="10" type="ORF">AAA799O18_00314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.276"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="433" mass="48774" checksum="742C651E7E9610D1" modified="2014-10-29" version="1">MKKMTKFEKLGLEKKLLNVLDDAGFVIPFPIQERAIPVLLESNDVIGQAHTGTGKTAAYALPMIQLIVPNQGIQGIIMAPTRELALQITSEIKRFAKNTGTKTATIYGGQGMGIQLDALRKKPEIIVATPGRLIDHLKRGTIKLNNIRHVVLDEADVMLDMGFIDDITFILDLTPEEKTTSLWSATMPPEIMRLAETNMKSPKRILVDSDDLSGAGIDQSFLVIKDREKSKFLLDFIHGNIGQCIVFCSTKIRTRLVAKSLYKSGESVVSIEGDMSQHRREETMLRFRKAKANILVATDVAARGIDIPQVALVINYDVPNQDMVYFHRIGRTARAGGKGRAITLVSYSSVGEWNEIKKQTKVKMTDLNEKLGIEIKIPDPLKRRESTRQSFHRRGNKSSKASNRYRAARDKYDKRKKKIQPITHSYFSKKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF3</accession>
    <name>A0A087RNF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="194" mass="21503" checksum="CBD24BE207E4251D" modified="2014-10-29" version="1">MKKFSKVLLVAIFTVFIVASIQSTSADHLELGGKGIFAGPEDANLDYLGDSKYKIHLQVVVRDSQGALVSVLETTSGEYLPNEITDGLFDQKFGEKEIVTVDDVKYEKVRITDTPTLEQRLVGLYPILSEKPMEINIQTSKAPEWASNWMIHYCADFKGHGLTCVPIFTTFAATAALTEGDVVVNQWTILRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG7</accession>
    <name>A0A087RNG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinyl-CoA ligase ADP-forming subunit beta protein</fullName>
            <ecNumber evidence="8">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sucC</name>
        <name evidence="8" type="ORF">AAA799O18_00346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.298"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="9"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="370" mass="40813" checksum="41DB047FDCB66639" modified="2014-10-29" version="1">MRLLEYQVKELFRAYGINVPDSVSSTNIEVGRNDAKKIGFPFVIKAQVPVGGRGKAGGIQKCYNEDEFELKYPQVLGMTIKGEKTRAILLEKMSEYEKEIYLSLFLNRSKRCYTVISSADGGVEIESVKDQIIREVGLGHVSKKVAEEIAKEIGLDKKSITYFVDILQKLSKLTVEKEAELTEINPLVILKDGSLLALDGKMITDDNSNFRHEELLKYREQTELEEKAEKSGFSLVELDGNIAVVGNGAGLVMSTFDMLADNGGKPACFLDVGGGATEESVYESLTLISKMKKVKAILVNLYGGIVKTTIVASAFVKAYDNNLIDLPVYARLMGAESEKSKDMLKNTKTKMFDSVEQAINGILMEVTKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ5</accession>
    <name>A0A087RNJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphoglycerate mutase GpmB protein</fullName>
            <ecNumber evidence="1">5.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmB</name>
        <name evidence="1" type="ORF">AAA799O18_00262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.237"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="202" mass="23169" checksum="E66404C0416550CD" modified="2014-10-29" version="1">MIIFLRHGQAENNVKRILAGHTEGVLLTKTGIKQAERIAKYLNPLDISAIYSSPIERAKHTAEIIAENNSLDYQLDDRLIEIDMGKFTLMNYDDMFAKYGNVFLKFYENDPVITEHEVESFPQVQRRVLDMVDYVIKKHGNQNVVLVTHMDPIKSILSIVLDLKPKTLFELVIANASLTIIKEQDQKLSLSAINAMNIDRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ8</accession>
    <name>A0A087RNJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="3">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ctaD</name>
        <name evidence="3" type="ORF">AAA799O18_00265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.240"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="513" mass="56830" checksum="64565811F45857F2" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL0</accession>
    <name>A0A087RNL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.252"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="168" mass="19199" checksum="73CF5EC5245054A7" modified="2014-10-29" version="1">MLSEWIQRVGSSVPRGFSRFYILDMLKKKQYTGKELIDFAVKQSDGKWKPSPGLIYPLLGRLLDEKLIQETTGGKYKITKRGSATTDDLETINNIVKNQLDVLFRIGNVGRFVALDMIERVSTIGSLLSENIAQMSKEEVQKYKKFLKSELEKMEKPPKKVGKKIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP9</accession>
    <name>A0A087RNP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="98" mass="11716" checksum="233CF9D1DCE84F0C" modified="2014-10-29" version="1">MNSDEIKNFLHDVKDDLVNLDGLVHYYDFLGNHNIRTIVFNPENAQSFFEGAVVAILEQRYREFFRSKFNVEMNEIIRLDLLELIRSYMPNIQKIFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ0</accession>
    <name>A0A087RNQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.214"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="198" mass="22667" checksum="4B9EA9DE8E9021AF" modified="2014-10-29" version="1">MGRRNREERRQKREDFVTKRSNIKRKNALLAAGILAIIAVIIGYASYTFITMEATGPGIPPGAGKLGDEHEHASMLVRIFGDKFDFSAPAYQVKSAWIHFESSDGNTIHRHASGVTVGYLFENLNMIVNEDCFIFSDGRQFCTNEDYSLKYYINHQSVRSINDYVFEDQDRILVSYGNETQEQITEQLKELDSQIIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ2</accession>
    <name>A0A087RNQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain signature protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="144" mass="16499" checksum="EB18596A89EBFAF0" modified="2014-10-29" version="1">MESYTLMTLTDCIFCDIINKKLPCHLIYNDNNQIAILDKYPIDIGHTLIITKKPHEKLTDMSIDEITELFSRIPKIVNAIIKATKADAFSIAQNNGKAAKQIVPHVHVHIIPRYNATGTLWTQRKIMKDSELNELAQKIRNFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ5</accession>
    <name>A0A087RNQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.218"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="118" mass="13454" checksum="4F95C6C172D07BD0" modified="2014-10-29" version="1">MKGILPKPTLLELDEYDINQRIIEALTTVCSHAVLFSIVGEAKDAVKISQELQLSLSTVYKTLSNLRKLTLVRIEKFEFSNEGKKIKYYRSKIKNAHISVNGDKSEVTLYPLRIKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ6</accession>
    <name>A0A087RNQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.219"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="109" mass="12589" checksum="ED332093A23FDB5F" modified="2014-10-29" version="1">MRHKITLPELKKYDITQKVIEALSDAESRSIIFSIIRRGKTANDLSNSLRIPLSSVYKKLSDLEYLTLVKVEKYFMSDKGRKFKVYRSRISKAEIIIKKPEPIVSLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ7</accession>
    <name>A0A087RNQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate--tRNA ligase protein</fullName>
            <ecNumber evidence="1">6.1.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="68" mass="7743" checksum="51BBCBBB37ADC25C" modified="2014-10-29" version="1">MIETELGEWRRTHYSSELGHNLDKSDVTVMGWISSVRGHGNILFVTIVDKMGEIKQAKTENKLKNIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU5</accession>
    <name>A0A087RNU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein NlpI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nlpI</name>
        <name evidence="2" type="ORF">AAA799O18_00168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.151"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="272" mass="31186" checksum="957774F5C83AE856" modified="2014-10-29" version="1">MIFFSAKEKTEDLIYQAMSLMEKGQPKTAVPIFKKILKNEPTNTTALYNLGLALNQLKKYQDAITCFEKVTDINPKYIAAINNRGIALAELGNTDGALEYYNKAIEIDPKYAPAHYNKGVLYDKLLQHENAIQSLDEAIKSDSGNVNTAFYKGIVLGKMKKHEEALNCFENIYRKHPKHMDAFFHKGIELAELGKHERALEIFDKLLHIHEDNVNVIYAMARSHAATYNVDRALYLLEQAIKKDRKSIKKWAIEDEFFDSLQDDPKFIKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNU6</accession>
    <name>A0A087RNU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="237" mass="27557" checksum="310E51FD023C4101" modified="2014-10-29" version="1">MVYTVKTVVLRPVLDLEETEQIVENRKTSRFRSMLQKPKKTDVHVHSLKLSYEAFLILSGKYSANFYRKVIHTINVNPDVKEVIIGGYTFPTKQGKGVIGKLSTKIKSSTRKKSQIDLELEEHVFLEEEKEVAFDHHGKEIKMPYKISKKFIESYPRRTLEKTKNNVKKPEITYDAAAKRLIDKLKKSVSVGRRNLEEKTTIDEIIELYVPIYEARLIGPKKNVRIMRIDGIRKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV3</accession>
    <name>A0A087RNV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lysine decarboxylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.159"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="168" mass="17528" checksum="DE4BCE434B9BAC6B" modified="2014-10-29" version="1">MKRQQILVIGNNDNGCTSEIEKLAYEVGSEVAKSGSVLITGGLGGVMRAACHGAQDAGGMTVGIIPQDDSSCANDFCDIVIPSGMGLMRDFLNAHSADGVIVVGGGSGTLSEICAAYMYKKPIVALKNSGGTATKYADQYLDHRKNVKIIGVETPQQAIKHILAQINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNV4</accession>
    <name>A0A087RNV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="41" mass="4918" checksum="0803CB8712F78D9F" modified="2014-10-29" version="1">MQKRTMPICFSENEYKLIEQFAKKRGMLNTSQVIEKILKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX4</accession>
    <name>A0A087RNX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AAA799O18_00197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.179"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFM15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="192" mass="21772" checksum="601B7EF9E5107E48" modified="2014-10-29" version="1">MKKYSSLEAIQQNVIICKKCNLCNDRKNAVPGKGNKFADIVFVGEAPGKNEDLLGKPFVGTAGKKLDNALKNSGLVRTEIYITNLVKCRPPKNRAPNNEEKIMCSDYLENELSIIKPKIICLMGNTAYNSILQGKEISKNHGRIVYKKNRVYFITFHPAALIYNKKLEKIFNDDIKKLVITLRKLNKKIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY6</accession>
    <name>A0A087RNY6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="3">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="183" mass="20682" checksum="B0971B4E35225548" modified="2014-10-29" version="1">MIGFGTLIILGIVIGSVSFSMFLFLDNLTVDVTSESGKPVNVNDVIFDIHFVSYHEVLKKDKEYTAFEKNLEMKGIATSEVPDGIYFQIQITAHNIGTETVRFTGGQFYLYDINNNKYDAVFIGYGDNELSLIDLETNDSVTVTTQFDIPYDDEMQYKVGILPDKFGLQDSKERGFICIKNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP44</accession>
    <name>A0A087RP44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional activator protein med</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">med</name>
        <name evidence="4" type="ORF">AAA799O18_00144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.125"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="465" mass="49620" checksum="BF40808384581744" modified="2014-10-29" version="1">MPPAHAEVTKVALVTDALFSDQGWGTNAYTAATNLSEKYGFELGTAESVAIPDIESTLRDFAEQDYDLIIAHGFQWTDPALTVSPDYPDTKIFVFTGYASGPGVASISPLQQEGTFPLGALAGMLTETNVVGFVGGQPYPNLINIFEGFKAGAMYTNPDVEVLVSWTDDWDDPAKGNAAAEAQIAQGADILFHTADTAGQGMIRAAQDHGIYAFGAVLDQNVTLDWASDTILTSFVLDIEKSFEMAYTITNEGNFEGVMIEPGIETGPGGPGDGIVYLAPFHEHEGAVPQDVKNNLDAIVSDIQNGHLVIPFTAEFTAAGESALTVDESVAATEVASEGGGGCLIATAAFGSEMAPQVQFLREIRDNTVLQTESGTSFMTGFNQFYYSFSPVIADYERENPAFKETVKLALTPLLTSLTLLQYADINSESEMLGYGIGVILLNIGMYFVAPAVLIMTVGKKILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP52</accession>
    <name>A0A087RP52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator MntR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mntR</name>
        <name evidence="6" type="ORF">AAA799O18_00152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.133"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="152" mass="17288" checksum="82CD64531EACAE57" modified="2014-10-29" version="1">MTTKDDEILFVGTAEAEHVEMYLKAIWHIKERKEEVKISTIAKILNVRQPSVVQMLKKLNEKQLVEYNKAGVILTENGENIGSSMMRNSRLLEVLMDSALKVEIDEEMVCGIEHHMNKQFTDALCTMLNHPRKCPHNHEIPLGACCAKNETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP53</accession>
    <name>A0A087RP53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="54" mass="6204" checksum="582900D14F4452CD" modified="2014-10-29" version="1">MTCFCGCENFEKNPNGRYLACVKCGHGRQNHDDEFRASARMNEELSQKRDSDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP56</accession>
    <name>A0A087RP56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent-cation tolerance protein CutA</fullName>
            <ecNumber evidence="2">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cutA</name>
        <name evidence="2" type="ORF">AAA799O18_00156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11816" checksum="E41297C54555BEAE" modified="2014-10-29" version="1">MKPAIIVSTFPDKQSITKIANQLVEKKLAACVNIIKISSVYTWKRKIENQSEYLALFKTTKKNLALLGKELRKLHPYDIPEIAEINVDSINQPYLNWLADSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP57</accession>
    <name>A0A087RP57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc metalloprotease RasP protein</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rasP</name>
        <name evidence="7" type="ORF">AAA799O18_00157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.138"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="203"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="398" mass="44192" checksum="A95E6FB7A86BDF78" modified="2014-10-29" version="1">MALDFLTENAIIYVLIAWVVILIIAKSLKLEKHGFTIKAYSLTYKNTQVQSVLSKMLTRTRRGIRIFADVSVVAGFLMMGFAFWFLLSNISNYFVEPTEFAELTVLIPGVTLTSASAILYFLLSIPIVLVIHEGAHGIVASLEKIKIKTGGFAIFIALFAGFVEPDEKEFDKAKKISRLRVIGAGATSNVIFAFALGVILLTNPLFALILPEPFLEWFYEAPDGVSIISIIEGSGAEKAGLQKNDVIIGIEGVPIITPLDFQKVDLKPGDTVTVTVKRDGQQLQFPVEIMSSPDDPDKGLVGIMRDNAFYKPVYNLIEWDPQVSMFLLWLWMISFFIGIINMLPLPILDGGKFIYTIIEKKASEVKINAIMFSIYGVTFTIFGLNIALSYMKSGWFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP78</accession>
    <name>A0A087RP78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA-dimethyltransferase protein</fullName>
            <ecNumber evidence="8">2.1.1.216</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm1</name>
        <name evidence="8" type="ORF">AAA799O18_00005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="396" mass="44973" checksum="999D640598BAE1A6" modified="2014-10-29" version="1">MRVLTIIGKKISRNLLQRIEEKLVEITEGSTKILVPEKSLKQKAPPKEPAFFNPVAAMNRDFSILAYSAFWENFDNPLLFLDGLTGLGARSLRVAKEIPNVEKVIGNDINSEALKIAQNSAALNKISNFEVSENEVCHFFGKYSKKEKRGSIVDVDPFGSPVKYFDCAIRATMHNGLLSVTATDLQVLHGLTKKACKRKYHGTPIKTEYSNEIAIRLILGCLDIVARRLDIQIIPQFVENDMHYYRIYVKILNRIDQDEHQGYITHCRSCGNRNCTTNQKKVCEVCNSQLEIAGPLWIGQMFNKKFIIDMMRQIPKFVVKKKCMSILEKSALEAEMPPTYYTLDEIASKMQRSPLKMKNAIKIINEAGFLSSPTSLNPTGFRTNCRIDNIIKLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP80</accession>
    <name>A0A087RP80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="118" mass="13554" checksum="EAE3C603169BD201" modified="2014-10-29" version="1">MDRLVNRTCEIVFNYGTDGMLQTELWKKLKLSNRDGSRLALKLERLGMITREKILENGRWTYKLLIRKSPVSTQSIEGGPCLICPVESKCSIDGEVSPKTCQYILDWVFVELKTSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP85</accession>
    <name>A0A087RP85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.11"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="80" mass="8906" checksum="6F1BFC79DE82FCDF" modified="2014-10-29" version="1">MAAKIEGMFELDDNSFEFLAIAFGRIGGQNIGVKLSEEIKNKLKEQGYNVDEVVDELQKKLISGNLSIPDGLKRESFVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP96</accession>
    <name>A0A087RP96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2 subunit beta protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eif2b</name>
        <name evidence="5" type="ORF">AAA799O18_00023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.21"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="4">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="140" mass="16269" checksum="F1D6B6B30D39B598" modified="2014-10-29" version="1">MVKSDYEKLLKRIEKNLSKTSDSTDTRFELPPVDVMWEGQRTFFRNFAEFPKMLRRDSTKLLQYLSKEFAVPAERIGDSAMFVGKRDPDDFTRLLKIYVSDYIECPTCKSPDTKIEKEKRISFLICEACGAKSTIKGKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC2</accession>
    <name>A0A087RPC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phosphoglucosamine mutase protein</fullName>
            <ecNumber evidence="9">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glmM</name>
        <name evidence="9" type="ORF">AAA799O18_00059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.50"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="357"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="432" mass="47754" checksum="9341631A2137FBAE" modified="2014-10-29" version="1">MKISISGIRGVFGKDLTIRDVLKFSKNFSALTSSKKCVIATDTRPSGRIIAETVKASLMESGMDVYDLGVAPTPVAFRESRKYGAGLIVTSSHNPIEWNGLKMIIGGRGINNEELDTVINDQTTDKSKIGTEFNIKSDYVNDAEKIIGKISGNPKVTVDIGGGAAKFVSSQLLRKIGCDVNTINDDLVKSSRGPDPTTDQLEELVSNTKDRDIGFAFDLDADRLVIVMNGEKKIPDVTLGLGVVKALELGYKNFVLSQDTSISIEKHIIQKGGTVFHSKVGEANVAEKMISTKSQVGGEGSSGGFILSDFNYCRDGILTSGLIASIIRKDSFREMLNFMKNYHIIRDKVECESQYHDELMKILHVKIKEKYGNLQTFDGLKATIDKDSWVLVRKSNTENIIRISAESNRLEMVRNIHLQMKELIKESYEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC4</accession>
    <name>A0A087RPC4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rps11</name>
        <name evidence="7" type="ORF">AAA799O18_00061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.52"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="192" mass="20645" checksum="0B9798DF74E7C4A3" modified="2014-10-29" version="1">MSETDTVVEKKEDVKDILKETTSEKAVESEKAVESEKAVESEKAVESEKAVESETEVKSEAKKEVKEKWGVAHIYSSYNNTIIHITDLTGAETVSISSGGHHVNADRYESSPFASMKAAGTVVEAAKTKGFNGLHIKVRAVGGVDSRVPGPGAQAAIRTLARGGFKIGRIDDVTPIPHDTTRKKGGKRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC6</accession>
    <name>A0A087RPC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.54"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="129" mass="14495" checksum="048C508D3C83E1D0" modified="2014-10-29" version="1">MSEEDNELEKLKAKRLAEMQKNFSSKQEQKNDTLSPREIVISKLGFRGLEVLENAEYQFPRETQIVVAKLAELISSNQVLEILDGGHLLALFRSIGINVRMKTKINVEEDGKFISLSDKLGTKLSSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE9</accession>
    <name>A0A087RPE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="237" mass="27705" checksum="CC1450FBB35D3685" modified="2014-10-29" version="1">MLALRDLSLKQEYRSDKDNVVSEFFIPCLTNSIQYDRTIEYISVKSLSTLTFGLENIKDHHAKIRLISGHRFTTSDLNSITKLFDHSKRRFNGNIIRDNKIGKIILDKKVKNLIKDDKILQLEEIIKDFKLEIKVAIPNSEYVDGVFEERLGIFRDSNDDVVAFSGTSNATFDAENRNFESVDVFTSWDDKSRVDQKIKNFEDLWTNNTNYVEVYDLSYAERSNLLKYSNDWVMDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF4</accession>
    <name>A0A087RPF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-regulated potassium-efflux system protein KefB</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kefB</name>
        <name evidence="6" type="ORF">AAA799O18_00101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.83"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="45"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="440" mass="46316" checksum="BEB915F14BB5B727" modified="2014-10-29" version="1">MKDFFLQIQSQDTVQSTMSENISNFVDRINPLQLPHESFVTDLAIIMILAAIVTLAFFKIRQPLIIGYLFAGMLIGPLSPLWTSFLGENGGTSAVTGIGILSDISALNLFADIGVILLLFVIGIEFPFAKIRSIGKVAVGAGTLGLFATLGVVFLVASALGLNFMDSLFIAAALSISSTAIIIKILEDAGKIKKESSILVLGVLIVEDVIAVILIASLESIALVGTVSIEAVVLVALVATGLIVGTFTIGRKVIPPLIDRVASAENREILLLSVLGVCFGYALLANVVGLSVAIGAFLAGVLVAESKSSEVSKILSSPIKDMFVAIFFVSVGALMDITQLESYIFIAIVLIAVTTAMKLGGNLLGNVIFRQSKEKSLRVAFALSAPRGEFSIVIVKVGVDVGVVSAFLFPLIGLISIITAFMSPFLVKIGDKIIPKLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPG1</accession>
    <name>A0A087RPG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pfdB</name>
        <name evidence="9" type="ORF">AAA799O18_00108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="128" mass="14468" checksum="4C8D6788F808A7D5" modified="2014-10-29" version="1">MSQNQQIPPVVQEQIAKLQQTQQNLQMILAQKQQLELEQLETEKALEELNKTNDGDAVFKHAGTILIKSNKKDLVEELEEKKELSKTKASLLAKQEERLKTSLKELETKIQEMIKKQSAGGTQQSPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH3</accession>
    <name>A0A087RPH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="52" mass="5382" checksum="62D773750A7D0DD9" modified="2014-10-29" version="1">MVNQQKKPVDKPAAKAKPAAKAKPAAKAKPAAKAKPAAKAKPAKLNLLQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH7</accession>
    <name>A0A087RPH7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">leuC</name>
        <name evidence="8" type="ORF">AAA799O18_00124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.106"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="423" mass="45502" checksum="4773C3C5CEAEBACE" modified="2014-10-29" version="1">MNITEKILARASGSENLEPGDVVFANVDKVMLHDVSGPGVIKTFEKLEKDGVVKVEKLFDPSMVWVAEDHFVPSAEKISAENISKLSKFTNQFGIKKHFKYGLGQYGICHTLSHEEGLVSPGDLYIGGDSHTNTTGALGAFACGLGHTDVAYVLLNGNLWFKVPETLYFKITGKLSEHVMAKDLILKIIGDITTEGGAGYAMQFAGDGISEMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLAERGVTEYNAVYDDDGAEYEKTFEYDVSELEPLVAKPFSPQNVSVVQETTGIEIDKSYIGSCTGAKYEDLEAVAKILKGRKVKVRTEVVPAAISIYKKAAENGLDKIFLDAGAVIGAPTCGACCGAHMGVLAKDEVCVSTTNRNFPGRMGHIDSKTYLTSPLVAAASAVTGKLTDPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI5</accession>
    <name>A0A087RPI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="52" mass="5592" checksum="68D54CD020CC7A11" modified="2014-10-29" version="1">MNPDNTNEEFTVCEDCKNPLENCTCVCPFCGERDKCECGLKLSNDDGAATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL18</accession>
    <name>A0A087RL18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000050">
        <property type="protein sequence ID" value="KFM14172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="115" mass="13209" checksum="8919B9113D6077B7" modified="2014-10-29" version="1" fragment="single">QLKTAEKFIGDTFVCIYGDSVFDFNLKNMISDHRKKKSFITMSLYEYKTNMKYGVIDTKNNGRVSAWNEKPEIKAKINMGCYVMESDILGFIPKNKPYGMDDVIKKAISXXXXXC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL23</accession>
    <name>A0A087RL23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000047">
        <property type="protein sequence ID" value="KFM14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="33" mass="3465" checksum="00F2320CDCE40F6E" modified="2014-10-29" version="1" fragment="single">EMSPAPFATSLTFAMLSSLSESGSNESFSPIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL25</accession>
    <name>A0A087RL25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl39e</name>
        <name evidence="5" type="ORF">AAA799O18_00772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000046">
        <property type="protein sequence ID" value="KFM14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.659"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="52" mass="6119" checksum="0F85C86291A38CD1" modified="2014-10-29" version="1">MAARKHSGRKIRLLKKQKQTSPVPAWIILKTKRVVRTNPKRRAWRQTDVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL27</accession>
    <name>A0A087RL27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000044">
        <property type="protein sequence ID" value="KFM14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="70" mass="8315" checksum="A3B3669E7AC7E932" modified="2014-10-29" version="1">MSNLEYAILNVCNEPKNKSEAYREIRKQFKIKISNRDFLSKVKDMLDMGYLNNVSKNKHEFLIQTSRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL29</accession>
    <name>A0A087RL29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000044">
        <property type="protein sequence ID" value="KFM14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="120" mass="14159" checksum="CA627CDB117E5338" modified="2014-10-29" version="1">MVVTTSLVIRITIEELNEIIVYAETNDIYDNRSGAPNKSGAVRKMMSIALRLEELKKETKDNPELLQQRVDELTAEREQDHELKWLEEQSYDKLKFILEKASEVKEKIYEERTRRLGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL30</accession>
    <name>A0A087RL30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000043">
        <property type="protein sequence ID" value="KFM14184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="71" mass="8496" checksum="172020609FD4F0AC" modified="2014-10-29" version="1" fragment="single">EKILEHKDTIFKISAVNKDVEYGVGFYEVYFTFQTYNDSKKYIWKVNILTEEISPVNSEARQMLNNVDYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL32</accession>
    <name>A0A087RL32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="2">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="8" type="ORF">AAA799O18_00765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000043">
        <property type="protein sequence ID" value="KFM14186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.652"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="7">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="223" mass="25770" checksum="98A2E980E8CAAC1D" modified="2014-10-29" version="1">MLKFLTSGKVKDVYEYEDGKLLFKFSNRVSAYDVKFEDEIPKKGEVLCKFAEYWFNKLGVPCHFVERRSDTEIVVRKLDMLPIECVVRGYFYGSLVSRWKDGKISLEDDTQTDLAAKLPNPIFDPTTKSTHDMPVNKEEATTQKLVTNDEYDLLSEESIKIYEKMVKIADNAGFILADLKLEFGREDNTIILADSMNFVCGQRMHIKLVKRRKHTINNFCVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL47</accession>
    <name>A0A087RL47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000040">
        <property type="protein sequence ID" value="KFM14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="96" mass="11085" checksum="08E8B42431819166" modified="2014-10-29" version="1">MTIPNKIKEFLDNQIQYYITEAQSYKEMAQEYSPKVDSVQDTAFGIIVGCIYSSFLQVYTNQKQTVNSNDMQEFTEIIMINARMIKDAIIGKNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RL89</accession>
    <name>A0A087RL89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000030">
        <property type="protein sequence ID" value="KFM14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.604"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="125" mass="14259" checksum="A69728B090DD8F71" modified="2014-10-29" version="1">MSMITTLSDENNSFLSRREITCDFKGLGGKLKKLEAIDMITKEFKLDGKFVIPIKLQNHTGLSKTTGIFYVYDDESLAKKHVNPVIFTRLDKAKTNNEKKEEVKADDKEKKEEVKADDKERGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLA6</accession>
    <name>A0A087RLA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000029">
        <property type="protein sequence ID" value="KFM14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.599"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="240" mass="26999" checksum="9CA7A649FD268384" modified="2014-10-29" version="1">MDEDGFLLSYEITGNVILIETFGASNVIIEYDSQDLISKTGKIWEFSVDAPIQYSLLMPKDSVIVEMSNFPASMQVDNDQSHLVLPEGQTNTSYYLSXXXXXXXXXXIPEEETPDNSLALYAVAIVAVGIVAIIAIKKSRPSRVTEPSSMITEKKPESQSLDSEAIFQAKPDLREDDKEIINFLSANGGQAYESELRKKFLQPRTTMWRAVKRLERYGIIEIEKKDLQNIVKLKSKLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB3</accession>
    <name>A0A087RLB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="84" mass="9879" checksum="D32D52DE778790CE" modified="2014-10-29" version="1">MKAVSWHGQRCWKLXXXXXEECKQLAEDFTSQLKLKISESGKLAWSALLETVNHDELVYKLTLKYLRRDGYDIGNRDRPEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB5</accession>
    <name>A0A087RLB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000028">
        <property type="protein sequence ID" value="KFM14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="33" mass="3728" checksum="06EF2ECE53F63F4B" modified="2014-10-29" version="1" fragment="single">VYIMGVNLTAMFLTMTVLAMKLKYEKTAQTTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLB6</accession>
    <name>A0A087RLB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000027">
        <property type="protein sequence ID" value="KFM14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="60" mass="6913" checksum="789D986C84CA7E79" modified="2014-10-29" version="1" fragment="single">MASKRRKTSRSKTRKTAKRKTAKRKTAKRKTAKRKTAKRKTAKRKTAKRKKPSSSKALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC2</accession>
    <name>A0A087RLC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.573"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="210" mass="23865" checksum="853BCD3C153FB0FC" modified="2014-10-29" version="1">MQLLGKLEIKSKEKIIEFLSSQQTGRISSIDENGYPQIIPMNFVFINEVIYMHSHIRGEKLDNIRRNKKVGFEVDKSLEFLPSYFSDPADASLADTLYISVVIKGNGSIVSDKEEKTTALNGLIKKYQPEGGYEPIKPEMEVLKEVEVIKIVPESLRGKYKIGQNMDMKSRIDLARQILERNSPTAKETLDIMGFEIIDGEPKLVDSKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLC4</accession>
    <name>A0A087RLC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylacetate reductase 1 protein</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tfdFI</name>
        <name evidence="3" type="ORF">AAA799O18_00664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.576"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="198" mass="21708" checksum="14FC0286A755CED8" modified="2014-10-29" version="1">MHTVRIPKVIQFGENALSEAEYPKNALVVTTAPPALSSKWLDRMGIQDYMLFDKVKPEPSIDDVNAVVSEYKGKNPSALIGLGGGSSMDVVKYASAEFGVEKILIPTTFGTGAEMTTYCVLKFDGKKKLLGPEERFLADRAIVDSYFMDGTPEQIVKNSVCDACAQATEGYDSKLGNDLTRTLCKQAFDVLHDAIIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLD2</accession>
    <name>A0A087RLD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000026">
        <property type="protein sequence ID" value="KFM14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="60" mass="6960" checksum="A7642693E8964205" modified="2014-10-29" version="1" fragment="single">MSKQERELMQLVDGIILEADPIKLSELQQIDINTQLEGVWFYDLCNPIERISQKPDITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE0</accession>
    <name>A0A087RLE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps8</name>
        <name evidence="5" type="ORF">AAA799O18_00642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.554"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="188" mass="21235" checksum="CCEB21425671C6FA" modified="2014-10-29" version="1">MEIVELVIHQGLKRNLVGVQNGVKDVVTIQLLYKNTIYTYADVVFVKSQYLWGLIKLGESMPAINVLANLFTTLYNSEKKTDCIILPASKLATKVLATLKNEGYIGEFEQIEDNRGGKFRIRLLAKITKCGVITPRFKVTKNEYNLWEERFLPSFNRGMLIVTTNQGVMSHHEAANKGLGGFLIGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE2</accession>
    <name>A0A087RLE2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rps4e</name>
        <name evidence="9" type="ORF">AAA799O18_00644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.557"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="7">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="238" mass="26488" checksum="08C5FD12BB1416EC" modified="2014-10-29" version="1">MGSIAGSKKLKRQMAPKFWGITRKDKRFVITVRPGGHPKDQSIPSAVLLRDTLKKVTTLREAKSVIYNGKVSVDGVTRKSLHHPIGLMDVITLEGTTDIYRLVPENGRLLKPLKIDSTEKSKKLVKVTSKVTIKEGKTQLGFHDGRSLITDTNANVNDTCLIQIPEQKILDVIKLEKNSQVIVTKGVNAGQIGRIDIIKEGTFSLPKRIDMIMADRKIEIPINLIMAIGKEKPLIQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLE3</accession>
    <name>A0A087RLE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L24P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000025">
        <property type="protein sequence ID" value="KFM14297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="139" mass="15854" checksum="11A84E0BB469E942" modified="2014-10-29" version="1">MQIYRATNQFRSKQLGSQLSKQLRKKYGRRSIRIVIGDTVKIIRGVYKGIDGKVTKISLAKNSIAVEGIQREKLKGGKVDQYIHSSNAMITSLNTEDKWRVKILEHKPKSKIKSMKADTKPEEKTSKNKIKKTPKKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI0</accession>
    <name>A0A087RLI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase B catalytic subunit protein</fullName>
            <ecNumber evidence="7">1.3.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AAA799O18_00598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.519"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="6">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="227" mass="24121" checksum="AF2267D18A09273F" modified="2014-10-29" version="1" fragment="single">NPGATNFAKMISSNNVVPIIVSLVGSVEDDFDFMIKQFENCKVSAYELNLSCPHVAKVGLEVGDDIELVKKIVKKVKSDTNVPVIAKVGLGTTNYLDTVSAACESGADGITAINTIRAMAIDVETQKPILSNKVGGLSGTPIKPIAVRCVYEISSKFDVPIIGCGGISTWQDAVEFILAGASAVQFGSVLGEHWIEVFAEINTGIQNYMEQKGYSTIGEMVGKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI1</accession>
    <name>A0A087RLI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dihydroorotate dehydrogenase B electron transfer subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrK</name>
        <name evidence="4" type="ORF">AAA799O18_00599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.520"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="255" mass="28466" checksum="6CFF63872ED4593E" modified="2014-10-29" version="1">MVKWLERQRNPNSHHICTIEKVIDETPTVRTLIFSDEILSNVLPGQFAMVWIPGVNELPMSVMITQEKNKAAFTVRKRGEPSTAMYNLTVGDYIGVRGPYGNSFDIKNGKLLLVGGGTGLVPLLRLITFCKPSHDITLLMGSQTKKEVFFEDLANKLLKKNKHQVITVTEDGTYGKKGFVTDVLEELFTKNSFDAIYTCGPELMMYKIVKLATSNQIFVQASLERMMKCGIGICGSCCINEDLDVVMVLFLMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLI9</accession>
    <name>A0A087RLI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000021">
        <property type="protein sequence ID" value="KFM14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="34" mass="3686" checksum="3A703FBF41078AC6" modified="2014-10-29" version="1" fragment="single">MKSKSSSTEPTKLTIIGTTLFEEIILAKFVAPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RLJ4</accession>
    <name>A0A087RLJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000020">
        <property type="protein sequence ID" value="KFM14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="185" mass="20516" checksum="4D29721DAD0CA6D1" modified="2014-10-29" version="1">MNIFELAEQNFLITFFVVIGIGLLQGAIMGRGVRSRFPSFKRHARTVSIILLALFSINAISGVLKFAEPVKVSVSELTIPVTIEEVFTIVVNVTGINAGVGTVIAIFVSITLIVFLKFAQIHQIARYFIFIVSCIVLIASLLGKFTDFVPTTFQIMLYAFYQFGITVGIFLVTRRKESDVLSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM60</accession>
    <name>A0A087RM60_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cobQ</name>
        <name evidence="8" type="ORF">AAA799O18_00587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000019">
        <property type="protein sequence ID" value="KFM14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.509"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="274" mass="30527" checksum="79871D4FF269C0FA" modified="2014-10-29" version="1">MVQGTASSAGKTTLVTALCRIFLEKGFSVAPFKAQNMSNYAYKGNDFEISRAQAVQALASRITISPDLNPILLKPLGDYRSSIFLRGKFYKKMHADDYYRKFVQKNGMKTVLRSFHALEKNHDLIIIEGAGSPAEINLTQYDIANMKLAEKTKSPVILITDIERGGSFGSIVGTLSLLEKKYQKKIKGFIFNKFRGDLDILKPGFRKLKQNTGKPVFGTIPLTKFLLPEEDSITSDSKQLALNNKNLKKIDSEIEKLSKVVKSSLNIGAIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM75</accession>
    <name>A0A087RM75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase protein</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="5" type="ORF">AAA799O18_00576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.500"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="60"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="355" mass="40274" checksum="665AEF46A83F56BC" modified="2014-10-29" version="1">MNKEFQKKLNELSKLSGYEKPKKISGSLKLDSNENFVIGKQFQSDLIDAAKKRCDIREYPFGGTEKLVAKLAKYLKVPSNMVGIGNGSDQILDLFLANFCTRKTRILTSEPTFAFFEERCNLYGVKMIKVQFSDGMTLDVDQFLSKSKNADLIYIDSPNNPTGFQFSKQDIQKIIKKFNGPIIIDEAYGEFSDYSVVNLVKNNDNLIVIRTFSKAFGLAGLRLGYFIANKKFTDIFSRVIQYPYPLNSFAIEVGILALQKLKQVSPVFSLIKKERERVIKNLKSYDIFEVFDSKANYILFDAKGLDSRVYNALAEQGISIRKLGKLGNHKGCLRVTIGTKEMNSKFLLAIRDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM77</accession>
    <name>A0A087RM77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="4">IGPD</shortName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hisB</name>
        <name evidence="5" type="ORF">AAA799O18_00578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000018">
        <property type="protein sequence ID" value="KFM14581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.502"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="195" mass="21355" checksum="2D03909877D88E09" modified="2014-10-29" version="1">MAIRKAKIKRETKETSVSISVNIDGSGKTSIDTGISFLDHLITSFGKHAMLDLTVQAKSKDKIEHHLIEDTAIAIASSIDKALGNRAGITRFSYASVPMDESLAETSLDLIKRPYSKIILLIKRNSVEGISKEDIEHFFQSLTLNLNSCVHVIVNYGDNDHHKIEAAIKSLAVALRNASLKDKKQKGIPSTKGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM87</accession>
    <name>A0A087RM87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase protein</fullName>
            <ecNumber evidence="2">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.487"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="267" mass="29486" checksum="488CE6ED8DFBA195" modified="2014-10-29" version="1">MMLYNPDTVAKSLAIGDPGDGRYVLKRLKQYNGIAQESNNEEILDAILLLAKTEGIFTEPAGGVSVSVLKKMVEDGVSVKIGKGKGQLNDGQVFGCEFYPAAETIGDVDANVFLGQSNFHAAGVALATNKPTYILDPYFNEIQEITEFAIKLQKKSTLAIYKASEAETFGVIVGLKEGQLSKLTALKFKKELERLGKIVHLIALTEITNERLRNLKYIDAFIQVACPRISTDMKFDKPLLSSPQATALIKILRKENVGEYFQIQHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RM93</accession>
    <name>A0A087RM93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">mptE</name>
        <name evidence="7" type="ORF">AAA799O18_00567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000017">
        <property type="protein sequence ID" value="KFM14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.493"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="249" mass="28150" checksum="C1F08F64E5BF4685" modified="2014-10-29" version="1">MTIKGWESKYREILKEFGYSKNRDRQSCKLLNSLLPNKTKIAEIKDLIWNRPVFIVGAGPSLPSCIPILRKYSNITKIVADGASRALIENNLRPSIVVTDLDGDITTLKRIGRTKTIIIVHAHGDNTEKLDLVKNFKNCIGTTQTKPLGKIHNFGGFTDGDRCVFLANRFKAKKIILFGMDFGTTIGSFSKTRIINKTIKIRKLRRGKKLLEWLAQKSESELYSTSAVKGFTKIKFEDIDNLINDKNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ3</accession>
    <name>A0A087RMJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.481"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="146" mass="16474" checksum="809D380B4D345254" modified="2014-10-29" version="1">MITEKIRKLLYEQKLGFVATVSPDGTPNLSPKGTIIVLDENTLAFADIRSPQTMKNLKSNPSIEINVVDPISRKGFRFKGTTEIISSGEKYKKILLQYRKSGVKSSIKSIVLVKVKQASEVLSPLYDLGLTEDEIKTRWKKHYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMJ5</accession>
    <name>A0A087RMJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin YgaF protein</fullName>
            <ecNumber evidence="5">1.11.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygaF</name>
        <name evidence="5" type="ORF">AAA799O18_00558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000016">
        <property type="protein sequence ID" value="KFM14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.484"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="154" mass="17707" checksum="067FB2A0D4038724" modified="2014-10-29" version="1">MIREGQSVPIFQLSDADGNTVKSNEFKGKKFVIYFYPKDFTPGCTVEADEFSRDYKKFQKDGIEIIGISKDDSESHKKFCEKMKIPYILLADTKTEVSKLFGVWGKKNFMGKEYMGIKRSTFLVNENGKIFKVFEKVKPKGHSKEVLEAYTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMK7</accession>
    <name>A0A087RMK7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Biotin synthase</fullName>
            <ecNumber evidence="3 12">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">bioB</name>
        <name evidence="15" type="ORF">AAA799O18_00534</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.465"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFM14711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="326" mass="36420" checksum="702BA142D313BDE4" modified="2014-10-29" version="1">MISIQEFISKSRDNIIKGKKITNSDASILFNSDNEFVDDLIDAANSITRHFHGLKIDIEELSNIKKNFCSEDCAYCAQSSFFNTKINDYLLPPPDQIVKQAFNAKREGANSFCLVAAWREPSPVDFEKVCKIINAVNEKVGISVECSLGFLTIEQAKKLKELGVKRYNHNLETCRSKFSEICSTHTYQDRVDTIKIARKAGLEICTGGIIGLGETRKQREELVFEIAKFNPEEVTVNLLVPMPGTPLELQKPLEIIEILRVFSTLRFLLPNSIIKISGGREHFLEDGGKKLLLGGANGIISAGYLTMGGNPIQKDFEMIKEINLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RML5</accession>
    <name>A0A087RML5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase protein</fullName>
            <ecNumber evidence="2">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thrC</name>
        <name evidence="2" type="ORF">AAA799O18_00542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000015">
        <property type="protein sequence ID" value="KFM14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.473"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="108"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="444" mass="49216" checksum="1AD1ADFC03BCFB56" modified="2014-10-29" version="1">MHNKAYLKCISPKCGKEYSISSTEFICVCGSLLDAKYKNNPPDSLKEVFYQRRNPQGSIFNESGVWRFRELLNFCEIDTEDLSQCSKHLVSLDGAEGRQSKPYHMSKVSKFIGIQNENLMLQPEGYNPSGSFKDNGMSAAVTHAKMTESKKIICASTGNTSASAGMFAANENIDCDVYIPEGEIAPGKLSQAYQFGTQLIHVKGNFDDAFSKSLEAAKQSDGYTVNSINPFRIEGQKTILYRALEFMNWEVPDWIVYPGGALGNTSSCGKAIMELYEWGWIKKIPRIAIINAEGANTLDVLYNGKFEGAELRWNKGDPDIKLIGRYYSKMQKDGIRPKTKATAIQIGKPANMVKALRTLEFTNGIVTTVTDNEMLDGMSIVGLNGFDCEMASGSVPAGIKKLLDNDLIKKDEKIIGILTGRQKEPLLPINYHNESSNQFARPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMN4</accession>
    <name>A0A087RMN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-methyltransferase TrmI protein</fullName>
            <ecNumber evidence="5">2.1.1.219</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmI</name>
        <name evidence="5" type="ORF">AAA799O18_00526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.219" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000014">
        <property type="protein sequence ID" value="KFM14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.458"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="284" mass="32361" checksum="06E182D43C359149" modified="2014-10-29" version="1">MTKIKQNNYVLFFYNDSKKWLAKISKNEQLHTHIGVIKHSDAIGREYGSRLVTNKDKYVYLFEPTIHDFVMKIQHGTQIVYPKDLGYIVARTGLTSGQKVVEIGTGSGSLTSFLAGIVKPRGHVYTYDVEPKFMKIAEKNIKKAGMSKYITMNESDFKKVKKLPHSEVDLVVVDLGDSWNVVPQARKMLKGSGGFVAICPTMNQLEKLVHVLVQNEFSDIECTEQILRHIEAREGKTRHSFRGIGHTTYLAYARKSFFDKKHIKKSKDTKAKVVTKKKVYSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMP5</accession>
    <name>A0A087RMP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="26" mass="2801" checksum="F1942C29A16C8516" modified="2014-10-29" version="1" fragment="single">MSEPEPIDGQKVEPVAEPEPVAEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMP6</accession>
    <name>A0A087RMP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="59" mass="6830" checksum="B2C24DFE00F8E307" modified="2014-10-29" version="1">MRFNLQRTLMNMKNTIKLTKKSDKDVYFQHLRLVLFGIATVGAIGFGIQFVFSVMTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ0</accession>
    <name>A0A087RMQ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="134" mass="15307" checksum="C8CB0A616FE3A2F8" modified="2014-10-29" version="1">MPINKEKLALRSEVNKNKPEFKRPESWRYKRLETSWRKPKGVDNHQRKQKSRGRPGLVKIGYGGPKIALGLHPSGYTDNLVHNINDLEKLNPKTDGVRIGHSVGTKKRKEIVIKAIGKKFKIFNARVSERASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ4</accession>
    <name>A0A087RMQ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ORF">AAA799O18_00493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.426"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="206" mass="23226" checksum="B8ED176A034602BA" modified="2014-10-29" version="1">MGKYTLPEMPYAYNALEPHIDAKTMEIHHTKHHQKYTDTMNGALEKLSSELQSKDIVDILSNINEVPDDVRGAINFNGGGYDNHKLFWNNMKPNGGGEPGGALADAINASFGSFADFKEQFSSKTAPIQGSGWGWLVYNPTSSKVEYKAMPNQTSPRTEGLIPLLGLDVWEHAYYLKYQNKRPDYIAAWWNVVNWEEVDNRLSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMQ6</accession>
    <name>A0A087RMQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">AAA799O18_00495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.428"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM14760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="425" mass="47123" checksum="C6EF244378BE8000" modified="2014-10-29" version="1">MFEKLGNAFSNVAKSLSEKELKEQDIDANLSQLEIALLESDVATEVIDKIKSNLKEKLIGSKVNRKEIEEFVKKSLIQDISNMFDQAGSFDLLENIKSKTDPQDPFLILFVGINGTGKTTTIAKIANLLQKNKISVVVAASDTFRAGAIEQLREHINRLNLKLVAQNYGSDPAAVARDALLYAKSHKVDCVLIDSAGRMQTSKNLMEQIEKISKVVNPDLKIFVGDSLAGNDTISQAREFHQYTDFDGAILTKSDADARGGAALSIVAVTKKPVVYVGTGQEYDDLELFNKRTFLETVFGKPTPEPTPEPTPEPTPEPVVAKTYEASTPPSENVPVFFLEKEKEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPENLHQNLHQNLHQNLHQNLHQNLHQNLHQKSQKLQLILLKELKLKTLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMR4</accession>
    <name>A0A087RMR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.436"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="213" mass="24124" checksum="D0DF25CFCD8899E3" modified="2014-10-29" version="1">MTELNFILYFLDSIFLQGDIFGIRGEGPLGSADPIVKGMLPSAVAVIGFSIMLNLFNAGVRKKLVDSVKMKRIMKETRAWQKERMKAFRSKDEGKIAELNKKSKYMNKMSMEMMQMNMRPMLITIIPLLLIFYFLMPSLFSYTVAVSPIPLNVIPVDFFELTCSSTKMAADAAAGLGPYCNVENEIYLWAWYFLTAIAFSGIIMKLTKTTMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMS3</accession>
    <name>A0A087RMS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase protein</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">serA</name>
        <name evidence="4" type="ORF">AAA799O18_00512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000013">
        <property type="protein sequence ID" value="KFM14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.444"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="109"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="310" mass="33815" checksum="D9E6AFA7AB8087F2" modified="2014-10-29" version="1">MSLNQSVLICDQVNPILKEILDKNGLKVTYEPEITTAQIAEKIGNFNVVVVRSRTKLVKELIEKADKCQIIARVGVGLDNIDQEAAKEKNIKVINAVEGAITAVAELVVGLMLSMAREIPRADREVRNGNWIKKEMMGSELKGKYLGIIGLGNIGKRLGRLARALNMNIIGYDVVAIDEEFSKEVGLMKSDIDTLLSSSDYISIHVPLLDSTKHMINAEKLKLMKKSAHIVNTSRGGVIDEEALYNALKAGNLESAALDVFEVEPATGNRLITLPNFIATPHIGAQTKEAQSLAANVIAEKIIQILRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT2</accession>
    <name>A0A087RMT2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">purM</name>
        <name evidence="9" type="ORF">AAA799O18_00475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.408"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="177"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="340" mass="36578" checksum="9373CFB732737FE5" modified="2014-10-29" version="1">MVTTYKKVGVDITEIKKSQAVIGRIISSTHNLQKFAKITHGFGHYAGVVQIPGGKLLATHTDGVGTKILIANTLKKYDTIGIDCVAMNVNDVICIGATPISFVDYIAANKNNQKIFKKVVSGLAKGAKKAEVPIIGGETAIMPDLFSGKGFMMDLAGTVVGMLSKKEMVLGKSISTGDAIIGIKSSGLHSNGYTLARKVLLSRYKLSDRIKGIGNLGNALLTPTEIYVKPVLEALAKCQVHGLAHITGGSFTKLLRLKNIGYDLNNLPKTPPLMQLIQDCGVEGKEMYKTFNMGIGFCVISPKNNVKKIRTIFKKHKLTTCEIGKITSKKGVFINSKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RMT6</accession>
    <name>A0A087RMT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000012">
        <property type="protein sequence ID" value="KFM14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="182"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="471" mass="54667" checksum="71A47D22C5821338" modified="2014-10-29" version="1">MKYLLFSISTILLIGIMLIPDIWAETCDFDPEQREFDIEPYYTGPLLDAHFHMPAAFAPPPVVAHELPYEIAVFDDHVSKDGLICMLDKQNIKSVIGFYPVLDNLPLDSIKDMKYFEEKHPDRVNAFLLPISISQWMKDEWPVLPGQDLEQYLEMLPFTKGYGEFAFYLEVYERQGEHLEADDPEMIETYEILEKRNMIFMSHPGNRDMPALLKMIEKYPNIIFLFHGEEIKKPQLSQILEKYTNVYYSLDYNMISNCCLHNNPQTDSKETFLPKYRDTFERTMKDELRIWKPIIEKHPDKIMWGTDILKPWHIDEEVQPLLIEMSRSFIGGLDPAVQEKYAYKNAERMLGMVKTTQLPVDTAIPAWIYFHTWVNNLIQLLISNVIIGAATIVAAIVGIVFAVRRRSGGTKRPKPARQDLEDYEEQYLQRQGQRPRRRHAKSRPTSSSCNSCGKPLKPTVKFCGSCGTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN36</accession>
    <name>A0A087RN36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">msrA</name>
        <name evidence="4" type="ORF">AAA799O18_00453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.390"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PMSR" evidence="3">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="151" mass="17339" checksum="2C184075B0429FDB" modified="2014-10-29" version="1">MKASFAAGCFWHVEEIFRKTSGVKSTQVGYSDGTTKNPTYEDVCTDTTGHAETVEVDYDPQEVSYEELLKIFWSNHNPTTLNRQGPDIGKQYRSVIFFHTPEQEKAAMEMKEKLNPIANEKFHSDIVTEIKPASDFYRAEEYHQQYLAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN48</accession>
    <name>A0A087RN48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000011">
        <property type="protein sequence ID" value="KFM14902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="218" mass="25122" checksum="D34522A70662910E" modified="2014-10-29" version="1">MLLRTKYPPTLKEWASIVNALKAGDQTVLLRKGGILEDSSGFVVGDKRSRFFLFPTFEHQEKKHIKPEFHKHLDNALSNKPSDGFNMLDCWARVVYENNIHSEDTINELSRFHILSDSYVKERIEWLPEKPMKVLFLKVYKVPGFEIPVLPEYNGCKSWIDLQEWEGQDASNTRLLIESIENNDAVLIHEKLDAKIEEFSDIVGGTPLSGKNGWTDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN78</accession>
    <name>A0A087RN78_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2070 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000010">
        <property type="protein sequence ID" value="KFM14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="307" mass="34556" checksum="477BE7BB6C39D67A" modified="2014-10-29" version="1" fragment="single">MGVRIFHGSVDNMSDSNDIQNIHKRYTFTLINPASFYVSLFSSVGIAVIFSILVFYNFIQNYEIFYHLPAAVGLLLATQYLDSRFTKHKEYSKSLHMSFFGNILWLITIVAGILGAVILSKELSLYYVAVGVFIFSSFRIGIMTTTLGISLKKSCVLCFVQPLAMFFVLIPIDMWSVLYHVETLAFGMVFLAVAVFWSYFTNRSGLPGIKSTHKLLQAYLQSVSQNDPTDMESIILETAKPSQISTSQIRFFTDENKNDFRMILPDLHPGPFHPVGGSDIPHQIYKTMNSSAMILHSVSDHSLNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN89</accession>
    <name>A0A087RN89_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">cca</name>
        <name evidence="11" type="ORF">AAA799O18_00408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="442" mass="50065" checksum="AA4366E024A2AA9A" modified="2014-10-29" version="1">MNSILSYAKKEATPSKKLQQKKQRVAKKACDLVSQCIEKHAQVVGFELGGSYAKGTWLPEKADIDIFVKFNKKTSEKDFRKIGTKIGFQSLKKHKPYTRHAEHPFVEAIIDGTRVNIVPCYDVSKGEWQSATDRSIYHTKFMSQKLSNSLKGEVRILKKFFLHIDVYGAEIAKEGFSGYVSEVLISYFGSFEKTIKKISELKKGQIIGKSTKKFDSPIVIIDPVDANRNLGTAISIDNLGKFVLASRVFLKNPSKKFFKKPISKHIMKNADKIIVIQFKVKERSDDIIWGQIKRASNALKTQLELGGFTVLRNSSTKDEKENAALIFLLHAKKIENSLVRSGPEISSKEHCEKFIEANLKKSQLMWISEKGKLQSLQKRKYDDVKLFLRDILKNNLKNSGIPKGLEKDFKKGVKIIDASKISTKSIKEAITNIAVTDETIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN94</accession>
    <name>A0A087RN94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="126" mass="14507" checksum="AC5EE22F303D30B7" modified="2014-10-29" version="1">MSDENKIDIKYLQALVLQESENDSIQELDSDFYNSISKFIGNLNSLEYEGVEAKIKKTLVDMVTELTTFLLKMRLEKASLDNSSSPILLDVEKYILNSQREMEERKEIILSRILSGKSKLLEPNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RN96</accession>
    <name>A0A087RN96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000009">
        <property type="protein sequence ID" value="KFM14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="160" mass="17879" checksum="51546379B20E6236" modified="2014-10-29" version="1">MTKWARIRKRKERRKAEVEAEEHRKAEEQPTAEVHTKDLSTQQEKISEVVQQPQKNTKHKSSQIQTSKPILSQIPRYVYLIAFFALLSGVFFPLITDDPREQNPDNVIKGTGTLFIGLVGAILVFKSTTSDKKRGILMGSGFGLIAVSLALIFSIASVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNA6</accession>
    <name>A0A087RNA6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rps7</name>
        <name evidence="8" type="ORF">AAA799O18_00388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.340"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="7">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="198" mass="22203" checksum="149DE0CA664177A4" modified="2014-10-29" version="1">MSSQNILLFRKWDLSEIEIKDIGLKTAICLKKTIVPMTFGRSALRRFNKADVNIVERLVNKLMHFGKKNAKNTGRMAGKKIHSYNVVKTAFEIINLKTGKNPVEVLIRAVENSAPNEDTTRIVYGGTVYHVSVDVAPIRRVDLALRFIADGVKEATFSNPKAMEEFLAEHLILSANNDPASPSVKRKNELERIAQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB0</accession>
    <name>A0A087RNB0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">leuS</name>
        <name evidence="11" type="ORF">AAA799O18_00397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.344"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="702"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="938"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="629"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM14964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="962" mass="110094" checksum="96F719E93C13A0BC" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNB1</accession>
    <name>A0A087RNB1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">alaS</name>
        <name evidence="13" type="ORF">AAA799O18_00398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="JOTC01000008">
        <property type="protein sequence ID" value="KFM14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.345"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="70"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFM14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="899" mass="101856" checksum="AC41695786F9ED04" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC1</accession>
    <name>A0A087RNC1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="3" type="ORF">AAA799O18_00361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.313"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="380" mass="41500" checksum="8AC5F279BB286DA1" modified="2014-10-29" version="1">MPYTGFVKYHVKLSFEVDGLVERADIIGAVFGQTEGLLGPEMNLNELQRASKVGRIEVDIHTSENTTDGNVLLPMSTDIDTCALIAAAIESIDKVGPFDCKFKLEGIDDVRASKKEDIVKRAKEIKQKWSTKSVSEGDTMLKDVHEGFSGKITTYGPNKLSCSTGIFDSPWIILVEGRADILNLLRAGYDNALAIEGAKIDESIKDFCAAKKKVVAFLDGDRAGGFILKELKSIVTIDVELRADSGVEVEELTPQRVADILKDTADDMKKETMEPVEVNEADKPLAIVVDKVYPDLNETLEAVGLDSNNEQLFKIPISELVDKLSTQTGTKYLVLDGIITQRLLDGAKQAGIECVIGHRIAKLSKHDGIALKTFTELGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC2</accession>
    <name>A0A087RNC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster insertion protein ErpA 2</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">erpA2</name>
        <name evidence="3" type="ORF">AAA799O18_00362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.314"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="154" mass="16573" checksum="4A82797FC2139C0F" modified="2014-10-29" version="1">MTTEQSHETSADHSCGCGESHGESHESSKPQEVVVESPQPQTQSGKLITITAKAAEKINEFMAEEKEKPEFLRIYVQGGGCSGLSYGMGFEKAAEEDDLTIEENGVKVLVDSMSQDHLKGANVDYIESLMGSGFKINNPNVTKSCSCGSSFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNC4</accession>
    <name>A0A087RNC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA ligase ADP-forming subunit alpha protein</fullName>
            <ecNumber evidence="3">6.2.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AAA799O18_00364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.316"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="706" mass="76370" checksum="00A35B2D51603470" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND1</accession>
    <name>A0A087RND1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="8" type="ORF">AAA799O18_00371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="114" mass="12910" checksum="DAA7FD0E59D9DFBF" modified="2014-10-29" version="1">MLEYLLNIIGSEWIIIIFVALILLLGTNRFPEAAKKIGKVVGEYNKAKNEIQNGMKDYTKENFEVSGPVKDERKKLEIMANTLGVDSKNKTNEELKKIVDSKIGQSQNETHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RND4</accession>
    <name>A0A087RND4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain type dehydrogenase-reductase VdlC protein</fullName>
            <ecNumber evidence="2">1.1.1.267</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vdlC</name>
        <name evidence="2" type="ORF">AAA799O18_00374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="2"/>
    <dbReference type="EMBL" id="JOTC01000007">
        <property type="protein sequence ID" value="KFM14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.326"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="279" mass="31020" checksum="DF3BDCF897FB40C1" modified="2014-10-29" version="1">MERVAVVTGTSSGIGFETALALAREGYYTYATMRNTTKGNKIKELALKENLKIDVLQLDVDDVNSTKNAIKNILDQKRRIDVLVNNAGWALWGCVEDVSVDEFKSQFETNFFSIIRLIQEVGPIMREQGSGTIVNVSSVVGRIGFPASPAYISSKFALEGLSESLRFEFAPFGVDVVIIEPGVIKTDFMKNMKIAKKSELDSVYRDITTKVISGVKMMAEMGTPPKEVANTIVKAVKDEKPLPRYIVGNDASMFLEAKKSKTDIEFENYLKKELYSTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF1</accession>
    <name>A0A087RNF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-finger in ubiquitin-hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="85" mass="9742" checksum="6D458591AF9F5B7F" modified="2014-10-29" version="1">MGTECEHFAQAKNQVSPNTKECEECEKEKLPWVALRMCLTCGHVGCCDSSVGLHATKHFKDTGHPVMIALPTKLWKWCYIHKNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF6</accession>
    <name>A0A087RNF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.287"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="205" mass="23551" checksum="0325B21F0DC4DE68" modified="2014-10-29" version="1">MGLDCIDLMYLHNAVEGQPQIPHDEFISQLKRVFEFYEVQRKKQNIRFYGLATWECFRVSKENSNFLSLTQVIDLAKQVGGSTHGFRFIQLPYNLQFDQAYMQKNQTINSNEMSILELAEQSGIGVFTSVPLMQGKLLEWIKNKPEFTHQSPAVNALQFIRSTPGVLAPLIGQKSDSHVKENLEILEIPPFSEEEFNTLLKKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF8</accession>
    <name>A0A087RNF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin bcp protein</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ORF">AAA799O18_00337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="152" mass="17337" checksum="A4537913D6D424BE" modified="2014-10-29" version="1">MEEGDLAPDFELEANDGTKITLKSFTEKNNVVLCFYPKNHLFACPSKKVFEMAKSVISVYSEIQSHNTKLFAISVDSVESQKKFVEEYNIPYLHLSDTQKDTCKKYSGTNIAGLAKRVTFIIDKNRIIKNIFQNIDVKNHGKQIVESLKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNF9</accession>
    <name>A0A087RNF9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA protection during starvation protein</fullName>
            <ecNumber evidence="1">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.290"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="195" mass="21983" checksum="47BC5F1DF7D9DBB6" modified="2014-10-29" version="1">MVKAKKPHVVGTEILKKNGIDVNKLIKELVSNASVEFTAYYYLTLLRANCTGMEGEGIKGVIEDARLEDLSHFESCIERIYQLGGSLPKDATRFIKMSGCEFLQLPPNPTNLKAILEKCLKAEQGAIVNWNRTCKMTLGKDPATYDIAKDILAEEIEHESWFLELLYARPSGHMRRKYSGERPHTGKHSRSLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG0</accession>
    <name>A0A087RNG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaJ</name>
        <name evidence="2" type="ORF">AAA799O18_00339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="370" mass="42166" checksum="EE02D1B02A4E52C4" modified="2014-10-29" version="1">MVESNYDILKIHDGATKKEIRIAYRNLVLQFHSDRGGDDEQFKKIKRAYEDLRIGKKYPDTMEERKEKAKFYSGDSDADKRRKNILLSQDITKEMKSAQEWAAALNRTDTTGVRLFGSNELGQMEFERKVTKTLSIKGKFWAGHFKYDNSVLMWGSITSPYFTPYEKYKTHIHVTKGSFKLIDSMQNKYDIDGGAKITVDHGDIEVGDIRGKRILVQDPQGRVGMSVTKEHFSTLEAINGKIVTGSVRDTVKLDADTVVVLNLIDNVKVMGRSILVYGSKVTHDVQFFLKEGGKIRFYDQGSGFDISDDATIQLENDKRIKIRDLKHANMISNGGKDITYDYLDNRDKKKHSKTNSFETKLSSIGKIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNG1</accession>
    <name>A0A087RNG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="132" mass="15176" checksum="F4C13B2A6526828F" modified="2014-10-29" version="1">MNHYKKFIKKGVNERISKIPFHNYAPIKRLSMLSKKRFPDSNTHIAVHFVNGNHKKMSEYSLLHKHNADEINLIISENSKLKYEIQLDDEVYKVSSPSTVFIPKGVKHKAKFISGKGVFICIILSGKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNH4</accession>
    <name>A0A087RNH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000006">
        <property type="protein sequence ID" value="KFM15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="154" mass="18187" checksum="7B8275768F0E4B3A" modified="2014-10-29" version="1">MVWTDKQGIEDALEVIEEGLYYLPRARTEYQSYYPSPQVFDVMTKWIGILEYIKAGLSGTAKLRIEDNKVKKVELSSKKWFLEKEIIPNDKEKIEDALQVCEYFISGLQQNLTEWKTTLEGIHFDPEVMKLQEQCRNSMEKIKYRLLGQRTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNI0</accession>
    <name>A0A087RNI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="512" mass="60617" checksum="5AD2FD2F19DA024E" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ0</accession>
    <name>A0A087RNJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.232"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020022">
        <property type="entry name" value="N-acetyl_sugar_amidoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03573">
        <property type="entry name" value="WbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="382" mass="45013" checksum="76B49066867AEF3D" modified="2014-10-29" version="1">MRYCVRCLYPDTKPELTFDQNGICSACINADMKEKIDWKQKRQEFIKILDKHRSKNKTNYDCIIPVSGGKDSTFQTYMIKKEFGLNPLVVNFHPDDQTDIGRKNLANLKRIGVDCVEFTPNPNVYLKLATFGLKEFGDFQWPEHIGIFTIPVQIAVRYNISLIIWGENPQLEYGRPTDINKDTILDREWNEKNGGYFLDKIKPKDMVKYGFELEDLRPYIYPSDEEINQVGVTGVFLGSYIKWDIFKQLEFVKKLGFSENDELKEGTYDKWENLDVYFTVFHDYFKFIKYGFGRTTDHASLEIRYGRISREDGLKLVKKHEGKIPRKYLKEFLKAAEITEEEFHKICDKFTNKDLFRSDKNGNLIKDKDGNLEKIQYDNFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNJ7</accession>
    <name>A0A087RNJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme-copper oxidase subunit 2 protein</fullName>
            <ecNumber evidence="7">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aoxA</name>
        <name evidence="7" type="ORF">AAA799O18_00264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.239"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="6">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="140" mass="16283" checksum="DE9DE102A4093870" modified="2014-10-29" version="1">MAHSNWAEWIYVAVVIALLVYVGAEAWNIERIIDHAPADAEIIKVTAQQWFWSFEHEDGTKEVGELHLKKDHAYKFEITSKDVNHNFNIPEYVVLLDAVPGRVNTVWFSPTETGEYDIQCREYCGLIHYNMRAKLFVEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK8</accession>
    <name>A0A087RNK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase/Fumarate reductase transmembrane subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AAA799O18_00280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFM15062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="142" mass="15824" checksum="79DE4EB0F475228A" modified="2014-10-29" version="1">MDKDRKEGIKGMANPGRYGIERVAYWLMRITGLGLLFYFIGHIYETSSLLDGKAAWNSMLELTQTTEGHIFLTLVIGMCVFHTGNGIRLMIAQAGFGLGKPRRPDYPYTPSSLNMKNKLCIYVTIGLAALAMMYGLGVMYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNK9</accession>
    <name>A0A087RNK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">frdA</name>
        <name evidence="11" type="ORF">AAA799O18_00281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.251"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="447"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="570" mass="63567" checksum="A822401578DCC674" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNL9</accession>
    <name>A0A087RNL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000005">
        <property type="protein sequence ID" value="KFM15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="265" mass="30950" checksum="6D422EFAFE0023B4" modified="2014-10-29" version="1">MNELRTLLINAVQQEINDENVAIFFSGGTDSLTCLFCCLELNIKPKLYTFHLEDYISEDVKISKKVARYFGLDVQIVPIKKNKNRLVSDIKDLIKNYDIHNKLKLQILYPFPYILENINEKFILTGLTADTLYGTNYHTNMTSSTEFNKLRKQAILMDEVDGYNALKKMVNNAEKKLVAPYRNQQVIDYFLKFSWNELNKPFQKQKSINAFNNYFEQLSVYRESSSLSINSKIVDWHQTLLSSELNKNNRNNIDGIIEDVHLNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNN6</accession>
    <name>A0A087RNN6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">AAA799O18_00218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.200"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="477" mass="52198" checksum="26FDF19BB30ADB69" modified="2014-10-29" version="1">MVKENCGVVGIFSVDGINVVPMLIDTLRALQHRGQEAWGIAVPGKSPLKKIGLVSSSANDFKNICTEYSSASAIGHIRYSTIGKSNLDNAQPLKVKDLCIAHNGTISNVEELSNMVGGCSFTPQKSSDTLVAAQRLVSLISEKGKFGDALSVLRNEMIGSYCFTFLSDDTSVYAARDPRGFRPLVLGKKTDGGTNIVASESSALSAVGADLIRDVTPGELIKFSKNGVESEMFSEEKQKAHCSFEFTYFAHPSSKMEGSNIYISRKKIGQFLAKKYPIKDADLVIPVPDSARPAALGYAQELGISFDEGLLKDRYSKKGPLRSFIEPHQSDRIEINRWIIPIKEIIEGKHVIVVDDSLVRGTSSKAIVKALRKAGARKISMVITYPPIKFPCYAGIDFPSQEELATYVDDKNYSDDEIVEKIRHDVGVDFLGYNDPENLAHAVGIPVDSMCFTCVSGNYDMLGIKPLFKSRQEMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNP7</accession>
    <name>A0A087RNP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpE</name>
        <name evidence="9" type="ORF">AAA799O18_00229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.211"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="7">
        <location>
            <begin position="193"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="459" mass="52476" checksum="EBBA60B7E83819F4" modified="2014-10-29" version="1">MDIFGHTSIPRIVSLDYTGTQFEIYNKISRNYSYSFLFESLTGPEELAETSIMGFDPEFVVKGYYNRVTIQDRNNSIKTIPTIEPLNTIKDLVQKTNDQSYRYLGGAVGIINYDAIRLWEKIPKDHSRNMNDRTIITEPIMEFGIYNDGILFDNKQKKSLYFYYDKNRVDEIKISESKFDKFTISDIKPNLNEDRFTKIVDKAKKYIYDGDIFQVVLSRKFSFRAHGDYLKVYQKLRSLNPSPYLYHMKMNEKIIIGSSPEMLLRVTNDQVETFPIAGTRKVTDDEVTNKRMKEELISDEKELAEHTMLVDLGRNDVGKVCDYGTVHVKELMEVKKFSHVQHMVTHVVGKIGKKYDMYDAFKAIFPAGTVSGAPKVRAMEIIDELEPESRGPYAGAVGYFSFNGCCDFAIAIRSIFADGKSGFVQAGAGIVFDSIPKNELKETDHKANAMLIALREASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNQ4</accession>
    <name>A0A087RNQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000004">
        <property type="protein sequence ID" value="KFM15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="76" mass="8655" checksum="01B1C8CDD2BBB63B" modified="2014-10-29" version="1">MICGYVTNNKQITRSLNSTPFFAITVLAFVFVFGLFIVGYDQGHIFSLLQGEQSFIDQFLHEFTHDLRHAAGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNW2</accession>
    <name>A0A087RNW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="136" mass="16185" checksum="7FFE4C42C77A5538" modified="2014-10-29" version="1">MNKSKFFTDLKPFIITYISVMSFSNFVFVLFSQTIRDILWSFFRDAGGTIILGLVFLFALTWLIKVRPHKFPKKYLVTSFDVYGKETQIVGIRTEFKNHDVAWSFMKFYKKSYPLHNFALVAEEKNHDKKIIFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNX2</accession>
    <name>A0A087RNX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator MntR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AAA799O18_00195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.177"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="153" mass="17867" checksum="1A05F7F911200939" modified="2014-10-29" version="1">MKKYSKRLESIKAARKTIKKESSTTREDYLEIISELVDLKGYATTLDISRYMNVSPPSVTKMLQKLDEKGYLEYEKYHGINLTEKGKQTANNIRQKHAILIDFFEILGISKEIANQDIEGIEHHLNPKTIRQLRKFITFLKSNPKIINEFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY0</accession>
    <name>A0A087RNY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-isopropylmalate synthase protein</fullName>
            <ecNumber evidence="6">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuA</name>
        <name evidence="6" type="ORF">AAA799O18_00203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="6"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.185"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFM15184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="503" mass="54675" checksum="721FF2160BF6597D" modified="2014-10-29" version="1">MKVRIFDTTLRDGEQSPGVALSPENKLNIAKKIDRLGVDAIETGFPVISEGEKNAIKMITQENLSAELCGLARTNQRDIDAVVDCGLKYVHTFIATSDIHLQYKLHLSQDQALEKAVESVEYAKSRGLQVEFSAEDATRTDRDFLKKIFSAVTKAGADRIDIPDTVGYSTPQYIAEITRDAIEATKLPISMHCHNDFGLAVANAISGIQAGAQCAHVTINGIGERAGNASLEELVMALQCLRFDQSWETNIKTELLYETSKYVSKLAGMPVQPNKAIIGENAFGHESGIHTHGVLSNPLTYEPISPEIVGRNRWLQVGKHAGAHGISAMLEEYGVQPDKDQLKQILEKVKSIGDQGKHVTDVELLSIANEVMGDSKLKRLVQLTGFSVSTGMGNMPYAFVKLNIDGEEHTATDYGVGPVDASLNAIQKITGKISEIRIKDYNLASISGGSTALCEVTVKLEDAMQNTVSSKSIGEDIVITSVQAVIDGMNRLLLKKILKQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY5</accession>
    <name>A0A087RNY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine 3-dehydrogenase protein</fullName>
            <ecNumber evidence="4">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tdh</name>
        <name evidence="4" type="ORF">AAA799O18_00208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.190"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="345" mass="38049" checksum="200F9A86CDCF8DD4" modified="2014-10-29" version="1">MKAAVVKSNSIIEIETVEKPSLGSHDIVVKMEACGICGSDVEKVFGKYGQPSMKLGHEPAGIITQVGSEVSDFNIGDRVFTHHHVACYSDDCHECSHGNETMCKKYYTSNLEPCGLAEEYVVSEWNISHGGVLKIPDSMSFEEAALIEPLACCIRAWNKFKHQKGDSAVILGVGPTGIMHAMLAKFFEFRKVFCLDLNNFRLDFASKIMFETVTIRSDDPNALEQIKSETDNQGVDVAIVATGSLRALQDAINFVRKGGTIVMFGVPSKGAKIELDMSVIYSKEITIVTTYAASDFDTRDALEKISNKKINVKQLITHKYHLHECQKAFEHAKSGQNAMKIIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RNY8</accession>
    <name>A0A087RNY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000003">
        <property type="protein sequence ID" value="KFM15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.192"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="248" mass="27926" checksum="36FE836BDE17A99E" modified="2014-10-29" version="1">MVQTRLIPNYPALMIDSQVKSLVVTDLHLGFEAKLSQNNIFLGKNTAVLESIKEIEKIIDKAKPDSLILLGDVKSGIKYITKIEWNDVPVFLEKIKKQISITLIPGNHDANIEKLIPEGISLATSKGIIVEDVLLTHGHTMPSENFSSVNKIIMGHVHPVFFQEESIINGERVWVTMKCEKQRIFPSKTGELEIIIMPTFNKHFYTIQKKFYKKSISPILDKIEVLEAKILTLDGTIIGNESLLPNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP34</accession>
    <name>A0A087RP34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinylbenzoate--CoA ligase protein</fullName>
            <ecNumber evidence="1">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menE</name>
        <name evidence="1" type="ORF">AAA799O18_00134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="49" mass="5676" checksum="B623C43147BD5823" modified="2014-10-29" version="1" fragment="single">KDGKKLNDEQVKNFCKKFLSKEKIPDVVKFVESLPKGPSGKILRREMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP39</accession>
    <name>A0A087RP39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxyureidoacrylate-ureidoacrylate amidohydrolase RutB protein</fullName>
            <ecNumber evidence="3">3.5.1.110</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rutB</name>
        <name evidence="3" type="ORF">AAA799O18_00139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.110" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.120"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="290" mass="31918" checksum="10CDBB375D69646D" modified="2014-10-29" version="1">MVMADDSLGPKAKVKEDSEMSKEEKLSRVQEDYETFLKTRTFKFPSWLYGPVQGKLLKVEIEDCPNFGDKAFVEFDSARTAIIVVDMQVDFCGENGYVDVMGYDLSLTAGPIEPIKNILDAARDGTDIKVIHTREGHMPNLADLPYNKLLRSKIIGKGVGIGDKPEGGEGQLLVRGEKNWDIIDELAPADGEYVIDKSAKGAFAHSDFGVTLKNLGITHLIMTGITTDVCVHTIMREANDIGYWCIVLKDCTAATNQGNYEAAIKQIKMQGGVFGWVSDSNKFINAIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP48</accession>
    <name>A0A087RP48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="294" mass="32762" checksum="A127D3BD2078AC8A" modified="2014-10-29" version="1">MKSVLDFEINTIGKSALNFIESYSDGDTIGETVKVFENTVYLKTRDDDLICLTSKDVKAPINLNLNPPVNFLELDCINKKAIKTSDGLKLETIGFNTKNSKIYPITKDHGIKSGLRNRILFSVDEMNLLDTSGSILDNHSPFFNELSDSIRLISESTQKHDLMKLSDQLSSIVGLGNGFTPSGDDFIVGFLFCLNRILLCSNDKSIKFIVMGNTNWASKKFIDYSQNDIVIEPLEVFVNFLLSGENKTKFPLMDLVPVGRSSGMDASIGAIIATVFVFDNDFRNLILTKLNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP60</accession>
    <name>A0A087RP60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc transporter ZupT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zupT</name>
        <name evidence="2" type="ORF">AAA799O18_00160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.143"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="404" mass="43094" checksum="48ACE0C3D27ADFF2" modified="2014-10-29" version="1">MQKIVPNQAWKDMLMEVKRSSRTKTAVSVIIPFLLLAVMIGYVFGPGSELIEFGVVLPEISIEKVEFVDSEIIATVRNTGPIAVDIVMADINDRIYPAAIEPDKHLERFESAVVRIPFEWNEGEPYAVGLTVGDGTRFEKQVDVAAPSIQPTAEMISYFALIGTYVGILPVLIGLLWFPFISKLSRSKYKFFLALTVGLLLFLGVSTAEEAIEISANNLSDIFNGILLVATVAVVSFLGLNYVGEKLKKRAGASKLAGPVAIALMIAIGIGLHNFGEGLAIGAAIVLGEAALGAFLIVGFALHNTTEGFAIAAPMARTKLMIGRLAAMGMIAGVPAIFGAWVGGFVYSPLAAVIFLAIGTGAIFQVIVSIMRWIQNEEGKLSNSSVLAGIAVGMIIMYITSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP63</accession>
    <name>A0A087RP63_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">AAA799O18_00163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JOTC01000002">
        <property type="protein sequence ID" value="KFM15267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.146"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="309" mass="34884" checksum="DD92ACFD394A2EDC" modified="2014-10-29" version="1">MNEFFGKNIISVKDFEKREFESVFDSVDKIMGMSRSQRSEIARGMVLGYMFFEASTRTRLSFEAAMALIGGTSLGISDVVTSSVKKGETLADTVKVLSAYVDVLVLRHSLDGSSRFAAEVADKPVINAGSGTEEHPTQTILDLFTIRKEKKKIDGLKIGITGDLKYGRTVYSFLYALRNYDVDVHLISPESLRVRSDTIYDIKKQISYTESTNLDEYISDLDVLYVTRIQKERFPDEEEYVKVKGSYVIDSAMVKKMKDDAIIMHPLPRVDEISVDVDSTKQARYFEQAEYGKYTRAALLGLILNEKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP75</accession>
    <name>A0A087RP75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative snoRNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.1"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="251"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="399" mass="44809" checksum="E9BD4741C82796A8" modified="2014-10-29" version="1">MYSTILTELGIAVLDNQKYVKIFPFENPAEEYVLVKKGQAKLDELRKFLPNGEMVITNDRGLLDILKKKSIDVQLMNNQQTDAIQSSKPKILVDSGFAEDENDAMDKLREFAIQLSSSKVTEVSQSQDLHIIQAINTLDETDKIINNFSSRLREWYGLHFPELDNLIDSINGYSQIVLSGKRENILKEDFENAGFSESKVEILSLVKEKSRGGDITEKNLGIVQTLAKQILTLFELRKTIEEHIEVKMKDEAPNISAVLGTAVGARILARAGSLKRLASMPASTIQVLGAEKALFRSLKTGANPPKHGILFQHATVHAAPKWQRGKIARAVAGKAAIAARVDVYKGGLNQTLLDKLNIRVQEIEKKYKEPVKKESKPEPKVKRKKSRRLDKRKRKNFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RP84</accession>
    <name>A0A087RP84_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mtnP</name>
        <name evidence="3" type="ORF">AAA799O18_00011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.10"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFM15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="268" mass="29687" checksum="7C231F3D9B60DB17" modified="2014-10-29" version="1">MVKDQAEIGIFGGTGIYDSGLLQNSEEITLETPYGKTSDTITIGNFQGRNIAFMPRHGKKHSIPPHLINYRANIWAFKELGIKGILAPSAVGSLKEEIKPGNFVLPSQFIDFTKSRKNSFSEDGKVIHISVAEPFCPELQKIVSSVAENVGLTMHENCIYACIEGPRFSTKAESRFYKSTGSDIIGMTLVPECQLAREAQICYVSISTVTDYDVWAEKPVTAKEVMDTLSKNVKVTKKLLKELFDKIPTDFASKRTCSCEKALTEAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA2</accession>
    <name>A0A087RPA2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">AAA799O18_00029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.27"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFM15306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="246" mass="27171" checksum="17D66D6287A1CD47" modified="2014-10-29" version="1">MTKFKTRIHKSSTQSRIILANDYDTLDEKLVPHTIRNIKTLHKYLCAIKLNFHLLLPLGKKEIARINKTAHQYGLQTIADVKLNDIGNTNEIATNALWSFGFDAVIVNPIMGLESLKKIVTVAHRQDKGVIALCHMSAPEAKTSYNINVKSSNNSKTKPLYQLFLKWAISSKADGIIVGATFPRIISNCKKITGKKLNIYSPGIGTQGGKAKETISNGSDFLIVGRTILNSKDPVNTVKQLQLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA7</accession>
    <name>A0A087RPA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.33"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="69" mass="7709" checksum="12D44D5D36560EA7" modified="2014-10-29" version="1">MKIKCPKCKENAELTPDFSLVACTKCDLEMSYGEYVRYIAHADSTYSDILGDYTGSTEGEKAGTLDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPA8</accession>
    <name>A0A087RPA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AAA799O18_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFM15312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="212" mass="23371" checksum="52B24B1B57515D1E" modified="2014-10-29" version="1">MEFLHESVLNLVGLAVGIIIGCISYFGFKNTGSPTLFRLSIAFIAIGIGFGILAFGYILDDSVTQTGKINRGITTLGVASQAVGYWFIAFSHTIKTFFPKSRYLRSVGIMPLFLVSFVSVEHILRAVSFILLVYGSIETMISYLNGKKKTTLFVAVGLALLGFGEFVSWYSFVFPETILYVGSIIIKICGLFSLGIPIFKIPLRKITFDENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB3</accession>
    <name>A0A087RPB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AAA799O18_00040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFM15317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="112" mass="12945" checksum="57AB464726BB4379" modified="2014-10-29" version="1">MDRIKLLSMKVLKENKEKFGIDFDQNKNTLNDITTIRSKPLRNKLAGYITRFLKNEKIELEKAKNMEMQEQAEDQNELADLDTEPASKKTVTVERTKSHDDKASTKDAEVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPB8</accession>
    <name>A0A087RPB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="213" mass="25505" checksum="DB3FAE0D7636B114" modified="2014-10-29" version="1">MIRYIYTQHDFVILSSDSPAKWFDDLIGVAYRYYDLRMNLVPLFHDFKQAQTFWRETIKWWNDHSIKIRFVETGNNYWFIMGAESTRVENNRFLFKILPISSHYERFKKGHEGTAFLRLGVYTKKYKKDVKNDAKCDCGHIKEDHAEEKDDDSCLFEDCDCKKFESFQINLLKKKKTVTDIKFLTEVEIKEDVLAWNCLSVNKYSKKEKDADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPC8</accession>
    <name>A0A087RPC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="3">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AAA799O18_00065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.56"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFM15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="255" mass="27528" checksum="8A17ECD347DA176B" modified="2014-10-29" version="1">MSSMTPKKIGDYKYQIDADSSIGMKVPVTIYADEKLLNKMMTDRTIKQAVNVSTLPGIQEHAIVLPDGHEGYGFPVGGVAAMDAEEGMISPGGVGYDINCGVRLLRTNLSEDNVRQKLKDLVTDLFNSIPSGVGSKGAIRLNPSQLDEVLVRGVSWAVDHGYGSNDDADVCEENGQIANADPNRVSDRARKRGSPQLGSLGSGNHFLEVQKVAEIHDEEAAKRMGIKKDSVTVLIHCGSRGFGHQVCSDYLRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPE5</accession>
    <name>A0A087RPE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="119" mass="14105" checksum="930A2A8485086C68" modified="2014-10-29" version="1">MVGLLSYPKRKLKKLIKEGEYKAAVDFGNTMEEEYRYDPDFLFIMAGIFYILEDAKKTLHYVDRVLEINEFDTDALALKLRIHQYFKENDRVIDCCKRILKIDSDAYEVRDILNKLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF2</accession>
    <name>A0A087RPF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="107" mass="12651" checksum="5CA09E52644E12C1" modified="2014-10-29" version="1">MDEKIEKIMQEKIHETMGKKNQIKLLIKLLPFYEPEDPDDDSYTVSPTTAFGYGIVIGRLYNSFYYQTRRVLKRQPTSDEFTDFIEFINKQHTLWEDLGSLDDPLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF3</accession>
    <name>A0A087RPF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.82"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="144" mass="16455" checksum="3E0F091E49753B2B" modified="2014-10-29" version="1">MANKEIKQLLERVHKDIGVIDFNGKNVPRIILTDRRFDEIMSKISGKPVSVNTDLNILQDGLGHVFVEIILNFSSGDIHEEFLIYANDSVEFFESLANTTMFALSPPQYSEVNQDKIFMVQLPKPEKAFQALEMIKNGIQKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPF5</accession>
    <name>A0A087RPF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.84"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="212" mass="24103" checksum="601090C9213F299D" modified="2014-10-29" version="1">MCDKTDSKKIPDISPLLKNLDNIKSEFVTLREYVGSSADELEEKISGVIEMLDRSNASSAEFHKKADSIIQELQKIRNAANKASSTTSKEVIGLLKLSEYQSNIRMQAESKYGSLQDIEKMAEQTAEIVNVFDKLSIESENKIPLPHEVRQWAINTIIDCADRWEIRFADVFNRLLESLGKNLLKESIRIQQVRDIFGTRAVDQIKNELDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH4</accession>
    <name>A0A087RPH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L13P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AAA799O18_00121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.103"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFM15378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="137" mass="15531" checksum="6A266808D9DB3C4A" modified="2014-10-29" version="1">MDGTNHIAGRLSSNVAKLLLQGNRVTIINSDKIMISGEKNSIVGEYKDFLRIASILHPKHGPFHPRRPDTIISRMIRGMLPRKKPSGKEALKRLRAYVGAPKELKTFKKIQFEKARIRKSSAYYVSMSELSKNVGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPH5</accession>
    <name>A0A087RPH5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps9</name>
        <name evidence="7" type="ORF">AAA799O18_00122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1502294.3.peg.104"/>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFM15379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="147" mass="16793" checksum="B19093F6B6D724D1" modified="2014-10-29" version="1">MARDEIYFATRKTAKAHVYITKGNGKIRINNVPIEMFQPKIAQEVILIPIEISEDLRNKVNISVRVRGGGFMGQAYASASGISRALIGWTKNKKDVKEHPFTKSQRNILKTKIDEFDRYLIKGDARRKEPKKFGGPGARTRKQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A087RPI6</accession>
    <name>A0A087RPI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AAA799O18_00133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marine Group I thaumarchaeote SCGC AAA799-O18</name>
        <dbReference type="NCBI Taxonomy" id="1502294"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Thaumarchaeota incertae sedis</taxon>
            <taxon>Marine Group I</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ngugi D.K."/>
                <person name="Blom J."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Baalawi W."/>
                <person name="Zhang G."/>
                <person name="Hikmawan T."/>
                <person name="Guan Y."/>
                <person name="Antunes A."/>
                <person name="Siam R."/>
                <person name="El-Dorry H."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC AAA799-O18</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JOTC01000001">
        <property type="protein sequence ID" value="KFM15390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000031363">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFM15390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000031363"/>
        </source>
    </evidence>
    <sequence length="86" mass="9725" checksum="A05DFB2F12F35849" modified="2014-10-29" version="1">MLPDKCSIREENRNCVNPPEYVITVISNDDQFMLGITCEKHKASVFSKIESLQNQGKVPKGTIKFENLKSVQTDCIRGDPDDLIQL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>